{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:39:06Z","timestamp":1790786346681,"version":"4.1.0"},"reference-count":108,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Peritoneal dialysis (PD) is a commonly used renal replacement therapy for patients with end-stage renal disease (ESRD). During PD, the peritoneum (PM), a semi-permeable membrane, is exposed to nonbiocompatible PD solutions. Peritonitis can occur, leading to structural and functional PM disorders, resulting in peritoneal fibrosis and ultrafiltration failure, which are important reasons for patients with ESRD to discontinue PD. Increasing evidence suggests that oxidative stress (OS) plays a key role in the pathogenesis of peritoneal fibrosis. Furthermore, zinc deficiency is often present to a certain extent in patients undergoing PD. As an essential trace element, zinc is also an antioxidant, potentially playing an anti-OS role and slowing down peritoneal fibrosis progression. This study summarises and analyses recent research conducted by domestic and foreign scholars on the possible mechanisms through which zinc prevents peritoneal fibrosis.<\/jats:p>","DOI":"10.3389\/fphar.2024.1436864","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T05:24:01Z","timestamp":1725427441000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Zinc: a potential star for regulating peritoneal fibrosis"],"prefix":"10.3389","volume":"15","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpeng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0184302","DOI":"10.1371\/journal.pone.0184302","article-title":"Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis","volume":"12","author":"Aguilera","year":"","journal-title":"Plos One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0173706","DOI":"10.1371\/journal.pone.0173706","article-title":"Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis","volume":"12","author":"Aguilera","year":"","journal-title":"Plos One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"L1132","DOI":"10.1152\/ajplung.00207.2006","article-title":"Zinc modulates cytokine-induced lung epithelial cell barrier permeability","volume":"291","author":"Bao","year":"2006","journal-title":"Am. J. Physiology-Lung Cell. Mol. Physiology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.4161\/cc.10.2.14477","article-title":"Decoding the chromatin modification landscape","volume":"10","author":"Bartke","year":"2014","journal-title":"Cell Cycle"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s11255-012-0334-6","article-title":"Oxidative stress in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and the significant role of vitamin C and E supplementation","volume":"45","author":"Boudouris","year":"2012","journal-title":"Int. Urology Nephrol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/35000025","article-title":"The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression","volume":"2","author":"Cano","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1146\/annurev-biochem-103019-102815","article-title":"Role of mammalian DNA methyltransferases in development","volume":"89","author":"Chen","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.brainres.2008.08.040","article-title":"Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms","volume":"1237","author":"Corniola","year":"2008","journal-title":"Brain Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"624529","DOI":"10.3389\/fphar.2020.624529","article-title":"Mitochondrial iron overload-mediated inhibition of nrf2-HO-1\/GPX4 assisted ALI-induced nephrotoxicity","volume":"11","author":"Deng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1681\/ASN.2009070694","article-title":"The pathophysiology of the peritoneal membrane","volume":"21","author":"Devuyst","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1146\/annurev-pharmtox-010818-021856","article-title":"Modulating NRF2 in disease: timing is everything","volume":"59","author":"Dodson","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1016\/j.ajpath.2014.04.014","article-title":"Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro","volume":"184","author":"Duan","year":"2014","journal-title":"Am. J. Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"5195","DOI":"10.3892\/mmr.2017.7236","article-title":"Zinc inhibits high glucose-induced NLRP3 inflammasome activation in human peritoneal mesothelial cells","volume":"16","author":"Fan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1093\/jn\/138.9.1664","article-title":"Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells","volume":"138","author":"Finamore","year":"2008","journal-title":"J. Nutr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/FJC.0b013e3181833eb8","article-title":"Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism","volume":"52","author":"Gandhi","year":"2008","journal-title":"J. Cardiovasc Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3892\/mmr.2019.10260","article-title":"Zinc supplementation inhibits the high glucose-induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway","volume":"20","author":"Gao","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.3390\/nu5041456","article-title":"Zinc supplementation alters plasma aluminum and selenium status of patients undergoing dialysis: a pilot study","volume":"5","author":"Guo","year":"2013","journal-title":"Nutrients"},{"key":"B19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.clinbiochem.2010.12.017","article-title":"Cu\/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis","volume":"44","author":"Guo","year":"2011","journal-title":"Clin. Biochem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s12011-009-8342-9","article-title":"Alterations of trace elements and oxidative stress in uremic patients with dementia","volume":"131","author":"Guo","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1046\/j.1523-1755.2001.059002463.x","article-title":"High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells","volume":"59","author":"Ha","year":"2001","journal-title":"Kidney Int."},{"key":"B22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jtemb.2005.02.004","article-title":"Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases","volume":"19","author":"Haase","year":"","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s10534-005-3707-9","article-title":"Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants","volume":"18","author":"Haase","year":"","journal-title":"BioMetals"},{"key":"B24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/s41581-020-0315-4","article-title":"The current and future landscape of dialysis","volume":"16","author":"Himmelfarb","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/nu10040471","article-title":"Zinc protects articular chondrocytes through changes in nrf2-mediated antioxidants, cytokines and matrix metalloproteinases","volume":"10","author":"Huang","year":"2018","journal-title":"Nutrients"},{"key":"B27","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.ceb.2005.08.001","article-title":"Molecular requirements for epithelial\u2013mesenchymal transition during tumor progression","volume":"17","author":"Huber","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"12132","DOI":"10.1074\/jbc.M511198200","article-title":"Phosphorylation of tyrosine 568 controls nuclear export of Nrf2","volume":"281","author":"Jain","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1038\/sj.onc.1202237","article-title":"Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes","volume":"17","author":"Jaiswal","year":"1998","journal-title":"Oncogen"},{"key":"B30","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00018-003-3148-y","article-title":"Overview of mammalian zinc transporters","volume":"61","author":"Kambe","year":"2004","journal-title":"Cell. Mol. Life Sci. (CMLS)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1096\/fj.10-171553","article-title":"Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression","volume":"25","author":"Kaspar","year":"2010","journal-title":"FASEB J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2020.05.010","article-title":"Zinc and the modulation of Nrf2 in human neuroblastoma cells","volume":"155","author":"Kaufman","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/s0041-008x(03)00167-4","article-title":"Zinc-induced NF-kappaB inhibition can be modulated by changes in the intracellular metallothionein level","volume":"190","author":"Kim","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"F662","DOI":"10.1152\/ajprenal.00421.2009","article-title":"Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure","volume":"298","author":"Kim","year":"2010","journal-title":"Am. J. Physiology-Renal Physiology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/1744-9987.12186","article-title":"Effect of DNA demethylation in experimental encapsulating peritoneal sclerosis","volume":"18","author":"Kim","year":"2014","journal-title":"Ther. Apher. Dialysis"},{"key":"B36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1089\/ars.2013.5825","article-title":"Taurine chloramine stimulates efferocytosis through upregulation of nrf2-mediated heme oxygenase-1 expression in murine macrophages: possible involvement of carbon monoxide","volume":"23","author":"Kim","year":"2015","journal-title":"Antioxidants and Redox Signal."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/ki.1996.198","article-title":"Zinc modulates mononuclear cellular calcitriol metabolism in peritoneal dialysis patients","volume":"49","author":"Kimmel","year":"1996","journal-title":"Kidney Int."},{"key":"B38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000109397","article-title":"Oxidative stress and asymmetric dimethylarginine is independently associated with carotid intima media thickness in peritoneal dialysis patients","volume":"28","author":"Kocak","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1172\/jci44595","article-title":"Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?","volume":"121","author":"Kriz","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGF-\u03b2\/Smads in renal fibrosis and inflammation","volume":"7","author":"Lan","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/jcmm.12239","article-title":"Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition","volume":"18","author":"Li","year":"2014","journal-title":"J. Cell Mol. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"117351","DOI":"10.1016\/j.lfs.2020.117351","article-title":"Zinc promotes functional recovery after spinal cord injury by activating Nrf2\/HO-1 defense pathway and inhibiting inflammation of NLRP3 in nerve cells","volume":"245","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1161\/01.Cir.0000165117.71483.0c","article-title":"p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart","volume":"111","author":"Li","year":"2005","journal-title":"Circulation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/biom13010028","article-title":"The important role of zinc in neurological diseases","volume":"13","author":"Li","year":"2022","journal-title":"Biomolecules"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3494867","DOI":"10.1155\/2017\/3494867","article-title":"Oxidative stress in patients undergoing peritoneal dialysis: a current review of the literature","volume":"2017","author":"Liakopoulos","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/0886022x.2022.2030360","article-title":"MiR-122-5p promotes peritoneal fibrosis in a rat model of peritoneal dialysis by targeting Smad5 to activate Wnt\/\u03b2-catenin pathway","volume":"44","author":"Liu","year":"2022","journal-title":"Ren. Fail."},{"key":"B47","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3109\/0886022x.2013.789960","article-title":"Reduced plasma zinc levels, lipid peroxidation, and inflammation biomarkers levels in hemodialysis patients: implications to cardiovascular mortality","volume":"35","author":"Lobo","year":"2013","journal-title":"Ren. Fail."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1106339","DOI":"10.3389\/fphar.2023.1106339","article-title":"Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation","volume":"14","author":"Lu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3892\/mmr.2014.2162","article-title":"Small interfering RNA targeting ILK inhibits EMT in human peritoneal mesothelial cells through phosphorylation of GSK\u20113\u03b2","volume":"10","author":"Luo","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/oby.21463","article-title":"Zinc delays the progression of obesity\u2010related glomerulopathy in mice via down\u2010regulating P38 MAPK\u2010mediated inflammation","volume":"24","author":"Luo","year":"2016","journal-title":"Obesity"},{"key":"B51","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10565-018-9438-9","article-title":"Olive leaf extract counteracts epithelial to mesenchymal transition process induced by peritoneal dialysis, through the inhibition of TGF\u03b21 signaling","volume":"35","author":"Lupinacci","year":"2018","journal-title":"Cell Biol. Toxicol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/jcp.25622","article-title":"Identification of a novel human E-cadherin splice variant and assessment of its effects upon EMT-related events","volume":"232","author":"Matos","year":"2016","journal-title":"J. Cell. Physiology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"18838","DOI":"10.1073\/pnas.1007387107","article-title":"Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals","volume":"107","author":"McMahon","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.taap.2018.09.033","article-title":"Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2","volume":"360","author":"McMahon","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1111\/j.1530-0277.2011.01488.x","article-title":"Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats","volume":"35","author":"Mehta","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1111\/j.1523-1755.2005.00237.x","article-title":"Benefits of switching from a conventional to a low-GDP bicarbonate\/lactate-buffered dialysis solution in a rat model","volume":"67","author":"Mortier","year":"2005","journal-title":"Kidney Int."},{"key":"B57","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3747\/pdi.2009.00073","article-title":"Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: a placebo-controlled study","volume":"30","author":"Nascimento","year":"2010","journal-title":"Perit. Dialysis Int. J. Int. Soc. Perit. Dialysis"},{"key":"B58","doi-asserted-by":"publisher","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1038\/sj.ki.5001506","article-title":"Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane","volume":"69","author":"Noh","year":"2006","journal-title":"Kidney Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12576-017-0571-7","article-title":"Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism","volume":"68","author":"Olechnowicz","year":"2017","journal-title":"J. Physiological Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.freeradbiomed.2012.08.568","article-title":"Zinc and the modulation of redox homeostasis","volume":"53","author":"Oteiza","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/ndt\/gfm540","article-title":"The TGF-beta-induced gene product, betaig-h3: its biological implications in peritoneal dialysis","volume":"23","author":"Park","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"B63","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/ki.2009.436","article-title":"Smad3-dependent and -independent pathways are involved in peritoneal membrane injury","volume":"77","author":"Patel","year":"2010","journal-title":"Kidney Int."},{"key":"B64","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e60776","DOI":"10.1371\/journal.pone.0060776","article-title":"Functional relevance of the switch of VEGF receptors\/co-receptors during peritoneal dialysis-induced mesothelial to mesenchymal transition","volume":"8","author":"Perez-Lozano","year":"2013","journal-title":"PLoS One"},{"key":"B66","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fnut.2014.00014","article-title":"Zinc is an antioxidant and anti-inflammatory agent: its role in human health","volume":"1","author":"Prasad","year":"2014","journal-title":"Front. Nutr."},{"key":"B67","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/antiox8060164","article-title":"Molecular mechanisms of zinc as a pro-antioxidant mediator: clinical therapeutic implications","volume":"8","author":"Prasad","year":"2019","journal-title":"Antioxidants"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.freeradbiomed.2004.07.007","article-title":"Antioxidant effect of zinc in humans","volume":"37","author":"Prasad","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1093\/ajcn\/85.3.837","article-title":"Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress","volume":"85","author":"Prasad","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"B70","first-page":"365","article-title":"Assessment of trace elements in sera of patients undergoing renal dialysis","volume":"35","author":"Rana","year":"2014","journal-title":"Saudi Med. J."},{"key":"B71","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3390\/biom10050768","article-title":"Unfavorable effects of peritoneal dialysis solutions on the peritoneal membrane: the role of oxidative stress","volume":"10","author":"Roumeliotis","year":"2020","journal-title":"Biomolecules"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.3390\/nu11081911","article-title":"Dietary antioxidant supplements and uric acid in chronic kidney disease: a review","volume":"11","author":"Roumeliotis","year":"2019","journal-title":"Nutrients"},{"key":"B73","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2174\/1570161118666200317151553","article-title":"Could antioxidant supplementation delay progression of cardiovascular disease in end-stage renal disease patients?","volume":"19","author":"Roumeliotis Stefanos","year":"2021","journal-title":"Curr. Vasc. Pharmacol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.3390\/nu11092112","article-title":"Crosstalk of Nrf2 with the trace elements selenium, iron, zinc, and copper","volume":"11","author":"Schwarz","year":"2019","journal-title":"Nutrients"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1080\/0886022x.2022.2118066","article-title":"The antioxidative effects of empagliflozin on high glucose-induced epithelial-mesenchymal transition in peritoneal mesothelial cells via the Nrf2\/HO-1 signaling","volume":"44","author":"Shi","year":"2022","journal-title":"Ren. Fail."},{"key":"B76","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/path.5352","article-title":"Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis","volume":"250","author":"Shi","year":"2019","journal-title":"J. Pathology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1242\/dmm.001321","article-title":"Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK\/NF-kappaB\/Snail1 pathway","volume":"1","author":"Strippoli","year":"2008","journal-title":"Dis. Models and Mech."},{"key":"B78","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.bcp.2009.04.009","article-title":"Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling","volume":"78","author":"Szuster-Ciesielska","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1872-034X.2007.00065.x","article-title":"Possible inhibitory effect of oral zinc supplementation on hepatic fibrosis through downregulation of TIMP-1: a pilot study","volume":"37","author":"Takahashi","year":"2007","journal-title":"Hepatol. Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1097\/01.Asn.0000013301.11876.7e","article-title":"Increased oxidative damage to peripheral blood leukocyte DNA in chronic peritoneal dialysis patients","volume":"13","author":"Tarng","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10157-011-0533-y","article-title":"Mechanisms and interventions in peritoneal fibrosis","volume":"16","author":"Tomino","year":"2012","journal-title":"Clin. Exp. Nephrol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"e0196844","DOI":"10.1371\/journal.pone.0196844","article-title":"Inhibition of the H3K4 methyltransferase SET7\/9 ameliorates peritoneal fibrosis","volume":"13","author":"Trackman","year":"2018","journal-title":"Plos One"},{"key":"B83","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1159\/000129650","article-title":"The effect of zinc supplements in cystic fibrosis patients","volume":"52","author":"Van Biervliet","year":"2008","journal-title":"Ann. Nutr. Metab."},{"key":"B84","doi-asserted-by":"publisher","first-page":"e32009","DOI":"10.1371\/journal.pone.0032009","article-title":"A crosstalk between the Smad and JNK signaling in the TGF-\u03b2-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells","volume":"7","author":"Vavvas","year":"2012","journal-title":"PLoS ONE"},{"key":"B85","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0002-9440(10)62979-3","article-title":"Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation","volume":"167","author":"Wang","year":"2005","journal-title":"Am. J. Pathol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.freeradbiomed.2012.12.019","article-title":"Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2\u2013ARE pathway","volume":"57","author":"Wang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.freeradbiomed.2011.04.019","article-title":"ROS-activated p38 MAPK\/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation","volume":"51","author":"Wang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1177\/0896860820938239","article-title":"Peritoneal fibrosis and epigenetic modulation","volume":"41","author":"Wang","year":"2020","journal-title":"Perit. Dialysis Int. J. Int. Soc. Perit. Dialysis"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.3390\/nu9121286","article-title":"Zinc as a gatekeeper of immune function","volume":"9","author":"Wessels","year":"2017","journal-title":"Nutrients"},{"key":"B90","doi-asserted-by":"publisher","first-page":"28258","DOI":"10.1074\/jbc.M303318200","article-title":"Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells","volume":"278","author":"Wu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"e49257","DOI":"10.1371\/journal.pone.0049257","article-title":"Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS ONE"},{"key":"B92","doi-asserted-by":"publisher","first-page":"88730","DOI":"10.18632\/oncotarget.20982","article-title":"Histone deacetylase 6 inhibition counteracts the epithelial-mesenchymal transition of peritoneal mesothelial cells and prevents peritoneal fibrosis","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/0196-9781(95)02030-6","article-title":"Differential effects of transforming growth factor-beta on osteoclast-like cell formation in mouse marrow culture: relation to the effect of zinc-chelating dipeptides","volume":"16","author":"Yamaguchi","year":"1995","journal-title":"Peptides"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtemb.2017.03.006","article-title":"The beneficial effects of zinc on diabetes-induced kidney damage in murine rodent model of type 1 diabetes mellitus","volume":"42","author":"Yang","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"102777","DOI":"10.1016\/j.redox.2023.102777","article-title":"Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia\/reoxygenation","volume":"64","author":"Yang","year":"2023","journal-title":"Redox Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1002\/hep.31147","article-title":"Immune\u2010responsive gene 1\/itaconate activates nuclear factor erythroid 2\u2013related factor 2 in hepatocytes to protect against liver ischemia\u2013reperfusion injury","volume":"72","author":"Yi","year":"2020","journal-title":"Hepatology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1053\/j.ajkd.2014.08.023","article-title":"Peritoneal dialysis in China: meeting the challenge of chronic kidney failure","volume":"65","author":"Yu","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"B98","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00467-008-0944-5","article-title":"Peritoneal morphologic changes in a peritoneal dialysis rat model correlate with angiopoietin\/Tie-2","volume":"24","author":"Yuan","year":"2009","journal-title":"Pediatr. Nephrol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1089\/ars.2005.7.1773","article-title":"Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: role of H(2)O(2)","volume":"7","author":"Zago Mp","year":"2005","journal-title":"Antioxid. Redox Signal"},{"key":"B100","volume-title":"The influence of vitamin E on the oxidative stress, microinflammation and endothelial dysfunction in CAPD patients","author":"Zhang","year":"2010"},{"key":"B101","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1186\/s12967-021-03077-w","article-title":"Low serum vitamin D concentration is correlated with anemia, microinflammation, and oxidative stress in patients with peritoneal dialysis","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Transl. Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.mehy.2013.03.036","article-title":"New insights into the pathogenesis and treatment of peritoneal fibrosis: a potential role of Wnt\/\u03b2-catenin induced epithelial to mesenchymal transition and stem cells for therapy","volume":"81","author":"Zhang","year":"","journal-title":"Med. Hypotheses"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.3892\/ijmm.2015.2170","article-title":"Effect of zinc on high glucose-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells","volume":"35","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.cellsig.2012.12.013","article-title":"Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis","volume":"25","author":"Zhang","year":"","journal-title":"Cell Signal"},{"key":"B105","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s12011-012-9473-y","article-title":"Zinc inhibits high glucose-induced apoptosis in peritoneal mesothelial cells","volume":"150","author":"Zhang","year":"","journal-title":"Biol. Trace Elem. Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s12011-012-9451-4","article-title":"Zinc supplementation attenuates high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelial cells","volume":"150","author":"Zhang","year":"","journal-title":"Biol. Trace Elem. Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"106064","DOI":"10.1016\/j.intimp.2019.106064","article-title":"Parthenolide, an NF-\u03baB inhibitor, alleviates peritoneal fibrosis by suppressing the TGF-\u03b2\/Smad pathway","volume":"78","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s11684-017-0571-2","article-title":"Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis","volume":"11","author":"Zhang","year":"2017","journal-title":"Front. Med."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1436864\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T05:24:07Z","timestamp":1725427447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1436864\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":108,"alternative-id":["10.3389\/fphar.2024.1436864"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1436864","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"article-number":"1436864"}}