{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:21:44Z","timestamp":1792002104095,"version":"4.4.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI 2021A01809 CI 2021B009"],"award-info":[{"award-number":["CI 2021A01809 CI 2021B009"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["Car-21"],"award-info":[{"award-number":["Car-21"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81803761"],"award-info":[{"award-number":["No. 81803761"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["No. 2019M652144"],"award-info":[{"award-number":["No. 2019M652144"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Osteoporosis is a common systemic metabolic disease characterized by a decrease in bone density and bone mass, destruction of bone tissue microstructure, and increased bone fragility leading to fracture susceptibility. Pharmacological treatment of osteoporosis is the focus of current research, and anti-osteoporosis drugs usually play a role in inhibiting bone resorption, promoting bone formation, and having a dual role. However, most of the drugs have the disadvantages of single target and high toxic and side effects. There are many types of traditional Chinese medicines (TCM), from a wide range of sources and mostly plants. Herbal plants have unique advantages in regulating the relationship between osteoporosis and the immune system, acupuncture therapy has significant therapeutic effects in combination with medicine for osteoporosis. The target cells and specific molecular mechanisms of TCM in preventing and treating osteoporosis have not been fully elucidated. At present, there is a lack of comprehensive understanding of the pathological mechanism of the disease. Therefore, a better understanding of the pathological signaling pathways and key molecules involved in the pathogenesis of osteoporosis is crucial for the design of therapeutic targets and drug development. In this paper, we review the development and current status of anti-osteoporosis drugs currently in clinical application and under development to provide relevant basis and reference for drug prevention and treatment of osteoporosis, with the aim of promoting pharmacological research and new drug development.<\/jats:p>","DOI":"10.3389\/fphar.2024.1456796","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T04:56:07Z","timestamp":1723438567000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":73,"title":["Osteoporosis treatment: current drugs and future developments"],"prefix":"10.3389","volume":"15","author":[{"given":"Ya-jing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hua","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao-hong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ping","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1097\/bor.0000000000000608","article-title":"Glucocorticoid-induced osteoporosis update","volume":"31","author":"Adami","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"14001","DOI":"10.1038\/boneres.2014.1","article-title":"Osteoporosis in men: a review","volume":"2","author":"Adler","year":"2014","journal-title":"Bone Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1002\/jcb.25447","article-title":"Calcium sensing receptor function supports osteoblast survival and acts as a Co-factor in PTH anabolic actions in bone","volume":"117","author":"Al-Dujaili","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"Cd000227","DOI":"10.1002\/14651858.CD000227.pub4","article-title":"Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men","volume":"2014","author":"Avenell","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.3390\/jcm10133002","article-title":"The treatment gap in osteoporosis","volume":"10","author":"Ayub","year":"2021","journal-title":"J. Clin. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1210\/jc.2019-00192","article-title":"Efficacy of pharmacological therapies for the prevention of fractures in postmenopausal women: a network meta-analysis","volume":"104","author":"Barrionuevo","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"111748","DOI":"10.1016\/j.msec.2020.111748","article-title":"Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration","volume":"120","author":"Bharadwaz","year":"2021","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.21037\/qims.2018.01.02","article-title":"Site specific measurements of bone formation using [(18)F] sodium fluoride PET\/CT","volume":"8","author":"Blake","year":"2018","journal-title":"Quant. Imaging Med. Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/obr.12822","article-title":"Beyond the bone: bone morphogenetic protein signaling in adipose tissue","volume":"20","author":"Bl\u00e1zquez-Medela","year":"2019","journal-title":"Obes. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.2165\/0003495-200868180-00012","article-title":"Teriparatide: a review of its use in osteoporosis","volume":"68","author":"Blick","year":"2008","journal-title":"Drugs"},{"key":"B11","first-page":"275","article-title":"Review of the safety and efficacy of risedronate for the treatment of male osteoporosis","volume":"2","author":"Bobba","year":"2007","journal-title":"Clin. Interv. Aging"},{"key":"B12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/s2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1056\/NEJMoa1204061","article-title":"Fracture risk and zoledronic acid therapy in men with osteoporosis","volume":"367","author":"Boonen","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1177\/0022034513500306","article-title":"Advances in the regulation of osteoclasts and osteoclast functions","volume":"92","author":"Boyce","year":"2013","journal-title":"J. Dent. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11914-017-0356-1","article-title":"T regulatory cells in bone remodelling","volume":"15","author":"Bozec","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.3390\/nu12082394","article-title":"Role of vitamin C in osteoporosis development and treatment-A literature review","volume":"12","author":"Brzezi\u0144ska","year":"2020","journal-title":"Nutrients"},{"key":"B17","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41467-018-08097-7","article-title":"Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00795-015-0099-y","article-title":"The osteocyte plays multiple roles in bone remodeling and mineral homeostasis","volume":"48","author":"Chen","year":"2015","journal-title":"Med. Mol. Morphol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/03008207.2017.1290085","article-title":"Osteoblast-osteoclast interactions","volume":"59","author":"Chen","year":"2018","journal-title":"Connect. Tissue Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"111697","DOI":"10.1016\/j.biopha.2021.111697","article-title":"Pitavastatin prevents ovariectomy-induced osteoporosis by regulating osteoclastic resorption and osteoblastic formation","volume":"139","author":"Cheon","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B21","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3390\/nu11030506","article-title":"Vitamin C activates osteoblastogenesis and inhibits osteoclastogenesis via wnt\/\u03b2-catenin\/ATF4 signaling pathways","volume":"11","author":"Choi","year":"2019","journal-title":"Nutrients"},{"key":"B22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12891-017-1399-2","article-title":"Strontium ranelate causes osteophytes overgrowth in a model of early phase osteoarthritis","volume":"18","author":"Chu","year":"2017","journal-title":"BMC Musculoskelet. Disord."},{"key":"B23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3390\/biom11040506","article-title":"The effects of calcium, magnesium, phosphorus, fluoride, and lead on bone tissue","volume":"11","author":"Ciosek","year":"2021","journal-title":"Biomolecules"},{"key":"B24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1159\/000491036","article-title":"Normocalcemic hyperparathyroidism","volume":"51","author":"Corbetta","year":"2019","journal-title":"Front. Horm. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1007\/s00296-018-4106-1","article-title":"Denosumab in the treatment of glucocorticoid-induced osteoporosis","volume":"38","author":"Coskun Benlidayi","year":"2018","journal-title":"Rheumatol. Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/s0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"115411","DOI":"10.1016\/j.bone.2020.115411","article-title":"History of alendronate","volume":"137","author":"Cummings","year":"2020","journal-title":"Bone"},{"key":"B28","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1517\/14656566.2013.782002","article-title":"The use of raloxifene in osteoporosis treatment","volume":"14","author":"D Amelio","year":"2013","journal-title":"Expert Opin. Pharmacother."},{"key":"B29","doi-asserted-by":"publisher","first-page":"b5463","DOI":"10.1136\/bmj.b5463","article-title":"Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe","volume":"340","year":"2010","journal-title":"Bmj"},{"key":"B30","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3390\/ijms22020625","article-title":"Mechanisms of bone fragility: from osteogenesis imperfecta to secondary osteoporosis","volume":"22","author":"El-Gazzar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1177\/0022034510384626","article-title":"Fluoride's effects on the formation of teeth and bones, and the influence of genetics","volume":"90","author":"Everett","year":"2011","journal-title":"J. Dent. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1039\/d1ra05799e","article-title":"Exploring the potential therapeutic effect of Eucommia ulmoides-Dipsaci Radix herbal pair on osteoporosis based on network pharmacology and molecular docking technology","volume":"12","author":"Feng","year":"2022","journal-title":"RSC Adv."},{"key":"B33","first-page":"948","article-title":"One year in review 2018: progress in osteoporosis treatment","volume":"36","author":"Figliomeni","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.3390\/nu12123625","article-title":"Vitamin K and osteoporosis","volume":"12","author":"Fusaro","year":"2020","journal-title":"Nutrients"},{"key":"B35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.drudis.2007.01.003","article-title":"Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)","volume":"12","author":"Gao","year":"2007","journal-title":"Drug Discov. Today"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.3390\/ijms21103538","article-title":"Hematological diseases and osteoporosis","volume":"21","author":"Gaudio","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.ecl.2018.07.003","article-title":"Physiology of parathyroid hormone","volume":"47","author":"Goltzman","year":"2018","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"B38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/path.5170","article-title":"Bone morphogenetic protein receptor signal transduction in human disease","volume":"247","author":"Gomez-Puerto","year":"2019","journal-title":"J. Pathol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1288591","DOI":"10.3389\/fmed.2023.1288591","article-title":"Research progress of plant medicine and Chinese herbal compounds in the treatment of rheumatoid arthritis combined with osteoporosis","volume":"10","author":"Gu","year":"2023","journal-title":"Front. Med. (Lausanne)"},{"key":"B40","doi-asserted-by":"publisher","first-page":"751","DOI":"10.3892\/ijmm.2020.4606","article-title":"Simvastatin inhibits the adipogenesis of bone marrow-derived mesenchymal stem cells through the downregulation of chemerin\/CMKLR1 signaling","volume":"46","author":"Guo","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"Cd002825","DOI":"10.1002\/14651858.Cd002825","article-title":"Fluoride for treating postmenopausal osteoporosis","volume":"2000","author":"Haguenauer","year":"2000","journal-title":"Cochrane Database Syst. Rev."},{"key":"B42","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.bone.2009.10.040","article-title":"A single dose zoledronic acid enhances pin fixation in high tibial osteotomy using the hemicallotasis technique. A double-blind placebo controlled randomized study in 46 patients","volume":"46","author":"Harding","year":"2010","journal-title":"Bone"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.3389\/fphar.2019.01344","article-title":"Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis","volume":"10","author":"He","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/cpt1976205593","article-title":"Etidronate disodium in postmenopausal osteoporosis","volume":"20","author":"Heaney","year":"1976","journal-title":"Clin. Pharmacol. Ther."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1517\/14712598.2010.526104","article-title":"Oral salmon calcitonin--pharmacology in osteoporosis","volume":"10","author":"Henriksen","year":"2010","journal-title":"Expert Opin. Biol. Ther."},{"key":"B46","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1634\/theoncologist.2018-0218","article-title":"Indirect evaluation of bone saturation with zoledronic acid after long-term dosing","volume":"24","author":"Hortobagyi","year":"2019","journal-title":"Oncologist"},{"key":"B47","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3389\/fendo.2020.00613","article-title":"Calcitonin induces bone formation by increasing expression of Wnt10b in osteoclasts in ovariectomy-induced osteoporotic rats","volume":"11","author":"Hsiao","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.3390\/nu6051971","article-title":"Vitamin K\u2082 therapy for postmenopausal osteoporosis","volume":"6","author":"Iwamoto","year":"2014","journal-title":"Nutrients"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1120457","DOI":"10.3389\/fphar.2023.1120457","article-title":"Overview on postmenopausal osteoporosis and periodontitis: the therapeutic potential of phytoestrogens against alveolar bone loss","volume":"14","author":"Jayusman","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fphar.2019.00202","article-title":"Tanshinones, critical pharmacological components in salvia miltiorrhiza","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"113379","DOI":"10.1016\/j.biopha.2022.113379","article-title":"Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes","volume":"153","author":"Jin","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B52","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s40266-016-0360-7","article-title":"Ibandronate: a review in Japanese patients with osteoporosis","volume":"33","author":"Keating","year":"2016","journal-title":"Drugs Aging"},{"key":"B53","doi-asserted-by":"publisher","first-page":"183","DOI":"10.6118\/jmm.2018.24.3.183","article-title":"The beneficial and adverse effects of raloxifene in menopausal women: a mini review","volume":"24","author":"Khorsand","year":"2018","journal-title":"J. Menopausal Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1172\/jci135712","article-title":"The microbiome adds to the complexity of parathyroid hormone action on bone","volume":"130","author":"Khosla","year":"2020","journal-title":"J. Clin. Investig."},{"key":"B55","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/s2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"6564","DOI":"10.3390\/ijms22126564","article-title":"The influence of strontium on bone tissue metabolism and its application in osteoporosis treatment","volume":"22","author":"Ko\u0142odziejska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/ptr.5955","article-title":"A comparative study on the effect of promoting the osteogenic function of osteoblasts using isoflavones from Radix Astragalus","volume":"32","author":"Kong","year":"2018","journal-title":"Phytother. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1359\/jbmr.081112","article-title":"Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine\/human) RANKL","volume":"24","author":"Kostenuik","year":"2009","journal-title":"J. Bone Min. Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1007\/s00198-014-2646-0","article-title":"PINP as a biological response marker during teriparatide treatment for osteoporosis","volume":"25","author":"Krege","year":"2014","journal-title":"Osteoporos. Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11914-019-00498-x","article-title":"Glucocorticoid-induced osteoporosis: new insights into the pathophysiology and treatments","volume":"17","author":"Lane","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1017\/s0029665108007003","article-title":"Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment","volume":"67","author":"Lanham-New","year":"2008","journal-title":"Proc. Nutr. Soc."},{"key":"B62","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.joim.2021.11.003","article-title":"Efficacy of the herbal pair, Radix Achyranthis Bidentatae and Eucommiae Cortex, in preventing glucocorticoid-induced osteoporosis in the zebrafish model","volume":"20","author":"Lee","year":"2022","journal-title":"J. Integr. Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.3390\/biom11091364","article-title":"Development of high affinity calcitonin analog fragments targeting extracellular domains of calcitonin family receptors","volume":"11","author":"Lee","year":"2021","journal-title":"Biomolecules"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.jmb.2020.01.028","article-title":"Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics","volume":"432","author":"Lee","year":"2020","journal-title":"J. Mol. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/jbmr.3930","article-title":"Abaloparatide at the same dose has the same effects on bone as PTH (1-34) in mice","volume":"35","author":"Le Henaff","year":"2020","journal-title":"J. Bone Min. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.ijbiomac.2021.11.030","article-title":"Benefits and mechanisms of polysaccharides from Chinese medicinal herbs for anti-osteoporosis therapy: a review","volume":"193","author":"Lei","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1136\/annrheumdis-2019-215714","article-title":"Diagnosis of osteoporosis in statin-treated patients is dose-dependent","volume":"78","author":"Leutner","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.2174\/0929867327666200330142432","article-title":"Osteoporosis: mechanism, molecular target and current status on drug development","volume":"28","author":"Li","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1080\/13697137.2022.2102894","article-title":"Clinical practice of traditional Chinese medicine for the treatment of postmenopausal osteoporosis: a literature review","volume":"25","author":"Li","year":"2022","journal-title":"Climacteric"},{"key":"B70","doi-asserted-by":"publisher","first-page":"4362","DOI":"10.3390\/nu6104362","article-title":"Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats","volume":"6","author":"Lim","year":"2014","journal-title":"Nutrients"},{"key":"B71","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e12613","DOI":"10.1111\/cpr.12613","article-title":"Fluorine-contained hydroxyapatite suppresses bone resorption through inhibiting osteoclasts differentiation and function in vitro and in vivo","volume":"52","author":"Liu","year":"2019","journal-title":"Cell. Prolif."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1038\/s41467-021-22131-1","article-title":"Osteoclasts protect bone blood vessels against senescence through the angiogenin\/plexin-B2 axis","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"B74","doi-asserted-by":"publisher","first-page":"Cd005467","DOI":"10.1002\/14651858.CD005467.pub2","article-title":"Chinese herbal medicines for treating osteoporosis","volume":"2014","author":"Liu","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"B75","doi-asserted-by":"publisher","first-page":"116052","DOI":"10.1016\/j.jep.2022.116052","article-title":"Pilose antler (Cervus elaphus Linnaeus) polysaccharide and polypeptide extract inhibits bone resorption in high turnover type osteoporosis by stimulating the MAKP and MMP-9 signaling pathways","volume":"304","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"5388","DOI":"10.3390\/ijms21155388","article-title":"Physical activity-dependent regulation of parathyroid hormone and calcium-phosphorous metabolism","volume":"21","author":"Lombardi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1007\/s00198-017-3996-1","article-title":"Trends in osteoporosis and low bone mass in older US adults, 2005-2006 through 2013-2014","volume":"28","author":"Looker","year":"2017","journal-title":"Osteoporos. Int."},{"key":"B78","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/joim.12873","article-title":"Treating osteoporosis to prevent fractures: current concepts and future developments","volume":"285","author":"Lorentzon","year":"2019","journal-title":"J. Intern Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"a022327","DOI":"10.1101\/cshperspect.a022327","article-title":"Bone morphogenetic protein-based therapeutic approaches","volume":"10","author":"Lowery","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1080\/14756366.2018.1465417","article-title":"Advances in the discovery of cathepsin K inhibitors on bone resorption","volume":"33","author":"Lu","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s10020-023-00625-6","article-title":"Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification","volume":"29","author":"Luo","year":"2023","journal-title":"Mol. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/ijms21093199","article-title":"The role of sclerostin in bone and ectopic calcification","volume":"21","author":"Mar\u00e9","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1161\/hq1001.097781","article-title":"Effect of statins on bone mineral density and bone histomorphometry in rodents","volume":"21","author":"Maritz","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s00198-016-3848-4","article-title":"Relationship between baseline characteristics and response to risedronate treatment for osteoporosis: data from three Japanese phase III trials","volume":"28","author":"Mawatari","year":"2017","journal-title":"Osteoporos. Int."},{"key":"B85","doi-asserted-by":"publisher","first-page":"115407","DOI":"10.1016\/j.bone.2020.115407","article-title":"History of risedronate","volume":"137","author":"McClung","year":"2020","journal-title":"Bone"},{"key":"B86","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/s2213-8587(19)30346-8","article-title":"Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study","volume":"7","author":"McClung","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1001\/jama.2016.11136","article-title":"Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial","volume":"316","author":"Miller","year":"2016","journal-title":"Jama"},{"key":"B88","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.3390\/ijms22052693","article-title":"The rationale for the intra-articular administration of clodronate in osteoarthritis","volume":"22","author":"Moretti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bcp.2016.04.010","article-title":"Pharmacological inhibition of cathepsin K: a promising novel approach for postmenopausal osteoporosis therapy","volume":"117","author":"Mukherjee","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1152\/physrev.00066.2017","article-title":"The activity of peptides of the calcitonin family in bone","volume":"99","author":"Naot","year":"2019","journal-title":"Physiol. Rev."},{"key":"B91","doi-asserted-by":"publisher","first-page":"Cd005326","DOI":"10.1002\/14651858.CD005326.pub3","article-title":"Strontium ranelate for preventing and treating postmenopausal osteoporosis","volume":"2006","author":"O Donnell","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"B92","doi-asserted-by":"publisher","first-page":"a031245","DOI":"10.1101\/cshperspect.a031245","article-title":"Osteoimmunology","volume":"9","author":"Okamoto","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B93","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/nyas.12969","article-title":"T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone","volume":"1364","author":"Pacifici","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1142\/s0192415x18500258","article-title":"The effectiveness of acupuncture for osteoporosis: a systematic review and meta-analysis","volume":"46","author":"Pan","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1002\/jbmr.4284","article-title":"Incidence of hip and subtrochanteric\/femoral shaft fractures in postmenopausal women with osteoporosis in the phase 3 long-term odanacatib fracture trial","volume":"36","author":"Papapoulos","year":"2021","journal-title":"J. Bone Min. Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"6504","DOI":"10.3390\/ijms22126504","article-title":"(18)F-Sodium fluoride PET as a diagnostic modality for metabolic, autoimmune, and osteogenic bone disorders: cellular mechanisms and clinical applications","volume":"22","author":"Park","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bone.2016.11.002","article-title":"Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality","volume":"95","author":"Paschalis","year":"2017","journal-title":"Bone"},{"key":"B98","doi-asserted-by":"publisher","first-page":"212","DOI":"10.4103\/tcmj.tcmj_233_20","article-title":"The molecular etiology and treatment of glucocorticoid-induced osteoporosis","volume":"33","author":"Peng","year":"2021","journal-title":"Tzu Chi Med. J."},{"key":"B99","doi-asserted-by":"publisher","first-page":"426","DOI":"10.7150\/thno.34126","article-title":"Type H blood vessels in bone modeling and remodeling","volume":"10","author":"Peng","year":"2020","journal-title":"Theranostics"},{"key":"B100","doi-asserted-by":"publisher","first-page":"911326","DOI":"10.3389\/fbioe.2022.911326","article-title":"Role of traditional Chinese medicine in bone regeneration and osteoporosis","volume":"10","author":"Peng","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"19723","DOI":"10.1074\/jbc.M212226200","article-title":"Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics","volume":"278","author":"Qin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1210\/jc.2004-1774","article-title":"Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of Peripheral Osteoporosis (TROPOS) study","volume":"90","author":"Reginster","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/bph.13622","article-title":"The potential health effects of dietary phytoestrogens","volume":"174","author":"Rietjens","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/jcb.1255","article-title":"Sodium fluoride induces changes on proteoglycans synthesized by avian osteoblasts in culture","volume":"83","author":"Rodr\u00edguez","year":"2001","journal-title":"J. Cell. Biochem."},{"key":"B105","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos. Int."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.4103\/1673-5374.213536","article-title":"Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system","volume":"12","author":"Segura-Uribe","year":"2017","journal-title":"Neural Regen. Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"782096","DOI":"10.3389\/fphar.2022.782096","article-title":"Epimedium for osteoporosis based on western and eastern medicine: an updated systematic review and meta-analysis","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3390\/nu14010180","article-title":"Calcium absorption from food products: food matrix effects","volume":"14","author":"Shkembi","year":"2021","journal-title":"Nutrients"},{"key":"B109","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1152\/physiol.00061.2014","article-title":"Physiological bone remodeling: systemic regulation and growth factor involvement","volume":"31","author":"Siddiqui","year":"2016","journal-title":"Physiol. (Bethesda)"},{"key":"B110","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.3390\/jcm11092382","article-title":"Secondary osteoporosis and metabolic bone diseases","volume":"11","author":"Sobh","year":"2022","journal-title":"J. Clin. Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"120601","DOI":"10.1016\/j.carbpol.2023.120601","article-title":"Structural characterization and anti-osteoporosis effects of polysaccharide purified from Eucommia ulmoides Oliver cortex based on its modulation on bone metabolism","volume":"306","author":"Song","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/bcp.13869","article-title":"Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis","volume":"85","author":"Stone","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.3390\/ijms19092490","article-title":"Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder","volume":"19","author":"Sugatani","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1289144","DOI":"10.3389\/fmed.2023.1289144","article-title":"Cornus officinalis: a potential herb for treatment of osteoporosis","volume":"10","author":"Tang","year":"2023","journal-title":"Front. Med. (Lausanne)"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"B116","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/s2213-8587(19)30255-4","article-title":"Combination denosumab and high dose teriparatide for postmenopausal osteoporosis (DATA-HD): a randomised, controlled phase 4 trial","volume":"7","author":"Tsai","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bone.2016.01.025","article-title":"Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells","volume":"85","author":"Tsukamoto","year":"2016","journal-title":"Bone"},{"key":"B119","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.3390\/cancers13102478","article-title":"The role of IGF\/IGF-IR-Signaling and extracellular matrix effectors in bone sarcoma pathogenesis","volume":"13","author":"Tzanakakis","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B120","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00774-018-0942-z","article-title":"Study design of multi-center, open-label randomized controlled, head-to-head trial comparing minodronic acid and raloxifene: Japanese Osteoporosis Intervention Trial (JOINT)-04","volume":"37","author":"Uemura","year":"2019","journal-title":"J. Bone Min. Metab."},{"key":"B121","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1359\/jbmr.081007","article-title":"Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats","volume":"24","author":"Vajda","year":"2009","journal-title":"J. Bone Min. Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.bone.2018.02.019","article-title":"Bone and blood interactions in human health and disease","volume":"119","author":"Valderr\u00e1bano","year":"2019","journal-title":"Bone"},{"key":"B123","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","article-title":"Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards","volume":"22","author":"Vasikaran","year":"2011","journal-title":"Osteoporos. Int."},{"key":"B124","doi-asserted-by":"publisher","first-page":"13640","DOI":"10.3390\/ijms222413640","article-title":"Management of osteoporosis in men: a narrative review","volume":"22","author":"Vescini","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1142\/s0192415x24500393","article-title":"The role of traditional Chinese medicines in the treatment of osteoporosis","volume":"52","author":"Wang","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"B126","doi-asserted-by":"publisher","first-page":"e2121106","DOI":"10.1001\/jamanetworkopen.2021.21106","article-title":"Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study","volume":"4","author":"Wang","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"B127","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00198-017-4255-1","article-title":"The effect of icariin on bone metabolism and its potential clinical application","volume":"29","author":"Wang","year":"2018","journal-title":"Osteoporos. Int."},{"key":"B128","doi-asserted-by":"publisher","first-page":"356260","DOI":"10.1155\/2013\/356260","article-title":"Chinese herbal medicine for osteoporosis: a systematic review of randomized controlled trails","volume":"2013","author":"Wang","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1210\/jc.2011-3045","article-title":"Osteoporosis in men: an Endocrine Society clinical practice guideline","volume":"97","author":"Watts","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B130","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00198-015-3386-5","article-title":"Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation","volume":"27","author":"Weaver","year":"2016","journal-title":"Osteoporos. Int."},{"key":"B131","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1093\/advances\/nmy086","article-title":"Calcium","volume":"10","author":"Weaver","year":"2019","journal-title":"Adv. Nutr."},{"key":"B132","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nrendo.2016.91","article-title":"Physiological and pathophysiological bone turnover - role of the immune system","volume":"12","author":"Weitzmann","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1172\/jci28550","article-title":"Estrogen deficiency and bone loss: an inflammatory tale","volume":"116","author":"Weitzmann","year":"2006","journal-title":"J. Clin. Investig."},{"key":"B134","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/ptr.2126","article-title":"The effect of crude extract from Radix Dipsaci on bone in mice","volume":"21","author":"Wong","year":"2007","journal-title":"Phytother. Res."},{"key":"B135","doi-asserted-by":"publisher","first-page":"687551","DOI":"10.3389\/fimmu.2021.687551","article-title":"T-cell mediated inflammation in postmenopausal osteoporosis","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Immunol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41413-022-00224-x","article-title":"Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration","volume":"10","author":"Wu","year":"2022","journal-title":"Bone Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bioactmat.2020.03.004","article-title":"Enhanced osteogenesis and therapy of osteoporosis using simvastatin loaded hybrid system","volume":"5","author":"Wu","year":"2020","journal-title":"Bioact. Mater"},{"key":"B138","doi-asserted-by":"publisher","first-page":"e19334","DOI":"10.1097\/md.0000000000019334","article-title":"Acupuncture and moxibustion for primary osteoporosis: an overview of systematic review","volume":"99","author":"Xu","year":"","journal-title":"Med. Baltim."},{"key":"B139","doi-asserted-by":"publisher","first-page":"110581","DOI":"10.1016\/j.biopha.2020.110581","article-title":"Radix Rehmanniae Praeparata promotes bone fracture healing through activation of TGF-\u03b2 signaling in mesenchymal progenitors","volume":"130","author":"Xu","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B140","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.joms.2017.03.016","article-title":"Pamidronate disodium leads to bone necrosis via suppression of wnt\/\u03b2-catenin signaling in human bone marrow mesenchymal stem cells In\u00a0Vitro","volume":"75","author":"Xu","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"B141","doi-asserted-by":"publisher","first-page":"5747298","DOI":"10.1155\/2019\/5747298","article-title":"Mechanism of action of icariin in bone marrow mesenchymal stem cells","volume":"2019","author":"Yang","year":"2019","journal-title":"Stem Cells Int."},{"key":"B142","doi-asserted-by":"publisher","first-page":"e0170674","DOI":"10.1371\/journal.pone.0170674","article-title":"Fluoride regulate osteoblastic transforming growth factor-\u03b21 signaling by mediating recycling of the type I receptor ALK5","volume":"12","author":"Yang","year":"2017","journal-title":"PLoS One"},{"key":"B143","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1080\/10717544.2022.2111479","article-title":"Human serum albumin-based nanoparticles alter raloxifene administration and improve bioavailability","volume":"29","author":"Yang","year":"2022","journal-title":"Drug Deliv."},{"key":"B144","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s43657-022-00074-x","article-title":"Chinese medicine phenomics (chinmedphenomics): personalized, precise and promising","volume":"2","author":"Yuan","year":"2022","journal-title":"Phenomics"},{"key":"B145","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3109\/13880209.2015.1079224","article-title":"Flavonoids of Herba Epimedii stimulate osteogenic differentiation and suppress adipogenic differentiation of primary mesenchymal stem cells via estrogen receptor pathway","volume":"54","author":"Zhang","year":"","journal-title":"Pharm. Biol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3389\/fcell.2020.00325","article-title":"Pros and cons of denosumab treatment for osteoporosis and implication for RANKL aptamer therapy","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jep.2016.05.025","article-title":"Traditional Chinese medicine formulas for the treatment of osteoporosis: implication for antiosteoporotic drug discovery","volume":"189","author":"Zhang","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"116820","DOI":"10.1016\/j.lfs.2019.116820","article-title":"Systems pharmacology dissection of action mechanisms of Dipsaci Radix for osteoporosis","volume":"235","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.2147\/dddt.S207823","article-title":"A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency","volume":"13","author":"Zhao","year":"2019","journal-title":"Drug Des. Devel Ther."},{"key":"B150","doi-asserted-by":"publisher","first-page":"6345857","DOI":"10.1155\/2018\/6345857","article-title":"Prevention and treatment of osteoporosis using Chinese medicinal plants: special emphasis on mechanisms of immune modulation","volume":"2018","author":"Zhao","year":"2018","journal-title":"J. Immunol. Res."},{"key":"B151","first-page":"943","article-title":"Progress of experimental research on prevention and treatment of osteoporosis by traditional Chinese medicine","volume":"23","author":"Zhao","year":"2003","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1235081","DOI":"10.3389\/fmed.2023.1235081","article-title":"Mechanisms of action and synergetic formulas of plant-based natural compounds from traditional Chinese medicine for managing osteoporosis: a literature review","volume":"10","author":"Zhou","year":"2023","journal-title":"Front. Med. (Lausanne)"},{"key":"B153","doi-asserted-by":"publisher","first-page":"e47058","DOI":"10.1371\/journal.pone.0047058","article-title":"Vitamin C prevents hypogonadal bone loss","volume":"7","author":"Zhu","year":"2012","journal-title":"PLoS One"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1456796\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T04:56:15Z","timestamp":1723438575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1456796\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":153,"alternative-id":["10.3389\/fphar.2024.1456796"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1456796","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]},"article-number":"1456796"}}