{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:16:25Z","timestamp":1753892185380,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Solid organ transplant recipients are at high risk for developing severe zoster-associated neuralgia, and the pharmaceutic therapies of pain management for these patients with limited organ function are challenging. Intravenous lidocaine infusion showed positive analgesic effects and is used for the management of neuropathic pain. This case series reports the safety and effectiveness of intravenous lidocaine infusion in the treatment of intractable zoster-associated neuralgia in solid organ transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case series presentation<\/jats:title><jats:p>Five solid organ transplant recipients suffering from refractory zoster-associated neuralgia (numeric rating scale 8\u201310, despite using high doses of antiepileptic drugs or combined with opioids) were enrolled. Intravenous lidocaine (5\u00a0mg\/kg ideal bodyweight) was administered over 1.5\u00a0h with the monitoring of vital signs. Pain intensity, patient satisfaction, adverse events, typical liver, and kidney function were evaluated. All subjects reported high satisfaction with their treatment and effective pain relief at the 6-month follow-up. One patient experienced short and mild numbness in the mouth and dizziness after the therapy, but no major adverse reactions were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case series provides evidence that intravenous lidocaine infusion provided effective pain relief as an analgesic treatment option for transplant patients with intractable zoster-associated neuralgia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphar.2024.1422778","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T05:09:07Z","timestamp":1721279347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: safety and efficacy of lidocaine infusion for the treatment of intractable zoster-associated neuralgia in solid organ transplant recipients"],"prefix":"10.3389","volume":"15","author":[{"given":"Huan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bixin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1212\/01.wnl.0000103237.62009.77","article-title":"Systemic lidocaine in pain due to peripheral nerve injury and predictors of response","volume":"62","author":"Attal","year":"2004","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1186\/s12889-015-1753-y","article-title":"Herpes zoster-associated mortality in Europe: a systematic review","volume":"15","author":"Bricout","year":"2015","journal-title":"BMC Public Health"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.3390\/jcm12113772","article-title":"Systemic anti-inflammatory effects of intravenous lidocaine in surgical patients: a systematic review and meta-analysis","volume":"12","author":"Castro","year":"2023","journal-title":"J. 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