{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:36:22Z","timestamp":1792092982735,"version":"4.4.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Psoriasis, a chronic skin condition characterized by systemic inflammation and altered gut microbiota, has been a target of Traditional Chinese Medicine (TCM) for centuries. Shenling Baizhu Powder (SLBZP), a TCM formulation, holds promise for treating inflammatory diseases, but its specific role in psoriasis and impact on gut microbiota is not fully understood.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> This study aims to elucidate the mechanism of SLBZP in treating psoriasis, integrating component analysis, network pharmacology, and experimental validation in mice models.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We commenced with a detailed component analysis of SLBZP using liquid chromatograph and mass spectrometer (LC-MS). Network pharmacology analysis was used to predict the potential action targets and pathways of SLBZP in psoriasis. An <jats:italic>in vivo<\/jats:italic> experiment was conducted with psoriasis mice models, treated with SLBZP. Therapeutic effects were assessed via symptomatology, histopathology, and immunohistochemical analysis. Gut microbiota composition was analyzed using 16S rRNA gene sequencing.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 42 main components and quality markers were identified, primarily from licorice and ginseng, including flavonoids, saponins and other markers. PPI topology analysis showed that TNF, IL-6, IL-1\u03b2, TP53 and JUN were the core DEPs. 168 signaling pathways including lipid and atherosclerosis, AGE-RAGE signaling pathway, IL-17 signaling pathway and Th17 cell differentiation were enriched by KEGG. SLBZP demonstrated significant therapeutic effects on psoriasis in mice, with alterations in skin pathology and biomarkers. Additionally, notable changes in gut microbiota composition were observed post-treatment, indicating a possible gut-skin axis involvement.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This research has pinpointed lipid metabolism as a key pathway in the treatment of psoriasis with SLBZP. It explores how SLBZP\u2019s modulation of gut microbiota and lipid metabolism can alleviate psoriasis, suggesting that balancing gut microbiota may reduce inflammation mediators and offer therapeutic benefits. This underscores lipid metabolism modulation as a potential new strategy in psoriasis treatment.<\/jats:p>","DOI":"10.3389\/fphar.2024.1362161","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T12:23:32Z","timestamp":1707913412000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder\u2019s role in psoriasis treatment"],"prefix":"10.3389","volume":"15","author":[{"given":"Bin","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.clindermatol.2023.09.019","article-title":"Targeting dysbiosis in psoriasis, atopic dermatitis, and hidradenitis suppurativa: the gut-skin axis and microbiome-directed therapy","volume":"41","author":"Aguwa","year":"2023","journal-title":"Clin. Dermatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"7618","DOI":"10.3390\/ijerph17207618","article-title":"The gut microbiota and inflammation: an overview","volume":"17","author":"Al Bander","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B3","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/imr.12891","article-title":"Lipids, inflammasomes, metabolism, and disease","volume":"297","author":"Anand","year":"2020","journal-title":"Immunol. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3390\/nu14071414","article-title":"Lipid metabolism in inflammation and immune function","volume":"14","author":"Andersen","year":"2022","journal-title":"Nutrients"},{"key":"B5","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.chom.2023.01.009","article-title":"Gut microbiome lipid metabolism and its impact on host physiology","volume":"31","author":"Brown","year":"2023","journal-title":"Cell Host Microbe"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.3390\/nu14142970","article-title":"Gut microbiota in psoriasis","volume":"14","author":"Buhas","year":"2022","journal-title":"Nutrients"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e967","DOI":"10.1002\/iid3.967","article-title":"Curcumin alleviates imiquimod-induced psoriasis-like inflammation and regulates gut microbiota of mice","volume":"11","author":"Cai","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"938932","DOI":"10.3389\/fphar.2022.938932","article-title":"Effect of Shenling Baizhu powder on immunity to diarrheal disease: a systematic review and meta-analysis","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.3390\/molecules24213943","article-title":"Lipidomic analysis of the protective effects of shenling Baizhu san on non-alcoholic fatty liver disease in rats","volume":"24","author":"Deng","year":"2019","journal-title":"Molecules"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1227309","DOI":"10.3389\/fmicb.2023.1227309","article-title":"Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes","volume":"14","author":"Du","year":"2023","journal-title":"Front. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1155614","DOI":"10.3389\/fnut.2023.1155614","article-title":"Editorial: the gut-skin-brain axis in human health and disease","volume":"10","author":"Ferraretto","year":"2023","journal-title":"Front. Nutr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.3390\/cells12222654","article-title":"Gut microbiota, inflammatory bowel disease, and cancer: the role of guardians of innate immunity","volume":"12","author":"Giambra","year":"2023","journal-title":"Cells"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3960989","DOI":"10.1155\/2021\/3960989","article-title":"Effects of ShenLing BaiZhu san supplementation on gut microbiota and oxidative stress in rats with ulcerative colitis","volume":"2021","author":"Gu","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/ptr.8038","article-title":"Liquiritin targeting Th17 cells differentiation and abnormal proliferation of keratinocytes alleviates psoriasis via NF-\u03baB and AP-1 pathway","volume":"38","author":"Guo","year":"2023","journal-title":"Phytother. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1215861","DOI":"10.3389\/fphar.2023.1215861","article-title":"Aminooxy acetic acid suppresses Th17-mediated psoriasis-like skin inflammation by inhibiting serine metabolism","volume":"14","author":"Lee","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1273714","DOI":"10.3389\/fmicb.2023.1273714","article-title":"Prickly Ash Seeds improve immunity of Hu sheep by changing the diversity and structure of gut microbiota","volume":"14","author":"Li","year":"2023","journal-title":"Front. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1124786","DOI":"10.3389\/fimmu.2023.1124786","article-title":"Crosstalk between cholesterol metabolism and psoriatic inflammation","volume":"14","author":"Luo","year":"2023","journal-title":"Front. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.ijbiomac.2022.09.246","article-title":"Polysaccharides derived from Shenling Baizhu San improve colitis via modulating tryptophan metabolism in mice","volume":"222","author":"Lv","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2096995","DOI":"10.1080\/19490976.2022.2096995","article-title":"Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases","volume":"14","author":"Mahmud","year":"2022","journal-title":"Gut Microbes"},{"key":"B22","doi-asserted-by":"publisher","first-page":"8479680","DOI":"10.1155\/2019\/8479680","article-title":"Chinese herbal medicine formula shenling Baizhu san ameliorates high-fat diet-induced NAFLD in rats by modulating hepatic MicroRNA expression profiles","volume":"2019","author":"Pan","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.joim.2021.07.004","article-title":"Hepatic protective effects of Shenling Baizhu powder, a herbal compound, against inflammatory damage via TLR4\/NLRP3 signalling pathway in rats with nonalcoholic fatty liver disease","volume":"19","author":"Pan","year":"2021","journal-title":"J. Integr. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e148552","DOI":"10.1172\/JCI148552","article-title":"Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies","volume":"132","author":"Robinson","year":"2022","journal-title":"J. Clin. Invest."},{"key":"B25","doi-asserted-by":"publisher","first-page":"859","DOI":"10.3390\/ijms21030859","article-title":"The roles of lipoprotein in psoriasis","volume":"21","author":"Shih","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.clindermatol.2021.08.021","article-title":"The skin microbiome and the gut-skin axis","volume":"39","author":"Sinha","year":"2021","journal-title":"Clin. Dermatol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/2475530320950268","article-title":"Oxidized lipids and lipoprotein dysfunction in psoriasis","volume":"5","author":"Sorokin","year":"2020","journal-title":"J. Psoriasis Psoriatic Arthritis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1279846","DOI":"10.3389\/fimmu.2023.1279846","article-title":"Metabolic influences on T cell in psoriasis: a literature review","volume":"14","author":"Su","year":"2023","journal-title":"Front. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1691\/ph.2021.1694","article-title":"Gut-skin\"axis: understanding psoriasis from the gut","volume":"76","author":"Su","year":"2021","journal-title":"Pharmazie"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/biomedicines10051037","article-title":"Gut-skin Axis: unravelling the connection between the gut microbiome and psoriasis","volume":"10","author":"Thye","year":"2022","journal-title":"Biomedicines"},{"key":"B31","doi-asserted-by":"publisher","first-page":"900916","DOI":"10.3389\/fmed.2022.900916","article-title":"Current evidence on the role of lipid lowering drugs in the treatment of psoriasis","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"153054","DOI":"10.1016\/j.phymed.2019.153054","article-title":"PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K\/Akt\/mTOR pathway","volume":"64","author":"Yue","year":"2019","journal-title":"Phytomedicine"},{"key":"B33","doi-asserted-by":"publisher","first-page":"206","DOI":"10.5455\/aim.2023.31.206-210","article-title":"Psoriasis area and severity index (PASI) objectivisation by flow cytometry analysis of major lymphocytes subsets","volume":"31","author":"Zecevic-Pasic","year":"2023","journal-title":"Acta Inf. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4687788","DOI":"10.1155\/2022\/4687788","article-title":"Mechanism of peitu shengjin formula shenlingbaizhu powder in treating bronchial asthma and allergic colitis through different diseases with simultaneous treatment based on network pharmacology and molecular docking","volume":"2022","author":"Zeng","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"938535","DOI":"10.3389\/fcvm.2022.938535","article-title":"Editorial: the roles of lipids in immunometabolism: the crosstalk between lipid metabolisms and inflammation","volume":"9","author":"Zhang","year":"","journal-title":"Front. Cardiovasc Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"988","DOI":"10.19540\/j.cnki.cjcmm.20210907.401","article-title":"Shenling Baizhu Powder alleviates chronic inflammation to prevent type 2 diabetes of ZDF rats via intestinal flora","volume":"47","author":"Zhang","year":"","journal-title":"Zhongguo Zhong Yao Za Zhi"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1362161\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T12:23:38Z","timestamp":1707913418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1362161\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,14]]},"references-count":36,"alternative-id":["10.3389\/fphar.2024.1362161"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1362161","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,14]]},"article-number":"1362161"}}