{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T18:38:25Z","timestamp":1779043105369,"version":"3.51.4"},"reference-count":124,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Traditional medicine uses the roots and rhizomes of <jats:italic>Polygonum bistorta<\/jats:italic> L. (Polygonaceae) to treat cough, bronchitis, and other respiratory infections. Our goal was to gain insights into the lung protective effects of the roots of <jats:italic>P. bistorta<\/jats:italic> L. against lipopolysaccharide-induced acute lung injury in rats, along with the possible mechanism(s). The outcomes revealed deliberate quantities of the total phenolic and flavonoid contents of 156.2 \u00b1 5.13 GAE\/g and 179.45 \u00b1 2.08\u00a0mg QE\/g, respectively. Crude extract possesses a maximum inhibitory potential of 81.77% \u00b1 0.62% for acetylcholinesterase against eserine. Acute oral toxicity study revealed LD<jats:sub>50<\/jats:sub> beyond 7\u00a0g\/kg. Plant extract markedly restored LPS-induced hypoxemia, pulmonary edema, histopathological alterations, and leukocyte infiltration in the lung. ELISA testing on BALF found that the plant extract efficiently reinstated superoxide dismutase, total anti-oxidant capacity, malondialdehyde, and total oxidative stress. qRT-PCR indicated a decline in the endotoxin-induced overproduction of pro-inflammatory markers, oxidative stress, transcription factor, and downregulated antioxidant potential in extract-treated groups. Furthermore, 24 metabolites were identified and quantified via GC-MS. A molecular docking procedure was implemented on the bioactive metabolites that were identified to evaluate their potential for inhibiting AChE. In conclusion, <jats:italic>P. bistorta<\/jats:italic> roots mitigate inflammation and oxidative stress by improving redox signaling and NF-\u0138\u03b2 (p65) pathways and can thus play a role in strategies for overcoming therapeutic challenges.<\/jats:p>","DOI":"10.3389\/fphar.2024.1500085","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T08:54:46Z","timestamp":1738745686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploration of the anti-inflammatory potential of Polygonum bistorta L.: protection against LPS-induced acute lung injury in rats via NF-\u0138\u03b2 pathway inhibition"],"prefix":"10.3389","volume":"15","author":[{"given":"Sajida","family":"Parveen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kashif ur Rehman","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid Muhammad","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan Y.","family":"Aati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areej M.","family":"Al-taweel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liaqat","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musaddique","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"108204","DOI":"10.1016\/j.intimp.2021.108204","article-title":"Potential therapeutic interventions of plant\u2013derived isoflavones against acute lung injury","volume":"101","author":"Aboushanab","year":"2021","journal-title":"Int. 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