{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:16:20Z","timestamp":1792084580928,"version":"4.4.0"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003896"],"award-info":[{"award-number":["82003896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H280003"],"award-info":[{"award-number":["LQ21H280003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Bai Hua Qian Hu (Qianhu; <jats:italic>Peucedanum praeruptorum<\/jats:italic> Dunn) is a classical medicinal plant traditionally prescribed for respiratory ailments, including cough, pulmonary hypertension, and asthma. In this review, we summarize the research progress of the toxicology, pharmacokinetics, pharmacology, phytochemistry, botany, quality control, and traditional uses of <jats:italic>P. praeruptorum<\/jats:italic> in order to support future investigations into the scientific and therapeutic promise of this important medicinal plant. Information pertaining to <jats:italic>P. praeruptorum<\/jats:italic> was collected from scientific databases (ScienceDirect, Springer, SciFinder, PubMed, Baidu Scholar, Google Scholar, Web of Science), as well as toxicology papers from local conferences, M. Sc. and Ph.D. theses and dissertations, local magazines, classic texts on Chinese botanical drugs, and peer-reviewed journals. The Plant List (<jats:ext-link>www.theplantlist.org<\/jats:ext-link>) was utilized to verify the taxonomy of <jats:italic>P. praeruptorum<\/jats:italic>. <jats:italic>P. praeruptorum<\/jats:italic> was found to contain more than 119 distinct phytochemicals, including simple coumarins, pyranocoumarins, furanocoumarins, flavonoids, ketones, organic acids, and sterols, among others (e.g., praeruptorins A and B). Both crude plant extracts and purified metabolites of <jats:italic>P. praeruptorum<\/jats:italic> have been reported as treatments for hypertension, osteoporosis, Huntington\u2019s disease, and cancer. In addition, extracts of <jats:italic>P. praeruptorum<\/jats:italic> are reported to exhibit diverse pharmacological activities, including osteogenic, anti-osteoclastogenic, antidepressant, neuroprotective, antitumor, and anti-inflammatory effects. Research into the pharmacology and phytochemistry of <jats:italic>P. praeruptorum<\/jats:italic> partially support both traditional uses and extraction methods. However, further research is required to elucidate the relationships between these metabolites, their molecular mechanisms, their structure-function roles, and their antagonistic and synergistic effects.<\/jats:p>","DOI":"10.3389\/fphar.2024.1352657","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T04:28:46Z","timestamp":1712118526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The traditional uses, pharmacology, and phytochemistry of Peucedanum praeruptorum Dunn"],"prefix":"10.3389","volume":"15","author":[{"given":"Qiongxiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinger","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1055\/s-2007-969780","article-title":"Studies on coumarins of a Chinese drug \u201cQian-Hu\u201d V. 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