{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:30:59Z","timestamp":1790994659430,"version":"4.1.0"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p><jats:italic>Kleinia<\/jats:italic> is a genus of over 50 species that are commonly used in primary care in several countries. This study seeks to inspire researchers to quickly discover and isolate the key active metabolites found in <jats:italic>Kleinia<\/jats:italic> taxa, thereby promoting the development of novel, safe, and effective therapies for a variety of illnesses. To this end, we performed a thorough search of English-language publications from PubMed, Scopus, ScienceDirect, Web of Science, Google Scholar, and ResearchGate. Our search utilized keywords such as \u201cethnobotany,\u201d \u201cgeographic distribution,\u201d \u201cethnomedicinal use,\u201d \u201cphytochemistry,\u201d \u201cpharmacological or bioactivities,\u201d and \u201ctoxicological activities\u201d related to the genus <jats:italic>Kleinia<\/jats:italic>. Chemical structures were depicted using Chemdraw<jats:sup>\u00ae<\/jats:sup> software. Literature highlights numerous <jats:italic>Kleinia<\/jats:italic> taxa used in traditional medicine for conditions like intestinal parasites, measles, smallpox, diabetes, edema, nerve disorders, sexual dysfunction, gastrointestinal issues, cancer and more. Phytochemical analysis identifies 77 secondary metabolites, mainly alkaloids, flavonoids, saponins, terpenes, and terpenoids and other miscellaneous metabolites. Among the <jats:italic>Kleinia<\/jats:italic> taxa, <jats:italic>K. anteuphorbium<\/jats:italic>, <jats:italic>K. longiflora<\/jats:italic>, <jats:italic>K. grandiflora<\/jats:italic>, <jats:italic>K. odora<\/jats:italic>, <jats:italic>K. squarrosa<\/jats:italic>, <jats:italic>K. abyssinica<\/jats:italic>, <jats:italic>K. pendula<\/jats:italic>, and <jats:italic>K. azoides<\/jats:italic> have been scientifically validated to exhibit various pharmacological activities. However, the existence of potentially harmful metabolites in <jats:italic>Kleinia<\/jats:italic> taxa, particularly pyrrolizidine alkaloids, emphasizes the significance of cautious application in traditional medicine and the need for rigorous toxicological assessments. In conclusion, this review highlights the promise of <jats:italic>Kleinia<\/jats:italic> taxa as significant medicinal resources and advocates for extensive bioprospecting. It encourages global pharmaceutical companies and academic institutions to conduct thorough investigations of the genus <jats:italic>Kleinia<\/jats:italic> to uncover new therapeutic possibilities.<\/jats:p>","DOI":"10.3389\/fphar.2024.1469887","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T06:17:56Z","timestamp":1736317076000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights"],"prefix":"10.3389","volume":"15","author":[{"given":"Bantayehu Addis","family":"Tegegne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfa","family":"Begashaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wubetu Yihunie","family":"Belay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengistie Kassahun","family":"Tariku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirsit Ketsela","family":"Zeleke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Jemal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamaru","family":"Getinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agumas Alemu","family":"Alehegn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abebe","family":"Dagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e38573","DOI":"10.1016\/j.heliyon.2024.e38573","article-title":"Exploring the therapeutic potential of Saudi Kleinia anteuphorbium (L.) 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