{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:14:41Z","timestamp":1792480481538,"version":"4.5.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and its prevalence is rapidly increasing. Antioxidants, lipid-lowering medications, and lifestyle interventions are the most commonly used treatment options for NAFLD, but their efficacy in inhibiting steatosis progression is limited and their long-term ineffectiveness and adverse effects have been widely reported. Therefore, it is important to gain a deeper understanding of the pathogenesis of NAFLD and to identify more effective therapeutic approaches. Mitochondrial homeostasis governs cellular redox biology, lipid metabolism, and cell death, all of which are crucial to control hepatic function. Recent findings have indicated that disruption of mitochondrial homeostasis occurs in the early stage of NAFLD and mitochondrial dysfunction reinforces disease progression. In this review, we summarize the physical roles of the mitochondria and describe their response and dysfunction in the context of NAFLD. We also discuss the drug targets associated with the mitochondria that are currently in the clinical trial phase of exploration. From our findings, we hope that the mitochondria may be a promising therapeutic target for the treatment of NAFLD.<\/jats:p>","DOI":"10.3389\/fphar.2024.1463187","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:26:05Z","timestamp":1725337565000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Targeting mitochondrial homeostasis in the treatment of non-alcoholic fatty liver disease: a review"],"prefix":"10.3389","volume":"15","author":[{"given":"Yalan","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e21620","DOI":"10.1096\/fj.202100067R","article-title":"Mitochondrial fusion and fission: the fine-tune balance for cellular homeostasis","volume":"35","author":"Adebayo","year":"2021","journal-title":"Faseb J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.conb.2021.09.005","article-title":"PTEN-induced kinase 1 (PINK1) and Parkin: unlocking a mitochondrial quality control pathway linked to Parkinson\u2019s disease","volume":"72","author":"Agarwal","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s0140-6736(15)00803-x","article-title":"Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study","volume":"387","author":"Armstrong","year":"2016","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.jhep.2022.03.017","article-title":"Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis","volume":"77","author":"Beaulant","year":"2022","journal-title":"J. Hepatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jare.2023.02.012","article-title":"FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner","volume":"55","author":"Bi","year":"2024","journal-title":"J. Adv. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s42255-020-0209-6","article-title":"Resolution of NASH and hepatic fibrosis by the GLP-1R\/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis","volume":"2","author":"Boland","year":"2020","journal-title":"Nat. Metab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41586-023-06537-z","article-title":"The power and potential of mitochondria transfer","volume":"623","author":"Borcherding","year":"2023","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/j.cmet.2022.08.010","article-title":"Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood","volume":"34","author":"Borcherding","year":"2022","journal-title":"Cell Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1089\/ars.2022.0097","article-title":"Lester packer: on his life and his legacy","volume":"38","author":"Cadenas","year":"2023","journal-title":"Antioxid. Redox Signal"},{"key":"B11","doi-asserted-by":"publisher","first-page":"101115","DOI":"10.1016\/j.gendis.2023.101115","article-title":"Mitochondrial dysfunction: a promising therapeutic target for liver diseases","volume":"11","author":"Chen","year":"2024","journal-title":"Genes Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"939","DOI":"10.14218\/jcth.2022.00067","article-title":"Reactive oxygen species and oxidative stress in the pathogenesis of MAFLD","volume":"10","author":"Clare","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1080\/13543784.2023.2263369","article-title":"Insulin sensitizers in 2023: lessons learned and new avenues for investigation","volume":"32","author":"Colca","year":"2023","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jhep.2021.09.008","article-title":"Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function","volume":"76","author":"da Silva Lima","year":"2022","journal-title":"J. Hepatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5422","DOI":"10.1073\/pnas.1303360110","article-title":"Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier","volume":"110","author":"Divakaruni","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B16","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41467-023-44057-6","article-title":"Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease","volume":"15","author":"Dong","year":"2024","journal-title":"Nat. Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.cmet.2018.03.001","article-title":"Mechanisms of action and therapeutic application of glucagon-like peptide-1","volume":"27","author":"Drucker","year":"2018","journal-title":"Cell Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.7150\/thno.21400","article-title":"Pro-inflammatory CXCR3 impairs mitochondrial function in experimental non-alcoholic steatohepatitis","volume":"7","author":"Du","year":"2017","journal-title":"Theranostics"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0245-z","article-title":"Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1\/FOXO3a-mediated autophagy and mitochondrial biogenesis","volume":"51","author":"Dusabimana","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"775382","DOI":"10.3389\/fnut.2021.775382","article-title":"Differential effects of oleic and palmitic acids on lipid droplet-mitochondria interaction in the hepatic cell line HepG2","volume":"8","author":"Eynaudi","year":"2021","journal-title":"Front. Nutr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/1753-0407.12555","article-title":"Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease","volume":"9","author":"Feng","year":"2017","journal-title":"J. Diabetes"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2017.01.003","article-title":"The endoplasmic reticulum-mitochondria coupling in health and disease: molecules, functions and significance","volume":"62","author":"Filadi","year":"2017","journal-title":"Cell Calcium"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/apt.16608","article-title":"Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non-alcoholic fatty liver disease assessed by magnetic resonance imaging","volume":"54","author":"Flint","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"G632","DOI":"10.1152\/ajpgi.00182.2014","article-title":"Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease","volume":"307","author":"Galloway","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e202105043","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"J. Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1097\/hep.0000000000000279","article-title":"Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease","volume":"78","author":"Gao","year":"2023","journal-title":"Hepatology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"102643","DOI":"10.1016\/j.redox.2023.102643","article-title":"Mitochondrial cholesterol: metabolism and impact on redox biology and disease","volume":"61","author":"Goicoechea","year":"2023","journal-title":"Redox Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.bbrc.2019.04.069","article-title":"IDH2 protects against nonalcoholic steatohepatitis by alleviating dyslipidemia regulated by oxidative stress","volume":"514","author":"Gong","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"108487","DOI":"10.1016\/j.diabres.2020.108487","article-title":"Liraglutide or insulin glargine treatments improves hepatic fat in obese patients with type 2 diabetes and nonalcoholic fatty liver disease in twenty-six weeks: a randomized placebo-controlled trial","volume":"170","author":"Guo","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B30","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jhep.2019.10.023","article-title":"Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase IIb study","volume":"72","author":"Harrison","year":"2020","journal-title":"J. Hepatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.cell.2019.04.010","article-title":"Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease","volume":"177","author":"Hern\u00e1ndez-Alvarez","year":"2019","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"eade7864","DOI":"10.1126\/sciadv.ade7864","article-title":"Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis","volume":"9","author":"Johnson","year":"2023","journal-title":"Sci. Adv."},{"key":"B33","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1530\/joe-19-0007","article-title":"Impact of exenatide on mitochondrial lipid metabolism in mice with nonalcoholic steatohepatitis","volume":"241","author":"Kalavalapalli","year":"2019","journal-title":"J. Endocrinol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1111\/dom.13007","article-title":"Comparative effects of liraglutide 3 mg vs structured lifestyle modification on body weight, liver fat and liver function in obese patients with non-alcoholic fatty liver disease: a pilot randomized trial","volume":"19","author":"Khoo","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"B35","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","article-title":"Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis","volume":"21","author":"Koliaki","year":"2015","journal-title":"Cell Metab."},{"key":"B36","doi-asserted-by":"publisher","first-page":"R47","DOI":"10.1093\/hmg\/ddae025","article-title":"Coordinating mitochondrial translation with assembly of the OXPHOS complexes","volume":"33","author":"Kremer","year":"2024","journal-title":"Hum. Mol. Genet."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1007\/s00125-020-05265-7","article-title":"Effect of dulaglutide on liver fat in patients with type 2 diabetes and NAFLD: randomised controlled trial (D-LIFT trial)","volume":"63","author":"Kuchay","year":"2020","journal-title":"Diabetologia"},{"key":"B38","doi-asserted-by":"publisher","first-page":"113869","DOI":"10.1016\/j.addr.2021.113869","article-title":"Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3390\/ijms23020739","article-title":"GLP-1a: going beyond traditional use","volume":"23","author":"Laurindo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"879","DOI":"10.14336\/ad.2022.1025","article-title":"Phosphatidylethanolamine N-methyltransferase: from functions to diseases","volume":"14","author":"Li","year":"2023","journal-title":"Aging Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6467","DOI":"10.18632\/aging.102972","article-title":"Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease","volume":"12","author":"Li","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"13039","DOI":"10.1021\/acs.jafc.3c09132","article-title":"Elevated PINK1\/parkin-dependent mitophagy and boosted mitochondrial function mediate protection of HepG2 cells from excess palmitic acid by hesperetin","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"B44","doi-asserted-by":"publisher","first-page":"101254","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/s2468-1253(23)00068-7","article-title":"Semaglutide 2\u00b74 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial","volume":"8","author":"Loomba","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"113291","DOI":"10.1016\/j.celrep.2023.113291","article-title":"Mitochondria-lysosome-related organelles mediate mitochondrial clearance during cellular dedifferentiation","volume":"42","author":"Ma","year":"2023","journal-title":"Cell Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"E552","DOI":"10.1152\/ajpendo.00147.2023","article-title":"Spatiotemporally quantitative in vivo imaging of mitochondrial fatty acid \u03b2-oxidation at cellular-level resolution in mice","volume":"325","author":"Matsumoto","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B49","doi-asserted-by":"publisher","first-page":"603292","DOI":"10.3389\/fcell.2020.603292","article-title":"Mitochondrial transfer and regulators of mesenchymal stromal cell function and therapeutic efficacy","volume":"8","author":"Mohammadalipour","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.2337\/dc22-er12","article-title":"Erratum. Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: a 54-week randomized phase 2b study","volume":"44","author":"Nahra","year":"2022","journal-title":"Diabetes Care"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/apt.16596","article-title":"Randomised clinical trial: pemafibrate, a novel selective peroxisome proliferator-activated receptor \u03b1 modulator (SPPARM\u03b1), versus placebo in patients with non-alcoholic fatty liver disease","volume":"54","author":"Nakajima","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.jhep.2023.07.033","article-title":"Incretins (GLP-1 receptor agonists and dual\/triple agonists) and the liver","volume":"79","author":"Newsome","year":"2023","journal-title":"J. Hepatol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1056\/NEJMoa2028395","article-title":"A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis","volume":"384","author":"Newsome","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1046130","DOI":"10.3389\/fendo.2022.1046130","article-title":"Semaglutide ameliorates metabolism and hepatic outcomes in an NAFLD mouse model","volume":"13","author":"Niu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B55","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1478-3231.1999.tb00064.x","article-title":"Hepatic expression of viral antigens, hepatocytic proliferative activity and histologic changes in liver biopsies of children with chronic hepatitis B after interferon-alpha therapy","volume":"19","author":"Ozer","year":"1999","journal-title":"Liver"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1038\/s41467-022-30629-5","article-title":"Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration","volume":"13","author":"Pedersen","year":"2022","journal-title":"Nat. Commun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/s41580-018-0092-0","article-title":"Mitochondrial proteins: from biogenesis to functional networks","volume":"20","author":"Pfanner","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41419-018-0292-8","article-title":"Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2","volume":"9","author":"Piacentini","year":"2018","journal-title":"Cell Death Dis."},{"key":"B59","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/febs.13820","article-title":"Mitochondrial biogenesis and clearance: a balancing act","volume":"284","author":"Ploumi","year":"2017","journal-title":"Febs J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.2337\/db11-0338","article-title":"Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis","volume":"60","author":"Poussin","year":"2011","journal-title":"Diabetes"},{"key":"B61","doi-asserted-by":"publisher","first-page":"7280","DOI":"10.3390\/ijms23137280","article-title":"Mitochondrial dysfunction plays central role in nonalcoholic fatty liver disease","volume":"23","author":"Ramanathan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"159029","DOI":"10.1016\/j.bbalip.2021.159029","article-title":"Role of the lipid transport protein StarD7 in mitochondrial dynamics","volume":"1866","author":"Rojas","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B63","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.jhep.2023.05.013","article-title":"A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease","volume":"79","author":"Romero-G\u00f3mez","year":"2023","journal-title":"J. Hepatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1087260","DOI":"10.3389\/fendo.2022.1087260","article-title":"Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)","volume":"13","author":"Rong","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1038\/nsmb.2160","article-title":"Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter","volume":"18","author":"Rubio-Cosials","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s2468-1253(20)30294-6","article-title":"Redefining fatty liver disease: an international patient perspective","volume":"6","author":"Shiha","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1080\/15548627.2021.1877469","article-title":"BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver","volume":"17","author":"Springer","year":"2021","journal-title":"Autophagy"},{"key":"B68","doi-asserted-by":"publisher","first-page":"40032","DOI":"10.1074\/jbc.M506510200","article-title":"Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects","volume":"280","author":"Steenbergen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molmet.2019.11.015","article-title":"Physical exercise and liver \u201cfitness\u201d: role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease","volume":"32","author":"Stevanovi\u0107","year":"2020","journal-title":"Mol. Metab."},{"key":"B70","doi-asserted-by":"publisher","first-page":"113214","DOI":"10.1016\/j.celrep.2023.113214","article-title":"LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport","volume":"42","author":"Sun","year":"","journal-title":"Cell Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s11658-023-00498-x","article-title":"Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer","volume":"28","author":"Sun","year":"","journal-title":"Cell Mol. Biol. Lett."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1007\/s00125-021-05488-2","article-title":"Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor","volume":"64","author":"Takeichi","year":"2021","journal-title":"Diabetologia"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e14016","DOI":"10.1111\/apha.14016","article-title":"Fifty years of the mitochondrial pyruvate carrier: new insights into its structure, function, and inhibition","volume":"238","author":"Tavoulari","year":"2023","journal-title":"Acta Physiol. (Oxf)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/j.jhep.2022.07.017","article-title":"MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM","volume":"77","author":"Tian","year":"2022","journal-title":"J. Hepatol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"B76","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/hep.27420","article-title":"ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis","volume":"61","author":"Wang","year":"2015","journal-title":"Hepatology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"119457","DOI":"10.1016\/j.biomaterials.2019.119457","article-title":"Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance","volume":"222","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"B78","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s12640-021-00460-9","article-title":"Liraglutide regulates mitochondrial quality control system through PGC-1\u03b1 in a mouse model of Parkinson's disease","volume":"40","author":"Wu","year":"2022","journal-title":"Neurotox. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s41418-020-00657-z","article-title":"Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy","volume":"28","author":"Xian","year":"2021","journal-title":"Cell Death Differ."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1002\/hep.30320","article-title":"Liraglutide, sitagliptin, and insulin glargine added to metformin: the effect on body weight and intrahepatic lipid in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease","volume":"69","author":"Yan","year":"2019","journal-title":"Hepatology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"B82","doi-asserted-by":"publisher","first-page":"172715","DOI":"10.1016\/j.ejphar.2019.172715","article-title":"Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy","volume":"864","author":"Yu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.3390\/biom12081079","article-title":"Progress in nonalcoholic fatty liver disease: SIRT family regulates mitochondrial biogenesis","volume":"12","author":"Zeng","year":"2022","journal-title":"Biomolecules"},{"key":"B84","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1016\/j.bbagen.2016.10.022","article-title":"Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK\/PGC-1\u03b1 pathway","volume":"1861","author":"Zhang","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"B85","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.jconrel.2023.02.032","article-title":"MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration","volume":"356","author":"Zhang","year":"","journal-title":"J. Control Release"},{"key":"B86","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.yexcr.2009.12.008","article-title":"Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells","volume":"316","author":"Zhang","year":"2010","journal-title":"Exp. Cell Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/hep.32651","article-title":"RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling","volume":"77","author":"Zhang","year":"","journal-title":"Hepatology"},{"key":"B88","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41392-019-0094-1","article-title":"DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy","volume":"4","author":"Zhou","year":"","journal-title":"Signal Transduct. Target Ther."},{"key":"B89","doi-asserted-by":"publisher","first-page":"101120","DOI":"10.1016\/j.redox.2019.101120","article-title":"Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy","volume":"21","author":"Zhou","year":"","journal-title":"Redox Biol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1463187\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:26:10Z","timestamp":1725337570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1463187\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":89,"alternative-id":["10.3389\/fphar.2024.1463187"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1463187","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"article-number":"1463187"}}