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In a rat heroin self-administration model, we examined the impact of rimonabant, a selective cannabinoid receptor indirect agonist, on the reconsolidation process of heroin-associated memory. The study showed that immediately administering rimonabant after conditioned stimuli (CS) exposure reduced the cue- and herion + cue-induced heroin-seeking behavior. The inhibitory effects lasted for a minimum of 28 days. The effect of Rimonabant on reduced drug-seeking was not shown when treated without CS exposure or 6\u00a0hours after CS exposure. These results demonstrate a disruptive role of rimonabant on the reconsolidation of heroin-associated memory and the therapeutic potential in relapse control concerning substance use disorder.<\/jats:p>","DOI":"10.3389\/fphar.2024.1361838","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T05:02:21Z","timestamp":1710997341000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interfering with reconsolidation by rimonabant results in blockade of heroin-associated memory"],"prefix":"10.3389","volume":"15","author":[{"given":"Jiang","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzhe","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuliang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.neuron.2008.07.004","article-title":"Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons","volume":"59","author":"Ambroggi","year":"2008","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s00213-023-06384-w","article-title":"Psilocybin prevents reinstatement of alcohol seeking by disrupting the reconsolidation of alcohol-related memories","volume":"240","author":"Benvenuti","year":"2023","journal-title":"Psychopharmacology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1038\/npp.2013.153","article-title":"Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala","volume":"38","author":"Blasio","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1080\/17460441.2020.1767581","article-title":"Novel therapeutic and drug development strategies for tobacco use disorder: endocannabinoid modulation","volume":"15","author":"Butler","year":"2020","journal-title":"Expert Opin. 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