{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:53:06Z","timestamp":1791924786003,"version":"4.3.4"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016060","name":"Stichting De Cock-Hadders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Dracaena trifasciata (Prain) Mabb<\/jats:italic>. [<jats:italic>Asparagaceae<\/jats:italic>; also known as <jats:italic>Sansevieria trifasciata Prain<\/jats:italic> (<jats:italic>ST<\/jats:italic>)] may have health-promoting activities, including resolution of diabetes mellitus (DM). This <jats:italic>in vitro<\/jats:italic> study evaluated whether and how a leaf extract of <jats:italic>ST<\/jats:italic> could directly protect pancreas-derived MIN6 cells against the diabetogenic toxin streptozotocin (STZ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Composition of the <jats:italic>ST<\/jats:italic> extract (by 100% methanol) was investigated using high resolution mass spectrometry, which revealed several compounds with beneficial bioactive efficacy. MIN6 cells were exposed to 50% lethal dose of STZ, with or without <jats:italic>ST<\/jats:italic> extract. Cell viability was assessed using the MTT method. Inflammatory activity of <jats:italic>ST<\/jats:italic> extract was assessed in MIN6 cells and macrophage-like RAW cells, and addition of TNF-\u03b1 to combinations of <jats:italic>ST<\/jats:italic> and STZ were tested on MIN6 cell viability. The role of the NF-\u03baB pathway in effects of STZ and <jats:italic>ST<\/jats:italic> were investigated using the proteosome inhibitor MG132.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exposure of MIN6 cells to the <jats:italic>ST<\/jats:italic> extract (in concentrations that did not notably affect MIN6 cells: 5-15 mg\/mL) was indeed able to minimize STZ-induced toxicity in MIN6 cells. Exposing macrophage-like RAW cells to <jats:italic>ST<\/jats:italic> extract (at 10-15 mg\/mL) increased TNF-\u03b1 gene expression, and this response was highly augmented by co-exposure to lipopolysaccharide (LPS, 1.0 mg\/mL), indicating that <jats:italic>ST<\/jats:italic> extract contained inflammatory compounds too. The implication of this finding was investigated by exposing MIN6 cells to a subthreshold dose (100 ng\/mL) of TNF-\u03b1, which 1) prevented the protective effect of the <jats:italic>ST<\/jats:italic> extract (10-15 mg\/mL) against STZ toxicity, and 2) caused <jats:italic>ST<\/jats:italic> to become toxic to MIN6 cells even without the presence of STZ. TNF-\u03b1 is known to activate the NF-\u03baB pathway leading to cell death, however, NF-\u03baB is also known to stimulate cell proliferation and survival. To investigate the relevance of the NF-\u03baB pathway in our findings, we treated MIN6 cells with the proteasome inhibitor MG132 (at doses \u22650.2 \u03bcM), and observed that <jats:italic>ST<\/jats:italic> extract was no longer able to block STZ toxicity in MIN6 cells (p &amp;lt; 0.05), and to block CIAP2 expression, an anti-apoptotic target downstream from NF-\u03baB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that a leaf extract of <jats:italic>ST<\/jats:italic> has anti-diabetogenic efficacy, which may depend on the integrity of the NF-\u03baB pathway. This protective effect appears to be impeded in a pro-inflammatory environment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphar.2025.1485952","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T05:28:47Z","timestamp":1744781327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Dracaena trifasciata (Prain) Mabb leaf extract protects MIN6 pancreas-derived beta cells against the diabetic toxin streptozotocin: role of the NF-\u03baB pathway"],"prefix":"10.3389","volume":"16","author":[{"given":"Christiaan Warner","family":"Hoornenborg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur","family":"Qomariyah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herson Antonio","family":"Gonz\u00e1lez-Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Petrus","family":"Van Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Moshage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertjan","family":"Van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.52711\/0974-360X.2022.00180","article-title":"Non-targeted screening with LC-HRMS and in-silico study on diabetic activity of ethyl acetate extract of Sanrego (Lunasia amara Blanco)","volume":"15","author":"Adriani","year":"2022","journal-title":"Res. 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