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Pharmacol."],"abstract":"<jats:title>Graphical Abstract<\/jats:title><jats:p><jats:fig><jats:caption><jats:p>This review seeks to offer a comprehensive look at how salidroside impacts gut microbiota and its potential therapeutic role in treating atherosclerosis. <jats:bold>(A)<\/jats:bold> Salidroside has been shown to have a positive impact on atherosclerosis by promoting the growth of beneficial bacteria and decreasing the levels of harmful bacteria in the body. <jats:bold>(B)<\/jats:bold> Salidroside has been shown to enhance the integrity and function of the intestinal mucosal barrier through its ability to suppress NF-\u03baB and p38 MAPK signaling pathways, modulate the NF-\u03baB\/MAPK\/JAK-STAT3 signaling pathways and increase the expression of antimicrobial peptides HD-5 and HD-6. <jats:bold>(C)<\/jats:bold> Salidroside can reduce TMAO production through reducing the abundance of <jats:italic>Firmicutes<\/jats:italic> and <jats:italic>Proteobacteria<\/jats:italic>. <jats:bold>(D)<\/jats:bold> Salidroside can improve the expression of SCFAs, through increasing the abundance of some special bacteria. <jats:bold>(E)<\/jats:bold> Salidroside can reduce LPS-induced inflammation, which is associated with the inhibition of the ROS-mediated PI3K\/AKT\/mTOR signaling pathway, the downregulation of exosome miR-199a-5p, and the attenuation of the Notch-Hes signaling pathway. <jats:bold>(F)<\/jats:bold> Salidroside can inhibit NLRP3-associated gut-coronary axis, including TLR4\/MyD88\/NF-\u03baB\/NLRP3 signaling pathway, AMPK\/NF-\u03baB\/NLRP3 signaling pathway, and P2X7\/NF-\u03baB\/NLRP3 signaling pathway.<\/jats:p><\/jats:caption><\/jats:fig><\/jats:p>","DOI":"10.3389\/fphar.2024.1400981","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T10:03:55Z","timestamp":1721210635000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of salidroside on atherosclerosis: potential contribution of gut microbiota"],"prefix":"10.3389","volume":"15","author":[{"given":"Si-Fan","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1996830","DOI":"10.1080\/21688370.2021.1996830","article-title":"Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions","volume":"10","author":"Alizadeh","year":"2022","journal-title":"Tissue Barriers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5420","DOI":"10.3390\/ijms24065420","article-title":"Role of the gut microbiome in the development of atherosclerotic cardiovascular disease","volume":"24","author":"Al Samarraie","year":"2023","journal-title":"Int. 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