{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:26:43Z","timestamp":1792632403682,"version":"4.5.0"},"reference-count":135,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> The aim of this study is to uncover the traditional Chinese medicine (TCM) treatments for chronic gastritis and their potential targets and pathways involved in the \u201cinflammation-cancer\u201d conversion in four stages. These findings can provide further support for future research into TCM and its active components.<\/jats:p><jats:p><jats:bold>Materials and methods:<\/jats:bold> The literature search encompassed PubMed, Web of Science, Google Scholar, CNKI, WanFang, and VIP, employing keywords such as \u201cchronic gastritis\u201d, \u201cgastric cancer\u201d, \u201ctraditional Chinese medicine\u201d, \u201cmedicinal herb\u201d, \u201cChinese herb\u201d, and \u201cnatural plant\u201d.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Herbal remedies may regulate the signaling pathways linked to the advancement of chronic gastritis. Under the multi-target and multi-pathway independent or combined reaction, the inflammatory microenvironment may be enhanced, leading to repair of damaged gastric mucosal cells, buffering the progress of mucosal atrophic degeneration via the decrease of inflammatory factor expression, inhibition of oxidative stress-induced damage, facilitation of microvascular neovascularization in the gastric mucosa and regulation of the processes of gastric mucosal cell differentiation and proliferation. Simultaneously, the decreased expression of inflammatory factors may impact the expression of associated oncogenes and regulate the malignant proliferation of cells, thereby achieving the treatment and prevention objectives of gastric cancer through the reduction of cell metastasis and apoptosis.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Chinese medicine formulations and individual drugs can be utilised at various stages of the \u201cinflammation-cancer\u201d progression of chronic gastritis to prevent and treat gastric cancer in a multi-level, multi-targeted, and multi-directional fashion. This can provide guidance for the accurate application of medicines during different stages of \u201cinflammation-cancer\u201d transformation. New insights into the mechanism of inflammation-cancer transformation and the development of novel drugs for chronic gastritis can be gained through an extensive investigation of TCM treatment in this condition.<\/jats:p>","DOI":"10.3389\/fphar.2024.1338471","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T05:09:03Z","timestamp":1713416943000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Research on the signaling pathway and the related mechanism of traditional Chinese medicine intervention in chronic gastritis of the \u201cinflammation-cancer transformation\u201d"],"prefix":"10.3389","volume":"15","author":[{"given":"Wang","family":"Yan-Rui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xue-Er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Mao-Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ya-Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Bo-Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhai","family":"Miao-Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.3389\/fonc.2020.01312","article-title":"Therapeutic implications of epidermal growth factor receptor (EGFR) in the treatment of metastatic gastric\/GEJ cancer","volume":"10","author":"Adashek","year":"2020","journal-title":"Front. Oncol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.semcancer.2019.07.009","article-title":"PI3K\/Akt\/mTOR inhibitors in cancer: at the bench and bedside","volume":"59","author":"Alzahrani","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"867","DOI":"10.13633\/j.cnki.zjtcm.2019.12.010","article-title":"Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis","volume":"39","author":"Bai","year":"2019","journal-title":"J. Tradit. Chin. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00262-013-1468-9","article-title":"Chronic inflammation and cancer: suppressing the suppressors","volume":"63","author":"Baniyash","year":"2014","journal-title":"Cancer Immunol. Immunother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0016-5085(93)90011-z","article-title":"Localization of transforming growth factor beta isoforms in the normal murine small intestine and colon","volume":"105","author":"Barnard","year":"1993","journal-title":"Gastroenterology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"B7","doi-asserted-by":"publisher","first-page":"424","DOI":"10.19378\/j.issn.1003-9783.2017.04.003","article-title":"Investigation of the mechanism of gastric plasmapheresis to reverse the EMT effect in gastric mucosa of rats with GPL based on TGF-\u03b2\/Smads signaling pathway","volume":"28","author":"Cai","year":"2017","journal-title":"New Chin. Med. Clin. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.13286\/j.1001-5213.2021.14.05","article-title":"An experimental study on the treatment of chronic atrophic gastritis with Picrasidine","volume":"41","author":"Cai","year":"2021","journal-title":"Chin. J. Hosp. Pharm."},{"key":"B9","article-title":"The effect of regulating the IL-23\/IL-17 signaling pathway with \u201cxiaojianzhong\u201d decoction on the rat of spleen-stomach deficient cold pattern of chronic non-atrophic gastritis","author":"Cao","year":"2018","journal-title":"Master, Shaanxi Univ. Chin. Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"107213","DOI":"10.1016\/j.intimp.2020.107213","article-title":"Gentiopicroside ameliorates ethanol-induced gastritis via regulating MMP-10 and pERK1\/2 signaling","volume":"90","author":"Chang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.3969\/j.issn.1008-0805.2018.11.027","article-title":"Regulative mechanism of renal inflammatory-related p38MAPK signaling pathway in diabetic nephropathy and interventional effects of Chinese herbal medicine","volume":"38","author":"Chen","year":"","journal-title":"Chin. J. Traditional Chin. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.13935\/j.cnki.sjzx.220819","article-title":"Recent therapeutic efficacy and mechanism of action of gualou xiebai banxia decoction flavored for the treatment of chronic atrophic gastritis","volume":"17","author":"Chen","year":"2022","journal-title":"World J. Integr. Med."},{"key":"B13","first-page":"2641","article-title":"Effects of traditional Chinese medicine Weiwei Kang on the expression of GLi protein in gastric mucosa of rats with chronic atrophic gastritis","volume":"29","author":"Chen","year":"","journal-title":"Lishizhen Med. Materia Medica Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.4268\/cjcmm20130721","article-title":"Effects of sapindus saponins on inflammatory response mediated by Ang II\/p38MAPK pathway and cardiac hypertrophy in spontaneously hypertensive rats","volume":"38","author":"Chen","year":"","journal-title":"Chin. J. Traditional Chin. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"14455","DOI":"10.1074\/jbc.RA118.003279","article-title":"The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer","volume":"293","author":"Chen","year":"","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"173267","DOI":"10.1016\/j.ejphar.2020.173267","article-title":"Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17\/EGFR","volume":"882","author":"Chen","year":"","journal-title":"Eur. J. Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.13288\/j.11-2166\/r.2020.18.015","article-title":"Effects of Xiaopi granules on miR-21-PTEN-PI3K\/AKT signaling pathway in gastric mucosa tissue of rats with gastric precancerous lesion model","volume":"61","author":"Chen","year":"","journal-title":"J. Traditional Chin. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1002\/cncr.10589","article-title":"beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer","volume":"62","author":"Clements","year":"2002","journal-title":"Cancer Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1093\/carcin\/bgp127","article-title":"Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability","volume":"30","author":"Colotta","year":"2009","journal-title":"Carcinogenesis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1042\/bj20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"B21","first-page":"21","article-title":"Effects of Shengyang Yiwei decoction on Wnt2 and \u03b2-catenin expressions in gastric tissue of mice with chronic gastritis","volume":"30","author":"Dilinaer","year":"2023","journal-title":"China Sci. Technol. Traditional Chin. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.13699\/j.cnki.1001-6821.2020.22.045","article-title":"Effects of astragalus polysaccharide on protein tyrosine kinase 1\/signal transducer and activator 3 signaling pathway in rats with chronic atrophic gastritis","volume":"36","author":"Dong","year":"2020","journal-title":"Chin. J. Clin. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.19879\/j.cnki.1005-5304.202004257","article-title":"Effects of Xiangsha Liujunzi decoction on PI3K signaling pathway correlation factor expression in gastric tissue of rats with chronic atrophic gastritis","volume":"27","author":"Duan","year":"2020","journal-title":"China J. Chin. Med. Inf."},{"key":"B24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.13729\/j.issn.1671-7813.Z20201493","article-title":"Effect of Jianpi Qinghua sanyu decoction on expressions of TXNDC5, NOX2, NF - \u03baB and TNF - \u03b1 in mucosa of rats with chronic atrophic gastritis","volume":"35","author":"Gao","year":"2021","journal-title":"J. Pract. TRADITIONAL Chin. Intern. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"B26","doi-asserted-by":"publisher","first-page":"116345","DOI":"10.1016\/j.jep.2023.116345","article-title":"Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia","volume":"309","author":"Han","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1158\/1535-7163.Mct-11-0682","article-title":"An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis","volume":"11","author":"Hanaki","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1097\/00029330-200712010-00008","article-title":"Inhibition of the proliferation of human gastric cancer cells SGC-7901 in vitro and in vivo using Bcl-2 siRNA","volume":"120","author":"Hao","year":"2007","journal-title":"Chin. Med. J. Engl."},{"key":"B29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.19879\/j.cnki.1005-5304.202007494","article-title":"Effects of huazhuo jiedu formula on the expression of Hippo signaling pathway related proteins RASSF1A, SAV1 and MST2 in rats with chronic atrophic gastritis","volume":"28","author":"Hao","year":"2021","journal-title":"China J. Traditional Chin. Med. Inf."},{"key":"B30","first-page":"93","article-title":"Efficacy of Huanglian Wenbian Tang combined with bismuth quadruple therapy in the treatment of Hpylori-associated chronic gastritis with damp-heat syndrome of spleen and stomach and its effect on the expression of TGF-\u03b21 and Smad3 in gastric mucosa","volume":"39","author":"He","year":"2021","journal-title":"Sichuan Tradit. Chin. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"a002915","DOI":"10.1101\/cshperspect.a002915","article-title":"Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling","volume":"2","author":"Heuberger","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jep.2018.09.015","article-title":"An ethanol extract of the rhizome of Atractylodes chinensis exerts anti-gastritis activities and inhibits Akt\/NF-\u03baB signaling","volume":"228","author":"Hossen","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"111465","DOI":"10.1016\/j.biopha.2021.111465","article-title":"Physiological and pathophysiological roles of acidic mammalian chitinase (CHIA) in multiple organs","volume":"138","author":"Hu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"738","DOI":"10.16295\/j.cnki.0257-358x.2022.07.008","article-title":"Study on the effect and mechanism of gastric safety and pylorus removing soup on hp-positive chronic gastritis","volume":"41","author":"Hu","year":"2022","journal-title":"Shandong J. Traditional Chin. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3760\/cma.j.issn.1673-4246.2019.02.013","article-title":"Effects of shidan granules on NF-\u03baB signaling pathway in rats with chronic atrophic gastritis with alloplastic hyperplasia model","volume":"41","author":"Hua","year":"2019","journal-title":"Int. J. Traditional Chin. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3969\/j.issn.1000-7156.2016.02.024","article-title":"Effects of Wang\u2019s Lianpu decoction on the expression of IL-6 and NF-\u03bab in gastric mucosa of rats with gastric precancerous lesions caused by dampness and heat in spleen and stomach","volume":"32","author":"Huang","year":"2016","journal-title":"Shanxi Tradit. Chin. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5085","DOI":"10.3748\/wjg.v19.i31.5085","article-title":"Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways","volume":"19","author":"Huang","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1177\/0192623311428477","article-title":"Cellular regulation of the inflammatory response","volume":"40","author":"Janssen","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"5606","DOI":"10.1158\/0008-5472.Can-11-1194","article-title":"TGF-\u03b2\/SMAD\/GLI2 signaling axis in cancer progression and metastasis","volume":"71","author":"Javelaud","year":"2011","journal-title":"Cancer Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5742","DOI":"10.1038\/sj.onc.1208928","article-title":"Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis","volume":"24","author":"Javelaud","year":"2005","journal-title":"Oncogene"},{"key":"B41","doi-asserted-by":"publisher","first-page":"117064","DOI":"10.1016\/j.lfs.2019.117064","article-title":"Baicalin protects against ethanol-induced chronic gastritis in rats by inhibiting Akt\/NF-\u03baB pathway","volume":"239","author":"Ji","year":"2019","journal-title":"Life Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"6857","DOI":"10.2147\/jir.S390448","article-title":"Analysis of staged features of gastritis-cancer transformation and identification of potential biomarkers in gastric cancer","volume":"15","author":"Jia","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"184","DOI":"10.19367\/j.cnki.1000-2707.2019.02.012","article-title":"Effects of the seedling medicine Polygonum cepa on the signaling pathway of TLRs in Helicobacter pylori infected gastritis cells","volume":"44","author":"Jiang","year":"2019","journal-title":"J. Guizhou Med. Univ."},{"key":"B44","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3969\/j.issn.1671-038X.2020.08.09","article-title":"Exploring the effects of Weiwei granules on patients with gastric precancerous lesions based on serum gastric function 3 items and Wnt\/\u03b2-catenin signaling pathway-related proteins","volume":"28","author":"Kang","year":"2020","journal-title":"Chin. J. Integr. Med. Dig."},{"key":"B45","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/coa.13724","article-title":"Narrow-band imaging for screening of oral premalignant or cancerous lesions: a systematic review and meta-analysis","volume":"46","author":"Kim","year":"2021","journal-title":"Clin. Otolaryngol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.3969\/j.issn.1000-7369.2023.10.025","article-title":"Professor Cao Zhiqun\u2019s experience of preventing and treating \u201cinflammation cancer transformation\u201d of chronic atrophic gastritis from the aspects of deficiency,stasis and poison","volume":"44","author":"Kong","year":"2023","journal-title":"Shanxi J. Traditional Chin. Medcine"},{"key":"B47","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"key":"B48","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3969\/j.issn.1671-038X.2017.04.12","article-title":"Effects of Banxia xiexin decoction on NF-\u03baB\/STAT3 signaling pathway in gastric mucosal tissues of rats with gastric precancerous lesions","volume":"25","author":"Li","year":"2017","journal-title":"Chin. J. Integr. Med. Dig."},{"key":"B49","first-page":"37","article-title":"Effects of gastric atrophy soup combined with cimetidine on gastric mucosal repair and Wnt pathway expression in rats with chronic atrophic gastritis model","volume":"37","author":"Li","year":"2019","journal-title":"Sichuan Tradit. Chin. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"291","DOI":"10.11569\/wcjd.v29.i6.291","article-title":"Modified Banxia Xiexin decoction for treatment of precancerous lesions of atrophic gastritis: efficacy and influence on TGF -\u03b21\/Smads signaling pathway","volume":"29","author":"Li","year":"","journal-title":"World Chin. Dig. J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4905089","DOI":"10.1155\/2018\/4905089","article-title":"Confirming the effects of qinghuayin against chronic atrophic gastritis and a preliminary observation of the involved inflammatory signaling pathways: an in vivo study","volume":"2018","author":"Li","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3969\/j.issn.1006-2157.2021.02.009","article-title":"Effects of spleen-strengthening, cleansing, and relaxing traditional Chinese medicine on SonicHedgehog signaling pathway in rats with chronic atrophic gastritis","volume":"44","author":"Li","year":"","journal-title":"J. Beijing Univ. Chin. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.13699\/j.cnki.1001-6821.2021.16.026","article-title":"Study on the mechanism of action of Gualou xiebai banxia decoction with added flavor on rats with chronic atrophic gastritis","volume":"37","author":"Li","year":"","journal-title":"Chin. J. Clin. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3969\/j.issn.1672-8467.2015.05.007","article-title":"Effects of astragaloside on rats with chronic atrophic gastritis","volume":"42","author":"Li","year":"2015","journal-title":"Fudan J. Med. Ed."},{"key":"B55","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3760\/cma.j.cn231536-20201031-00110","article-title":"MAPK\/ERK signaling pathway and malignant phenotype of gastric cancer","volume":"43","author":"Li","year":"2020","journal-title":"Int. J. Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.19540\/j.cnki.cjcmm.20221126.503","article-title":"Thoughts of treatment of tumor diseases based on toxic pathogen theory","volume":"48","author":"Liao","year":"2023","journal-title":"China J. Chin. materia medica"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.4268\/cjcmm20161623","article-title":"Effects of Xiangsha Liujunzi decoction on TLR signal pathway in gastric mucosa tissues of rats with Helicobacter pylori-induced chronic atrophic gastritis","volume":"41","author":"Lin","year":"2016","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.3969\/j.issn.1008-8849.2022.19.003","article-title":"Effects of Yiguan decoction on thyroid function and TGF-\u03b21\/Smad pathway in rats with chronic atrophic gastritis with precancerous lesions","volume":"31","author":"Lin","year":"2022","journal-title":"Mod. J. Integr. Chin. West. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"","journal-title":"Signal Transduct. Target Ther."},{"key":"B60","doi-asserted-by":"publisher","first-page":"19","DOI":"10.13286\/j.1001-5213.2022.01.04","article-title":"Protective effect of Bacitracinol against Helicobacter pylori-induced gastritis in mice","volume":"42","author":"Liu","year":"","journal-title":"Chin. J. Hosp. Pharmacol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.3969\/j.issn.1005-9202.2019.11.056","article-title":"Effects of coerulein granules on NF-\u03baB signal transduction pathway in rats with chronic non-atrophic gastritis","volume":"39","author":"Liu","year":"2019","journal-title":"Chin. J. Gerontology"},{"key":"B62","article-title":"Study on the molecular mechanism of mTOR\/HIF--1\u03b1\/SIRT6 signaling pathway mediated aerobic glycolysis in gastric precancerous lesions mediated by gastropancreatin","author":"Liu","year":"2020","journal-title":"Guangzhou Univ. Traditional Chin. Med"},{"key":"B63","first-page":"1431","article-title":"Thinking and strategy of traditional Chinese medicine in regulating the precancerous microenvironment of gastric \u2018inflammation-cancer transformation","volume":"38","author":"Liu","year":"","journal-title":"CJTCMP"},{"key":"B64","doi-asserted-by":"publisher","first-page":"560","DOI":"10.12360\/CPB202205055","article-title":"Exploring the mechanism of Jiawei danggui shaoyao powder for the treatment of chronic atrophic gastritis based on network pharmacology and experimental validation","volume":"39","author":"Liu","year":"","journal-title":"Chin. Pharmacol. Bull."},{"key":"B65","doi-asserted-by":"publisher","first-page":"812","DOI":"10.13463\/j.cnki.jlzyy.2022.07.018","article-title":"Effect of modified Shashen Maidong Decoction on rats with chronic atrophic gastritis by regulating EGFR\/MAPK signaling pathway","volume":"42","author":"Liu","year":"","journal-title":"Jilin J. Chin. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"112","DOI":"10.20116\/j.issn2095-0616.2023.17.26","article-title":"Exploration of the treatment of chronic atrophic gastritis based on the three causes differentiation of \"deficiency, toxin, and stasis","volume":"13","author":"Ma","year":"2023","journal-title":"CHINA Med. Pharm."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3219001","DOI":"10.1155\/2022\/3219001","article-title":"Curcumol undermines SDF-1\u03b1\/CXCR4\/NF-\u03baB signaling pathway to suppress the progression of chronic atrophic gastritis (CAG) and gastric cancer","volume":"2022","author":"Ma","year":"","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"898680","DOI":"10.3389\/fphar.2022.898680","article-title":"Metabolomics profiles associated with the treatment of zuojin pill on patients with chronic nonatrophic gastritis","volume":"13","author":"Ma","year":"","journal-title":"Front. Pharmacol."},{"key":"B69","first-page":"3838","article-title":"Screening of effective sites of galangal against Helicobacter pylori-associated gastritis and inhibition of NF-\u03baB signaling pathway","volume":"36","author":"Ma","year":"2021","journal-title":"Chin. J. Traditional Chin. Med."},{"key":"B70","article-title":"Effect of the traditional Chinese medicine Weifuchun on regulating atrophic gastritis through RUNX 3\/TGF-beta\/Smad signaling pathway","author":"Ma","year":"2018"},{"key":"B71","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.lfs.2010.04.010","article-title":"Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG","volume":"86","author":"Manikandan","year":"2010","journal-title":"Life Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1158\/1078-0432.Ccr-15-0946","article-title":"Prognostic utility of molecular factors by age at diagnosis of colorectal cancer","volume":"22","author":"McCleary","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jcmgh.2017.01.004","article-title":"Hedgehog signaling links chronic inflammation to gastric cancer precursor lesions","volume":"3","author":"Merchant","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/path.2785","article-title":"The dynamic roles of TGF-\u03b2 in cancer","volume":"223","author":"Meulmeester","year":"2011","journal-title":"J. Pathol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ccell.2018.07.009","article-title":"Notch signaling in the tumor microenvironment","volume":"34","author":"Meurette","year":"2018","journal-title":"Cancer Cell."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"key":"B77","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/cas.13423","article-title":"Involvement of local renin-angiotensin system in immunosuppression of tumor microenvironment","volume":"109","author":"Nakamura","year":"2018","journal-title":"Cancer Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.13241\/j.cnki.pmb.2021.08.007","article-title":"Effects of baicalin on OPG\/RANKL axis in mice modeling chronic atrophic gastritis","volume":"21","author":"Niu","year":"2021","journal-title":"Adv. Mod. Biomed."},{"key":"B79","first-page":"115","article-title":"Effect of GastroSu granules on the expression of TFF2 and NF-\u03baB in gastric mucosa of patients with chronic atrophic gastritis","volume":"29","author":"Pan","year":"2019","journal-title":"Zhejiang J. Integr. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.jfma.2020.01.003","article-title":"Is chronic atrophic gastritis the missing link between atrophic glossitis, gastric parietal cell antibody positivity and hematological deficiencies?","volume":"119","author":"Pellicano","year":"2020","journal-title":"J. Formos. Med. Assoc."},{"key":"B81","doi-asserted-by":"publisher","first-page":"e2112","DOI":"10.7717\/peerj.2112","article-title":"Aberrant methylation of PCDH10 and RASSF1A genes in blood samples for non-invasive diagnosis and prognostic assessment of gastric cancer","volume":"4","author":"Pimson","year":"2016","journal-title":"PeerJ"},{"key":"B82","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1158\/1078-0432.Ccr-14-0809","article-title":"Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer","volume":"21","author":"Previs","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3969\/j.issn.1006-5709.2006.01.006","article-title":"Expression of factor-\u03baB and epidermal growth factor receptor in gastric cancer and precancerous lesions","author":"Pu","year":"2006","journal-title":"J. Gastroenterology Hepatology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.16016\/j.1000-5404.202103002","article-title":"In vitro experimental study on the inhibition of human gastric cancer cells by Wuzhuine via MAPK signaling pathway","volume":"43","author":"Qian","year":"2021","journal-title":"J. Third Mil. Med. Univ."},{"key":"B85","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.intimp.2017.09.011","article-title":"The effect of Astragaloside IV on ethanol-induced gastric mucosal injury in rats: involvement of inflammation","volume":"52","author":"Qin","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1359\/jbmr.2003.18.10.1842","article-title":"BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop","volume":"18","author":"Rawadi","year":"2003","journal-title":"J. Bone Min. Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2058738418759180","DOI":"10.1177\/2058738418759180","article-title":"Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblasts","volume":"32","author":"Ren","year":"2018","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"210736","DOI":"10.1155\/2013\/210736","article-title":"AP-1\/IRF-3 targeted anti-inflammatory activity of andrographolide isolated from andrographis paniculata","volume":"2013","author":"Shen","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"4782","DOI":"10.19540\/j.cnki.cjcmm.20210521.401","article-title":"Study on the protective effect of total triterpenes of papaya against Helicobacter pylori-induced gastritis in mice","volume":"46","author":"Shi","year":"2021","journal-title":"Chin. J. Traditional Chin. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jtcm.2018.03.001","article-title":"Jinghua Weikang capsule protects against Helicobacter pylori-induced inflammatory responses via the nuclear factor-kappa B signaling pathway","volume":"38","author":"Shi","year":"2018","journal-title":"J. Tradit. Chin. Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"266","DOI":"10.13463\/j.cnki.cczyy.2013.02.041","article-title":"Study on the mechanism of traditional Chinese medicine reversing multi-drug resistance of gastric cancer cells","volume":"29","author":"Shu","year":"2013","journal-title":"J. Changchun Univ. Traditional Chin. Med."},{"key":"B92","first-page":"1308","article-title":"Akt-Mdm2-P53 mechanism of chronic atrophic gastritis in rats treated with Weiwei kang","volume":"40","author":"Song","year":"2020","journal-title":"Chin. J. Gerontology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"473","DOI":"10.13463\/j.cnki.cczyy.2020.03.020","article-title":"Mechanism of action of Xiefuning granules on chronic non-atrophic gastritis in rats based on JAK2\/STAT3 axis","volume":"36","author":"Sun","year":"","journal-title":"J. Changchun Univ. Traditional Chin. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.6039\/j.issn.1001-0408.2020.11.05","article-title":"Effects of Zhitong shunqi capsule on JAK\/STAT signaling pathway in rats with chronic atrophic gastritis model","volume":"31","author":"Sun","year":"","journal-title":"China Pharm."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.3977\/j.issn.1005-8478.2012.23.13","article-title":"Research progress of NF-\u03baB signaling pathway and intervertebral disc degeneration","volume":"20","author":"Sun","year":"2012","journal-title":"Chin. J. Orthop. Surg."},{"key":"B96","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.3969\/j.issn.1000-7369.2022.11.003","article-title":"Exploring the mechanism of Xiangren WeiShu decoction for the treatment of chronic non-atrophic gastritis in rats based on the JAK2\/STAT3 signaling pathway","volume":"43","author":"Tang","year":"2022","journal-title":"Shanxi Tradit. Chin. Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"37","DOI":"10.13729\/j.issn.1671-7813.Z20210805","article-title":"Discussion on molecular mechanism of compound gastritis mixture inhibiting progress of chronic atrophic gastritis from JAK1\/STAT3 signaling pathway","volume":"35","author":"Tian","year":"2021","journal-title":"J. Pract. TRADITIONAL Chin. Intern. Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"113893","DOI":"10.1016\/j.jep.2021.113893","article-title":"Zuojin Pill ameliorates chronic atrophic gastritis induced by MNNG through TGF-\u03b21\/PI3K\/Akt axis","volume":"271","author":"Tong","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nri3902","article-title":"Immunological hallmarks of stromal cells in the tumour microenvironment","volume":"15","author":"Turley","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1136\/gut.51.5.628","article-title":"Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract","volume":"51","author":"Van den Brink","year":"2002","journal-title":"Gut"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.13463\/j.cnki.cczyy.2021.06.026","article-title":"Effect of Hewei fanliu Kang on the expression of p38MAPK protein and COX-2 mRNA in gastric mucosa of rats with bile reflux gastritis","volume":"37","author":"Wang","year":"2021","journal-title":"J. Changchun Univ. Traditional Chin. Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1089\/dna.2017.3922","article-title":"miR-21 inhibitors modulate biological functions of gastric cancer cells via PTEN\/PI3K\/mTOR pathway","volume":"37","author":"Wang","year":"2018","journal-title":"DNA Cell. Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.13863\/j.issn1001-4454.2016.06.043","article-title":"Effects of wogonin on Apoptosis,Invasion,Migration and wnt\/\u03b2-catenin signaling pathway of gastric cancer cells SGC7901","volume":"39","author":"Wang","year":"2016","journal-title":"Zhong Yao Cai"},{"key":"B105","doi-asserted-by":"publisher","first-page":"93","DOI":"10.12677\/hjbm.2023.131010","article-title":"The role of Hippo\/YAP pathway in the crosstalk of tumor cell signaling pathways","volume":"13","author":"Wang","year":"2023","journal-title":"Hans J. Biomed."},{"key":"B106","doi-asserted-by":"publisher","first-page":"109570","DOI":"10.1016\/j.biopha.2019.109570","article-title":"Antitumor effects of immunity-enhancing traditional Chinese medicine","volume":"121","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.13192\/j.issn.1000-1719.2018.05.059","article-title":"Effects of an Gastric Tang on PI3K\/Akt signaling pathway in rats with chronic atrophic gastritis","volume":"45","author":"Wei","year":"2018","journal-title":"Liaoning J. Chin. Med."},{"key":"B108","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3969\/j.issn.1006-2157.2015.02.006","article-title":"Effects of Yiqi Huayu Jiedu method on EGFR\/MAPK signal pathway in rats with chronic atrophic gastritis exhibiting dysplasia","volume":"38","author":"Wei","year":"2015","journal-title":"J. Beijing Univ. Traditional Chin. Med."},{"key":"B109","doi-asserted-by":"publisher","first-page":"e66014","DOI":"10.7554\/eLife.66014","article-title":"Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses","volume":"10","author":"Wilmes","year":"2021","journal-title":"Elife"},{"key":"B110","doi-asserted-by":"publisher","first-page":"19863","DOI":"10.18632\/oncotarget.7887","article-title":"Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"key":"B111","doi-asserted-by":"publisher","first-page":"576","DOI":"10.3781\/j.issn.1000-7431.2006.06.020","article-title":"Progress of PI3K\/Akt signaling pathway in malignant tumors","author":"Xia","year":"2006","journal-title":"Cancer"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.16333\/j.1001-6880.2022.11.002","article-title":"Study on the mechanism of action of Rhizoma Coptidis and Rhizoma Pinelliae in the treatment of chronic atrophic gastritis","volume":"34","author":"Xiang","year":"2022","journal-title":"Nat. Prod. Res. Dev."},{"key":"B113","doi-asserted-by":"publisher","first-page":"60","DOI":"10.13523\/j.cb.20101011","article-title":"Advances in human Toll-like receptor-targeted drug research","volume":"30","author":"Xin","year":"2010","journal-title":"Chin. J. Bioeng."},{"key":"B114","doi-asserted-by":"publisher","first-page":"120266","DOI":"10.1016\/j.lfs.2021.120266","article-title":"Berberine inhibits gastric cancer development and progression by regulating the JAK2\/STAT3 pathway and downregulating IL-6","volume":"290","author":"Xu","year":"2022","journal-title":"Life Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"878","DOI":"10.3892\/etm.2021.10310","article-title":"Jianpiyiqi formula ameliorates chronic atrophic gastritis in rats by modulating the Wnt\/\u03b2-catenin signaling pathway","volume":"22","author":"Yan","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B116","first-page":"4800","article-title":"Effects of Jianpi Yiqi Formula on expression of PI3K-Akt signaling pathway in gastric tissue of rats with chronic atrophic gastritis","volume":"34","author":"Yan","year":"2019","journal-title":"China J. Traditional Chin. Med."},{"key":"B117","volume-title":"Basic theory of traditional Chinese medicine","author":"Yang","year":"2021"},{"key":"B118","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.3390\/ijms22073385","article-title":"Evodiamine inhibits Helicobacter pylori growth and Helicobacter pylori-induced inflammation","volume":"22","author":"Yang","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"118903","DOI":"10.1016\/j.lfs.2020.118903","article-title":"Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis","volume":"266","author":"Yang","year":"","journal-title":"Life Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"391","DOI":"10.16073\/j.cnki.cjcpt.2010.05.013","article-title":"Advances in the study of P53 and NF-\u03baB and gastric cancer","volume":"17","author":"Yang","year":"2010","journal-title":"Chin. J. Tumor Control"},{"key":"B121","first-page":"34","article-title":"Effects of Shuang Pu San on TGF-\u03b21\/Smad3 signaling pathway in gastric mucosa cells of rats with chronic atrophic gastritis","volume":"47","author":"Yang","year":"2016","journal-title":"Jiangxi Tradit. Chin. Med."},{"key":"B122","first-page":"41","article-title":"Analysis of the intervention effect of Chai Shao Liu Jun Tang plus reduction on rats with chronic atrophic gastritis based on NF-\u03baB signaling pathway","volume":"40","author":"Yi","year":"2022","journal-title":"Sichuan Tradit. Chin. Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"88","DOI":"10.13422\/j.cnki.syfjx.20230499","article-title":"Exploring the mechanism of action of atrophic gastric tonic soup on chronic atrophic gastritis in rats based on NF-\u03baB signaling pathway","volume":"29","author":"You","year":"2023","journal-title":"Chin. J. Exp. Formulary"},{"key":"B124","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.3390\/nu12082355","article-title":"Protective effects of wheat peptides against ethanol-induced gastric mucosal lesions in rats: vasodilation and anti-inflammation","volume":"12","author":"Yu","year":"2020","journal-title":"Nutrients"},{"key":"B125","doi-asserted-by":"publisher","first-page":"126","DOI":"10.16368\/j.issn.1674-8999.2021.01.028","article-title":"Exploring the effects of Qifang weitong Granules on epithelial mesenchymal transformation of human gastric adenocarcinoma AGS cells based on TGF-\u03b2\/smad signaling pathway","volume":"36","author":"Yuan","year":"2021","journal-title":"J. Chin. Med."},{"key":"B126","first-page":"2869","article-title":"Effect of Mieyou Decoction on PTEN-PI3K-Akt-FoxO apoptotic signal pathway in the H.Pylori-associated gastritis mice with spleen-stomach damp-heat syndrome","volume":"29","author":"Zeng","year":"2020","journal-title":"Mod. J. Integr. Traditional Chin. West. Med."},{"key":"B127","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3969\/j.issn.1007-6948.2015.02.034","article-title":"A study of the correlation between uncontrolled inflammation and tumors","volume":"21","author":"Zhang","year":"2015","journal-title":"Chin. J. Integr. Chin. West. Med. Surg."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1058012","DOI":"10.3389\/fphar.2022.1058012","article-title":"Incarvillea compacta Maxim ameliorates inflammatory response via inhibiting PI3K\/AKT pathway and NLRP3 activation","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B129","first-page":"297","article-title":"Wenweishu Capsule alleviates gastric mucosal lesion in rats with chronic gastritis by inhibiting NF-\u03baB pathway","volume":"36","author":"Zhang","year":"2020","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"B130","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3969\/j.issn.1009-0460.2019.04.002","article-title":"Effects of tiny RNA-1297 on invasive migration and notch\/zeb1 signaling pathway in gastric cancer cells","volume":"24","author":"Zhang","year":"2019","journal-title":"J. Clin. Oncol. J. Clin. Oncol."},{"key":"B131","first-page":"376","article-title":"Effects of Astragalus, Panax ginseng and their combinations on apoptosis and proliferation of gastric mucosa cells in rats with chronic atrophic gastritis","volume":"25","author":"Zhao","year":"","journal-title":"Chin. J. Integr. Med. Gastroenterology"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3969\/j.issn.1674-1749.2017.11.005","article-title":"Regulation of hedgehog signaling pathway in MNNG-induced precancerous rats with atrophic gastritis by the method of Yiqi huoxue circulation","volume":"10","author":"Zhao","year":"","journal-title":"Glob. Chin. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.3969\/j.issn.1674-1749.2017.12.003","article-title":"Effects of astragaloside and ginsenoside Rg1 on the regulation of Hedgehog signaling pathway in rats with chronic atrophic gastritis","volume":"10","author":"Zhao","year":"","journal-title":"Glob. Chin. Med."},{"key":"B134","doi-asserted-by":"publisher","first-page":"4128","DOI":"10.19540\/j.cnki.cjcmm.20220325.701","article-title":"Effects of Jiawei Xiaoyao powder on SOCS3\/TLR4 signaling pathway in chronic atrophic gastritis rats","volume":"47","author":"Zheng","year":"2022","journal-title":"Chin. J. Traditional Chin. Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/s0140-6736(19)30427-1","article-title":"Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"394","author":"Zhou","year":"2019","journal-title":"Lancet"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1338471\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T05:32:31Z","timestamp":1713418351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1338471\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":135,"alternative-id":["10.3389\/fphar.2024.1338471"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1338471","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]},"article-number":"1338471"}}