{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:13:29Z","timestamp":1753892009733,"version":"3.41.2"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Plant polysaccharide are widely studied as potential prebiotics because of their potential to protect and enhance the immunity of lambs.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this study, the polysaccharide content of <jats:italic>Alhagi maurorum<\/jats:italic> Medik from Aksu (AK) and Shanshan (SS) at different cutting periods was determined, and the functions of <jats:italic>Alhagi maurorum<\/jats:italic> Medik polysaccharide were investigated to useas an immunomodulator.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Our results indicated that the content of <jats:italic>Alhagi maurorum<\/jats:italic> Medik polysaccharide is the highest at the maturity stage, and the polysaccharide content of <jats:italic>Alhagi maurorum<\/jats:italic> Medik produced in Shanshan area is higher as compared to the Aksu area. The serum IgG, duodenum IgA, TNF-\u03b1, IL-4, IL-10 contents, jejunum IgA, TNF-\u03b1, IL-4, IL-17 contents, ileum IgA, IL-17 contents, duodenum villus height, crypt depth and jejunum crypt depth of lambs were significantly adjusted in the SS group as compared to CK control group and AK groups (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Furthemore, the sequencing results showed that SS polysaccharide promoted the release of large amounts of IgA and enhanced the immunal function of intestine by regulating the IgA production pathway and B-cell receptor signaling to activate B cells in the T-dependent pathway.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> Altogether, <jats:italic>Alhagi maurorum<\/jats:italic> Medik polysaccharide from SS group holds a promising potential to be used as a valuable immunopotentiator for optimizing the immune system of intestine in lambs.<\/jats:p>","DOI":"10.3389\/fphar.2024.1422461","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:55:43Z","timestamp":1721019343000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Alhagi maurorum Medik polysaccharide derived from different regions on the intestinal immune functions of lambs"],"prefix":"10.3389","volume":"15","author":[{"given":"Zulikeyan","family":"Manafu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronglijiao","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xieraili","family":"Malajiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulimire","family":"Abulikemu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayibike","family":"Bierdelieke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanhai","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelijiang","family":"Wusiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saifuding","family":"Abula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3934\/Allergy.2021001","article-title":"Spleen in innate and adaptive immunity regulation","volume":"5","author":"Aliyu","year":"2021","journal-title":"AIMS Allergy Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"136225","DOI":"10.1016\/j.foodchem.2023.136225","article-title":"Longan pulp polysaccharides regulate gut microbiota and metabolites to protect intestinal epithelial barrier","volume":"422","author":"Bai","year":"2023","journal-title":"Food Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41580-020-0278-0","article-title":"Cell fate specification and differentiation in the adult mammalian intestine","volume":"22","author":"Beumer","year":"2021","journal-title":"Nat. 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