{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:53:18Z","timestamp":1770893598617,"version":"3.50.1"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872870\u300182070312 \u548c 31400983"],"award-info":[{"award-number":["81872870\u300182070312 \u548c 31400983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH-Q19155 \u578b"],"award-info":[{"award-number":["LBH-Q19155 \u578b"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transient Receptor Potential Melastatin 4 (TRPM4), a non-selective cation channel, plays a critical role in cardiac conduction abnormalities. Brg1, an ATP-dependent chromatin remodeler, is essential for regulating gene expression in both heart development and disease. Our previous studies demonstrated Brg1 impacted on cardiac sodium\/potassium channels and electrophysiological stability, its influence on TRPM4 expression and function remained unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the role of Brg1 in regulating TRPM4 expression and function through overexpression and knockdown experiments in mouse cardiomyocytes and TRPM4-overexpressing HEK293 cells by western blot, qPCR, immunofluorescence staining and patch clamp techniques. Cardiomyocytes were exposed to hypoxia for 12\u00a0h to mimic cardiac stress, and Brg1 inhibition was performed to assess its impact on TRPM4 under hypoxia. Bioinformatic analyses (STRING and JASPAR databases), Co-immunoprecipitation (Co-IP), dual luciferase reporter assays, and Chromatin Immunoprecipitation (ChIP) were employed to study the interaction between Brg1, RUNX1, and TRPM4 transcription regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brg1 positively regulated TRPM4 expression in mouse cardiomyocytes and modulated TRPM4 current in TRPM4-overexpressing HEK293 cells. Brg1 inhibition markedly diminishes TRPM4\u2019s hyperexpression in cardiomyocytes exposed to hypoxia. Integrative analyses utilizing STRNG databases and Protein Data Bank unveiled a putative interaction between Brg1 and the transcription factor RUNX1, and we substantiated the interaction between Brg1 and RUNX1. Several binding sites of RUNX1 with the TRPM4 promoter region were predicted by the JASPAR database, and empirical validation substantiated Brg1 modulated TRPM4 promoter activity via RUNX1 engagement. ChIP confirmed that Brg1 interacted with RUNX1 forming a transcriptional complex that located in TRPM4 promoter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that Brg1 and RUNX1 formed a transcriptional complex that modulated TRPM4 expression and function, especially under hypoxic conditions. These findings provided new insights into TRPM4 regulation and highlighted its potential as a therapeutic target for cardiac hypoxia-related disorders.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphar.2024.1494205","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:28:43Z","timestamp":1733977723000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes"],"prefix":"10.3389","volume":"15","author":[{"given":"Tao","family":"Ban","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meimei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzhao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.bcp.2012.06.021","article-title":"TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology","volume":"84","author":"Abriel","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"6615038","DOI":"10.1155\/2020\/6615038","article-title":"Inherited cardiac arrhythmia syndromes: focus on molecular mechanisms underlying TRPM4 channelopathies","volume":"2020","author":"Amarouch","year":"2020","journal-title":"Cardiovasc Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neulet.2013.02.011","article-title":"Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells","volume":"541","author":"Amarouch","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B4","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1126\/science.aar4510","article-title":"Structure of the human TRPM4 ion channel in a lipid nanodisc","volume":"359","author":"Autzen","year":"2018","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/jcp.22240","article-title":"The human SWI\/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes","volume":"225","author":"Bakshi","year":"2010","journal-title":"J. Cell Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.1093\/emboj\/20.17.4935","article-title":"The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation","volume":"20","author":"Barker","year":"2001","journal-title":"Embo J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/cvr\/cvr135","article-title":"Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death","volume":"91","author":"Becerra","year":"2011","journal-title":"Cardiovasc Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.carpath.2013.09.003","article-title":"SWI\/SNF chromatin-remodeling complexes in cardiovascular development and disease","volume":"23","author":"Bevilacqua","year":"2014","journal-title":"Cardiovasc Pathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ejphar.2016.11.045","article-title":"Na(+)\/Ca(2+) exchanger 1 inhibition abolishes ischemic tolerance induced by ischemic preconditioning in different cardiac models","volume":"794","author":"Castaldo","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"16677","DOI":"10.1074\/jbc.M312288200","article-title":"Transcription factors and nuclear receptors interact with the SWI\/SNF complex through the BAF60c subunit","volume":"279","author":"Debril","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1152\/physrev.00026.2014","article-title":"Transient receptor potential channels in the vasculature","volume":"95","author":"Earley","year":"2015","journal-title":"Physiol. Rev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1161\/01.RES.0000147311.54833.03","article-title":"Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries","volume":"95","author":"Earley","year":"2004","journal-title":"Circ. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e2841","DOI":"10.1038\/cddis.2017.236","article-title":"Brg1-mediated Nrf2\/HO-1 pathway activation alleviates hepatic ischemia-reperfusion injury","volume":"8","author":"Ge","year":"2017","journal-title":"Cell Death Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/cvr\/cvv213","article-title":"TRPM4 in cardiac electrical activity","volume":"108","author":"Guinamard","year":"2015","journal-title":"Cardiovasc Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1113\/jphysiol.2004.063974","article-title":"Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes","volume":"558","author":"Guinamard","year":"2004","journal-title":"J. Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1152\/physiol.00004.2010","article-title":"Physiological roles of the TRPM4 channel extracted from background currents","volume":"25","author":"Guinamard","year":"2010","journal-title":"Physiol. (Bethesda)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1161\/01.HYP.0000237864.65019.a5","article-title":"Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats","volume":"48","author":"Guinamard","year":"2006","journal-title":"Hypertension"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1111\/bph.12582","article-title":"The TRPM4 channel inhibitor 9-phenanthrol","volume":"171","author":"Guinamard","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nature24997","article-title":"Structures of the calcium-activated, non-selective cation channel TRPM4","volume":"552","author":"Guo","year":"2017","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nature09130","article-title":"Chromatin regulation by Brg1 underlies heart muscle development and disease","volume":"466","author":"Hang","year":"2010","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1093\/nar\/gkv046","article-title":"Spatial re-organization of myogenic regulatory sequences temporally controls gene expression","volume":"43","author":"Harada","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1756-8935-3-21","article-title":"Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation","volume":"3","author":"He","year":"2010","journal-title":"Epigenetics Chromatin"},{"key":"B23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12881-017-0397-4","article-title":"TRPM4 non-selective cation channel variants in long QT syndrome","volume":"18","author":"Hof","year":"2017","journal-title":"BMC Med. Genet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1111\/bph.12414","article-title":"Transient receptor potential (TRP) channels: a clinical perspective","volume":"171","author":"Kaneko","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00395-015-0501-x","article-title":"The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy","volume":"110","author":"Kecsk\u00e9s","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1634\/stemcells.2008-0710","article-title":"SWI\/SNF-Brg1 regulates self-renewal and occupies core pluripotency-related genes in embryonic stem cells","volume":"27","author":"Kidder","year":"2009","journal-title":"Stem Cells"},{"key":"B27","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.coph.2013.12.003","article-title":"TRPM4 channels in the cardiovascular system","volume":"15","author":"Kruse","year":"2014","journal-title":"Curr. Opin. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1161\/CIRCRESAHA.108.188748","article-title":"TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells","volume":"104","author":"Kwan","year":"2009","journal-title":"Circ. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e15407","DOI":"10.7717\/peerj.15407","article-title":"PFI-3 induces vasorelaxation with potency to reduce extracellular calcium influx in rat mesenteric artery","volume":"11","author":"Li","year":"2023","journal-title":"PeerJ"},{"key":"B30","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/s41401-023-01170-y","article-title":"Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction","volume":"45","author":"Li","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e013112","DOI":"10.1161\/JAHA.119.013112","article-title":"MicroRNA-101 protects against cardiac remodeling following myocardial infarction via downregulation of runt-related transcription factor 1","volume":"8","author":"Li","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e54131","DOI":"10.1371\/journal.pone.0054131","article-title":"Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1161\/CIRCGENETICS.109.930867","article-title":"Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease","volume":"3","author":"Liu","year":"2010","journal-title":"Circ. Cardiovasc Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"176039","DOI":"10.1016\/j.ejphar.2023.176039","article-title":"The role of BRG1 in epigenetic regulation of cardiovascular diseases","volume":"957","author":"Ma","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1161\/CIRCRESAHA.114.302835","article-title":"Increased \u03b2-adrenergic inotropy in ventricular myocardium from Trpm4-\/- mice","volume":"114","author":"Mathar","year":"2014","journal-title":"Circ. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ydbio.2016.04.003","article-title":"Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specification","volume":"413","author":"Matsumoto","year":"2016","journal-title":"Dev. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1161\/CIRCULATIONAHA.117.028911","article-title":"Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction","volume":"137","author":"McCarroll","year":"2018","journal-title":"Circulation"},{"key":"B38","doi-asserted-by":"publisher","first-page":"re3","DOI":"10.1126\/stke.2722005re3","article-title":"The TRP superfamily of cation channels","volume":"2005","author":"Montell","year":"2005","journal-title":"Sci. STKE"},{"key":"B39","doi-asserted-by":"publisher","first-page":"8528239","DOI":"10.1155\/2021\/8528239","article-title":"Dihydrolycorine attenuates cardiac fibrosis and dysfunction by downregulating Runx1 following myocardial infarction","volume":"2021","author":"Ni","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3389\/fphys.2019.00802","article-title":"AAV9-Mediated overexpression of TRPM4 increases the incidence of stress-induced ventricular arrhythmias in mice","volume":"10","author":"Pironet","year":"2019","journal-title":"Front. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1093\/cvr\/cvaa034","article-title":"RUNX1: an emerging therapeutic target for cardiovascular disease","volume":"116","author":"Riddell","year":"2020","journal-title":"Cardiovasc Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e004311","DOI":"10.1161\/CIRCHEARTFAILURE.117.004311","article-title":"Relaxation and the role of calcium in isolated contracting myocardium from patients with hypertensive heart disease and heart failure with preserved ejection fraction","volume":"10","author":"Runte","year":"2017","journal-title":"Circ. Heart Fail"},{"key":"B43","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/ijms23010389","article-title":"Dynamic distribution of HIG2A between the mitochondria and the nucleus in response to hypoxia and oxidative stress","volume":"23","author":"Salazar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.bbrc.2019.10.109","article-title":"BRG1 deficiency in endothelial cells alleviates thioacetamide induced liver fibrosis in mice","volume":"521","author":"Shao","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1160227","DOI":"10.3389\/fcell.2023.1160227","article-title":"Regulation of the Wnt signaling pathway during myogenesis by the mammalian SWI\/SNF ATPase BRG1","volume":"11","author":"Sharma","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3390\/cells10030636","article-title":"TRPM4 participates in aldosterone-salt-induced electrical atrial remodeling in mice","volume":"10","author":"Simard","year":"2021","journal-title":"Cells"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1007\/s00424-020-02476-0","article-title":"TRPM4 non-selective cation channel in human atrial fibroblast growth","volume":"472","author":"Simard","year":"2020","journal-title":"Pflugers Arch."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1111\/j.1476-5381.2011.01715.x","article-title":"Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle","volume":"165","author":"Simard","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"23261","DOI":"10.1038\/srep23261","article-title":"Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia\/reperfusion in mice","volume":"6","author":"So","year":"2016","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1126\/science.1068356","article-title":"Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation","volume":"295","author":"Soutoglou","year":"2002","journal-title":"Science"},{"key":"B51","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/humu.21599","article-title":"Mutational spectrum in the Ca(2+)--activated cation channel gene TRPM4 in patients with cardiac conductance disturbances","volume":"33","author":"Stallmeyer","year":"2012","journal-title":"Hum. Mutat."},{"key":"B52","doi-asserted-by":"publisher","first-page":"e001625","DOI":"10.1161\/JAHA.114.001625","article-title":"Variants of transient receptor potential melastatin member 4 in childhood atrioventricular block","volume":"5","author":"Syam","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"B53","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fncel.2014.00052","article-title":"Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects","volume":"8","author":"Syam","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-3-540-34891-7_16","article-title":"Insights into TRPM4 function, regulation and physiological role","author":"Vennekens","year":"2007","journal-title":"Handb. Exp. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/cells7060062","article-title":"Role of the TRPM4 channel in cardiovascular physiology and pathophysiology","volume":"7","author":"Wang","year":"2018","journal-title":"Cells"},{"key":"B56","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/cvr\/cvy163","article-title":"Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NF\u03baB-mediated leucocyte recruitment after myocardial infarction","volume":"115","author":"Wang","year":"2019","journal-title":"Cardiovasc Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/nature24674","article-title":"Electron cryo-microscopy structure of a human TRPM4 channel","volume":"552","author":"Winkler","year":"2017","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","first-page":"000633","DOI":"10.1128\/MCB.00063-19","article-title":"Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI\/SNF chromatin remodeling enzyme","volume":"39","author":"Witwicka","year":"2019","journal-title":"Mol. Cell Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.toxlet.2019.04.035","article-title":"Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide","volume":"312","author":"Yu","year":"2019","journal-title":"Toxicol. Lett."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1494205\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:28:48Z","timestamp":1733977728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1494205\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":59,"alternative-id":["10.3389\/fphar.2024.1494205"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1494205","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"article-number":"1494205"}}