{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:03:06Z","timestamp":1792875786103,"version":"4.5.0"},"reference-count":422,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function, which significantly increases pain and social burden. However, few therapeutic interventions are effective in preventing or mitigating the progression of AD. An increasing number of recent studies support the hypothesis that the gut microbiome and its metabolites may be associated with upstream regulators of AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this review, we comprehensively explore the potential mechanisms and currently available interventions targeting the microbiome for the improvement of AD. Our discussion is structured around modern research advancements in AD, the bidirectional communication between the gut and brain, the multi-target regulatory effects of microbial metabolites on AD, and therapeutic strategies aimed at modulating gut microbiota to manage AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The gut microbiota plays a crucial role in the pathogenesis of AD through continuous bidirectional communication via the microbiota-gut-brain axis. Among these, microbial metabolites such as lipids, amino acids, bile acids and neurotransmitters, especially sphingolipids and phospholipids, may serve as central components of the gut-brain axis, regulating AD-related pathogenic mechanisms including \u03b2-amyloid metabolism, Tau protein phosphorylation, and neuroinflammation. Additionally, interventions such as probiotic administration, fecal microbiota transplantation, and antibiotic use have also provided evidence supporting the association between gut microbiota and AD. At the same time, we propose an innovative strategy for treating AD: a healthy lifestyle combined with targeted probiotics and other potential therapeutic interventions, aiming to restore intestinal ecology and microbiota balance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite previous efforts, the molecular mechanisms by which gut microbes act on AD have yet to be fully described. However, intestinal microorganisms may become an essential target for connecting the gut-brain axis and improving the symptoms of AD. At the same time, it requires joint exploration by multiple centers and multiple disciplines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2024.1459655","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T08:44:27Z","timestamp":1726649067000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Gut microbiota metabolites: potential therapeutic targets for Alzheimer\u2019s disease?"],"prefix":"10.3389","volume":"15","author":[{"given":"Shanshan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3390\/nu16040538","article-title":"Potential therapeutic effects of Bifidobacterium breve MCC1274 on Alzheimer's disease pathologies in AppNL-G-F mice","volume":"16","author":"Abdelhamid","year":"2024","journal-title":"Nutrients"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/nu16081211","article-title":"Effectiveness of partially hydrolyzed guar gum on cognitive function and sleep efficiency in healthy elderly subjects in a randomized, double-blind, placebo-controlled, and parallel-group study","volume":"16","author":"Abe","year":"2024","journal-title":"Nutrients"},{"key":"B3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/s41575-023-00890-0","article-title":"Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota-gut-brain axis","volume":"21","author":"Aburto","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s12964-024-01612-y","article-title":"Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R","volume":"22","author":"Ackmann","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e2345687","DOI":"10.1001\/jamanetworkopen.2023.45687","article-title":"Economic evaluation of exercise or cognitive and social enrichment activities for improved cognition after stroke","volume":"6","author":"Adjetey","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"B6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.bbi.2019.09.019","article-title":"Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"83","author":"Agostini","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1016\/j.clnu.2022.09.012","article-title":"The gut microbiome, mild cognitive impairment, and probiotics: a randomized clinical trial in middle-aged and older adults","volume":"41","author":"Aljumaah","year":"2022","journal-title":"Clin. Nutr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"2023 Alzheimer's disease facts and figures","volume":"19","year":"2023","journal-title":"Alzheimers Dement."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1016\/s0047-6374(01)00310-4","article-title":"Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches?","volume":"122","author":"Amenta","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.cell.2013.11.042","article-title":"Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells","volume":"156","author":"An","year":"2014","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"105198","DOI":"10.1016\/j.nbd.2020.105198","article-title":"Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease","volume":"148","author":"Andersen","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.3390\/cells12212531","article-title":"Advancing Alzheimer's therapeutics: exploring the impact of physical exercise in animal models and patients","volume":"12","author":"Andrade-Guerrero","year":"2023","journal-title":"Cells"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.3390\/nu11081887","article-title":"Metabolic endotoxemia: a potential underlying mechanism of the relationship between dietary fat intake and risk for cognitive impairments in humans?","volume":"11","author":"Andr\u00e9","year":"2019","journal-title":"Nutrients"},{"key":"B14","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12974-019-1494-4","article-title":"Antibiotics, gut microbiota, and Alzheimer's disease","volume":"16","author":"Angelucci","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1173660","DOI":"10.3389\/fnut.2023.1173660","article-title":"The role of probiotics and prebiotics in modulating of the gut-brain axis","volume":"10","author":"Ansari","year":"2023","journal-title":"Front. Nutr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"eaat8462","DOI":"10.1126\/scitranslmed.aat8462","article-title":"A\u03b2 and tau prion-like activities decline with longevity in the Alzheimer's disease human brain","volume":"11","author":"Aoyagi","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/JAD-220148","article-title":"Effect of probiotic Bifidobacterium breve in improving cognitive function and preventing brain atrophy in older patients with suspected mild cognitive impairment: results of a 24-week randomized, double-blind, placebo-controlled trial","volume":"88","author":"Asaoka","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"103460","DOI":"10.1016\/j.nicl.2023.103460","article-title":"Protective effects of sleep duration and physical activity on cognitive performance are influenced by \u03b2-amyloid and brain volume but not tau burden among cognitively unimpaired older adults","volume":"39","author":"Aslanyan","year":"2023","journal-title":"Neuroimage Clin."},{"key":"B19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s13668-024-00539-7","article-title":"Modulation of gut microbiota through dietary intervention in neuroinflammation and Alzheimer's and Parkinson's diseases","volume":"13","author":"Ayten","year":"2024","journal-title":"Curr. Nutr. Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.3390\/nu15194175","article-title":"Effect of continuous ingestion of bifidobacteria and dietary fiber on improvement in cognitive function: a randomized, double-blind, placebo-controlled trial","volume":"15","author":"Azuma","year":"2023","journal-title":"Nutrients"},{"key":"B21","doi-asserted-by":"publisher","first-page":"123260","DOI":"10.1016\/j.ijbiomac.2023.123260","article-title":"Lipopolysaccharide induced neuroprotective effects of bacterial protease against Alzheimer's disease in male Wistar albino rats","volume":"230","author":"Azzam","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1289819","DOI":"10.3389\/fmicb.2023.1289819","article-title":"Role and interaction of bacterial sphingolipids in human health","volume":"14","author":"Bai","year":"2023","journal-title":"Front. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.bbi.2023.04.015","article-title":"Correlations between kynurenines in plasma and CSF, and their relation to markers of Alzheimer's disease pathology","volume":"111","author":"Bakker","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41579-023-00890-6","article-title":"Intrahost evolution of the gut microbiota","volume":"21","author":"Barreto","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1365-2672.2012.05344.x","article-title":"\u03b3-Aminobutyric acid production by culturable bacteria from the human intestine","volume":"113","author":"Barrett","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1001\/jama.2014.17103","article-title":"Diagnosis and treatment of Clostridium difficile in adults: a systematic review","volume":"313","author":"Bbagdasarian","year":"2015","journal-title":"JAMA"},{"key":"B27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40168-024-01748-6","article-title":"Horizontal gene transfer after faecal microbiota transplantation in adolescents with obesity","volume":"12","author":"Behling","year":"2024","journal-title":"Microbiome"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1016\/j.jmb.2018.08.019","article-title":"Ursodeoxycholic acid improves mitochondrial function and redistributes Drp1 in fibroblasts from patients with either sporadic or familial Alzheimer's disease","volume":"430","author":"Bell","year":"2018","journal-title":"J. Mol. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00213-020-05665-y","article-title":"A specific dietary fibre supplementation improves cognitive performance-an exploratory randomised, placebo-controlled, crossover study","volume":"238","author":"Berding","year":"2021","journal-title":"Psychopharmacol. Berl."},{"key":"B30","doi-asserted-by":"publisher","first-page":"105192","DOI":"10.1016\/j.neubiorev.2023.105192","article-title":"New perspectives on the basal forebrain cholinergic system in Alzheimer's disease","volume":"150","author":"Berry","year":"2023","journal-title":"Neurosci. Biobehav Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1093\/brain\/awz193","article-title":"Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases","volume":"142","author":"Betts","year":"2019","journal-title":"Brain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13024-021-00500-0","article-title":"CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice","volume":"16","author":"Bhargavan","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"B33","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbz155","article-title":"Current challenges and best-practice protocols for microbiome analysis","volume":"22","author":"Bharti","year":"2021","journal-title":"Brief. Bioinform"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1002\/alz.12088","article-title":"GABAergic dysfunction in excitatory and inhibitory (E\/I) imbalance drives the pathogenesis of Alzheimer's disease","volume":"16","author":"Bi","year":"2020","journal-title":"Alzheimers Dement."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.3390\/jcm11144119","article-title":"Fecal microbiota transplantation as new therapeutic avenue for human diseases","volume":"11","author":"Biazzo","year":"2022","journal-title":"J. Clin. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3233\/JAD-230061","article-title":"Accelerated breakdown of phosphatidylcholine and phosphatidylethanolamine is a predominant brain metabolic defect in Alzheimer's disease","volume":"93","author":"Blusztajn","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0079-6107(93)90009-9","article-title":"Regulation of serotonin synthesis","volume":"60","author":"Boadle-Biber","year":"1993","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1681\/ASN.2019070728","article-title":"Uremic toxic blood-brain barrier disruption mediated by AhR activation leads to cognitive impairment during experimental renal dysfunction","volume":"31","author":"Bobot","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1152\/physrev.00002.2012","article-title":"Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis","volume":"93","author":"Bohdanowicz","year":"2013","journal-title":"Physiol. Rev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1038\/s41598-017-02587-2","article-title":"Microbiota modulation counteracts Alzheimer's disease progression influencing neuronal proteolysis and gut hormones plasma levels","volume":"7","author":"Bonfili","year":"2017","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"7987","DOI":"10.1007\/s12035-018-0973-4","article-title":"SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model","volume":"55","author":"Bonfili","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neurobiolaging.2019.11.004","article-title":"Gut microbiota manipulation through probiotics oral administration restores glucose homeostasis in a mouse model of Alzheimer's disease","volume":"87","author":"Bonfili","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"B43","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.clnu.2022.01.025","article-title":"Gut microbiota modulation in Alzheimer's disease: focus on lipid metabolism","volume":"41","author":"Bonfili","year":"2022","journal-title":"Clin. Nutr."},{"key":"B44","doi-asserted-by":"publisher","first-page":"6031478","DOI":"10.1155\/2017\/6031478","article-title":"Noradrenergic modulation of cognition in health and disease","volume":"2017","author":"Borodovitsyna","year":"2017","journal-title":"Neural Plast."},{"key":"B45","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13024-023-00700-w","article-title":"Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner","volume":"19","author":"Bosch","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"B46","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1186\/s12877-023-04342-x","article-title":"Tango-therapy vs physical exercise in older people with dementia; a randomized controlled trial","volume":"23","author":"Bracco","year":"2023","journal-title":"BMC Geriatr."},{"key":"B47","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B48","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13024-024-00722-y","article-title":"The endotoxin hypothesis of Alzheimer's disease","volume":"19","author":"Brown","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"B49","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.chom.2019.04.002","article-title":"Bacteroides-derived sphingolipids are critical for maintaining intestinal homeostasis and symbiosis","volume":"25","author":"Brown","year":"","journal-title":"Cell Host Microbe"},{"key":"B50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.arr.2019.01.003","article-title":"Exploring the relationship between physical activity, beta-amyloid and tau: a narrative review","volume":"50","author":"Brown","year":"","journal-title":"Ageing Res. Rev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.chom.2023.01.009","article-title":"Gut microbiome lipid metabolism and its impact on host physiology","volume":"31","author":"Brown","year":"2023","journal-title":"Cell Host Microbe"},{"key":"B52","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40478-023-01524-x","article-title":"Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer's disease","volume":"11","author":"Brymer","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/bph.14871","article-title":"Microbiota-dependent and -independent effects of dietary fibre on human health","volume":"177","author":"Cai","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2211184","DOI":"10.1080\/19490976.2023.2211184","article-title":"SaaS sRNA promotes Salmonella intestinal invasion via modulating MAPK inflammatory pathway","volume":"15","author":"Cai","year":"2023","journal-title":"Gut Microbes"},{"key":"B55","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.tins.2007.03.001","article-title":"Dopamine-mediated regulation of corticostriatal synaptic plasticity","volume":"30","author":"Calabresi","year":"2007","journal-title":"Trends Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13024-024-00702-2","article-title":"Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid \u03b2 aggregates in vivo in a mouse model of Alzheimer's disease","volume":"19","author":"Calvo-Rodriguez","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"B58","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12974-020-02054-2","article-title":"Comparisons of neuroinflammation, microglial activation, and degeneration of the locus coeruleus-norepinephrine system in APP\/PS1 and aging mice","volume":"18","author":"Cao","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"B59","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1038\/s41380-023-02140-w","article-title":"The GABAergic system in Alzheimer's disease: a systematic review with meta-analysis","volume":"28","author":"Carello-Collar","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.immuni.2024.03.010","article-title":"Innate immune activation in neurodegenerative diseases","volume":"57","author":"Castro-Gomez","year":"2024","journal-title":"Immunity"},{"key":"B61","doi-asserted-by":"publisher","first-page":"eaaf9794","DOI":"10.1126\/science.aaf9794","article-title":"Kynurenines: tryptophan's metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1523\/JNEUROSCI.1483-17.2017","article-title":"Locus coeruleus ablation exacerbates cognitive deficits, neuropathology, and lethality in P301S tau transgenic mice","volume":"38","author":"Chalermpalanupap","year":"2018","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1073\/pnas.87.4.1352","article-title":"Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type","volume":"87","author":"Chalmers","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13024-023-00635-2","article-title":"The gut microbiome regulates astrocyte reaction to A\u03b2 amyloidosis through microglial dependent and independent mechanisms","volume":"18","author":"Chandra","year":"","journal-title":"Mol. Neurodegener."},{"key":"B65","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13024-023-00595-7","article-title":"The gut microbiome in Alzheimer's disease: what we know and what remains to be explored","volume":"18","author":"Chandra","year":"","journal-title":"Mol. Neurodegener."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.3390\/ijms21082676","article-title":"D-Glutamate and gut microbiota in Alzheimer's disease","volume":"21","author":"Chang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"eabb8255","DOI":"10.1126\/science.abb8255","article-title":"Tau: enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies","volume":"371","author":"Chang","year":"2021","journal-title":"Science"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e01902","DOI":"10.1128\/mBio.01902-17","article-title":"Gut symbiont Bacteroides fragilis secretes a eukaryotic-like ubiquitin protein that mediates intraspecies antagonism","volume":"8","author":"Chatzidaki-Livanis","year":"2017","journal-title":"mBio"},{"key":"B69","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1039\/c7fo01342f","article-title":"Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP\/PS1 cells and SAMP8 mice","volume":"9","author":"Che","year":"2018","journal-title":"Food Funct."},{"key":"B70","doi-asserted-by":"publisher","first-page":"eaba0466","DOI":"10.1126\/sciadv.aba0466","article-title":"Gut dysbiosis contributes to amyloid pathology, associated with C\/EBP\u03b2\/AEP signaling activation in Alzheimer's disease mouse model","volume":"6","author":"Chen","year":"2020","journal-title":"Sci. Adv."},{"key":"B71","doi-asserted-by":"publisher","first-page":"109358","DOI":"10.1016\/j.jnutbio.2023.109358","article-title":"Gut microbiota-bile acids-glucagon like peptide-1 axis contributes the resistance to high fat diet-induced obesity in mice","volume":"117","author":"Chen","year":"","journal-title":"J. Nutr. Biochem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid beta: structure, biology and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"B73","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12974-021-02175-2","article-title":"Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease","volume":"18","author":"Chen","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"B74","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12974-019-1552-y","article-title":"Butyrate suppresses demyelination and enhances remyelination","volume":"16","author":"Chen","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B75","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"","journal-title":"Nature"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/j.immuni.2022.10.016","article-title":"Emerging roles of innate and adaptive immunity in Alzheimer's disease","volume":"55","author":"Chen","year":"2022","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.3233\/JAD-220721","article-title":"Neural stem cells in the treatment of Alzheimer's disease: current status, challenges, and future prospects","volume":"94","author":"Chen","year":"","journal-title":"J. Alzheimers Dis."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2302310","DOI":"10.1080\/19490976.2024.2302310","article-title":"Gut microbiota-driven metabolic alterations reveal gut-brain communication in Alzheimer's disease model mice","volume":"16","author":"Chen","year":"2024","journal-title":"Gut Microbes"},{"key":"B79","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.bbi.2022.10.022","article-title":"Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice","volume":"107","author":"Cheng","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"B80","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13195-020-00694-3","article-title":"Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer's disease and vascular cognitive impairment","volume":"12","author":"Chua","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.cmet.2018.05.006","article-title":"Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota","volume":"27","author":"Cignarella","year":"2018","journal-title":"Cell Metab."},{"key":"B82","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e59826","DOI":"10.7554\/eLife.59826","article-title":"Microbiota-derived short chain fatty acids modulate microglia and promote A\u03b2 plaque deposition","volume":"10","author":"Colombo","year":"2021","journal-title":"Elife"},{"key":"B84","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13195-021-00780-0","article-title":"CERTL reduces C16 ceramide, amyloid-\u03b2 levels, and inflammation in a model of Alzheimer's disease","volume":"13","author":"Crivelli","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"B85","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s40478-023-01633-7","article-title":"Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse","volume":"11","author":"Crivelli","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"B86","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"B88","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3390\/ijms21030941","article-title":"The nootropic drug \u0391-glyceryl-phosphoryl-ethanolamine exerts neuroprotective effects in human hippocampal cells","volume":"21","author":"Daniele","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2206504","DOI":"10.1080\/19490976.2023.2206504","article-title":"Interlink between the gut microbiota and inflammation in the context of oxidative stress in Alzheimer's disease progression","volume":"15","author":"Das","year":"2023","journal-title":"Gut Microbes"},{"key":"B91","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/SHK.0000000000001934","article-title":"Fecal microbiota transfer attenuates gut dysbiosis and functional deficits after traumatic brain injury","volume":"57","author":"Davis","year":"2022","journal-title":"Shock"},{"key":"B92","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/jamaneurol.2016.3232","article-title":"Association of amyloid pathology with myelin alteration in preclinical alzheimer disease","volume":"74","author":"Dean","year":"2017","journal-title":"JAMA Neurol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13195-023-01303-9","article-title":"Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease","volume":"15","author":"Delgado-Peraza","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"B94","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.18632\/aging.102810","article-title":"Efficacy of probiotics on cognition, and biomarkers of inflammation and oxidative stress in adults with Alzheimer's disease or mild cognitive impairment - a meta-analysis of randomized controlled trials","volume":"12","author":"Den","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"eabj1895","DOI":"10.1126\/scitranslmed.abj1895","article-title":"Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice","volume":"14","author":"De Palma","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","article-title":"Myelin dysfunction drives amyloid-\u03b2 deposition in models of Alzheimer's disease","volume":"618","author":"Depp","year":"2023","journal-title":"Nature"},{"key":"B97","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.bbi.2023.11.015","article-title":"Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice","volume":"115","author":"Di Castro","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.3390\/microorganisms10091838","article-title":"Gut bacteria and neurotransmitters","volume":"10","author":"Dicks","year":"2022","journal-title":"Microorganisms"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s00394-021-02790-y","article-title":"Amino acid intake and plasma concentrations and their interplay with gut microbiota in vegans and omnivores in Germany","volume":"61","author":"Dietrich","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"B100","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3233\/JAD-160567","article-title":"Sphingolipid-enriched extracellular vesicles and Alzheimer's disease: a decade of research","volume":"60","author":"Dinkins","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B101","doi-asserted-by":"publisher","first-page":"412","DOI":"10.3390\/nu16030412","article-title":"The role of diet and gut microbiota in Alzheimer's disease","volume":"16","author":"Dissanayaka","year":"2024","journal-title":"Nutrients"},{"key":"B102","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.3390\/ijms24044157","article-title":"The crosstalk between intestinal epithelial cells and mast cells is modulated by the probiotic supplementation in Co-culture models","volume":"24","author":"di Vito","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13195-022-00966-0","article-title":"Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease","volume":"14","author":"Dodge","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"B104","doi-asserted-by":"publisher","first-page":"8183","DOI":"10.1038\/s41598-020-64797-5","article-title":"Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice","volume":"10","author":"Dodiya","year":"2020","journal-title":"Sci. Rep."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1084\/jem.20182386","article-title":"Sex-specific effects of microbiome perturbations on cerebral A\u03b2 amyloidosis and microglia phenotypes","volume":"216","author":"Dodiya","year":"2019","journal-title":"J. Exp. Med."},{"key":"B106","doi-asserted-by":"publisher","first-page":"105314","DOI":"10.1016\/j.phrs.2020.105314","article-title":"The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology","volume":"164","author":"Doifode","year":"2021","journal-title":"Pharmacol. Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"19618","DOI":"10.1038\/srep19618","article-title":"The aryl hydrocarbon receptor promotes aging phenotypes across species","volume":"6","author":"Eckers","year":"2016","journal-title":"Sci. Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.3390\/nu14132661","article-title":"Overlapping mechanisms of action of brain-active bacteria and bacterial metabolites in the pathogenesis of common brain diseases","volume":"4","author":"Eicher","year":"2022","journal-title":"Nutrients"},{"key":"B109","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1210\/jcem.82.11.4339","article-title":"Substantial production of dopamine in the human gastrointestinal tract","volume":"82","author":"Eisenhofer","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B110","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jcmgh.2020.08.002","article-title":"Human-derived Bifidobacterium dentium modulates the mammalian serotonergic system and gut-brain Axis","volume":"11","author":"Engevik","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.bbi.2022.12.013","article-title":"Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice","volume":"108","author":"Engler-Chiurazzi","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1016\/j.cmet.2021.10.010","article-title":"Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease","volume":"33","author":"Erny","year":"2021","journal-title":"Cell Metab."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1826746","article-title":"B. adolescentis ameliorates chronic colitis by regulating Treg\/Th2 response and gut microbiota remodeling","volume":"13","author":"Fan","year":"2021","journal-title":"Gut Microbes"},{"key":"B114","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.7150\/thno.81951","article-title":"High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization","volume":"13","author":"Feng","year":"2023","journal-title":"Theranostics"},{"key":"B115","doi-asserted-by":"publisher","first-page":"eabo2984","DOI":"10.1126\/scitranslmed.abo2984","article-title":"Gut microbiome composition may be an indicator of preclinical Alzheimer's disease","volume":"15","author":"Ferreiro","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"B116","doi-asserted-by":"publisher","first-page":"e12835","DOI":"10.1111\/nan.12835","article-title":"Early loss of locus coeruleus innervation promotes cognitive and neuropathological changes before amyloid plaque deposition in a transgenic rat model of Alzheimer's disease","volume":"48","author":"Flores-Aguilar","year":"2022","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3390\/cells12040657","article-title":"Mechanisms of blood-brain barrier protection by microbiota-derived short-chain fatty acids","volume":"12","author":"Fock","year":"2023","journal-title":"Cells"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1277102","DOI":"10.3389\/fimmu.2023.1277102","article-title":"The role of intestinal microbes on intestinal barrier function and host immunity from a metabolite perspective","volume":"14","author":"Fu","year":"2023","journal-title":"Front. Immunol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.1523\/JNEUROSCI.1720-20.2020","article-title":"Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons","volume":"40","author":"Fukabori","year":"2020","journal-title":"J. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1021\/acs.jafc.3c05119","article-title":"Protective properties of intestinal alkaline phosphatase supplementation on the intestinal barrier: interactions and effects","volume":"72","author":"Gao","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"B121","doi-asserted-by":"publisher","first-page":"658354","DOI":"10.3389\/fimmu.2021.658354","article-title":"Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation","volume":"12","author":"Gasaly","year":"2021","journal-title":"Front. Immunol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","year":"2022","journal-title":"Lancet Public Health"},{"key":"B123","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.micpath.2005.05.002","article-title":"The load of Chlamydia pneumoniae in the Alzheimer's brain varies with APOE genotype","volume":"39","author":"G\u00e9rard","year":"2005","journal-title":"Microb. Pathog."},{"key":"B124","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1523\/JNEUROSCI.1092-19.2019","article-title":"Locus coeruleus norepinephrine drives stress-induced increases in basolateral amygdala firing and impairs extinction learning","volume":"40","author":"Giustino","year":"2020","journal-title":"J. Neurosci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00401-019-02053-5","article-title":"A\u03b2-induced acceleration of Alzheimer-related \u03c4-pathology spreading and its association with prion protein","volume":"138","author":"Gomes","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"8704","DOI":"10.3390\/ijms21228704","article-title":"Impaired expression of GABA signaling components in the Alzheimer's disease middle temporal gyrus","volume":"21","author":"Govindpani","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"112065","DOI":"10.1016\/j.exger.2022.112065","article-title":"Mediterranean diet and structural neuroimaging biomarkers of Alzheimer's and cerebrovascular disease: a systematic review","volume":"172","author":"Gregory","year":"2023","journal-title":"Exp. Gerontol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/00005072-199907000-00008","article-title":"Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease","volume":"58","author":"Guan","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1179\/135100002125000550","article-title":"Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease","volume":"7","author":"Guillemin","year":"2002","journal-title":"Redox Rep."},{"key":"B130","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41564-019-0620-5","article-title":"Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide","volume":"5","author":"G\u00fcnther","year":"2020","journal-title":"Nat. Microbiol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"15333175231211082","DOI":"10.1177\/15333175231211082","article-title":"Aerobic treadmill exercise upregulates epidermal growth factor levels and improves learning and memory in d-galactose-Induced aging in a mouse model","volume":"38","author":"Guo","year":"","journal-title":"Am. J. Alzheimers Dis. Other Demen"},{"key":"B132","doi-asserted-by":"publisher","first-page":"4915","DOI":"10.3390\/nu15234915","article-title":"Intermittent fasting on neurologic diseases: potential role of gut microbiota","volume":"15","author":"Guo","year":"","journal-title":"Nutrients"},{"key":"B133","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1038\/s41467-022-29506-y","article-title":"Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model","volume":"13","author":"Hamilton","year":"2022","journal-title":"Nat. Commun."},{"key":"B134","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41582-021-00520-w","article-title":"Developing the ATX(N) classification for use across the Alzheimer disease continuum","volume":"17","author":"Hampel","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0304-3940(87)90016-4","article-title":"A disorder of cortical GABAergic innervation in Alzheimer's disease","volume":"73","author":"Hardy","year":"1987","journal-title":"Neurosci. Lett."},{"key":"B136","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"B137","doi-asserted-by":"publisher","first-page":"2305476","DOI":"10.1080\/19490976.2024.2305476","article-title":"Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model","volume":"16","author":"Hayer","year":"2024","journal-title":"Gut Microbes"},{"key":"B138","doi-asserted-by":"publisher","first-page":"111959","DOI":"10.1016\/j.exger.2022.111959","article-title":"The preventive effects of probiotic Akkermansia muciniphila on D-galactose\/AlCl3 mediated Alzheimer's disease-like rats","volume":"170","author":"He","year":"2022","journal-title":"Exp. Gerontol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.mib.2017.12.011","article-title":"Sphingolipids in host-microbial interactions","volume":"43","author":"Heaver","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/s41564-022-01152-6","article-title":"Characterization of inositol lipid metabolism in gut-associated Bacteroidetes","volume":"7","author":"Heaver","year":"2022","journal-title":"Nat. Microbiol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"165531","DOI":"10.1016\/j.bbadis.2019.08.007","article-title":"Adenovirus 36 improves glycemic control and markers of Alzheimer's disease pathogenesis","volume":"1865","author":"Hegde","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B142","doi-asserted-by":"publisher","first-page":"8411","DOI":"10.1523\/JNEUROSCI.2745-14.2015","article-title":"Astrocytes are primed by chronic neurodegeneration to produce exaggerated chemokine and cell infiltration responses to acute stimulation with the cytokines IL-1\u03b2 and TNF-\u03b1","volume":"35","author":"Hennessy","year":"2015","journal-title":"J. Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1093\/brain\/116.6.1425","article-title":"A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate","volume":"116","author":"Heyes","year":"1993","journal-title":"Brain"},{"key":"B144","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/14737175.2018.1400909","article-title":"Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms","volume":"18","author":"Ho","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"B145","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jalz.2008.12.001","article-title":"Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease?","volume":"5","author":"Honjo","year":"2009","journal-title":"Alzheimers Dement."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/s0024-3205(02)02478-5","article-title":"Evolutional study on acetylcholine expression","volume":"72","author":"Horiuchi","year":"2003","journal-title":"Life Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/alz.12421","article-title":"Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: a randomized trial","volume":"18","author":"Hoscheidt","year":"2022","journal-title":"Alzheimers Dement."},{"key":"B148","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1080\/1040841X.2021.2018401","article-title":"Interplay between gut microbiota and bile acids in diarrhoea-predominant irritable bowel syndrome: a review","volume":"48","author":"Hou","year":"2022","journal-title":"Crit. Rev. Microbiol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s40168-018-0439-y","article-title":"Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier","volume":"6","author":"Hoyles","year":"2018","journal-title":"Microbiome"},{"key":"B150","doi-asserted-by":"publisher","first-page":"12847","DOI":"10.3390\/ijms241612847","article-title":"Aerobic exercise facilitates the nuclear translocation of SREBP2 by activating AKT\/SEC24D to contribute cholesterol homeostasis for improving cognition in APP\/PS1 mice","volume":"24","author":"Hu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B151","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bbi.2021.09.021","article-title":"From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders","volume":"99","author":"Huang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"B152","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.3390\/nu11102265","article-title":"Functional expression of choline transporters in the blood-brain barrier","volume":"11","author":"Inazu","year":"2019","journal-title":"Nutrients"},{"key":"B153","doi-asserted-by":"publisher","first-page":"4920","DOI":"10.3390\/ijms21144920","article-title":"The use of antimicrobial and antiviral drugs in Alzheimer's disease","volume":"21","author":"Iqbal","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2019.03.015","article-title":"Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-\u03b2 and tau","volume":"80","author":"Jacobs","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"B155","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12979-024-00435-2","article-title":"The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people","volume":"21","author":"Jacobs","year":"2024","journal-title":"Immun. Ageing"},{"key":"B156","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/WCO.0000000000001042","article-title":"The role of the locus coeruleus\/norepinephrine system in the pathogenesis of neurodegenerative disorders: an update","volume":"35","author":"JaMalatt","year":"2022","journal-title":"Curr. Opin. Neurol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1017\/S0007114520002330","article-title":"Healthy and unhealthy dietary patterns and the risk of chronic disease: an umbrella review of meta-analyses of prospective cohort studies","volume":"124","author":"Jayedi","year":"2020","journal-title":"Br. J. Nutr."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2021.08.213","article-title":"GSK3\u03b2 is involved in promoting Alzheimer's disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor proteinNL-F\/NL-F knock-in mice","volume":"98","author":"Jiang","year":"","journal-title":"Brain Behav. Immun."},{"key":"B159","doi-asserted-by":"publisher","first-page":"109452","DOI":"10.1016\/j.cbi.2021.109452","article-title":"Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice","volume":"341","author":"Jiang","year":"","journal-title":"Chem. Biol. Interact."},{"key":"B160","doi-asserted-by":"publisher","first-page":"2167172","DOI":"10.1080\/19490976.2023.2167172","article-title":"Gut-derived \u03b2-amyloid: likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis","volume":"15","author":"Jin","year":"2023","journal-title":"Gut Microbes"},{"key":"B161","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nm.3639","article-title":"GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease","volume":"20","author":"Jo","year":"2014","journal-title":"Nat. Med."},{"key":"B162","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1038\/s41467-020-16274-w","article-title":"Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels","volume":"11","author":"Johnson","year":"2020","journal-title":"Nat. Commun."},{"key":"B163","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/glia.24285","article-title":"Deletion of MyD88 in astrocytes prevents \u03b2-amyloid-induced neuropathology in mice","volume":"71","author":"Jong Huat","year":"2023","journal-title":"Glia"},{"key":"B164","doi-asserted-by":"publisher","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer's disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural Regen. Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1056\/NEJMc1803103","article-title":"Fecal microbiota transplantation for primary Clostridium difficile infection","volume":"378","author":"Juul","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"B166","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/jnc.14284","article-title":"Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease","volume":"146","author":"Kaczmarczyk","year":"2017","journal-title":"J. Neurochem."},{"key":"B167","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.jalz.2010.06.001","article-title":"Metabolomic changes in autopsy-confirmed Alzheimer's disease","volume":"7","author":"Kaddurah-Daouk","year":"2011","journal-title":"Alzheimers Dement."},{"key":"B168","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.bbi.2020.11.001","article-title":"Myelin as a regulator of development of the microbiota-gut-brain axis","volume":"91","author":"Keogh","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"B169","doi-asserted-by":"publisher","first-page":"14300","DOI":"10.1038\/s41598-023-41415-8","article-title":"Effect of exercise on the hypothalamic-pituitary-gonadal axis in a rat model of Alzheimer's disease","volume":"13","author":"Khairy","year":"2023","journal-title":"Sci. Rep."},{"key":"B170","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1021\/acs.accounts.8b00377","article-title":"Atomistic and coarse grain simulations of the cell envelope of gram-negative bacteria: what have we learned?","volume":"52","author":"Khalid","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"B171","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40035-021-00273-y","article-title":"Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications","volume":"10","author":"Kim","year":"2021","journal-title":"Transl. Neurodegener."},{"key":"B172","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1136\/gutjnl-2018-317431","article-title":"Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model","volume":"69","author":"Kim","year":"2020","journal-title":"Gut"},{"key":"B173","doi-asserted-by":"publisher","first-page":"5573","DOI":"10.1002\/alz.13162","article-title":"Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease","volume":"19","author":"Knapskog","year":"2023","journal-title":"Alzheimers Dement."},{"key":"B174","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000500602","article-title":"Targeting the enteric nervous system to treat metabolic disorders? \u201cEnterosynes\u201d as therapeutic gut factors","volume":"110","author":"Knauf","year":"2020","journal-title":"Neuroendocrinology"},{"key":"B175","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B176","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1194\/jlr.M081877","article-title":"Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes","volume":"59","author":"Kong","year":"2018","journal-title":"J. Lipid Res."},{"key":"B177","doi-asserted-by":"publisher","first-page":"7188","DOI":"10.1038\/s41380-021-01194-y","article-title":"Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility","volume":"26","author":"Korn","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"B178","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13195-019-0514-z","article-title":"Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time","volume":"11","author":"Kuhn","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"B179","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"B180","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13024-022-00580-6","article-title":"Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer's disease in Tg2576 mice","volume":"17","author":"La Barbera","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"B181","doi-asserted-by":"publisher","first-page":"101900","DOI":"10.1016\/j.pneurobio.2020.101900","article-title":"Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor","volume":"197","author":"Labus","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1001\/jama.2009.1547","article-title":"DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model","volume":"302","author":"Lambracht-Washington","year":"2009","journal-title":"JAMA"},{"key":"B183","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.chom.2022.05.002","article-title":"Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids","volume":"30","author":"Le","year":"2022","journal-title":"Cell Host Microbe"},{"key":"B184","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1007\/s12035-017-0550-2","article-title":"Activation of glucagon-like peptide-1 receptor promotes neuroprotection in experimental autoimmune encephalomyelitis by reducing neuroinflammatory responses","volume":"55","author":"Lee","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1001\/jama.2015.18098","article-title":"Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: a randomized clinical trial","volume":"315","author":"Lee","year":"2016","journal-title":"JAMA"},{"key":"B186","doi-asserted-by":"publisher","first-page":"1042865","DOI":"10.3389\/fnins.2022.1042865","article-title":"Manipulation of the diet-microbiota-brain axis in Alzheimer's disease","volume":"16","author":"Lee","year":"2022","journal-title":"Front. Neurosci."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s12272-019-01196-z","article-title":"The regulation of glutamic acid decarboxylases in GABA neurotransmission in the brain","volume":"42","author":"Lee","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"B188","doi-asserted-by":"publisher","first-page":"108477","DOI":"10.1016\/j.neuropharm.2021.108477","article-title":"Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats","volume":"187","author":"Leon","year":"2021","journal-title":"Neuropharmacology"},{"key":"B189","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13195-022-01151-z","article-title":"CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer's disease","volume":"14","author":"Lerner","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"B190","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1126\/science.1058189","article-title":"Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP","volume":"293","author":"Lewis","year":"2001","journal-title":"Science"},{"key":"B191","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.jalz.2019.07.002","article-title":"Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota","volume":"15","author":"Li","year":"2019","journal-title":"Alzheimers Dement."},{"key":"B192","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12974-022-02489-9","article-title":"Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn","volume":"19","author":"Li","year":"","journal-title":"J. Neuroinflammation"},{"key":"B193","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.3390\/microorganisms11122854","article-title":"Application of dominant gut microbiota promises to replace fecal microbiota transplantation as a new treatment for Alzheimer's disease","volume":"11","author":"Li","year":"","journal-title":"Microorganisms"},{"key":"B194","doi-asserted-by":"publisher","first-page":"2252764","DOI":"10.1080\/19490976.2023.2252764","article-title":"Akkermansia muciniphila supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses","volume":"15","author":"Li","year":"","journal-title":"Gut Microbes"},{"key":"B195","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1039\/d3fo05337g","article-title":"The antioxidant strain Lactiplantibacillus plantarum AS21 and Clostridium butyricum ameliorate DSS-induced colitis in mice by remodeling the assembly of intestinal microbiota and improving gut functions","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"key":"B196","doi-asserted-by":"publisher","first-page":"2096994","DOI":"10.1080\/19490976.2022.2096994","article-title":"Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent \u03b3\u03b4 T cells","volume":"14","author":"Li","year":"","journal-title":"Gut Microbes"},{"key":"B197","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12974-023-02958-9","article-title":"Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice","volume":"20","author":"Liang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1038\/jcbfm.2013.82","article-title":"Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease","volume":"33","author":"Lin","year":"2013","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B199","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40035-024-00400-5","article-title":"Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease","volume":"13","author":"Lin","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"B200","doi-asserted-by":"publisher","first-page":"7152","DOI":"10.1021\/acs.jafc.0c02807","article-title":"Anti-neuroinflammatory effect of short-chain fatty acid acetate against Alzheimer's disease via upregulating GPR41 and inhibiting ERK\/JNK\/NF-\u03baB","volume":"68","author":"Liu","year":"","journal-title":"J. Agric. Food Chem."},{"key":"B201","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.bbi.2021.04.005","article-title":"Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis","volume":"95","author":"Liu","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"B202","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3233\/JAD-200499","article-title":"Dietary pattern, diet quality, and dementia: a systematic review and meta-analysis of prospective cohort studies","volume":"78","author":"Liu","year":"","journal-title":"J. Alzheimers Dis."},{"key":"B203","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/s41467-020-14676-4","article-title":"Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment","volume":"11","author":"Liu","year":"","journal-title":"Nat. Commun."},{"key":"B204","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.nbd.2012.09.003","article-title":"Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP\/PS1 mice","volume":"50","author":"Lo","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B205","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1002\/alz.12341","article-title":"Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1\u03b2 drives amplified responses in primed astrocytes and neuronal network dysfunction","volume":"17","author":"Lopez-Rodriguez","year":"2021","journal-title":"Alzheimers Dement."},{"key":"B207","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.3390\/biom11081091","article-title":"Neurotransmitter profiles are altered in the gut and brain of mice mono-associated with Bifidobacterium dentium","volume":"11","author":"Luck","year":"2021","journal-title":"Biomolecules"},{"key":"B208","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13024-024-00720-0","article-title":"Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics","volume":"19","author":"Luo","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"B209","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B210","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12974-023-02693-1","article-title":"5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption","volume":"20","author":"Ma","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B211","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/ije\/dyaa099","article-title":"Higher risk of dementia in English older individuals who are overweight or obese","volume":"49","author":"Ma","year":"2020","journal-title":"Int. J. Epidemiol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3390\/toxins10100404","article-title":"Uremia impacts VE-cadherin and ZO-1 expression in human endothelial cell-to-cell junctions","volume":"10","author":"Maciel","year":"2018","journal-title":"Toxins (Basel)"},{"key":"B213","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jalz.2018.07.217","article-title":"Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome","volume":"15","author":"MahmoudianDehkordi","year":"2019","journal-title":"Alzheimers Dement."},{"key":"B214","doi-asserted-by":"publisher","first-page":"683","DOI":"10.3233\/JAD-200306","article-title":"Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer's disease","volume":"78","author":"Marizzoni","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"B215","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13195-023-01218-5","article-title":"A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers","volume":"15","author":"Marizzoni","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"B216","doi-asserted-by":"publisher","first-page":"4390","DOI":"10.1038\/s41380-023-02177-x","article-title":"Poorer aging trajectories are associated with elevated serotonin synthesis capacity","volume":"28","author":"Markova","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"B217","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1210\/en.2016-1839","article-title":"The diverse metabolic roles of peripheral serotonin","volume":"158","author":"Martin","year":"2017","journal-title":"Endocrinology"},{"key":"B218","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.neuropharm.2017.06.026","article-title":"Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease","volume":"123","author":"Mast","year":"2017","journal-title":"Neuropharmacology"},{"key":"B219","doi-asserted-by":"publisher","first-page":"101340","DOI":"10.1016\/j.smrv.2020.101340","article-title":"Sleep, circadian rhythm, and gut microbiota","volume":"53","author":"Matenchuk","year":"2020","journal-title":"Sleep. Med. Rev."},{"key":"B220","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.3389\/fimmu.2018.01832","article-title":"Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice","volume":"9","author":"Matt","year":"2018","journal-title":"Front. Immunol."},{"key":"B221","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1001\/jamaneurol.2023.4596","article-title":"Plasma biomarker strategy for selecting patients with alzheimer disease for antiamyloid immunotherapies","volume":"81","author":"Mattsson-Carlgren","year":"2024","journal-title":"JAMA Neurol."},{"key":"B222","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12937-023-00893-2","article-title":"Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review","volume":"22","author":"Mazandarani","year":"2023","journal-title":"Nutr. J."},{"key":"B223","doi-asserted-by":"publisher","first-page":"G228","DOI":"10.1152\/ajpgi.00373.2003","article-title":"Gastric distension-induced release of 5-HT stimulates c-fos expression in specific brain nuclei via 5-HT3 receptors in conscious rats","volume":"287","author":"Mazda","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1038\/s41467-020-16090-2","article-title":"A mechanistic account of serotonin's impact on mood","volume":"11","author":"Michely","year":"2020","journal-title":"Nat. Commun."},{"key":"B225","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3233\/JAD-160451","article-title":"Bacterial amyloid and DNA are important constituents of senile plaques: further evidence of the spirochetal and biofilm nature of senile plaques","volume":"53","author":"Miklossy","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B226","doi-asserted-by":"publisher","first-page":"30028","DOI":"10.1038\/srep30028","article-title":"Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease","volume":"6","author":"Minter","year":"2016","journal-title":"Sci. Rep."},{"key":"B227","doi-asserted-by":"publisher","first-page":"1098412","DOI":"10.3389\/fmicb.2023.1098412","article-title":"Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome?","volume":"14","author":"Miri","year":"2023","journal-title":"Front. Microbiol."},{"key":"B228","first-page":"20","volume-title":"The world of gut bacteria","author":"Mitsuoka","year":"1970"},{"key":"B229","doi-asserted-by":"publisher","first-page":"100997","DOI":"10.1016\/j.molmet.2020.100997","article-title":"Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity","volume":"37","author":"Molinaro","year":"2020","journal-title":"Mol. Metab."},{"key":"B230","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1111\/bph.14546","article-title":"The involvement of microglia in Alzheimer's disease: a new dog in the fight","volume":"176","author":"Moore","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"B231","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota-brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12974-019-1417-4","article-title":"Anti-inflammatory and cognitive effects of interferon-\u03b21a (IFN\u03b21a) in a rat model of Alzheimer's disease","volume":"16","author":"Mud\u00f2","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B233","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ebiom.2019.08.032","article-title":"Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment","volume":"47","author":"Nagpal","year":"2019","journal-title":"EBioMedicine"},{"key":"B234","doi-asserted-by":"publisher","first-page":"10806","DOI":"10.1038\/s41598-023-37062-8","article-title":"A diet rich in fermentable fiber promotes robust changes in the intestinal microbiota, mitigates intestinal permeability, and attenuates autoimmune uveitis","volume":"13","author":"Nakamura","year":"2023","journal-title":"Sci. Rep."},{"key":"B235","doi-asserted-by":"publisher","first-page":"157114","DOI":"10.1016\/j.scitotenv.2022.157114","article-title":"Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease","volume":"844","author":"Nemergut","year":"2022","journal-title":"Sci. Total Environ."},{"key":"B236","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.3390\/ijms24044047","article-title":"Gut microbiota and Alzheimer's disease: how to study and apply their relationship","volume":"24","author":"Nguyen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B237","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jalz.2018.08.012","article-title":"Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: relationship to neuroimaging and CSF biomarkers","volume":"15","author":"Nho","year":"2019","journal-title":"Alzheimers Dement."},{"key":"B238","doi-asserted-by":"publisher","first-page":"9795","DOI":"10.1021\/acs.jafc.3c09675","article-title":"Mechanism explanation on improved cognitive ability of D-gal inducing aged mice model by Lactiplantibacillus plantarum MWFLp-182 via the microbiota-gut-brain Axis","volume":"72","author":"Nie","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"B239","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1006\/clin.1994.1168","article-title":"Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease","volume":"73","author":"Nijhuis","year":"1994","journal-title":"Clin. Immunol. Immunopathol."},{"key":"B240","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1038\/s41467-024-46116-y","article-title":"Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial","volume":"15","author":"Ni Lochlainn","year":"2024","journal-title":"Nat. Commun."},{"key":"B241","doi-asserted-by":"publisher","first-page":"984","DOI":"10.2174\/1567205019666211222115142","article-title":"Association of dietary prebiotic consumption with reduced risk of Alzheimer's disease in a multiethnic population","volume":"18","author":"Nishikawa","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"B242","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/nmo.12110","article-title":"Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods","volume":"25","author":"Nishino","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"B243","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2023.2299744","article-title":"The therapeutic potential of dietary intervention: based on the mechanism of a tryptophan derivative-indole propionic acid on metabolic disorders","volume":"8","author":"Niu","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B244","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1111\/j.1474-9726.2012.00845.x","article-title":"High tryptophan diet reduces CA1 intraneuronal \u03b2-amyloid in the triple transgenic mouse model of Alzheimer's disease","volume":"11","author":"Noristani","year":"2012","journal-title":"Aging Cell"},{"key":"B245","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s13311-017-0597-9","article-title":"The microbiome-gut-behavior Axis: crosstalk between the gut microbiome and oligodendrocytes modulates behavioral responses","volume":"15","author":"Ntranos","year":"2018","journal-title":"Neurotherapeutics"},{"key":"B246","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s12035-012-8256-y","article-title":"TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-\u03b2 deposition in APP\/PS1 mice","volume":"45","author":"Nunes","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"B247","doi-asserted-by":"publisher","first-page":"483","DOI":"10.14283\/jpad.2021.33","article-title":"Tauroursodeoxycholic acid attenuates diet-induced and age-related peripheral endoplasmic reticulum stress and cerebral amyloid pathology in a mouse model of Alzheimer's disease","volume":"8","author":"Ochiai","year":"2021","journal-title":"J. Prev. Alzheimers Dis."},{"key":"B248","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-020-2395-5","article-title":"A neurotransmitter produced by gut bacteria modulates host sensory behaviour","volume":"583","author":"O\u2019Donnell","year":"2020","journal-title":"Nature"},{"key":"B249","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.3390\/jcm10061299","article-title":"Gut microbiota interaction with the central nervous system throughout life","volume":"10","author":"Ojeda","year":"2021","journal-title":"J. Clin. Med."},{"key":"B250","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1152\/ajplegacy.1973.224.6.1450","article-title":"Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids","volume":"224","author":"Oldendorf","year":"1973","journal-title":"Am. J. Physiol."},{"key":"B251","doi-asserted-by":"publisher","first-page":"3466","DOI":"10.3390\/nu15153466","article-title":"Intake of Lactiplantibacillus plantarum HEAL9 improves cognition in moderately stressed subjects: a randomized controlled study","volume":"15","author":"\u00d6nning","year":"2023","journal-title":"Nutrients"},{"key":"B252","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11095-017-2312-2","article-title":"Dihydroceramide desaturase 1 inhibitors reduce amyloid-\u03b2 levels in primary neurons from an Alzheimer's disease transgenic model","volume":"35","author":"Ord\u00f3\u00f1ez-Guti\u00e9rrez","year":"2018","journal-title":"Pharm. Res."},{"key":"B253","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13195-024-01482-z","article-title":"Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial","volume":"16","author":"Ornish","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"B254","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.bbi.2023.03.002","article-title":"Reduction in GABAB on glia induce Alzheimer's disease related changes","volume":"110","author":"Osse","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"B255","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/jnc.14313","article-title":"Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia","volume":"144","author":"O\u2019Sullivan","year":"2018","journal-title":"J. Neurochem."},{"key":"B256","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41387-020-0115-8","article-title":"Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease","volume":"10","author":"Ou","year":"2020","journal-title":"Nutr. Diabetes"},{"key":"B257","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.3390\/molecules27113417","article-title":"Identification of new non-BBB permeable tryptophan hydroxylase inhibitors for treating obesity and fatty liver disease","volume":"27","author":"Pagire","year":"2022","journal-title":"Molecules"},{"key":"B258","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/s41586-023-06799-7","article-title":"A new antibiotic traps lipopolysaccharide in its intermembrane transporter","volume":"625","author":"Pahil","year":"2024","journal-title":"Nature"},{"key":"B259","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/s43587-022-00311-y","article-title":"Intermittent fasting protects against Alzheimer's disease in mice by altering metabolism through remodeling of the gut microbiota","volume":"2","author":"Pan","year":"2022","journal-title":"Nat. Aging"},{"key":"B260","doi-asserted-by":"publisher","first-page":"e2300601","DOI":"10.1002\/mnfr.202300601","article-title":"A high-tryptophan diet alleviated cognitive impairment and neuroinflammation in APP\/PS1 mice through activating aryl hydrocarbon receptor via the regulation of gut microbiota","volume":"68","author":"Pan","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"B261","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1093\/brain\/awz244","article-title":"Time to test antibacterial therapy in Alzheimer's disease","volume":"142","author":"Panza","year":"2019","journal-title":"Brain"},{"key":"B262","doi-asserted-by":"publisher","first-page":"6449","DOI":"10.18632\/aging.204230","article-title":"Fecal microbiota transplantation can improve cognition in patients with cognitive decline and Clostridioides difficile infection","volume":"14","author":"Park","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"B263","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.3390\/cells8121573","article-title":"Role of ceramidases in sphingolipid metabolism and human diseases","volume":"8","author":"Parveen","year":"2019","journal-title":"Cells"},{"key":"B264","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1038\/s41380-022-01565-z","article-title":"The synapse as a treatment avenue for Alzheimer's Disease","volume":"27","author":"Peng","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B265","doi-asserted-by":"publisher","first-page":"122871","DOI":"10.1016\/j.lfs.2024.122871","article-title":"High-intensity interval training and medium-intensity continuous training may affect cognitive function through regulation of intestinal microbial composition and its metabolite LPS by the gut-brain axis","volume":"352","author":"Peng","year":"2024","journal-title":"Life Sci."},{"key":"B266","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature23658","article-title":"Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors","volume":"549","author":"Penn","year":"2017","journal-title":"Nature"},{"key":"B267","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1093\/brain\/awab436","article-title":"Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease","volume":"145","author":"Peris","year":"2022","journal-title":"Brain"},{"key":"B268","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1007\/s13311-019-00737-0","article-title":"CYP46A1 activation by efavirenz leads to behavioral improvement without significant changes in amyloid plaque load in the brain of 5XFAD mice","volume":"16","author":"Petrov","year":"2019","journal-title":"Neurotherapeutics"},{"key":"B269","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1023\/a:1011603916962","article-title":"Brain membrane phospholipid alterations in Alzheimer's disease","volume":"26","author":"Pettegrew","year":"2001","journal-title":"Neurochem. Res."},{"key":"B270","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"key":"B271","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1176\/ajp.149.2.251","article-title":"Glutamate and other CSF amino acids in Alzheimer's disease","volume":"149","author":"Pomara","year":"1992","journal-title":"Am. J. Psychiatry"},{"key":"B272","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1176\/appi.ajp.157.4.638","article-title":"Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease","volume":"157","author":"Porter","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"B273","doi-asserted-by":"publisher","first-page":"101907","DOI":"10.1016\/j.arr.2023.101907","article-title":"The role of dopamine in NLRP3 inflammasome inhibition: implications for neurodegenerative diseases","volume":"87","author":"Possemato","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"B274","doi-asserted-by":"publisher","first-page":"101191","DOI":"10.1016\/j.arr.2020.101191","article-title":"Defective mitophagy in Alzheimer's disease","volume":"64","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"B275","doi-asserted-by":"publisher","first-page":"2282790","DOI":"10.1080\/19490976.2023.2282790","article-title":"Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP\/PS1 mice","volume":"15","author":"Qian","year":"2023","journal-title":"Gut Microbes"},{"key":"B276","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.14336\/AD.2021.1215","article-title":"Mechanisms of short-chain fatty acids derived from gut microbiota in Alzheimer's disease","volume":"13","author":"Qian","year":"2022","journal-title":"Aging Dis."},{"key":"B277","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13024-021-00488-7","article-title":"Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment","volume":"16","author":"Qiu","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"B278","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1002\/glia.24007","article-title":"Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP\/PS1-transgenic mice","volume":"69","author":"Quan","year":"2021","journal-title":"Glia"},{"key":"B279","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1007\/s12035-020-01945-y","article-title":"Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease","volume":"57","author":"Rai","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B280","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/alz.12362","article-title":"Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060)","volume":"17","author":"Rajan","year":"2021","journal-title":"Alzheimers Dement."},{"key":"B281","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.3233\/JAD-221153","article-title":"Sporadic use of antibiotics in older adults and the risk of dementia: a nested case-control study based on German health claims data","volume":"93","author":"Raku\u0161a","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"B282","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.1172\/JCI96209","article-title":"Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology","volume":"128","author":"Rangasamy","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B283","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41586-020-2156-5","article-title":"LRP1 is a master regulator of tau uptake and spread","volume":"580","author":"Rauch","year":"2020","journal-title":"Nature"},{"key":"B284","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/s41590-023-01622-x","article-title":"CD8+ T cells pump the brakes on Alzheimer's disease","volume":"24","author":"Reagin","year":"2023","journal-title":"Nat. Immunol."},{"key":"B285","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1093\/hmg\/ddab091","article-title":"Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease","volume":"30","author":"Reddy","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"B286","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.bbi.2010.10.009","article-title":"CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS","volume":"25","author":"Regen","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B287","doi-asserted-by":"publisher","first-page":"e022701","DOI":"10.1161\/JAHA.121.022701","article-title":"Inhibition of aryl hydrocarbon receptor attenuates hyperglycemia-induced hematoma expansion in an intracerebral hemorrhage mouse model","volume":"10","author":"Ren","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"B288","doi-asserted-by":"publisher","first-page":"101543","DOI":"10.1016\/j.xcrm.2024.101543","article-title":"Increased intestinal bile acid absorption contributes to age-related cognitive impairment","volume":"24","author":"Ren","year":"2024","journal-title":"Cell Rep. Med."},{"key":"B289","doi-asserted-by":"publisher","first-page":"13045","DOI":"10.3390\/ijms232113045","article-title":"Linking nonalcoholic fatty liver disease and brain disease: focusing on bile acid signaling","volume":"23","author":"Ren","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B290","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.nbd.2005.05.027","article-title":"Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP\/tau transgenic mice","volume":"20","author":"Rib\u00e9","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"B291","doi-asserted-by":"publisher","first-page":"eaao4827","DOI":"10.1126\/science.aao4827","article-title":"Secreted amyloid-\u03b2 precursor protein functions as a GABABR1a ligand to modulate synaptic transmission","volume":"363","author":"Rice","year":"2019","journal-title":"Science"},{"key":"B292","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3233\/JAD-230403","article-title":"COCOA consortium:. A remotely coached multimodal lifestyle intervention for Alzheimer's disease ameliorates functional and cognitive outcomes","volume":"96","author":"Roach","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"B293","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s40478-021-01246-y","article-title":"Synaptic tau: a pathological or physiological phenomenon?","volume":"9","author":"Robbins","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"B294","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br. J. Nutr."},{"key":"B295","doi-asserted-by":"publisher","first-page":"635704","DOI":"10.3389\/fimmu.2021.635704","article-title":"The impact of dietary sphingolipids on intestinal microbiota and gastrointestinal immune homeostasis","volume":"12","author":"Rohrhofer","year":"2021","journal-title":"Front. Immunol."},{"key":"B296","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/brain\/105.2.313","article-title":"A post-mortem study of the cholinergic and GABA systems in senile dementia","volume":"105","author":"Rossor","year":"1982","journal-title":"Brain"},{"key":"B297","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.3390\/ijms22062973","article-title":"Tryptophan metabolism and gut-brain homeostasis","volume":"22","author":"Roth","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B298","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1111\/j.1471-4159.1993.tb07443.x","article-title":"Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation","volume":"61","author":"Saito","year":"1993","journal-title":"J. Neurochem."},{"key":"B299","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00109-023-02289-5","article-title":"Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: role of tryptophan metabolites generated by gut host-microbiota","volume":"101","author":"Salminen","year":"2023","journal-title":"J. Mol. Med. Berl."},{"key":"B300","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.brainres.2005.12.134","article-title":"Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1","volume":"1094","author":"Samura","year":"2006","journal-title":"Brain Res."},{"key":"B301","doi-asserted-by":"publisher","first-page":"993","DOI":"10.3233\/JAD-230004","article-title":"Observed improvement in cognition during a personalized lifestyle intervention in people with cognitive decline","volume":"94","author":"Sandison","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"B302","doi-asserted-by":"publisher","first-page":"166942","DOI":"10.1016\/j.bbadis.2023.166942","article-title":"Protective effects of SSRI, Citalopram in mutant APP and mutant Tau expressed dorsal raphe neurons in Alzheimer's disease","volume":"1870","author":"Sawant","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B303","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.3389\/fimmu.2017.01905","article-title":"Neuroinflammation: microglia and T cells get ready to tango","volume":"8","author":"Schetters","year":"2018","journal-title":"Front. Immunol."},{"key":"B304","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41579-019-0213-6","article-title":"Microbial genes and pathways in inflammatory bowel disease","volume":"17","author":"Schirmer","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"B305","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s11064-005-6962-9","article-title":"Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling","volume":"30","author":"Schliebs","year":"2005","journal-title":"Neurochem. Res."},{"key":"B306","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s40478-017-0472-2","article-title":"Alzheimer's disease pathological lesions activate the spleen tyrosine kinase","volume":"5","author":"Schweig","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"B307","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s42255-019-0083-2","article-title":"Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-\u03b3 stimulation","volume":"1","author":"Seim","year":"2019","journal-title":"Nat. Metab."},{"key":"B308","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","article-title":"Emerging diagnostics and therapeutics for Alzheimer disease","volume":"29","author":"Self","year":"2023","journal-title":"Nat. Med."},{"key":"B309","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41422-019-0227-7","article-title":"The microbiome: a target for Alzheimer disease?","volume":"29","author":"Seo","year":"2019","journal-title":"Cell Res."},{"key":"B310","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s12276-023-01146-2","article-title":"Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies","volume":"56","author":"Seo","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"B311","doi-asserted-by":"publisher","first-page":"eadd1236","DOI":"10.1126\/science.add1236","article-title":"ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy","volume":"379","author":"Seo","year":"2023","journal-title":"Science"},{"key":"B312","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12272-021-01327-5","article-title":"The role of mucosal barriers in human gut health","volume":"44","author":"Seo","year":"2021","journal-title":"Arch. Pharm. Res."},{"key":"B313","doi-asserted-by":"publisher","first-page":"6664","DOI":"10.1038\/s41467-021-26992-4","article-title":"Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts","volume":"12","author":"Shaler","year":"2021","journal-title":"Nat. Commun."},{"key":"B314","doi-asserted-by":"publisher","first-page":"13079","DOI":"10.1021\/acsami.2c01090","article-title":"Self-fluorescent lone tryptophan nanoparticles as theranostic agents against Alzheimer's disease","volume":"14","author":"Sharma","year":"2022","journal-title":"ACS Appl. Mater Interfaces"},{"key":"B315","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3233\/JAD-210259","article-title":"Altered gut microbiota in adults with subjective cognitive decline: the SILCODE study","volume":"82","author":"Sheng","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"B316","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13195-022-00977-x","article-title":"Combination of gut microbiota and plasma amyloid-\u03b2 as a potential index for identifying preclinical Alzheimer's disease: a cross-sectional analysis from the SILCODE study","volume":"14","author":"Sheng","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"B317","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s40168-021-01172-0","article-title":"A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites","volume":"9","author":"Shi","year":"2021","journal-title":"Microbiome"},{"key":"B318","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3390\/nu15010051","article-title":"Probiotic Bifidobacterium longum BB68S improves cognitive functions in healthy older adults: a randomized, double-blind, placebo-controlled trial","volume":"15","author":"Shi","year":"2022","journal-title":"Nutrients"},{"key":"B319","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00401-007-0211-z","article-title":"Amyloid precursor protein cytoplasmic domain with phospho-Thr668 accumulates in Alzheimer's disease and its transgenic models: a role to mediate interaction of Abeta and tau","volume":"113","author":"Shin","year":"2007","journal-title":"Acta Neuropathol."},{"key":"B320","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.nut.2018.02.005","article-title":"Anti-inflammatory effect of multistrain probiotic formulation (L. rhamnosus, B. lactis, and B. longum)","volume":"53","author":"Sichetti","year":"2018","journal-title":"Nutrition"},{"key":"B321","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1126\/science.abb8575","article-title":"Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets","volume":"370","author":"Sierksma","year":"2020","journal-title":"Science"},{"key":"B322","doi-asserted-by":"publisher","first-page":"e2272","DOI":"10.1212\/WNL.0000000000011772","article-title":"Age-at-Onset and APOE-related heterogeneity in pathologically confirmed sporadic alzheimer disease","volume":"96","author":"Smirnov","year":"2021","journal-title":"Neurology"},{"key":"B323","doi-asserted-by":"publisher","first-page":"1348844","DOI":"10.3389\/fnins.2024.1348844","article-title":"Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer's disease","volume":"18","author":"Song","year":"2024","journal-title":"Front. Neurosci."},{"key":"B324","doi-asserted-by":"publisher","first-page":"115471","DOI":"10.1016\/j.psychres.2023.115471","article-title":"Selective serotonin reuptake inhibitor use, age-related neuropathology and cognition in late-life","volume":"328","author":"Sood","year":"2023","journal-title":"Psychiatry Res."},{"key":"B325","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jalz.2011.04.006","article-title":"Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease","volume":"8","author":"Sparks Stein","year":"2012","journal-title":"Alzheimers Dement."},{"key":"B326","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/s41380-024-02408-9","article-title":"Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease","volume":"29","author":"Spoleti","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"B327","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41564-018-0307-3","article-title":"GABA-modulating bacteria of the human gut microbiota","volume":"4","author":"Strandwitz","year":"2019","journal-title":"Nat. Microbiol."},{"key":"B328","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1038\/s41590-023-01604-z","article-title":"CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer's disease pathology","volume":"24","author":"Su","year":"2023","journal-title":"Nat. Immunol."},{"key":"B329","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1021\/acs.jafc.8b07313","article-title":"Fructooligosaccharides ameliorating cognitive deficits and neurodegeneration in APP\/PS1 transgenic mice through modulating gut microbiota","volume":"67","author":"Sun","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"B330","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.bbi.2022.08.003","article-title":"Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP\/PS1 mice","volume":"106","author":"Sun","year":"","journal-title":"Brain Behav. Immun."},{"key":"B331","doi-asserted-by":"publisher","first-page":"11560","DOI":"10.3390\/ijms231911560","article-title":"Comparative metagenomics and metabolomes reveals abnormal metabolism activity is associated with gut microbiota in Alzheimer's disease mice","volume":"23","author":"Sun","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B332","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/s41467-022-28493-4","article-title":"Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease","volume":"13","author":"Sun","year":"","journal-title":"Nat. Commun."},{"key":"B333","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1007\/s00253-020-10461-x","article-title":"Bidirectional interactions between curcumin and gut microbiota in transgenic mice with Alzheimer's disease","volume":"104","author":"Sun","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B334","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/s0022-2275(20)42702-6","article-title":"Distribution and fatty acid composition of phosphoglycerides in normal human brain","volume":"9","author":"Svennerholm","year":"1968","journal-title":"J. Lipid Res."},{"key":"B335","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/ana.25982","article-title":"Gut microbial ecosystem in Parkinson disease: new clinicobiological insights from multi-omics","volume":"89","author":"Tan","year":"2021","journal-title":"Ann. Neurol."},{"key":"B336","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1093\/jn\/nxab123","article-title":"Bigu-style fasting affects metabolic health by modulating taurine, glucose, and cholesterol homeostasis in healthy young adults","volume":"151","author":"Tang","year":"","journal-title":"J. Nutr."},{"key":"B337","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41583-021-00443-x","article-title":"The role of GABAergic signalling in neurodevelopmental disorders","volume":"22","author":"Tang","year":"","journal-title":"Nat. Rev. Neurosci."},{"key":"B338","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1177\/00220345221076772","article-title":"Treponema denticola induces alzheimer-like tau hyperphosphorylation by activating hippocampal neuroinflammation in mice","volume":"101","author":"Tang","year":"2022","journal-title":"J. Dent. Res."},{"key":"B339","doi-asserted-by":"publisher","first-page":"104814","DOI":"10.1016\/j.neubiorev.2022.104814","article-title":"The gut microbiome and Alzheimer's disease: complex and bidirectional interactions","volume":"141","author":"Tarawneh","year":"2022","journal-title":"Neurosci. Biobehav Rev."},{"key":"B340","doi-asserted-by":"publisher","first-page":"106070","DOI":"10.1016\/j.nbd.2023.106070","article-title":"MRI-based basal forebrain atrophy and volumetric signatures associated with limbic TDP-43 compared to Alzheimer's disease pathology","volume":"180","author":"Teipel","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"B341","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bbi.2021.11.023","article-title":"Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: a randomized clinical trial","volume":"100","author":"Tian","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"B342","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1742-2094-6-36","article-title":"Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease","volume":"6","author":"Ting","year":"2009","journal-title":"J. Neuroinflammation"},{"key":"B343","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s12866-020-02018-9","article-title":"Comparison of different modes of antibiotic delivery on gut microbiota depletion efficiency and body composition in mouse","volume":"20","author":"Tirelle","year":"2020","journal-title":"BMC Microbiol."},{"key":"B344","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.3748\/wjg.v23.i15.2696","article-title":"Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: a preliminary study","volume":"23","author":"Toscano","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"B345","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.neuron.2005.08.023","article-title":"GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells","volume":"47","author":"Tozuka","year":"2005","journal-title":"Neuron"},{"key":"B346","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s13311-018-0611-x","article-title":"Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections-a nationwide, population-based cohort study in taiwan","volume":"15","author":"Tzeng","year":"2018","journal-title":"Neurotherapeutics"},{"key":"B347","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/s41593-023-01315-6","article-title":"Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience","volume":"26","author":"Udeochu","year":"2023","journal-title":"Nat. Neurosci."},{"key":"B348","doi-asserted-by":"publisher","first-page":"k2179","DOI":"10.1136\/bmj.k2179","article-title":"Role of the gut microbiota in nutrition and health","volume":"361","author":"Valdes","year":"2018","journal-title":"BMJ"},{"key":"B349","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer","year":"2019","journal-title":"Nat. Microbiol."},{"key":"B350","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1093\/advances\/nmz054","article-title":"The mediterranean, dietary approaches to stop hypertension (DASH), and mediterranean-DASH intervention for neurodegenerative delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimer's disease-A review","volume":"10","author":"van den Brink","year":"2019","journal-title":"Adv. Nutr."},{"key":"B351","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.plipres.2012.07.001","article-title":"Sphingolipids: critical players in Alzheimer's disease","volume":"51","author":"van Echten-Deckert","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"B352","doi-asserted-by":"publisher","first-page":"e1002482","DOI":"10.1371\/journal.pmed.1002482","article-title":"Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: a targeted metabolomics study","volume":"15","author":"Varma","year":"2018","journal-title":"PLoS Med."},{"key":"B353","doi-asserted-by":"publisher","first-page":"e1003615","DOI":"10.1371\/journal.pmed.1003615","article-title":"Bile acid synthesis, modulation, and dementia: a metabolomic, transcriptomic, and pharmacoepidemiologic study","volume":"18","author":"Varma","year":"2021","journal-title":"PLoS Med."},{"key":"B354","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1002\/gps.4962","article-title":"Role of physical activity in ameliorating neuropsychiatric symptoms in Alzheimer disease: a narrative review","volume":"34","author":"Veronese","year":"2019","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"B355","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1073\/pnas.0607919104","article-title":"Multiple-motor based transport and its regulation by Tau","volume":"104","author":"Vershinin","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B356","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/s41593-021-00823-7","article-title":"A genetically encoded sensor for measuring serotonin dynamics","volume":"24","author":"Wan","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B357","doi-asserted-by":"publisher","first-page":"112152","DOI":"10.1016\/j.celrep.2023.112152","article-title":"Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer's disease","volume":"42","author":"Wang","year":"","journal-title":"Cell Rep."},{"key":"B358","doi-asserted-by":"publisher","first-page":"18524","DOI":"10.1021\/acs.jafc.3c03533","article-title":"Clostridium butyricum alleviates DEHP plasticizer-induced learning and memory impairment in mice via gut-brain Axis","volume":"71","author":"Wang","year":"","journal-title":"J. Agric. Food Chem."},{"key":"B359","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1021\/acsnano.3c09311","article-title":"High-performance plasma biomarker panel for Alzheimer's disease screening using a femtomolar-level label-free biosensing system","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"B360","doi-asserted-by":"publisher","first-page":"4618","DOI":"10.1007\/s12035-023-03340-9","article-title":"Connecting the gut microbiota and neurodegenerative diseases: the role of bile acids","volume":"60","author":"Wang","year":"","journal-title":"Mol. Neurobiol."},{"key":"B361","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/s41422-019-0216-x","article-title":"Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression","volume":"29","author":"Wang","year":"2019","journal-title":"Cell Res."},{"key":"B362","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40168-022-01452-3","article-title":"Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation","volume":"11","author":"Wang","year":"","journal-title":"Microbiome"},{"key":"B363","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12974-020-01873-7","article-title":"27-Hydroxycholesterol contributes to cognitive deficits in APP\/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"B364","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1016\/j.apsb.2023.08.009","article-title":"Targeting the blood-brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays","volume":"13","author":"Wang","year":"","journal-title":"Acta Pharm. Sin. B"},{"key":"B365","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41579-022-00712-1","article-title":"Carbohydrate-active enzymes (CAZymes) in the gut microbiome","volume":"20","author":"Wardman","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"B366","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.2353\/ajpath.2009.080680","article-title":"Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies","volume":"174","author":"Wei","year":"2009","journal-title":"Am. J. Pathol."},{"key":"B367","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1016\/j.ajpath.2014.07.004","article-title":"MyD88 is dispensable for cerebral amyloidosis and neuroinflammation in APP\/PS1 transgenic mice","volume":"184","author":"Weitz","year":"2014","journal-title":"Am. J. Pathol."},{"key":"B368","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.brainresbull.2020.08.017","article-title":"Gut microbiome improves postoperative cognitive function by decreasing permeability of the blood-brain barrier in aged mice","volume":"164","author":"Wen","year":"2020","journal-title":"Brain Res. Bull."},{"key":"B369","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41392-022-01148-y","article-title":"Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain","volume":"7","author":"Wen","year":"","journal-title":"Signal Transduct. Target Ther."},{"key":"B370","doi-asserted-by":"publisher","first-page":"158372","DOI":"10.1016\/j.scitotenv.2022.158372","article-title":"Uptake, distribution, and depuration of emerging per- and polyfluoroalkyl substances in mice: role of gut microbiota","volume":"853","author":"Wen","year":"","journal-title":"Sci. Total Environ."},{"key":"B371","doi-asserted-by":"publisher","first-page":"105047","DOI":"10.1016\/j.nbd.2020.105047","article-title":"Neuroprotective activity of ursodeoxycholic acid in CHMP2BIntron5 models of frontotemporal dementia","volume":"144","author":"West","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B372","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13195-020-00741-z","article-title":"AddNeuroMed consortium. Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease","volume":"13","author":"Whiley","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"B373","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1073\/pnas.0812874106","article-title":"Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites","volume":"106","author":"Wikoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B374","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.bbi.2021.03.019","article-title":"Inflammation, negative affect, and amyloid burden in Alzheimer's disease: insights from the kynurenine pathway","volume":"95","author":"Willette","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"B375","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41586-021-03669-y","article-title":"Microbiota regulate social behaviour via stress response neurons in the brain","volume":"595","author":"Wu","year":"2021","journal-title":"Nature"},{"key":"B376","doi-asserted-by":"publisher","first-page":"e14187","DOI":"10.1111\/acel.14187","article-title":"Amygdala neuronal dyshomeostasis via 5-HT receptors mediates mood and cognitive defects in Alzheimer's disease","volume":"8","author":"Wu","year":"2024","journal-title":"Aging Cell"},{"key":"B377","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.bbi.2017.06.002","article-title":"Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice","volume":"65","author":"Wu","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B378","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.1038\/s41467-023-41283-w","article-title":"Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C\/EBP\u03b2 transgenic mice","volume":"14","author":"Xia","year":"2023","journal-title":"Nat. Commun."},{"key":"B379","doi-asserted-by":"publisher","first-page":"1281233","DOI":"10.3389\/fmicb.2023.1281233","article-title":"Fecal microbiota transplantation: a novel strategy for treating Alzheimer's disease","volume":"14","author":"Xiang","year":"2023","journal-title":"Front. Microbiol."},{"key":"B380","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bbi.2024.03.031","article-title":"Multi-strain probiotics ameliorate Alzheimer's-like cognitive impairment and pathological changes through the AKT\/GSK-3\u03b2 pathway in senescence-accelerated mouse prone 8 mice","volume":"119","author":"Xiao-Hang","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"B381","doi-asserted-by":"publisher","first-page":"e111515","DOI":"10.15252\/embj.2022111515","article-title":"Gut microbiota regulates blood-cerebrospinal fluid barrier function and A\u03b2 pathology","volume":"42","author":"Xie","year":"","journal-title":"EMBO J."},{"key":"B382","doi-asserted-by":"publisher","first-page":"e12306","DOI":"10.1002\/jev2.12306","article-title":"Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling","volume":"12","author":"Xie","year":"","journal-title":"J. Extracell. Vesicles"},{"key":"B383","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.ijbiomac.2020.05.180","article-title":"Yeast \u03b2-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in A\u03b21-42-induced AD-like mice","volume":"161","author":"Xu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"B384","doi-asserted-by":"publisher","first-page":"111188","DOI":"10.1016\/j.intimp.2023.111188","article-title":"Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier","volume":"126","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B385","doi-asserted-by":"publisher","first-page":"122022","DOI":"10.1016\/j.lfs.2023.122022","article-title":"Unveiling the role of gut-brain axis in regulating neurodegenerative diseases: a comprehensive review","volume":"330","author":"Yadav","year":"2023","journal-title":"Life Sci."},{"key":"B386","doi-asserted-by":"publisher","first-page":"591571","DOI":"10.3389\/fimmu.2020.591571","article-title":"Potential role of phosphoglycerol dihydroceramide produced by periodontal pathogen Porphyromonas gingivalis in the pathogenesis of Alzheimer's disease","volume":"11","author":"Yamada","year":"2020","journal-title":"Front. Immunol."},{"key":"B387","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1016\/j.cell.2022.09.024","article-title":"Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"B388","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s12031-020-01750-1","article-title":"Lipopolysaccharide-induced exosomal miR-146a is involved in altered expression of Alzheimer's risk genes via suppression of TLR4 signaling","volume":"71","author":"Yang","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"B389","doi-asserted-by":"publisher","first-page":"122042","DOI":"10.1016\/j.lfs.2023.122042","article-title":"Aerobic exercise regulates GPR81 signal pathway and mediates complement-microglia axis homeostasis on synaptic protection in the early stage of Alzheimer's disease","volume":"331","author":"Yang","year":"","journal-title":"Life Sci."},{"key":"B390","doi-asserted-by":"publisher","first-page":"111992","DOI":"10.1016\/j.nut.2023.111992","article-title":"Intermittent fasting ameliorates neuronal ferroptosis and cognitive impairment in mice after traumatic brain injury","volume":"109","author":"Yang","year":"","journal-title":"Nutrition"},{"key":"B391","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40035-017-0089-1","article-title":"The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease","volume":"6","author":"Yang","year":"2017","journal-title":"Transl. Neurodegener."},{"key":"B392","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.apsb.2019.07.001","article-title":"Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice","volume":"10","author":"Yang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"B393","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.chom.2020.11.011","article-title":"Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways","volume":"29","author":"Ye","year":"2021","journal-title":"Cell Host Microbe"},{"key":"B394","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13024-023-00692-7","article-title":"Amyloid-\u03b2 specific regulatory T cells attenuate Alzheimer's disease pathobiology in APP\/PS1 mice","volume":"18","author":"Yeapuri","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"B395","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s40478-023-01702-x","article-title":"Nuclear face of Tau: an inside player in neurodegeneration","volume":"11","author":"Younas","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"B396","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.18632\/aging.205432","article-title":"Treadmill exercise can regulate the redox balance in the livers of APP\/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis","volume":"16","author":"Yuan","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"B397","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/pcn.12637","article-title":"Therapeutic role of rifampicin in Alzheimer's disease","volume":"72","author":"Yulug","year":"2018","journal-title":"Psychiatry Clin. Neurosci."},{"key":"B398","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.molmet.2017.03.006","article-title":"Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway","volume":"6","author":"Yusta","year":"2017","journal-title":"Mol. Metab."},{"key":"B399","doi-asserted-by":"publisher","first-page":"111116","DOI":"10.1016\/j.mce.2020.111116","article-title":"The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model","volume":"521","author":"Zangerolamo","year":"2021","journal-title":"Mol. Cell Endocrinol."},{"key":"B400","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1111\/ejn.15783","article-title":"\u03b1-Glyceryl-phosphoryl-ethanolamine protects human hippocampal neurons from ageing-induced cellular alterations","volume":"56","author":"Zappelli","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"B401","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1038\/s41467-018-05336-9","article-title":"Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism","volume":"9","author":"Zarrinpar","year":"2018","journal-title":"Nat. Commun."},{"key":"B402","doi-asserted-by":"publisher","first-page":"107685","DOI":"10.1016\/j.neuropharm.2019.107685","article-title":"Gut microbiota depletion from early adolescence alters adult immunological and neurobehavioral responses in a mouse model of multiple sclerosis","volume":"157","author":"Zeraati","year":"2019","journal-title":"Neuropharmacology"},{"key":"B403","doi-asserted-by":"publisher","first-page":"115448","DOI":"10.1016\/j.ecoenv.2023.115448","article-title":"Mannan oligosaccharides selenium ameliorates intestinal mucosal barrier, and regulate intestinal microbiota to prevent Enterotoxigenic Escherichia coli -induced diarrhea in weaned piglets","volume":"264","author":"Zha","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B404","doi-asserted-by":"publisher","first-page":"785644","DOI":"10.3389\/fimmu.2022.785644","article-title":"Implications of gut microbiota in neurodegenerative diseases","volume":"13","author":"Zhang","year":"","journal-title":"Front. Immunol."},{"key":"B405","doi-asserted-by":"publisher","first-page":"12371","DOI":"10.1039\/d2fo02871a","article-title":"Hawthorn flavonoid ameliorates cognitive deficit in mice with Alzheimer's disease by increasing the levels of Bifidobacteriales in gut microbiota and docosapentaenoic acid in serum metabolites","volume":"13","author":"Zhang","year":"","journal-title":"Food Funct."},{"key":"B406","doi-asserted-by":"publisher","first-page":"12800","DOI":"10.1021\/acs.jafc.9b08309","article-title":"Dietary pattern, gut microbiota, and Alzheimer's disease","volume":"68","author":"Zhang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"B407","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1007\/s00394-023-03208-7","article-title":"Prebiotics modulate the microbiota-gut-brain axis and ameliorate cognitive impairment in APP\/PS1 mice","volume":"62","author":"Zhang","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"B408","doi-asserted-by":"publisher","first-page":"844","DOI":"10.3390\/nu16060844","article-title":"Live and heat-inactivated Streptococcus thermophilus MN-ZLW-002 mediate the gut-brain Axis, alleviating cognitive dysfunction in APP\/PS1 mice","volume":"16","author":"Zhang","year":"2024","journal-title":"Nutrients"},{"key":"B409","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s12974-023-02915-6","article-title":"Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease","volume":"20","author":"Zhao","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B410","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1038\/s41380-024-02428-5","article-title":"Microbial infection promotes amyloid pathology in a mouse model of Alzheimer's disease via modulating \u03b3-secretase","volume":"29","author":"Zhao","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"B411","doi-asserted-by":"publisher","first-page":"113188","DOI":"10.1016\/j.biopha.2022.113188","article-title":"The role and therapeutic implication of protein tyrosine phosphatases in Alzheimer's disease","volume":"151","author":"Zhao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B412","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3389\/fcimb.2017.00318","article-title":"Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD Hippocampus","volume":"7","author":"Zhao","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B413","doi-asserted-by":"publisher","first-page":"24125","DOI":"10.1038\/srep24125","article-title":"The brain metabolome of male rats across the lifespan","volume":"6","author":"Zheng","year":"2016","journal-title":"Sci. Rep."},{"key":"B414","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/glia.23558","article-title":"Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide","volume":"67","author":"Zhong","year":"2019","journal-title":"Glia"},{"key":"B415","doi-asserted-by":"publisher","first-page":"5569","DOI":"10.1093\/cercor\/bhac036","article-title":"Selective impairment of circuits between prefrontal cortex glutamatergic neurons and basal forebrain cholinergic neurons in a tauopathy mouse model","volume":"32","author":"Zhong","year":"2022","journal-title":"Cereb. Cortex"},{"key":"B416","doi-asserted-by":"publisher","first-page":"170060","DOI":"10.1016\/j.scitotenv.2024.170060","article-title":"Cold exposure, gut microbiota and health implications: a narrative review","volume":"916","author":"Zhou","year":"2024","journal-title":"Sci. Total Environ."},{"key":"B417","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1007\/s11064-019-02748-x","article-title":"Imbalance of microglial TLR4\/TREM2 in LPS-treated APP\/PS1 transgenic mice: a potential link between Alzheimer's disease and systemic inflammation","volume":"44","author":"Zhou","year":"2019","journal-title":"Neurochem. Res."},{"key":"B418","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s40168-023-01589-9","article-title":"Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice","volume":"11","author":"Zhou","year":"","journal-title":"Microbiome"},{"key":"B419","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.1523\/JNEUROSCI.0724-23.2023","article-title":"Dietary fiber and microbiota metabolite receptors enhance cognition and alleviate disease in the 5xFAD mouse model of Alzheimer's disease","volume":"43","author":"Zhou","year":"","journal-title":"J. Neurosci."},{"key":"B420","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13024-022-00562-8","article-title":"Trem2 deletion enhances tau dispersion and pathology through microglia exosomes","volume":"17","author":"Zhu","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"B421","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.semcdb.2022.03.013","article-title":"Impairments of glutamatergic synaptic transmission in Alzheimer's disease","volume":"139","author":"Zott","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"B422","doi-asserted-by":"publisher","first-page":"964","DOI":"10.14336\/AD.2022.1127","article-title":"Gut microbiota is an impact factor based on the brain-gut Axis to Alzheimer's disease: a systematic review","volume":"14","author":"Zou","year":"2023","journal-title":"Aging Dis."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1459655\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T08:44:31Z","timestamp":1726649071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1459655\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":422,"alternative-id":["10.3389\/fphar.2024.1459655"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1459655","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,17]]},"article-number":"1459655"}}