{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:48:58Z","timestamp":1790790538993,"version":"4.1.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Acori Tatarinowii Rhizoma (ATR) is a well-known traditional Chinese medicine that is used for treating neuropathic diseases. However, there is little information about the safety of ATR.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The present study evaluated the acute and subacute oral toxicity of a water extract of ATR in Institute of Cancer Research (ICR) mice. In acute trials, a single administration of extract at a dose 5,000\u00a0mg\/kg body weight led to no clinical signs of toxicity or mortality, indicating that the lethal dose (LD50) exceeded 5,000\u00a0mg\/kg. A subacute toxicity test was done using daily doses of 1,250, 2,500, and 5,000\u00a0mg\/kg of the ATR extract for 28\u00a0days, which did not show any adverse clinical symptoms or mortality. However, the male renal organ index and urea level in mice given 5,000\u00a0mg\/kg was obviously abnormal, which was consistent with pathological results and suggested that this dose might cause kidney injury.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Doses of ATR lower than 2,500\u00a0mg\/kg could be regarded as safe, although the potential cumulative effects of long-term use of high doses of ATR need to be considered.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> The study highlights the function of ATR in reducing blood lipids and provides a new idea for its widespread clinical use in the future.<\/jats:p>","DOI":"10.3389\/fphar.2024.1377876","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T08:46:46Z","timestamp":1710838006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity"],"prefix":"10.3389","volume":"15","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4238","DOI":"10.1016\/j.bmc.2010.04.096","article-title":"Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors","volume":"18","author":"Arg\u00fcelles","year":"2010","journal-title":"Bioorg Med. 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