{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:39:12Z","timestamp":1793126352253,"version":"4.5.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Plants and their extracts have been integral to the development of medicinal treatments throughout history, offering a vast array of compounds for innovative therapies. <jats:italic>Baccaurea motleyana<\/jats:italic> M\u00fcll. Arg., commonly known as Rambai, is an evergreen tree with economic importance in the Old-World Tropics.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold> The study investigates its phytochemical composition through Gas Chromatography-Mass Spectrometry (GC-MS) and evaluates its pharmacological properties, including antidiabetic, antidiarrheal, antimicrobial, and antidepressant effects.<\/jats:p><jats:p><jats:bold>Result and Discussion:<\/jats:bold> The GC-MS analysis revealed 15 bioactive compounds in the methanol extract, with Phenol, 3,5-bis(1,1-dimethylethyl)-, Methyl stearate, and Hexadecanoic acid, methyl ester being the predominant ones. The cytotoxicity assay demonstrated significant activity in the ethyl acetate fraction. Antimicrobial assays indicated mild to moderate antibacterial activity. <jats:italic>In vivo<\/jats:italic> studies on mice revealed significant hypoglycemic, antidiarrheal, and antidepressant properties. Molecular docking studies against EGFR, DHFR, GLUT-3, KOR, and MOA identified promising compounds with potential therapeutic effects. The identified compounds exhibited favorable ADME\/T properties, emphasizing their potential for drug development. The study underscores the promising therapeutic potential of <jats:italic>Baccaurea motleyana<\/jats:italic>, showcasing its diverse bioactive compounds with significant medicinal properties.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These findings lay the groundwork for future research, emphasizing the exploration of <jats:italic>B. motleyana<\/jats:italic> as a source of natural remedies for addressing prevalent health conditions.<\/jats:p>","DOI":"10.3389\/fphar.2024.1359815","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:23:47Z","timestamp":1709184227000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Phyto-pharmacological evaluation and characterization of the methanolic extract of the Baccaurea motleyana M\u00fcll. Arg. seed: promising insights into its therapeutic uses"],"prefix":"10.3389","volume":"15","author":[{"given":"Suriya Akter","family":"Shompa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasin","family":"Hasnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima Jahan","family":"Riti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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