{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:25:39Z","timestamp":1789129539388,"version":"build-2803163510"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Chronic prostatitis is a prevalent male urinary system disorder characterized by pelvic discomfort or pain, bladder dysfunction, sexual dysfunction, and infertility. Pain and lower urinary tract symptoms (LUTS) are the most common symptoms, significantly impacting patients\u2019 quality of life and driving them to seek medical attention. Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective calcium ion-dependent cation channel in the TRPV channel family that is widely distributed in neural tissue and plays a role in signal transmission. In this review, we provide a comprehensive overview of the current understanding of the role of TRPV1 in chronic prostatitis. The discussion focuses on the connection between TRPV1 and prostatitis pain and LUTS, and highlights the potential for targeting this channel in the development of novel treatment strategies.<\/jats:p>","DOI":"10.3389\/fphar.2024.1459683","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T04:34:08Z","timestamp":1726720448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The role of TRPV1 in chronic prostatitis: a review"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhipeng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongmin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/med.21427","article-title":"Medicinal chemistry, pharmacology, and clinical implications of TRPV1 receptor antagonists","volume":"37","author":"Aghazadeh Tabrizi","year":"2017","journal-title":"Med. Res. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3390\/plants12020339","article-title":"Natural active ingredients and TRPV1 modulation: focus on key chemical moieties involved in ligand\u2013target interaction","volume":"12","author":"Andrei","year":"2023","journal-title":"Plants"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.eururo.2006.04.006","article-title":"Effect of intravesical resiniferatoxin (RTX) on lower urinary tract symptoms, urodynamic parameters, and quality of life of patients with urodynamic increased bladder sensation","volume":"50","author":"Apostolidis","year":"2006","journal-title":"Eur. Urol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/pros.24101","article-title":"Prostate-to-bladder cross-sensitization in a model of zymosan-induced chronic pelvic pain syndrome in rats","volume":"81","author":"Aydogdu","year":"2021","journal-title":"Prostate"},{"key":"B5","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1146\/annurev-pharmtox-010919-023238","article-title":"TRP channel cooperation for nociception: therapeutic opportunities","volume":"61","author":"Bamps","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-3-642-54215-2_9","article-title":"TRPV1","volume":"222","author":"Bevan","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.mayocp.2016.08.011","article-title":"Anorectal and pelvic pain","volume":"91","author":"Bharucha","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"B8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00281-018-0674-0","article-title":"Role of neurogenic inflammation in local communication in the visceral mucosa","volume":"40","author":"Birder","year":"2018","journal-title":"Seminars Immunopathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.jpain.2017.01.009","article-title":"Safety, pharmacokinetics, and pharmacodynamics study in healthy subjects of oral NEO6860, a modality selective transient receptor potential vanilloid subtype 1 antagonist","volume":"18","author":"Brown","year":"2017","journal-title":"J. Pain"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3389\/fonc.2019.01087","article-title":"Inflammation, cancer and immunity-implication of TRPV1 channel","volume":"9","author":"Bujak","year":"2019","journal-title":"Front. Oncol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"764.e1","DOI":"10.1016\/j.urology.2010.04.002","article-title":"Distribution of convergent afferents innervating bladder and prostate at dorsal root Ganglia in rats","volume":"76","author":"Chen","year":"2010","journal-title":"Urology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4111\/kju.2012.53.2.109","article-title":"Effect of prostatitis on lower urinary tract symptoms: retrospective analysis of prostate biopsy tissue","volume":"53","author":"Chung","year":"2012","journal-title":"Korean J. Urology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1051\/medsci\/2013296012","article-title":"TRPV1 in neuropathic pain: from animal models to therapeutical prospects","volume":"29","author":"Danigo","year":"2013","journal-title":"Med. Sci. Paris."},{"key":"B15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.eururo.2005.01.009","article-title":"The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate","volume":"48","author":"Dinis","year":"2005","journal-title":"Eur. Urol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.juro.2011.11.116","article-title":"Role of mast cells in male chronic pelvic pain","volume":"187","author":"Done","year":"2012","journal-title":"J. Urology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/0306-4522(92)90237-v","article-title":"Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo","volume":"49","author":"Donnerer","year":"1992","journal-title":"Neuroscience"},{"key":"B18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.autneu.2017.03.004","article-title":"Neurite outgrowth in cultured mouse pelvic ganglia - effects of neurotrophins and bladder tissue","volume":"205","author":"Ekman","year":"2017","journal-title":"Aut. Neurosci. basic and Clin."},{"key":"B19","doi-asserted-by":"publisher","first-page":"554195","DOI":"10.3389\/fphys.2020.554195","article-title":"The mysteries of capsaicin-sensitive afferents","volume":"11","author":"Fischer","year":"2020","journal-title":"Front. Physiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/oxfordjournals.bmb.a072189","article-title":"Peptides and neurogenic inflammation","volume":"43","author":"Foreman","year":"1987","journal-title":"Br. Med. Bull."},{"key":"B21","doi-asserted-by":"publisher","first-page":"CD012552","DOI":"10.1002\/14651858.CD012552.pub2","article-title":"Pharmacological interventions for treating chronic prostatitis\/chronic pelvic pain syndrome","volume":"2019","author":"Franco","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"E422","DOI":"10.1111\/j.1464-410X.2012.11187.x","article-title":"Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input","volume":"110","author":"Frias","year":"2012","journal-title":"BJU Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.3390\/molecules21060797","article-title":"Capsaicin, nociception and pain","volume":"21","author":"Frias","year":"2016","journal-title":"Molecules"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1113\/JP277452","article-title":"Bladder overactivity and afferent hyperexcitability induced by prostate\u2010to\u2010bladder cross\u2010sensitization in rats with prostatic inflammation","volume":"597","author":"Funahashi","year":"2019","journal-title":"J. Physiology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/13543776.2021.1854225","article-title":"A patent review of transient receptor potential vanilloid type 1 modulators (2014-present)","volume":"31","author":"Gao","year":"2021","journal-title":"Expert Opin. Ther. Pat."},{"key":"B26","doi-asserted-by":"publisher","first-page":"G301","DOI":"10.1152\/ajpgi.00272.2017","article-title":"Cross-organ sensitization between the colon and bladder: to pee or not to pee?","volume":"314","author":"Grundy","year":"2018","journal-title":"Am. J. Physiology. Gastrointest. Liver Physiology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0028-3908(03)00305-8","article-title":"Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1\/TRPV1) antagonist","volume":"46","author":"Gunthorpe","year":"2004","journal-title":"Neuropharmacology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fncel.2019.00271","article-title":"Human dorsal root ganglia","volume":"13","author":"Haberberger","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5534\/wjmh.220248","article-title":"Autonomic nervous system dysfunction is related to chronic prostatitis\/chronic pelvic pain syndrome","volume":"41","author":"He","year":"2023","journal-title":"World J. Men\u2019s Health"},{"key":"B30","first-page":"1","article-title":"TRPV1: a stress response protein in the central nervous system","volume":"1","author":"Ho","year":"2012","journal-title":"Am. J. Neurodegener. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"855376","DOI":"10.3389\/fnmol.2022.855376","article-title":"Loss of the sympathetic signal produces sterile inflammation of the prostate","volume":"15","author":"Hu","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2174\/1876386301306010095","article-title":"Resiniferatoxin for pain treatment: an interventional approach to personalized pain medicine","volume":"6","author":"Iadarola","year":"2013","journal-title":"open pain J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s40265-020-01429-2","article-title":"TRPV1-Targeted drugs in development for human pain conditions","volume":"81","author":"Iftinca","year":"2021","journal-title":"Drugs"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/pros.24227","article-title":"Therapeutic effects of nerve growth factor-targeting therapy on bladder overactivity in rats with prostatic inflammation","volume":"81","author":"Igarashi","year":"2021","journal-title":"Prostate"},{"key":"B35","doi-asserted-by":"publisher","first-page":"348","DOI":"10.14218\/JERP.2023.00013","article-title":"Role of transient receptor potential vanilloid 1 in Health and disease","volume":"8","author":"Jaffal","year":"2023","journal-title":"J. Explor. Res. Pharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1002\/cne.24884","article-title":"Perineural application of resiniferatoxin on uninjured L3 and L4 nerves completely alleviates thermal and mechanical hypersensitivity following L5 nerve injury in rats","volume":"528","author":"Javed","year":"2020","journal-title":"J. Comp. Neurology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e7021","DOI":"10.1371\/journal.pone.0007021","article-title":"Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia","volume":"4","author":"Jeffry","year":"2009","journal-title":"PloS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.2174\/156802611796904924","article-title":"Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials","volume":"11","author":"Kissin","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1590\/S1677-5538.IBJU.2015.0254","article-title":"The relationship between histological prostatitis and lower urinary tract symptoms and sexual function","volume":"42","author":"Kumsar","year":"2016","journal-title":"Int. Braz J Urol Official J. Braz. Soc. Urology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.urology.2015.03.007","article-title":"Animal models of urologic chronic pelvic pain syndromes: findings from the multidisciplinary approach to the study of chronic pelvic pain research network","volume":"85","author":"Lai","year":"2015","journal-title":"Urology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.2147\/JIR.S458132","article-title":"Sertraline alleviates chronic prostatitis by regulating the TRPV1 channel","volume":"17","author":"Lao","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"4811","DOI":"10.3390\/ijms24054811","article-title":"Activation of mast cells by neuropeptides: the role of pro-inflammatory and anti-inflammatory cytokines","volume":"24","author":"Lauritano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/1756287209103922","article-title":"TRP family proteins in the lower urinary tract: translating basic science into new clinical prospective","volume":"1","author":"Lazzeri","year":"2009","journal-title":"Ther. Adv. Urology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.eururo.2004.08.007","article-title":"Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder","volume":"46","author":"Lazzeri","year":"2004","journal-title":"Eur. Urol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/s0090-4295(01)01143-8","article-title":"Neurophysiologic testing in chronic pelvic pain syndrome: a pilot study","volume":"58","author":"Lee","year":"2001","journal-title":"Urology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1002\/pros.23170","article-title":"Retrograde double-labeling demonstrates convergent afferent innervation of the prostate and bladder","volume":"76","author":"Lee","year":"2016","journal-title":"Prostate"},{"key":"B47","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3390\/toxins9100310","article-title":"The influence of resiniferatoxin (RTX) and tetrodotoxin (TTX) on the distribution, relative frequency, and chemical coding of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall","volume":"9","author":"Lepiarczyk","year":"2017","journal-title":"Toxins"},{"key":"B48","doi-asserted-by":"publisher","first-page":"56","DOI":"10.13702\/j.1000-0607.20211148","article-title":"Effect of electroacupuncture on the morphology of prostate and degranulation of mast cells in rats with chronic nonbacterial prostatitis","volume":"48","author":"Li","year":"2023","journal-title":"Zhen Ci Yan Jiu = Acupunct. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1152\/jn.01344.2007","article-title":"Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1","volume":"100","author":"Light","year":"2008","journal-title":"J. Neurophysiology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/s0022-5347(17)38701-3","article-title":"Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans","volume":"142","author":"Maggi","year":"1989","journal-title":"J. Urology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"0","DOI":"10.5680\/lhuii000014","article-title":"Evaluation of chronic prostatitis\/chronic pelvic pain syndrome","author":"Magistro","year":"2019","journal-title":"Ger. Med. Sci."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.02.1208","article-title":"Mp25-05 enhanced bladder pain sensitivity due to the prostate-to-bladder afferent cross sensitization in A rat model of prostatitis","volume":"193","author":"Majima","year":"2015","journal-title":"J. Urology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mcn.2015.02.001","article-title":"The importance of TRPV1-sensitisation factors for the development of neuropathic pain","volume":"65","author":"Malek","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.3390\/ijms24055001","article-title":"Molecular mechanisms of neurogenic inflammation of the skin","volume":"24","author":"Marek-Jozefowicz","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"102870","DOI":"10.1016\/j.ceca.2024.102870","article-title":"TRPV1: receptor structure, activation, modulation and role in neuro-immune interactions and pain","volume":"119","author":"Maximiano","year":"2024","journal-title":"Cell Calcium"},{"key":"B56","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ucl.2017.04.014","article-title":"New frontiers of basic science research in neurogenic lower urinary tract dysfunction","volume":"44","author":"Miyazato","year":"2017","journal-title":"Urologic Clin. N. Am."},{"key":"B57","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.prnil.2017.04.001","article-title":"Relation between histological prostatitis and lower urinary tract symptoms and erectile function","volume":"5","author":"Mizuno","year":"2017","journal-title":"Prostate Int."},{"key":"B58","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s12264-017-0200-8","article-title":"Regulation of pain and itch by TRP channels","volume":"34","author":"Moore","year":"2017","journal-title":"Neurosci. Bull."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1038\/s41467-023-38162-9","article-title":"Human TRPV1 structure and inhibition by the analgesic SB-366791","volume":"14","author":"Neuberger","year":"2023","journal-title":"Nat. Commun."},{"key":"B60","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1002\/pros.23794","article-title":"Long-lasting bladder overactivity and bladder afferent hyperexcitability in rats with chemically-induced prostatic inflammation","volume":"79","author":"Ni","year":"2019","journal-title":"Prostate"},{"key":"B61","doi-asserted-by":"publisher","first-page":"120524","DOI":"10.1016\/j.lfs.2022.120524","article-title":"Nerve growth factor-mediated Na+ channel plasticity of bladder afferent neurons in mice with spinal cord injury","volume":"298","author":"Ni","year":"2022","journal-title":"Life Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"S133","DOI":"10.5489\/cuaj.12201","article-title":"Lower urinary tract symptoms associated with prostatitis","volume":"6","author":"Nickel","year":"2012","journal-title":"Can. Urological Assoc. J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"90","DOI":"10.5213\/inj.1836124.062","article-title":"Neurologic mechanisms underlying voiding dysfunction due to prostatitis in a rat model of nonbacterial prostatic inflammation","volume":"22","author":"Park","year":"2018","journal-title":"Int. Neurourol. J."},{"key":"B64","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s40266-021-00890-2","article-title":"Diagnostic and management strategies for patients with chronic prostatitis and chronic pelvic pain syndrome","volume":"38","author":"Pena","year":"2021","journal-title":"Drugs and Aging"},{"key":"B65","doi-asserted-by":"publisher","first-page":"5639","DOI":"10.1113\/JP279909","article-title":"TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure","volume":"598","author":"Phan","year":"2020","journal-title":"J. physiology"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.230352","article-title":"Cannabidiol alleviates chronic prostatitis and chronic pelvic pain syndrome via CB2 receptor activation and TRPV1 desensitization","volume":"42","author":"Piao","year":"2024","journal-title":"World J. Men\u2019s Health"},{"key":"B67","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/pcan.2016.8","article-title":"Chronic prostatitis\/chronic pelvic pain syndrome: a review of evaluation and therapy","volume":"19","author":"Polackwich","year":"2016","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.pain.2014.04.009","article-title":"Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome","volume":"155","author":"Roman","year":"2014","journal-title":"Pain"},{"key":"B69","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/pros.23913","article-title":"TRPV1 in experimental autoimmune prostatitis","volume":"80","author":"Roman","year":"2020","journal-title":"Prostate"},{"key":"B70","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1365-2125.2011.04040.x","article-title":"An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects","volume":"72","author":"Round","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.npep.2016.01.003","article-title":"TRPV currents and their role in the nociception and neuroplasticity","volume":"57","author":"Satheesh","year":"2016","journal-title":"Neuropeptides"},{"key":"B72","doi-asserted-by":"publisher","first-page":"R534","DOI":"10.1152\/ajpregu.00367.2009","article-title":"Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function","volume":"298","author":"Schnegelsberg","year":"2010","journal-title":"Am. J. physiology. Regul. Integr. Comp. physiology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.juro.2016.03.077","article-title":"Chronic prostatitis induces bladder hypersensitivity and sensitizes bladder afferents in the mouse","volume":"196","author":"Schwartz","year":"2016","journal-title":"J. Urology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1097\/j.pain.0000000000000201","article-title":"Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis","volume":"156","author":"Schwartz","year":"2015","journal-title":"Pain"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2299","article-title":"Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces evoked pain in healthy volunteers, a randomized, double-blind, placebo-controlled, crossover study","author":"Segerdahl","year":"2024","journal-title":"Eur. J. Pain"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1097\/j.pain.0000000000001973","article-title":"Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization","volume":"161","author":"Shiers","year":"2020","journal-title":"Pain"},{"key":"B77","doi-asserted-by":"publisher","first-page":"7885","DOI":"10.3390\/ijms24097885","article-title":"Molecular mechanisms of neurogenic lower urinary tract dysfunction after spinal cord injury","volume":"24","author":"Shimizu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neulet.2018.06.049","article-title":"Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury","volume":"683","author":"Shimizu","year":"2018","journal-title":"Neurosci. Lett."},{"key":"B79","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1152\/jn.00024.2009","article-title":"The role of the TRPV1 endogenous agonist N-Oleoyldopamine in modulation of nociceptive signaling at the spinal cord level","volume":"102","author":"Spicarova","year":"2009","journal-title":"J. Neurophysiology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/tvst.11.11.15","article-title":"Topical ocular TRPV1 antagonist SAF312 (libvatrep) demonstrates safety, low systemic exposure, and No anesthetic effect in healthy participants","volume":"11","author":"Stasi","year":"2022","journal-title":"Transl. Vis. Sci. and Technol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1085\/jgp.200609576","article-title":"Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane","volume":"128","author":"Stein","year":"2006","journal-title":"J. General Physiology"},{"key":"B82","first-page":"159","article-title":"Vanilloid (Capsaicin) receptors and mechanisms","volume":"51","author":"Szallasi","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1097\/00029330-200709020-00013","article-title":"Intrathecal administration of resiniferatoxin produces analgesia against prostatodynia in rats","volume":"120","author":"Tang","year":"2007","journal-title":"Chin. Med. J."},{"key":"B84","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbadis.2010.12.014","article-title":"Mast cells and inflammation","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochimica Biophysica Acta"},{"key":"B85","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/tvst.12.3.7","article-title":"Topical ocular TRPV1 antagonist SAF312 (Libvatrep) for postoperative pain after photorefractive keratectomy","volume":"12","author":"Thompson","year":"2023","journal-title":"Transl. Vis. Sci. and Technol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1007\/s00424-018-2188-y","article-title":"Potential therapeutic value of transient receptor potential channels in male urogenital system","volume":"470","author":"Toktanis","year":"2018","journal-title":"Pflugers Archiv Eur. J. physiology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.urology.2005.11.028","article-title":"Heat\/burning sensation induced by topical application of capsaicin on perineal cutaneous area: new approach in diagnosis and treatment of chronic prostatitis\/chronic pelvic pain syndrome?","volume":"67","author":"Turini","year":"2006","journal-title":"Urology"},{"key":"B88","first-page":"185","article-title":"The effect of asymptomatic histological prostatitis on sexual function and lower urinary tract symptoms","volume":"69","author":"Urkmez","year":"2016","journal-title":"Arch. Espanoles De. Urol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41585-021-00428-6","article-title":"Transient receptor potential channels in sensory mechanisms of the lower urinary tract","volume":"18","author":"Vanneste","year":"2021","journal-title":"Nat. Rev. Urol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e00001","DOI":"10.1097\/IMNA-D-22-00001","article-title":"Traditional Chinese medicine regulates inflammatory factors in chronic prostatitis\/chronic pelvic pain syndrome: a review","volume":"10","author":"Wang","year":"2023","journal-title":"Integr. Med. Nephrol. Androl."},{"key":"B91","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.neuron.2014.09.030","article-title":"A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission","volume":"84","author":"Wong","year":"2014","journal-title":"Neuron"},{"key":"B92","doi-asserted-by":"publisher","first-page":"172836","DOI":"10.1016\/j.ejphar.2019.172836","article-title":"Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats","volume":"867","author":"Wu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"81","DOI":"10.4111\/kju.2014.55.2.81","article-title":"Neural mechanisms underlying lower urinary tract dysfunction","volume":"55","author":"Yoshimura","year":"2014","journal-title":"Korean J. Urology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"e13302","DOI":"10.1111\/and.13302","article-title":"Upregulation of TRPV1 in spinal dorsal root ganglion by activating NGF-TrkA pathway contributes to pelvic organ cross-sensitisation in rats with experimental autoimmune prostatitis","volume":"51","author":"Zhang","year":"2019","journal-title":"Andrologia"},{"key":"B95","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.1038\/sj.emboj.7600893","article-title":"NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels","volume":"24","author":"Zhang","year":"2005","journal-title":"EMBO J."},{"key":"B96","first-page":"399","article-title":"Role of mast cells in experimental autoimmune prostatitis in rats","volume":"23","author":"Zheng","year":"2017","journal-title":"Zhonghua Nan Ke Xue = Natl. J. Androl."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1459683\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T04:34:14Z","timestamp":1726720454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1459683\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":96,"alternative-id":["10.3389\/fphar.2024.1459683"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1459683","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]},"article-number":"1459683"}}