{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T11:38:42Z","timestamp":1794310722598,"version":"4.9.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Heracleum<\/jats:italic>\n                      L. has been known as \u201chogweed\u201d and used for inflammatory diseases, including fever, enteritis, and bronchitis, for many years worldwide. The\n                      <jats:italic>Heracleum<\/jats:italic>\n                      genus is also prominently recognized for its high content of coumarins, which are considered a significant group of natural compounds known for their noteworthy anti-inflammatory properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present study evaluated the anti-inflammatory activity of dichloromethane and methanolic extracts from\n                      <jats:italic>H. paphlagonicum<\/jats:italic>\n                      ,\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>ternatum<\/jats:italic>\n                      ,\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>elegans<\/jats:italic>\n                      , and\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>cyclocarpum<\/jats:italic>\n                      (100\u00a0mg\/kg), which have not been previously investigated for their anti-inflammatory properties. Inflammation models induced by carrageenan, prostaglandin E2, and serotonin were employed to evaluate anti-inflammatory activity, using indomethacin (10\u00a0mg\/kg) as the reference standard. Statistical differences between treatment and control groups were evaluated using ANOVA with Student-Newman-Keuls\n                      <jats:italic>post-hoc<\/jats:italic>\n                      tests. Additionally, the coumarin contents of the extracts were quantified as mg\/g by high-performance liquid chromatography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and discussion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>cyclocarpum<\/jats:italic>\n                      roots displayed the highest inhibition for carrageenan, prostaglandin E2, and serotonin-induced hind paw edema, with inhibition ranges of 22.8%\u201336.9%, 5.4%\u201335.7%, and 3.9%\u201317.9%, respectively, while the inhibition ranges for indomethacin were 12.8%\u201344.3%, 2.7%\u201341.3%, and 7.1%\u201330.6%, respectively. The highest bergapten and imperatorin quantities were found in\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>cyclocarpum<\/jats:italic>\n                      roots (0.49% and 0.14%) and in\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp. elegans roots, which had the highest xanthotoxin level (0.06%). Angelicin was detected in\n                      <jats:italic>H. paphlagonicum<\/jats:italic>\n                      ,\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>elegans<\/jats:italic>\n                      , and\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>cyclocarpum<\/jats:italic>\n                      roots at concentrations of 0.04%, 0.04%, and 0.02%, respectively. The correlation between the highest inhibitory activity observed in\n                      <jats:italic>H. sphondylium<\/jats:italic>\n                      subsp.\n                      <jats:italic>cyclocarpum<\/jats:italic>\n                      roots and the elevated levels of coumarins, particularly bergapten and imperatorin, suggests a potential link between coumarin concentration and anti-inflammatory effects. Additionally, our findings support the traditional use of this genus for treating inflammatory disorders. Further investigations are necessary to identify the active compounds and elucidate the mechanisms of action of these plants, potentially leading to the discovery of novel therapeutic options for the treatment of inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2024.1494786","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T02:02:37Z","timestamp":1736128957000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemical investigation and assessment of the anti-inflammatory activity of four Heracleum taxa growing in Turkey"],"prefix":"10.3389","volume":"15","author":[{"given":"Ekin","family":"Kurtul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"K\u00fcpeli Akkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fc\u015fra","family":"Karpuz A\u011f\u00f6ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fc\u015fra","family":"Yaylac\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Bahad\u0131r Ac\u0131kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Sobarzo-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1279359","DOI":"10.1155\/2021\/1279359","article-title":"Protective effect of bergapten against human erythrocyte hemolysis and protein denaturation in vitro","volume":"2021","author":"Aidoo","year":"2021","journal-title":"Int. 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