{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:04:22Z","timestamp":1792760662021,"version":"4.5.0"},"reference-count":165,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells. This activation is achieved by releasing diverse molecules from platelets, including lipids (eicosanoids), growth and angiogenic factors, and extracellular vesicles (EVs) rich in various RNA species. Antiplatelet agents like low-dose aspirin can prevent cardiovascular disease and cancer by inhibiting platelet functions beyond the antithrombotic action. Throughout the initial phases of tumorigenesis, the activation of platelets induces the overexpression of cyclooxygenase (COX)-2 in stromal cells, leading to increased biosynthesis of prostaglandin (PG)E\n                    <jats:sub>2<\/jats:sub>\n                    . This prostanoid can contribute to tumor development by inhibiting apoptosis, promoting cancer cell proliferation and migration, and immune evasion. Notably, platelets induce the epithelial-mesenchymal transition (EMT) in tumor cells, enhancing their metastatic potential. Two platelet eicosanoids, PGE\n                    <jats:sub>2<\/jats:sub>\n                    (generated as a minor product of COX-1) and 12S-hydroxyeicosatetraenoic acid (HETE) [derived from the platelet-type 12-lipoxygenase (LOX)], contribute to EMT. In addition to the pharmacological inhibition of eicosanoid biosynthesis, a potential strategy for mitigating platelet-induced metastasis might encompass the inhibition of direct interactions between platelets and cancer cells. For example, there is promise in utilizing revacept to inhibit the interaction between platelet collagen receptors (particularly GPVI) and galectin-3 in cancer cells. Identifying these novel platelet functions suggests the potential application of antiplatelet agents, such as low-dose aspirin, in mitigating cancer risk, particularly in the case of colorectal cancer. It is necessary to investigate the effectiveness of other antiplatelet drugs, such as ADP P2Y\n                    <jats:sub>12<\/jats:sub>\n                    receptor antagonists, in cancer prevention. Other new antiplatelet drugs, such as revacept and selective 12-LOX inhibitors, currently under clinical development, are of interest due to their low risk of bleeding. Platelets and EVs carry important clinical information because they contain specific proteins and RNAs associated with disease conditions. Their analysis can improve the accuracy of liquid biopsies for early cancer detection, monitoring progression, and assessing drug response.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2024.1520488","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T01:39:55Z","timestamp":1734917995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention"],"prefix":"10.3389","volume":"15","author":[{"given":"Annalisa","family":"Contursi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Tacconelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Di Berardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"De Michele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Patrignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1161\/ATVBAHA.117.309868","article-title":"First selective 12-LOX inhibitor, ML355, impairs thrombus formation and vessel occlusion in vivo with minimal effects on hemostasis","volume":"37","author":"Adili","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1136\/pgmj.2007.059188","article-title":"Heparin induced thrombocytopenia: diagnosis and management update","volume":"83","author":"Ahmed","year":"2007","journal-title":"Postgrad. Med. J."},{"key":"B3","first-page":"65","article-title":"Platelets: essential components of the immune system","volume":"16","author":"Ali","year":"2015","journal-title":"Curr. Trends Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1111\/jth.14537","article-title":"Cell surface expression of HLA I molecules as a marker of young platelets","volume":"17","author":"Ang\u00e9nieux","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"B5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1161\/ATVBAHA.120.315445","article-title":"Heparin-induced thrombocytopenia: a focus on thrombosis","volume":"41","author":"Arepally","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/jth.12905","article-title":"Human platelet IgG Fc receptor Fc\u03b3RIIA in immunity and thrombosis","volume":"13","author":"Arman","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"B7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.omtn.2019.02.005","article-title":"Circular RNAs in cancer","volume":"16","author":"Bach","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B8","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/s0301-472x(02)00791-9","article-title":"Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells","volume":"30","author":"Baj-Krzyworzeka","year":"2002","journal-title":"Exp. Hematol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ccr.2005.02.013","article-title":"Smoldering and polarized inflammation in the initiation and promotion of malignant disease","volume":"7","author":"Balkwill","year":"2005","journal-title":"Cancer Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fphar.2018.00066","article-title":"P2Y12 receptors in tumorigenesis and metastasis","volume":"9","author":"Ballerini","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"R187","DOI":"10.1530\/ERC-12-0085","article-title":"The reactive stroma microenvironment and prostate cancer progression","volume":"19","author":"Barron","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"7545","DOI":"10.1074\/jbc.274.11.7545","article-title":"Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C\/mitogen-activated protein kinase-dependent pathway","volume":"274","author":"Barry","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1172\/JCI119385","article-title":"Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles","volume":"99","author":"Barry","year":"1997","journal-title":"J. Clin. Investigation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1182\/blood-2013-02-485011","article-title":"Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response","volume":"123","author":"Battinelli","year":"2014","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1056\/NEJMoa061355","article-title":"Celecoxib for the prevention of sporadic colorectal adenomas","volume":"355","author":"Bertagnolli","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.ccell.2015.09.018","article-title":"RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics","volume":"28","author":"Best","year":"2015","journal-title":"Cancer Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/14737159.2019.1675515","article-title":"Clinical utility of emerging biomarkers in prostate cancer liquid biopsies","volume":"20","author":"Boerrigter","year":"2020","journal-title":"Expert Rev. Mol. Diagn"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1172\/JCI22123","article-title":"Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer","volume":"114","author":"Boucharaba","year":"2004","journal-title":"J. Clin. Invest"},{"key":"B19","doi-asserted-by":"publisher","first-page":"9643","DOI":"10.1073\/pnas.0600979103","article-title":"The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases","volume":"103","author":"Boucharaba","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1182\/blood.v74.2.658.bloodjournal742658","article-title":"Platelet-melanoma cell interaction is mediated by the glycoprotein IIb-IIIa complex","volume":"74","author":"Boukerche","year":"1989","journal-title":"Blood"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1161\/CIRCRESAHA.114.301611","article-title":"Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity","volume":"114","author":"Boulaftali","year":"2014","journal-title":"Circ. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1182\/blood-2008-02-142125","article-title":"Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets","volume":"112","author":"Boylan","year":"2008","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"106506","DOI":"10.1016\/j.phrs.2022.106506","article-title":"The specific deletion of cyclooxygenase-1 in megakaryocytes\/platelets reduces intestinal polyposis in ApcMin\/+ mice","volume":"185","author":"Bruno","year":"2022","journal-title":"Pharmacol. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"22143","DOI":"10.1074\/jbc.M115.641092","article-title":"Lysophosphatidic acid initiates epithelial to mesenchymal transition and induces \u03b2-Catenin-mediated transcription in epithelial ovarian carcinoma","volume":"290","author":"Burkhalter","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1056\/NEJMoa0801297","article-title":"Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome","volume":"359","author":"Burn","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/S0140-6736(11)61049-0","article-title":"Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial","volume":"378","author":"Burn","year":"2011","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1016\/S0140-6736(20)30366-4","article-title":"Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial","volume":"395","author":"Burn","year":"2020","journal-title":"Lancet"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-5793(87)80865-7","article-title":"Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division","volume":"220","author":"Celis","year":"1987","journal-title":"FEBS Lett."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"B30","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.coi.2005.11.006","article-title":"Colony-stimulating factor-1 in immunity and inflammation","volume":"18","author":"Chitu","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"E1550-E1559","DOI":"10.1073\/pnas.1720553115","article-title":"Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration","volume":"115","author":"Cloutier","year":"2018","journal-title":"PNAS"},{"key":"B32","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.atherosclerosis.2020.12.017","article-title":"The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events","volume":"319","author":"Coenen","year":"2021","journal-title":"Atherosclerosis"},{"key":"B33","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/jth.14730","article-title":"Structure and function of the ubiquitin-proteasome system in platelets","volume":"18","author":"Colberg","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"B34","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3390\/cancers15020350","article-title":"Tumor-educated platelet extracellular vesicles: proteomic profiling and crosstalk with colorectal cancer cells","volume":"15","author":"Contursi","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1007\/s00018-017-2536-7","article-title":"Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting","volume":"74","author":"Contursi","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"100109","DOI":"10.1016\/j.jlr.2021.100109","article-title":"Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase","volume":"62","author":"Contursi","year":"2021","journal-title":"J. Lipid Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"115252","DOI":"10.1016\/j.bcp.2022.115252","article-title":"Biology and pharmacology of platelet-type 12-lipoxygenase in platelets, cancer cells, and their crosstalk","volume":"205","author":"Contursi","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"105744","DOI":"10.1016\/j.phrs.2021.105744","article-title":"Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A2 is unrestrained","volume":"170","author":"D\u2019Agostino","year":"2021","journal-title":"Pharmacol. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molimm.2019.04.011","article-title":"Long non-coding RNA: classification, biogenesis and functions in blood cells","volume":"112","author":"Dahariya","year":"2019","journal-title":"Mol. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/j.1572-0241.2004.04129.x","article-title":"Platelets in inflammatory bowel disease:clinical, pathogenic, and therapeutic implications","volume":"99","author":"Danese","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1586\/14737140.2016.1123626","article-title":"Pembrolizumab for the treatment of PD-L1 positive advanced or metastatic non-small cell lung cancer","volume":"16","author":"Dang","year":"2016","journal-title":"Expert Rev. Anticancer Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1056\/NEJMra071014","article-title":"Platelet activation and atherothrombosis","volume":"357","author":"Dav\u00ec","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"7360","DOI":"10.3390\/ijms22147360","article-title":"Platelet and erythrocyte extravasation across inflamed corneal venules depend on CD18, neutrophils, and mast cell degranulation","volume":"22","author":"De La Cruz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1056\/NEJM200007063430107","article-title":"The immune system First of two parts","volume":"343","author":"Delves","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1172\/JCI117442","article-title":"A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2","volume":"94","author":"Diacovo","year":"1994","journal-title":"J. Clin. Invest"},{"key":"B47","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/bcpt.12156","article-title":"Role of platelets in inflammation and cancer: novel therapeutic strategies","volume":"114","author":"Dovizio","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1124\/mol.113.084988","article-title":"Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells","volume":"84","author":"Dovizio","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/ni1102-991","article-title":"Cancer immunoediting: from immunosurveillance to tumor escape","volume":"3","author":"Dunn","year":"2002","journal-title":"Nat. Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s1074-7613(03)00177-8","article-title":"Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments","volume":"19","author":"Elzey","year":"2003","journal-title":"Immunity"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1053\/j.gastro.2019.12.032","article-title":"Associations of pathogenic variants in MLH1, MSH2, and MSH6 with risk of colorectal adenomas and tumors and with somatic mutations in patients with Lynch syndrome","volume":"158","author":"Engel","year":"2020","journal-title":"Gastroenterology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1182\/blood.v93.3.876.403k25_876_885","article-title":"Platelet\/polymorphonuclear leukocyte interaction: P-selectin triggers protein-tyrosine phosphorylation-dependent CD11b\/CD18 adhesion: role of PSGL-1 as a signaling molecule","volume":"93","author":"Evangelista","year":"1999","journal-title":"Blood"},{"key":"B53","doi-asserted-by":"publisher","first-page":"31720","DOI":"10.1074\/jbc.M104036200","article-title":"Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts","volume":"276","author":"Faour","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"e0170775","DOI":"10.1371\/journal.pone.0170775","article-title":"The influence of BRAF and KRAS mutation status on the association between aspirin use and survival after colon cancer diagnosis","volume":"12","author":"Frouws","year":"2017","journal-title":"PLoS One"},{"key":"B55","doi-asserted-by":"publisher","first-page":"782","DOI":"10.5603\/CJ.a2018.0045","article-title":"P2Y12 antagonist ticagrelor inhibits the release of procoagulant extracellular vesicles from activated platelets","volume":"26","author":"Gasecka","year":"2019","journal-title":"Cardiol. J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41569-023-00854-6","article-title":"Current concepts and novel targets for antiplatelet therapy","volume":"20","author":"Gawaz","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1172\/JCI27196","article-title":"Platelets in inflammation and atherogenesis","volume":"115","author":"Gawaz","year":"2005","journal-title":"J. Clin. Invest"},{"key":"B58","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrc3004","article-title":"Contribution of platelets to tumour metastasis","volume":"11","author":"Gay","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"B59","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.blre.2014.10.003","article-title":"Platelet secretion: from haemostasis to wound healing and beyond","volume":"29","author":"Golebiewska","year":"2015","journal-title":"Blood Rev."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1182\/blood-2014-08-595652","article-title":"Platelet 12-LOX scores a HIT","volume":"124","author":"Goodall","year":"2014","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1055\/a-1393-8339","article-title":"Platelets and matrix metalloproteinases: a bidirectional interaction with multiple pathophysiologic implications","volume":"41","author":"Gresele","year":"2021","journal-title":"Hamostaseologie"},{"key":"B62","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1172\/JCI27291","article-title":"Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities","volume":"116","author":"Grosser","year":"2006","journal-title":"J. Clin. Invest"},{"key":"B63","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev.pathol.1.110304.100230","article-title":"Immunobiology and pathogenesis of viral hepatitis","volume":"1","author":"Guidotti","year":"2006","journal-title":"Annu. Rev. Pathology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"32462","DOI":"10.18632\/oncotarget.8655","article-title":"Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells","volume":"7","author":"Guillem-Llobat","year":"2016","journal-title":"Oncotarget"},{"key":"B65","doi-asserted-by":"publisher","first-page":"37664","DOI":"10.18632\/oncotarget.9224","article-title":"Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug\/Snail2 in ovarian cancer cells via G\u03b1i2, Src, and HIF1\u03b1 signaling nexus","volume":"7","author":"Ha","year":"2016","journal-title":"Oncotarget"},{"key":"B66","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1080\/09537100801990582","article-title":"Message in the platelet-more than just vestigial mRNA","volume":"19","author":"Harrison","year":"2008","journal-title":"Platelets"},{"key":"B67","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"B68","doi-asserted-by":"publisher","first-page":"7005","DOI":"10.1038\/s41467-021-27303-7","article-title":"Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer","volume":"12","author":"Hinterleitner","year":"2021","journal-title":"Nat. Commun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"80","DOI":"10.31083\/j.fbl2902080","article-title":"Tumor-educated platelet RNA and circulating free RNA: emerging liquid biopsy markers for different tumor types","volume":"29","author":"Hu","year":"2024","journal-title":"Front. Biosci. Landmark Ed."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1002\/ijc.23173","article-title":"Inflammation and cancer: an ancient link with novel potentials","volume":"121","author":"Hussain","year":"2007","journal-title":"Int. J. Cancer"},{"key":"B71","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/MOH.0b013e32833e77ee","article-title":"Clinical relevance of microparticles from platelets and megakaryocytes","volume":"17","author":"Italiano","year":"2010","journal-title":"Curr. Opin. Hematol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/ijc.20657","article-title":"Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer","volume":"113","author":"Janowska-Wieczorek","year":"2005","journal-title":"Int. J. Cancer"},{"key":"B73","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3486","article-title":"TALENs: a widely applicable technology for targeted genome editing","volume":"14","author":"Joung","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1084\/jem.20160801","article-title":"PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity","volume":"214","author":"Juneja","year":"2017","journal-title":"J. Exp. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ab.2018.01.030","article-title":"Platelet-derived microparticles analysis: techniques, challenges and recommendations","volume":"546","author":"Kailashiya","year":"2018","journal-title":"Anal. Biochem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investigation"},{"key":"B77","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"B78","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/nri3789","article-title":"Immune cell promotion of metastasis","volume":"15","author":"Kitamura","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","article-title":"Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis","volume":"20","author":"Labelle","year":"2011","journal-title":"Cancer Cell"},{"key":"B80","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1182\/blood-2013-03-492801","article-title":"Activated platelets can deliver mRNA regulatory Ago2\u22c5microRNA complexes to endothelial cells via microparticles","volume":"122","author":"Laffont","year":"2013","journal-title":"Blood"},{"key":"B81","doi-asserted-by":"publisher","first-page":"eaan2787","DOI":"10.1126\/scisignal.aan2787","article-title":"Networks of enzymatically oxidized membranelipids support calcium-dependent coagulation factor binding to maintain hemostasis","volume":"10","author":"Lauder","year":"2017","journal-title":"Sci. Signal."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1182\/blood-2014-04-568683","article-title":"Interaction of platelet-derived autotaxin with tumor integrin \u03b1V\u03b23 controls metastasis of breast cancer cells to bone","volume":"124","author":"Leblanc","year":"2014","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","first-page":"110389","DOI":"10.1016\/j.biopha.2020.110389","article-title":"Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: recent advancement","volume":"129","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1056\/NEJMoa1207756","article-title":"Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival","volume":"367","author":"Liao","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1161\/ATVBAHA.108.179705","article-title":"Inflammation in atherosclerosis","volume":"32","author":"Libby","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1463216","DOI":"10.1155\/2017\/1463216","article-title":"Activated platelets induce an anti-inflammatory response of monocytes\/macrophages through cross-regulation of PGE2 and cytokines","volume":"2017","author":"Linke","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"B87","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1021\/jm4016476","article-title":"Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase","volume":"57","author":"Luci","year":"2014","journal-title":"J. Med. Chem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1182\/bloodadvances.2021005590","article-title":"The incidence of cancer-associated thrombosis is increasing over time","volume":"6","author":"Mahajan","year":"2022","journal-title":"Blood Adv."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1182\/blood.2019002649","article-title":"Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3","volume":"135","author":"Mammadova-Bach","year":"2020","journal-title":"Blood"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e88245","DOI":"10.1172\/jci.insight.88245","article-title":"Platelet integrin \u03b16\u03b21 controls lung metastasis through direct binding to cancer cell-derived ADAM9","volume":"1","author":"Mammadova-Bach","year":"2016","journal-title":"JCI Insight"},{"key":"B91","first-page":"4425","article-title":"Differential colon cancer cell adhesion to E-P-and L-selectin: role of mucin-type glycoproteins","volume":"55","author":"Mannori","year":"1995","journal-title":"Cancer Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"B93","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.canlet.2008.05.003","article-title":"Cancer and inflammation: a complex relationship","volume":"267","author":"Mantovani","year":"2008","journal-title":"Cancer Lett."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.3390\/ijms19102877","article-title":"Blood-based cancer biomarkers in liquid biopsy: a promising non-invasive alternative to tissue biopsy","volume":"19","author":"Marrugo-Ram\u00edrez","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.tcb.2005.09.002","article-title":"Inflammatory cells during wound repair: the good, the bad and the ugly","volume":"15","author":"Martin","year":"2005","journal-title":"Trends Cell Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature17038","article-title":"Metastatic colonization by circulating tumour cells","volume":"529","author":"Massagu\u00e9","year":"2016","journal-title":"Nature"},{"key":"B97","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1001\/jamacardio.2021.0475","article-title":"Efficacy and safety of revacept, a novel lesion-directed competitive antagonist to platelet glycoprotein VI, in patients undergoing elective percutaneous coronary intervention for stable ischemic heart disease: the randomized, double-blind, placebo-controlled ISAR-PLASTER phase 2 trial","volume":"6","author":"Mayer","year":"2021","journal-title":"JAMA Cardiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1158\/1078-0432.CCR-09-0788","article-title":"Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward","volume":"16","author":"Menter","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1182\/blood-2016-11-751099","article-title":"Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth","volume":"130","author":"Michael","year":"2017","journal-title":"Blood"},{"key":"B100","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nrc1143","article-title":"The emerging role of lysophosphatidic acid in cancer","volume":"3","author":"Mills","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"B101","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1182\/blood-2013-03-492447","article-title":"A novel and essential role for Fc\u03b3RIIa in cancer cell-induced platelet activation","volume":"123","author":"Mitrugno","year":"2014","journal-title":"Blood"},{"key":"B102","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/eurheartj\/ehab631","article-title":"Matrix metalloproteinase-2 on activated platelets triggers endothelial PAR-1 initiating atherosclerosis","volume":"43","author":"Momi","year":"2022","journal-title":"Eur. Heart J."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/0959-8049(95)00181-h","article-title":"ApcMin: a mouse model for intestinal and mammary tumorigenesis","author":"Moser","year":"1995","journal-title":"Eur. J. Cancer 31A"},{"key":"B104","doi-asserted-by":"publisher","first-page":"5189","DOI":"10.1182\/blood-2010-09-299719","article-title":"Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity","volume":"117","author":"Nagalla","year":"2011","journal-title":"Blood"},{"key":"B105","volume-title":"Excellence NICE-effectiveness of aspirin in the prevention of colorectal cancer in people with Lynch syndrome","year":"2020"},{"key":"B106","first-page":"1723","article-title":"Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines","volume":"150","author":"Negus","year":"1997","journal-title":"Am. J. Pathol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ccr.2006.10.002","article-title":"Thrombin induces tumor growth, metastasis, and angiogenesis: evidence for a thrombin-regulated dormant tumor phenotype","volume":"10","author":"Nierodzik","year":"2006","journal-title":"Cancer Cell"},{"key":"B108","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1182\/blood-2011-03-344408","article-title":"Blood platelets contain tumor-derived RNA biomarkers","volume":"118","author":"Nilsson","year":"2011","journal-title":"Blood"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.18632\/oncotarget.6279","article-title":"Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer","volume":"7","author":"Nilsson","year":"2016","journal-title":"Oncotarget"},{"key":"B110","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/s0092-8674(00)81988-1","article-title":"Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)","volume":"87","author":"Oshima","year":"1996","journal-title":"Cell"},{"key":"B111","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.bbalip.2014.09.016","article-title":"Cyclooxygenase inhibitors: from pharmacology to clinical read-outs","volume":"1851","author":"Patrignani","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B112","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jacc.2016.05.083","article-title":"Aspirin and cancer","volume":"68","author":"Patrignani","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1080\/09537104.2018.1492105","article-title":"Aspirin, platelet inhibition and cancer prevention","volume":"29","author":"Patrignani","year":"2018","journal-title":"Platelets"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1111\/jth.12637","article-title":"Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action","volume":"12","author":"Patrignani","year":"2014","journal-title":"J. Thromb. Haemost."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1362217","DOI":"10.3389\/fphar.2024.1362217","article-title":"Optimizing aspirin dose for colorectal cancer patients through deep phenotyping using novel biomarkers of drug action","author":"Patrignani","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41569-019-0225-y","article-title":"Role of aspirin in primary prevention of cardiovascular disease","volume":"16","author":"Patrono","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1056\/NEJMra052717","article-title":"Low-dose aspirin for the prevention of atherothrombosis","volume":"353","author":"Patrono","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1172\/JCI13418","article-title":"Cyclooxygenase selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs","volume":"108","author":"Patrono","year":"2001","journal-title":"J. Clin. Invest"},{"key":"B118","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-3-319-47462-5_25","article-title":"The migration of platelets and their interaction with other migrating cells","volume-title":"Platelets in thrombotic and non-thrombotic disorders","author":"Petito","year":"2017"},{"key":"B119","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1164\/rccm.200702-214OC","article-title":"Allergen induces the migration of platelets to lung tissue in allergic asthma","volume":"177","author":"Pitchford","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1182\/blood-2004-06-2282","article-title":"Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation","volume":"105","author":"Pitchford","year":"2005","journal-title":"Blood"},{"key":"B121","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1067\/mai.2003.1514","article-title":"Platelets are essential for leukocyte recruitment in allergic inflammation","volume":"112","author":"Pitchford","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1158\/0008-5472.CAN-11-1872","article-title":"Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells","volume":"72","author":"Placke","year":"2012","journal-title":"Cancer Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1161\/ATVBAHA.120.314644","article-title":"Platelet extracellular vesicles: beyond the blood","volume":"41","author":"Puhm","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"eaai7911","DOI":"10.1126\/sciimmunol.aai7911","article-title":"Platelets subvert T cell immunity against cancer via GARP-TGF\u03b2 axis","volume":"2","author":"Rachidi","year":"2017","journal-title":"Sci. Immunol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1161\/ATVBAHA.118.310967","article-title":"Noncanonical matrix metalloprotease 1\u2013protease-activated receptor 1 signaling drives progression of atherosclerosis","volume":"38","author":"Rana","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/sj.leu.2404296","article-title":"Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"B127","doi-asserted-by":"publisher","first-page":"6288","DOI":"10.1182\/blood-2011-12-396440","article-title":"Platelets and platelet-like particles mediate intercellular RNA transfer","volume":"119","author":"Risitano","year":"2012","journal-title":"Blood"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1161\/CIRCRESAHA.113.300512","article-title":"Platelets as cellular effectors of inflammation in vascular diseases","volume":"112","author":"Rondina","year":"2013","journal-title":"Circ. Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1749-6632.1985.tb11865.x","article-title":"Platelets, macrophages, endothelium, and growth factors. Their effects upon cells and their possible roles in atherogenesis","volume":"454","author":"Ross","year":"1985","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3390\/cells11040725","article-title":"Antiplatelet agents affecting GPCR signaling implicated in tumor metastasis","volume":"11","author":"Rovati","year":"2022","journal-title":"Cells"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4199\/C00007ED1V01Y201002ISP004","article-title":"Platelet-vessel wall interactions in hemostasis and thrombosis","volume":"2","author":"Rumbaut","year":"2010","journal-title":"San. Rafael Morgan Claypool Life Sci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1124\/jpet.119.259382","article-title":"Platelet-specific deletion of cyclooxygenase-1 ameliorates dextran sulfate sodium-induced colitis in mice","volume":"370","author":"Sacco","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B133","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1084\/jem.20020267","article-title":"The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1","volume":"196","author":"Santoso","year":"2002","journal-title":"J. Exp. Med."},{"key":"B134","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3390\/genes13030460","article-title":"Aspirin colorectal cancer prevention in Lynch syndrome: recommendations in the era of precision medicine","volume":"13","author":"Serrano","year":"2022","journal-title":"Genes (Basel)"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1272971","DOI":"10.3389\/fcvm.2023.1272971","article-title":"Novel strategies in antithrombotic therapy: targeting thrombosis while preserving hemostasis","volume":"10","author":"Sim","year":"2023","journal-title":"Front. Cardiovasc Med."},{"key":"B136","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1084\/jem.192.2.193","article-title":"Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b\/CD18)","volume":"192","author":"Simon","year":"2000","journal-title":"J. Exp. Med."},{"key":"B137","doi-asserted-by":"publisher","first-page":"E2165","DOI":"10.1073\/pnas.1209182109","article-title":"Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B","volume":"109","author":"Sitia","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"e98459","DOI":"10.1172\/jci.insight.98459","article-title":"Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies","volume":"3","author":"Slatter","year":"2018","journal-title":"JCI Insight"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1111\/j.1538-7836.2009.03586.x","article-title":"Platelet functions beyond hemostasis","volume":"7","author":"Smyth","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"B141","doi-asserted-by":"publisher","first-page":"108420","DOI":"10.1016\/j.pharmthera.2023.108420","article-title":"Bioactive lipid regulation of platelet function, hemostasis, and thrombosis","volume":"246","author":"Stanger","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"B142","doi-asserted-by":"publisher","first-page":"97464","DOI":"10.18632\/oncotarget.22136","article-title":"Platelet microparticle-mediated transfer of miR-939 to epithelial ovarian cancer cells promotes epithelial to mesenchymal transition","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"B143","doi-asserted-by":"publisher","first-page":"6891","DOI":"10.1074\/jbc.M109.078428","article-title":"Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation","volume":"285","author":"Thomas","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B144","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/978-1-4615-4793-8_89","article-title":"12-lipoxygenase expression in human melanoma cell lines","volume":"469","author":"Tim\u00e1r","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.tips.2017.08.001","article-title":"Targeting 12-lipoxygenase as a potential novel antiplatelet therapy","volume":"38","author":"Tourdot","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"13445","DOI":"10.1073\/pnas.0901944106","article-title":"GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells","volume":"106","author":"Tran","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B147","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B148","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1152\/jappl.1997.82.2.592","article-title":"Thromboxane A2 mediates increased pulmonary microvascular permeability after intestinal reperfusion","volume":"82","author":"Turnage","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1016\/s0022-5347(05)65620-0","article-title":"Reactive stroma in prostate cancer progression","volume":"166","author":"Tuxhorn","year":"2001","journal-title":"J. Urol."},{"key":"B150","first-page":"2912","article-title":"Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling","volume":"8","author":"Tuxhorn","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1161\/CIRCULATIONAHA.110.980623","article-title":"Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans","volume":"123","author":"Ungerer","year":"2011","journal-title":"Circulation"},{"key":"B152","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1111\/jth.12976","article-title":"Platelets and their microparticles as key players in pathophysiological responses","volume":"13","author":"Varon","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"B153","doi-asserted-by":"publisher","first-page":"e211","DOI":"10.1038\/cddis.2011.94","article-title":"Microparticles from apoptotic platelets promote resident macrophage differentiation","volume":"2","author":"Vasina","year":"2011","journal-title":"Cell Death and Dis."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijcme.2014.03.002","article-title":"Microvascular inflammation in atherosclerosis","volume":"3","author":"Vitiello","year":"2014","journal-title":"IJC Metab. Endocr."},{"key":"B155","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1097\/PPO.0000000000000003","article-title":"An inflammatory mediator, prostaglandin E2, in colorectal cancer","volume":"19","author":"Wang","year":"2013","journal-title":"Cancer J."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1172\/JCI118575","article-title":"Activated platelets signal chemokine synthesis by human monocytes","volume":"97","author":"Weyrich","year":"1996","journal-title":"J. Clin. Invest"},{"key":"B157","doi-asserted-by":"publisher","first-page":"17304","DOI":"10.1074\/jbc.M109.003194","article-title":"Unique ligand selectivity of the GPR92\/LPA5 lysophosphatidate receptor indicates role in human platelet activation","volume":"284","author":"Williams","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B158","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/jth.14643","article-title":"Molecular basis of protease-activated receptor 1 signaling diversity","volume":"18","author":"Willis Fox","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"B159","doi-asserted-by":"publisher","first-page":"5597","DOI":"10.1158\/0008-5472.CAN-19-3176","article-title":"Inhibition of IL-1\u03b2 by canakinumab may be effective against diverse molecular subtypes of lung cancer: an exploratory analysis of the CANTOS trial","volume":"80","author":"Wong","year":"2020","journal-title":"Cancer Res."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1084\/jem.190.12.1769","article-title":"Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration","volume":"190","author":"Yang","year":"1999","journal-title":"J. Exp. Med."},{"key":"B161","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1017\/S1462399408000719","article-title":"Galectins: structure, function and therapeutic potential","volume":"10","author":"Yang","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"B162","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1182\/blood-2014-05-575878","article-title":"Platelet 12-LOX is essential for Fc\u03b3RIIa-mediated platelet activation","volume":"124","author":"Yeung","year":"2014","journal-title":"Blood"},{"key":"B163","doi-asserted-by":"publisher","first-page":"24805","DOI":"10.1016\/s0021-9258(18)35835-6","article-title":"Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene","volume":"267","author":"Yoshimoto","year":"1992","journal-title":"J. Biol. Chem."},{"key":"B164","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1016\/j.yexcr.2012.07.021","article-title":"IL1\u03b2-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells","volume":"318","author":"Zhu","year":"2012","journal-title":"Exp. Cell Res."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1520488\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T01:40:06Z","timestamp":1734918006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2024.1520488\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":165,"alternative-id":["10.3389\/fphar.2024.1520488"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2024.1520488","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"article-number":"1520488"}}