{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:23:20Z","timestamp":1788186200208,"version":"build-2803163510"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The excessive proliferation of <jats:italic>Cutibacterium acnes (C. acnes)<\/jats:italic> is an important reason for the occurrence of acne vulgaris, and genetic detection ratio of <jats:italic>C. acnes<\/jats:italic> in acne is as high as 60.5%. Until now, the treatment of <jats:italic>C. acnes<\/jats:italic> is mainly limited to antibiotics, but some strains of <jats:italic>C. acnes<\/jats:italic> produce antimicrobial resistances, making it difficult for clinical treatment. Additionally, antibiotics can cause severe adverse effects. Therefore, more and more people are paying attention to phytochemicals. It is well known that plants can synthesize a range of secondary metabolites, named phytochemicals, part of which have antibacterial properties. Additionally, the main advantages of phytochemicals are that they have good efficacies and less side effects, so they are suitable choices for medical treatment. This review mainly discusses the effects and mechanisms of phytochemicals against <jats:italic>C. acnes<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fphar.2024.1476670","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:25:43Z","timestamp":1733718343000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemicals, promising strategies combating Cutibacterium acnes"],"prefix":"10.3389","volume":"15","author":[{"given":"Cuilian","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1001\/jamadermatol.2017.1297","article-title":"Antibiotic resistance in acne treatment","volume":"153","author":"Adler","year":"2017","journal-title":"JAMA Dermatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.tim.2022.10.006","article-title":"Cutibacterium acnes","volume":"31","author":"Ahle","year":"2023","journal-title":"Trends Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ijfoodmicro.2012.08.004","article-title":"Inactivation of Alicyclobacillus acidoterrestris in orange juice by saponin extracts combined with heat-treatment","volume":"159","author":"Alberice","year":"2012","journal-title":"Int. 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