{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:55:48Z","timestamp":1792529748730,"version":"4.5.0"},"reference-count":172,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, and anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer\u2019s Disease (AD), Parkinson\u2019s Disease (PD), Dementia, Multiple Sclerosis (MS), Stroke, and Huntington\u2019s Disease (HD). Polyphenols have been extensively studied for their ability to regulate inflammatory responses by modulating the activity of pro-inflammatory genes and influencing signal transduction pathways, thereby reducing neuroinflammation and neuronal death. Additionally, polyphenols have shown promise in modulating various cellular signaling pathways associated with neuronal viability, synaptic plasticity, and cognitive function. Epidemiological and clinical studies highlight the potential of polyphenol-rich diets to decrease the risk and alleviate symptoms of neurodegenerative disorders and neuroinflammation. Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the body\u2019s immune response. This review emphasizes the growing body of evidence supporting the therapeutic potential of polyphenols in combating neurodegeneration and neuroinflammation, as well as enhancing brain health. Despite the substantial evidence and promising hypotheses, further research and clinical investigations are necessary to fully understand the role of polyphenols and establish them as advanced therapeutic targets for age-related neurodegenerative diseases and neuroinflammatory conditions.<\/jats:p>","DOI":"10.3389\/fphar.2025.1492517","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T02:15:23Z","timestamp":1737684923000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":134,"title":["Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review"],"prefix":"10.3389","volume":"16","author":[{"given":"Maroua","family":"Jalouli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Ataur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasanur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Halim","family":"Harrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Seon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sojin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Nyeo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonglee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.34172\/ps.2024.11","article-title":"A critical review on the bioavailability promotion of the food bioactive compounds: nano lipid carriers perspective","author":"Abbasi","year":"2024","journal-title":"Pharm. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/biof.1936","article-title":"Cannabinoids in neuroinflammatory disorders: focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases","volume":"49","author":"Abd\u2010Nikfarjam","year":"2023","journal-title":"BioFactors"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1347987","DOI":"10.3389\/fnagi.2024.1347987","article-title":"The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets","volume":"16","author":"Adamu","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7604","DOI":"10.3390\/molecules27217604","article-title":"Green tea catechins attenuate neurodegenerative diseases and cognitive deficits","volume":"27","author":"Afzal","year":"2022","journal-title":"Molecules"},{"key":"B5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11010-023-04922-w","article-title":"Flavonoids and Alzheimer\u2019s disease: reviewing the evidence for neuroprotective potential","volume":"480","author":"Al Amin","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"116376","DOI":"10.1016\/j.biopha.2024.116376","article-title":"Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer\u2019s disease","volume":"174","author":"Albadrani","year":"2024","journal-title":"Biomed. and Pharmacother."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2856063","DOI":"10.1155\/2018\/2856063","article-title":"Mangiferin and morin attenuate oxidative stress, mitochondrial dysfunction, and neurocytotoxicity, induced by amyloid beta oligomers","volume":"2018","author":"Alberdi","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.7150\/ijbs.90982","article-title":"Polyphenols targeting NF-\u03baB pathway in neurological disorders: what we know so far?","volume":"20","author":"Al Mamun","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neulet.2007.03.025","article-title":"Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells","volume":"418","author":"Amazzal","year":"2007","journal-title":"Neurosci. Lett."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1348151","DOI":"10.3389\/fnins.2024.1348151","article-title":"Neuroprotective effects of Flavonoids: endoplasmic reticulum as the target","volume":"18","author":"Amiri","year":"2024","journal-title":"Front. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1124\/jpet.124.002065","article-title":"Role of mitogen-activated protein kinase kinase kinase kinase 4 signaling in liver and metabolic diseases","volume":"390","author":"Ampadu","year":"2024","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B12","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3390\/antiox13060681","article-title":"Protein oxidative modifications in neurodegenerative diseases: from advances in detection and modelling to their use as disease biomarkers","volume":"13","author":"Anjo","year":"2024","journal-title":"Antioxidants"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e13989","DOI":"10.1111\/jfbc.13989","article-title":"Dietary biomolecules as promising regenerative agents for peripheral nerve injury: an emerging nutraceutical\u2010based therapeutic approach","volume":"45","author":"Anwar","year":"2021","journal-title":"J. Food Biochem."},{"key":"B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-94753-8_2-1","article-title":"Apigenin: chemistry and pharmacology","volume-title":"Handbook of dietary flavonoids","author":"Aprotosoaie","year":"2023"},{"key":"B15","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1080\/1028415X.2023.2243089","article-title":"Naringenin: its chemistry and roles in neuroprotection","volume":"27","author":"Atoki","year":"2024","journal-title":"Nutr. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.3389\/fimmu.2019.01000","article-title":"Regulation of toll-like receptor (TLR) signaling pathway by polyphenols in the treatment of age-linked neurodegenerative diseases: focus on TLR4 signaling","volume":"10","author":"Azam","year":"2019","journal-title":"Front. Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7307","DOI":"10.1007\/s00210-024-03109-4","article-title":"A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets","volume":"397","author":"Aziz","year":"2024","journal-title":"Naunyn-Schmiedeberg's Archives Pharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1002\/ptr.8200","article-title":"Neuroprotective and anti\u2010inflammatory effects of curcumin in Alzheimer's disease: targeting neuroinflammation strategies","volume":"38","author":"Azzini","year":"2024","journal-title":"Phytotherapy Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s13596-020-00428-8","article-title":"Neuroprotective effect of organic and inorganically grown tea on oxidative damage in rat model of Alzheimer\u2019s disease","volume":"20","author":"Bagchi","year":"2020","journal-title":"Adv. Traditional Med."},{"key":"B20","first-page":"253","article-title":"Impact of curcumin on aging: its manifestations and limitations","volume-title":"Curcumin and neurodegenerative diseases: from traditional to translational medicines","author":"Banji","year":"2024"},{"key":"B21","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41583-024-00813-1","article-title":"The molecular determinants of microglial developmental dynamics","volume":"25","author":"Barry-Carroll","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"105896","DOI":"10.1016\/j.fitote.2024.105896","article-title":"Bioactivities of morroniside: a comprehensive review of pharmacological properties and molecular mechanisms","volume":"175","author":"Bhuia","year":"2024","journal-title":"Fitoterapia"},{"key":"B23","doi-asserted-by":"publisher","first-page":"891748","DOI":"10.1155\/2013\/891748","article-title":"Polyphenols: multipotent therapeutic agents in neurodegenerative diseases","volume":"2013","author":"Bhullar","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1080\/10408347.2022.2105641","article-title":"Bioactive flavonoids: a comprehensive review on pharmacokinetics and analytical aspects","volume":"54","author":"Billowria","year":"2024","journal-title":"Crit. Rev. Anal. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"578180","DOI":"10.1016\/j.jneuroim.2023.578180","article-title":"Microglia mediated neuroinflammation in neurodegenerative diseases: a review on the cell signaling pathways involved in microglial activation","volume":"383","author":"Biswas","year":"2023","journal-title":"J. Neuroimmunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"11746","DOI":"10.3390\/ijms231911746","article-title":"A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells","volume":"23","author":"Biswas","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.3390\/nu16152550","article-title":"Polyphenols: secondary metabolites with a biological impression","volume":"16","author":"Bolat","year":"2024","journal-title":"Nutrients"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.3390\/nu16152399","article-title":"Therapeutic potential of natural compounds acting through epigenetic mechanisms in cardiovascular diseases: current findings and future directions","volume":"16","author":"Bontempo","year":"2024","journal-title":"Nutrients"},{"key":"B29","doi-asserted-by":"publisher","first-page":"921941","DOI":"10.1155\/2012\/921941","article-title":"Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system","volume":"2012","author":"Bournival","year":"2012","journal-title":"Oxid. Med. Cell Longev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1080\/87559129.2023.2273929","article-title":"Effects of polyphenol-rich extracts on inflammatory bowel diseases","volume":"40","author":"Caban","year":"2023","journal-title":"Food Rev. Int."},{"key":"B31","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/antiox13010127","article-title":"Using redox proteomics to gain new insights into neurodegenerative disease and protein modification","volume":"13","author":"Cadenas-Garrido","year":"2024","journal-title":"Antioxidants"},{"key":"B32","doi-asserted-by":"publisher","first-page":"7812","DOI":"10.1039\/d4fo01396d","article-title":"Circulating low-molecular-weight (poly) phenol metabolites in the brain: unveiling in vitro and in vivo blood\u2013brain barrier transport","volume":"15","author":"Carecho","year":"2024","journal-title":"Food and Funct."},{"key":"B33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/B978-0-12-411462-3.00007-2","article-title":"Polyphenols, nerve growth factor, brain-derived neurotrophic factor, and the brain","volume-title":"Bioactive nutraceuticals and dietary supplements in neurological and brain disease","author":"Carito","year":"2015"},{"key":"B34","doi-asserted-by":"publisher","first-page":"846","DOI":"10.4103\/1673-5374.382232","article-title":"Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer\u2019s agents","volume":"19","author":"Castillo-Ordo\u00f1ez","year":"2024","journal-title":"Neural Regen. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.3390\/ijms25095041","article-title":"Exploring the role of apigenin in neuroinflammation: insights and implications","volume":"25","author":"Charri\u00e8re","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"109622","DOI":"10.1016\/j.jnutbio.2024.109622","article-title":"Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: a Systematic review","volume":"129","author":"Chatterjee","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"116481","DOI":"10.1016\/j.biopha.2024.116481","article-title":"Research progress on Sirtuins (SIRTs) family modulators","volume":"174","author":"Chen","year":"","journal-title":"Biomed. and Pharmacother."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1080\/10408398.2022.2121261","article-title":"Kaempferol and atherosclerosis: from mechanism to medicine","volume":"64","author":"Chen","year":"","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JAD-231222","article-title":"Polyphenols and diets as current and potential nutrition senotherapeutics in Alzheimer\u2019s disease: findings from clinical trials","author":"Chen","year":"","journal-title":"J. Alzheimer's Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1089\/ars.2012.4803","article-title":"Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium","volume":"19","author":"Chen","year":"2013","journal-title":"Antioxidants and redox Signal."},{"key":"B41","doi-asserted-by":"publisher","first-page":"118353","DOI":"10.1016\/j.jep.2024.118353","article-title":"Resveratrol targeting NRF2 disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage in mice pulmonary infection","volume":"332","author":"Chi","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1007\/s11064-023-03907-x","article-title":"Mitochondrial complex I inhibition in dopaminergic neurons causes altered protein profile and protein oxidation: implications for Parkinson\u2019s disease","volume":"48","author":"Chithra","year":"2023","journal-title":"Neurochem. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuro.2022.12.007","article-title":"Naringin enhances long-term potentiation and recovers learning and memory deficits of amyloid-beta induced Alzheimer\u2019s disease-like behavioral rat model","volume":"95","author":"Choi","year":"2023","journal-title":"Neurotoxicology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1080\/10408398.2018.1550384","article-title":"An outlook on the role of decaffeinated coffee in neurodegenerative diseases","volume":"60","author":"Colombo","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/nu16040507","article-title":"Targeting metabolic diseases: the role of nutraceuticals in modulating oxidative stress and inflammation","volume":"16","author":"Dama","year":"2024","journal-title":"Nutrients"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s11064-016-1853-9","article-title":"The effects of ellagic acid upon brain cells: a mechanistic view and future directions","volume":"41","author":"de Oliveira","year":"2016","journal-title":"Neurochem. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/bcpt.14011","article-title":"Effects of quercetin in preclinical models of Parkinson's disease: a systematic review","volume":"135","author":"de Oliveira Vian","year":"2024","journal-title":"Basic and Clin. Pharmacol. and Toxicol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11033-023-09021-z","article-title":"Oxidative stress in Alzheimer\u2019s disease: current knowledge of signaling pathways and therapeutics","volume":"51","author":"Dhapola","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"B49","first-page":"50","article-title":"Genistein as a neuroprotective agent: a comprehensive review of its potential in neurodegenerative diseases","volume":"1","author":"Dogra","year":"2023","journal-title":"J. Pharma Insights Res."},{"key":"B50","doi-asserted-by":"crossref","first-page":"e533","DOI":"10.1093\/nutrit\/nuae034","article-title":"From the gut to the brain: the long journey of phenolic compounds with neurocognitive effects","volume":"83","author":"Dom\u00ednguez-L\u00f3pez","year":"2025","journal-title":"Nutr. Rev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"100099","DOI":"10.1016\/j.arres.2024.100099","article-title":"Anti-and pro-oxidant properties of polyphenols and their role in modulating glutathione synthesis, activity and cellular redox potential: potential synergies for disease management","volume":"11","author":"Dzah","year":"2024","journal-title":"Adv. Redox Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2020.1810625","article-title":"Treatment with the flavonoid 7, 8-Dihydroxyflavone: a promising strategy for a constellation of body and brain disorders","volume":"62","author":"Emili","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B53","doi-asserted-by":"publisher","first-page":"150358","DOI":"10.1016\/j.bbrc.2024.150358","article-title":"Pterostilbene alleviates MPTP-induced neurotoxicity by targeting neuroinflammation and oxidative stress","volume":"729","author":"Fan","year":"2024","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1408620","DOI":"10.3389\/fnut.2024.1408620","article-title":"Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: recent advances and perspectives","volume":"11","author":"Fang","year":"2024","journal-title":"Front. Nutr."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-024-04234-0","article-title":"Resveratrol inhibits VDAC1-mediated mitochondrial dysfunction to mitigate pathological progression in Parkinson\u2019s disease model","author":"Feng","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1360065","DOI":"10.3389\/fimmu.2024.1360065","article-title":"Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases","volume":"15","author":"Ferreira","year":"2024","journal-title":"Front. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"562","DOI":"10.2174\/1570159X14666161026151545","article-title":"Polyphenols beyond barriers: a glimpse into the brain","volume":"15","author":"Figueira","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"105798","DOI":"10.1016\/j.neuint.2024.105798","article-title":"Combating Parkinson\u2019s disease with plant-derived polyphenols: targeting oxidative stress and neuroinflammation","volume":"178","author":"Gahtani","year":"2024","journal-title":"Neurochem. Int."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.3390\/ijms25073995","article-title":"Neuroinflammation in neurodegenerative disorders: current knowledge and therapeutic implications","volume":"25","author":"Giri","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2024.2357701","article-title":"Unveiling the neuroprotective properties of isoflavones: current evidence, molecular mechanisms and future perspectives","author":"Gong","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-981-99-7269-2_10","article-title":"Phytochemicals and natural extracts, secondary metabolites of plants and improvement of brain function","volume-title":"Neuroprotective effects of phytochemicals in brain ageing","author":"Gopathy","year":"2024"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3454","DOI":"10.3390\/nu15153454","article-title":"Polyphenols and their impact on the prevention of neurodegenerative diseases and development","volume":"15","author":"Grabska-Koby\u0142ecka","year":"2023","journal-title":"Nutrients"},{"key":"B63","doi-asserted-by":"publisher","first-page":"898","DOI":"10.3390\/ani10050898","article-title":"Evaluation of neuroprotective effects of quercetin against aflatoxin B1-intoxicated mice","volume":"10","author":"Gugliandolo","year":"2020","journal-title":"Animals"},{"key":"B64","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/B978-0-443-18951-7.00021-9","article-title":"Nutraceutical interventions in Alzheimer's disease","volume-title":"Nutraceutical fruits and foods for neurodegenerative disorders","author":"Gujarathi","year":"2024"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.4103\/1673-5374.385845","article-title":"Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases","volume":"19","author":"Han","year":"2024","journal-title":"Neural Regen. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2303817","DOI":"10.1002\/adhm.202303817","article-title":"Antioxidant hydrogels: antioxidant mechanisms, design strategies, and applications in the treatment of oxidative stress\u2010related diseases","volume":"13","author":"Hu","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"B67","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3177\/jnsv.67.234","article-title":"Combination of lutein and DHA alleviate H2O2 induced cytotoxicity in PC12 cells by regulating the MAPK pathway","volume":"67","author":"Hu","year":"2021","journal-title":"J. Nutr. Sci. vitaminology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"100235","DOI":"10.1016\/j.crbiot.2024.100235","article-title":"A new frontier in neuropharmacology: recent progress in natural products research for blood\u2013brain barrier crossing","volume":"8","author":"Isabel","year":"2024","journal-title":"Curr. Res. Biotechnol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1007\/s12035-023-03706-z","article-title":"Polyphenols targeting MAP kinase signaling pathway in neurological diseases: understanding molecular mechanisms and therapeutic targets","volume":"61","author":"Islam","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"349","DOI":"10.37360\/blacpma.24.23.3.24","article-title":"Pharmacotherapeutic potential of Vitis vinifera (grape) in age-related neurological diseases","volume":"23","author":"Jadidian","year":"2024","journal-title":"Bol. Latinoam. del Caribe Plantas Med. Arom\u00e1ticas"},{"key":"B71","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.mam.2017.11.003","article-title":"Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation","volume":"61","author":"Jaeger","year":"2018","journal-title":"Mol. aspects Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-1-4939-9465-6_2","article-title":"Neuroprotective agents","author":"Jain","year":"2019","journal-title":"Handb. Neuroprotection"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Archives Toxicol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e11951","DOI":"10.1371\/journal.pone.0011951","article-title":"Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies","volume":"5","author":"Kang","year":"2010","journal-title":"PloS one"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s11064-008-9633-9","article-title":"Artepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathways","volume":"33","author":"Kano","year":"2008","journal-title":"Neurochem. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1080\/1028415X.2024.2325233","article-title":"Natural compounds for oxidative stress and neuroprotection in schizophrenia: composition, mechanisms, and therapeutic potential","volume":"27","author":"Khan","year":"2024","journal-title":"Nutr. Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"935","DOI":"10.2147\/RMHP.S456765","article-title":"Effect of regular aerobic exercise on cognitive function, depression level and regulative role of neurotrophic factor: a prospective cohort study in the young and the middle-aged sample","volume":"17","author":"Kong","year":"2024","journal-title":"Risk Manag. Healthc. Policy"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.13931","article-title":"Ferulic acid: extraction, estimation, bioactivity and applications for human health and food","author":"Kumar","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"B79","doi-asserted-by":"publisher","first-page":"104835","DOI":"10.1016\/j.neuint.2020.104835","article-title":"Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: role of TLR4\/NF-\u03baB, p38 MAPK\/JNK, Nrf2\/ARE signaling","volume":"140","author":"Kwatra","year":"2020","journal-title":"Neurochem. Int."},{"key":"B80","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1124\/dmd.124.001282","article-title":"Deciphering acetaminophen-induced hepatotoxicity: the crucial role of transcription factors like nuclear factor erythroid 2\u2013related factor 2 as genetic determinants of susceptibility to drug-induced liver injury","volume":"52","author":"Laddha","year":"2024","journal-title":"Drug Metabolism Dispos."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2308677","DOI":"10.1002\/advs.202308677","article-title":"Progress in the treatment of central nervous system diseases based on nanosized traditional Chinese medicine","volume":"11","author":"Li","year":"","journal-title":"Adv. Sci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1021\/acs.jafc.3c07536","article-title":"Therapeutic potential of natural compounds from herbs and nutraceuticals in alleviating neurological disorders: targeting the wnt signaling pathway","volume":"72","author":"Li","year":"","journal-title":"J. Agric. Food Chem."},{"key":"B83","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.3390\/molecules28145527","article-title":"Artemisinin confers neuroprotection against 6-OHDA-induced neuronal injury in vitro and in vivo through activation of the ERK1\/2 pathway","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1425839","DOI":"10.3389\/fnut.2024.1425839","article-title":"Neurodegenerative diseases and catechins:(\u2212)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress","volume":"11","author":"Li","year":"","journal-title":"Front. Nutr."},{"key":"B85","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s40263-017-0451-y","article-title":"Therapeutic potential of baicalein in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"31","author":"Li","year":"2017","journal-title":"CNS drugs"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1002\/ptr.8156","article-title":"Regulation of mitophagy and mitochondrial function: natural compounds as potential therapeutic strategies for Parkinson's disease","volume":"38","author":"Liang","year":"2024","journal-title":"Phytotherapy Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1111\/jnc.15955","article-title":"Protein aggregation: a detrimental symptom or an adaptation mechanism?","volume":"168","author":"Lippi","year":"2024","journal-title":"J. Neurochem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"118420","DOI":"10.1016\/j.jep.2024.118420","article-title":"Pharmacokinetic study and neuropharmacological effects of Atractylenolide \u2162 to improve cognitive impairment via PI3K\/AKT\/GSK3\u03b2 pathway in intracerebroventricular-streptozotocin rats","volume":"333","author":"Liu","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"138739","DOI":"10.1016\/j.foodchem.2024.138739","article-title":"Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis","volume":"446","author":"Liu","year":"","journal-title":"Food Chem."},{"key":"B90","doi-asserted-by":"publisher","first-page":"106812","DOI":"10.1016\/j.phrs.2023.106812","article-title":"Phenolic metabolites as therapeutic in inflammation and neoplasms: molecular pathways explaining their efficacy","volume":"193","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"541","DOI":"10.2147\/IJN.S443692","article-title":"Nano-drug delivery systems based on natural products","volume":"19","author":"Lv","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"B92","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/biom14040426","article-title":"Corinthian currants promote the expression of paraoxonase-1 and enhance the antioxidant status in serum and brain of 5xFAD mouse model of Alzheimer\u2019s disease","volume":"14","author":"Lymperopoulos","year":"2024","journal-title":"Biomolecules"},{"key":"B93","doi-asserted-by":"publisher","first-page":"101021","DOI":"10.1016\/j.gendis.2023.04.041","article-title":"The molecular genetics of PI3K\/PTEN\/AKT\/mTOR pathway in the malformations of cortical development","volume":"11","author":"Ma","year":"2024","journal-title":"Genes and Dis."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1002\/ptr.8192","article-title":"Phytomedicine for neurodegenerative diseases: the road ahead","volume":"38","author":"Madhubala","year":"2024","journal-title":"Phytotherapy Res."},{"key":"B95","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1201\/9781003386247-7","article-title":"Flavonoids and polyphenols","volume-title":"Bioactive compounds from food","author":"Majedi","year":"2024"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1007\/s12033-023-00783-2","article-title":"Exploring the potential therapeutic approach using ginsenosides for the management of neurodegenerative disorders","volume":"66","author":"Manju","year":"2024","journal-title":"Mol. Biotechnol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"148793","DOI":"10.1016\/j.brainres.2024.148793","article-title":"Could protein phosphatase 2A and glycogen synthase kinase-3 beta be targeted by natural compounds to ameliorate Alzheimer\u2019s pathologies?","volume":"1829","author":"Manoharan","year":"2024","journal-title":"Brain Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3390\/metabo14060327","article-title":"Comprehensive strategies for metabolic syndrome: how nutrition, dietary polyphenols, physical activity, and lifestyle modifications address diabesity, cardiovascular diseases, and neurodegenerative conditions","volume":"14","author":"Martemucci","year":"2024","journal-title":"Metabolites"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3390\/cells10061542","article-title":"Neuroprotective effects of physical activity via the adaptation of astrocytes","volume":"10","author":"Maugeri","year":"2021","journal-title":"Cells"},{"key":"B100","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/B978-0-323-99971-7.00014-X","article-title":"Dietary polyphenols to maintain healthier brain measures and cognitive function, as mediated by gut microbiota metabolites","volume-title":"The gut-brain Axis","author":"Mayer","year":"2024"},{"key":"B101","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3390\/antiox12030663","article-title":"The potential of flavonoids and flavonoid metabolites in the treatment of neurodegenerative pathology in disorders of cognitive decline","volume":"12","author":"Melrose","year":"2023","journal-title":"Antioxidants"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.stemcr.2024.06.013","article-title":"Human microglial cells as a therapeutic target in a neurodevelopmental disease model","volume":"19","author":"Mesci","year":"2024","journal-title":"Stem Cell Rep."},{"key":"B103","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.3390\/molecules28052306","article-title":"Neuroprotective effects of carnosic acid: insight into its mechanisms of action","volume":"28","author":"Mirza","year":"2023","journal-title":"Molecules"},{"key":"B104","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2174\/0127724328268507231218051058","article-title":"Insights into the therapeutic and pharmacological properties of resveratrol as a nutraceutical antioxidant polyphenol in health promotion and disease prevention","volume":"19","author":"Mohammadi","year":"2024","journal-title":"Curr. Rev. Clin. Exp. Pharmacol. Former. Curr. Clin. Pharmacol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.3390\/antiox11081566","article-title":"Green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG): a time for a new player in the treatment of respiratory diseases?","volume":"11","author":"Mokra","year":"2022","journal-title":"Antioxidants"},{"key":"B106","doi-asserted-by":"crossref","DOI":"10.2174\/0118715273273539231114095300","volume-title":"Natural compounds as inhibitors of A\u03b2 peptide and tau aggregation","author":"Monteiro","year":"2024"},{"key":"B107","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3390\/nu16020233","article-title":"The effects of polyphenol supplementation on BDNF, cytokines and cognition in trained male cyclists following acute ozone exposure during high-intensity cycling","volume":"16","author":"Morton","year":"2024","journal-title":"Nutrients"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e02656","DOI":"10.1016\/j.heliyon.2019.e02656","article-title":"Contrast bath-induced neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway","volume":"5","author":"Motoda","year":"2019","journal-title":"Heliyon"},{"key":"B109","doi-asserted-by":"publisher","first-page":"e54103","DOI":"10.7759\/cureus.54103","article-title":"Protective effect of ferulic acid on acetylcholinesterase and amyloid beta peptide plaque formation in Alzheimer\u2019s disease: an in vitro study","volume":"16","author":"Mugundhan","year":"2024","journal-title":"Cureus"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.3390\/molecules27041319","article-title":"Protective effect of quercetin 3-O-glucuronide against cisplatin cytotoxicity in renal tubular cells","volume":"27","author":"Mu\u00f1oz-Reyes","year":"2022","journal-title":"Molecules"},{"key":"B111","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/jox14010014","article-title":"Phenolic compounds of therapeutic interest in neuroprotection","volume":"14","author":"N\u00e1jera-Maldonado","year":"2024","journal-title":"J. Xenobiotics"},{"key":"B112","doi-asserted-by":"publisher","first-page":"e202302065","DOI":"10.1002\/cbdv.202302065","article-title":"Grape pomace polyphenols reduce acute inflammatory response induced by carrageenan in a murine model","volume":"21","author":"Nery\u2010Flores","year":"2024","journal-title":"Chem. and Biodivers."},{"key":"B113","doi-asserted-by":"publisher","first-page":"102197","DOI":"10.1016\/j.apmt.2024.102197","article-title":"Unearthing nature's remedy: an exploration into Lycopodium's medicinal and therapeutic potential","volume":"38","author":"Niinuma","year":"2024","journal-title":"Appl. Mater. Today"},{"key":"B114","doi-asserted-by":"publisher","first-page":"116359","DOI":"10.1016\/j.ejmech.2024.116359","article-title":"Natural polyphenol: their pathogenesis-targeting therapeutic potential in Alzheimer's disease","volume":"269","author":"Niu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"B115","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.3390\/cimb46030153","article-title":"Deciphering glioblastoma: fundamental and novel insights into the biology and therapeutic strategies of gliomas","volume":"46","author":"Onciul","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1080\/07315724.2021.1981487","article-title":"The role and mechanisms of action of catechins in neurodegenerative diseases","volume":"42","author":"\u00d6zduran","year":"2023","journal-title":"J. Am. Nutr. Assoc."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.3390\/antiox12081628","article-title":"Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer\u2019s disease","volume":"12","author":"Plascencia-Villa","year":"2023","journal-title":"Antioxidants"},{"key":"B118","doi-asserted-by":"publisher","first-page":"640648","DOI":"10.3389\/fnins.2021.640648","article-title":"Citrus polyphenols in brain health and disease: current perspectives","volume":"15","author":"Pontifex","year":"2021","journal-title":"Front. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2174\/2589977515666230502153206","article-title":"Signaling pathways and molecular process of natural polyphenols in the amelioration of inflammatory bowel disease: a privileged scaffold in new drug discovery","volume":"16","author":"Prakash","year":"2024","journal-title":"Curr. Drug Res. Rev. Former. Curr. Drug Abuse Rev."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.31024\/ajpp.2019.5.s1.1","article-title":"A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent","volume":"5","author":"Prasad","year":"2019","journal-title":"Asian J. Pharm. Pharmacol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"606","DOI":"10.3390\/antiox13050606","article-title":"Role of epigenetic modulation in neurodegenerative diseases: implications of phytochemical interventions","volume":"13","author":"Prasanth","year":"2024","journal-title":"Antioxidants"},{"key":"B122","doi-asserted-by":"publisher","first-page":"14432","DOI":"10.1021\/acs.jafc.3c06238","article-title":"Pterostilbene as a therapeutic alternative for central nervous system disorders: a review of the current status and perspectives","volume":"71","author":"Qu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"B123","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3390\/antiox12020428","article-title":"Recent advances in cellular signaling interplay between redox metabolism and autophagy modulation in cancer: an overview of molecular mechanisms and therapeutic interventions","volume":"12","author":"Rahman","year":"2023","journal-title":"Antioxidants"},{"key":"B124","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bbagen.2016.10.025","article-title":"Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells","volume":"1861","author":"Rahman","year":"2017","journal-title":"Biochimica Biophysica Acta (BBA)-General Subj."},{"key":"B125","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3390\/antiox10030408","article-title":"Antioxidant compound, oxyresveratrol, inhibits APP production through the AMPK\/ULK1\/mTOR-mediated autophagy pathway in mouse cortical astrocytes","volume":"10","author":"Rahman","year":"2021","journal-title":"Antioxidants"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.3390\/biomedicines10051027","article-title":"Autophagy modulation in aggresome formation: emerging implications and treatments of Alzheimer\u2019s disease","volume":"10","author":"Rahman","year":"2022","journal-title":"Biomedicines"},{"key":"B127","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1007\/s11064-024-04199-5","article-title":"Therapeutic potential of Fingolimod on psychological symptoms and cognitive function in Neuropsychiatric and Neurological disorders","volume":"49","author":"Rahmati-Dehkordi","year":"2024","journal-title":"Neurochem. Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.2174\/1568026623666230710162217","article-title":"Therapeutic potential and molecular mechanisms of the multitargeted flavonoid fisetin","volume":"23","author":"Rauf","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"key":"B129","doi-asserted-by":"publisher","first-page":"174492","DOI":"10.1016\/j.ejphar.2021.174492","article-title":"Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: an updated review","volume":"910","author":"Ravula","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3390\/antiox13040429","article-title":"Dietary polyphenols: review on chemistry\/sources, bioavailability\/metabolism, antioxidant effects, and their role in disease management","volume":"13","author":"Rudrapal","year":"2024","journal-title":"Antioxidants"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1474267","DOI":"10.3389\/fonc.2024.1474267","article-title":"The role of genetic and epigenetic modifications as potential biomarkers in the diagnosis and prognosis of thyroid cancer","volume":"14","author":"Sabi","year":"2024","journal-title":"Front. Oncol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/1028415X.2017.1391933","article-title":"Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke","volume":"22","author":"Schreihofer","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.3390\/nu13072232","article-title":"Therapeutic effects of catechins in less common neurological and neurodegenerative disorders","volume":"13","author":"Sebastiani","year":"2021","journal-title":"Nutrients"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.3390\/antiox13101220","article-title":"Dietary polyphenols, food processing and gut microbiome: recent findings on bioavailability, bioactivity, and gut microbiome interplay","volume":"13","author":"Sejbuk","year":"2024","journal-title":"Antioxidants"},{"key":"B135","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/med.21985","article-title":"The entrancing role of dietary polyphenols against the most frequent aging\u2010associated diseases","volume":"44","author":"Shah","year":"2024","journal-title":"Med. Res. Rev."},{"key":"B136","doi-asserted-by":"publisher","first-page":"5491","DOI":"10.1080\/10408398.2022.2155106","article-title":"Potential implications of polyphenolic compounds in neurodegenerative diseases","volume":"64","author":"Shi","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B137","doi-asserted-by":"publisher","first-page":"565700","DOI":"10.3389\/fphar.2020.565700","article-title":"The pharmacological action of kaempferol in central nervous system diseases: a review","volume":"11","author":"Silva dos Santos","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"102321","DOI":"10.1016\/j.arr.2024.102321","article-title":"Advances in gene therapy approaches targeting neuro-inflammation in neurodegenerative diseases","volume":"98","author":"Singh","year":"","journal-title":"Ageing Res. Rev."},{"key":"B139","first-page":"205","article-title":"Antioxidant properties of nutraceuticals","volume-title":"Immune-boosting nutraceuticals for better human health","author":"Singh","year":""},{"key":"B140","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/ptr.8101","article-title":"Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: a comprehensive review of preclinical and clinical evidence","volume":"38","author":"Soca\u0142a","year":"2024","journal-title":"Phytotherapy Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"7","DOI":"10.31665\/jfb.2024.18376","article-title":"The influence of food matrix and processing methods on the bioaccessibility of lutein: a review","volume":"26","author":"Song","year":"2024","journal-title":"J. Food Bioact."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1456730","DOI":"10.3389\/fnut.2024.1456730","article-title":"Polyphenols in health and food processing: antibacterial, anti-inflammatory, and antioxidant insights","volume":"11","author":"Sun","year":"2024","journal-title":"Front. Nutr."},{"key":"B143","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3390\/antiox4010204","article-title":"Silymarin as a natural antioxidant: an overview of the current evidence and perspectives","volume":"4","author":"Surai","year":"2015","journal-title":"Antioxidants"},{"key":"B144","doi-asserted-by":"publisher","first-page":"597","DOI":"10.26599\/fshw.2022.9250140","article-title":"Resveratrol combats chronic diseases through enhancing mitochondrial quality","volume":"13","author":"Tao","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"B145","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s11064-023-04046-z","article-title":"Natural phenolic compounds with neuroprotective effects","volume":"49","author":"Tavan","year":"2024","journal-title":"Neurochem. Res."},{"key":"B146","doi-asserted-by":"publisher","first-page":"112668","DOI":"10.1016\/j.biopha.2022.112668","article-title":"Targeting neuroinflammation by polyphenols: a promising therapeutic approach against inflammation-associated depression","volume":"147","author":"Tayab","year":"2022","journal-title":"Biomed. and Pharmacother."},{"key":"B147","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/ijms19103199","article-title":"Pharmacoepigenomic interventions as novel potential treatments for Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"19","author":"Teijido","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/9781394203932.ch7","article-title":"Polyphenols for dyes application","author":"Thakur","year":"2024","journal-title":"Sci. Eng. Polyphenols Fundam. Industrial Scale Appl."},{"key":"B149","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3390\/ph17070831","article-title":"Targeting microglia in neuroinflammation: H3 receptor antagonists as a novel therapeutic approach for Alzheimer\u2019s disease, Parkinson\u2019s disease, and autism spectrum disorder","volume":"17","author":"Thomas","year":"2024","journal-title":"Pharmaceuticals"},{"key":"B150","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/biom11010102","article-title":"Blueberry supplementation in neuronal health and protective technologies for efficient delivery of blueberry anthocyanins","volume":"11","author":"Tran","year":"2021","journal-title":"Biomolecules"},{"key":"B151","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.3390\/ijms25073665","article-title":"Molecular mechanisms of neuroprotection after the intermittent exposures of hypercapnic hypoxia","volume":"25","author":"Tregub","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B152","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/B978-0-443-23763-8.00029-4","article-title":"Neuroprotection induced by epigallocatechin-3-gallate","volume-title":"Natural molecules in neuroprotection and neurotoxicity","author":"Tripathi","year":"2024"},{"key":"B153","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.1080\/10408398.2022.2139222","article-title":"Polyphenols and inflammatory bowel disease: natural products with therapeutic effects?","volume":"64","author":"Vaghari-Tabari","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B154","doi-asserted-by":"publisher","first-page":"914273","DOI":"10.1155\/2012\/914273","article-title":"Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects","volume":"2012","author":"Vauzour","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B155","doi-asserted-by":"publisher","first-page":"5906","DOI":"10.3390\/ijms25115906","article-title":"A comprehensive analytical review of polyphenols: evaluating neuroprotection in Alzheimer\u2019s disease","volume":"25","author":"Vicente-Zurdo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B156","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mcn.2017.04.004","article-title":"Crosstalk control and limits of physiological c-Jun N-terminal kinase activity for cell viability and neurite stability in differentiated PC12 cells","volume":"82","author":"Waetzig","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"104939","DOI":"10.1016\/j.neuint.2020.104939","article-title":"Therapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders","volume":"143","author":"Walia","year":"2021","journal-title":"Neurochem. Int."},{"key":"B158","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s11270-024-07284-1","article-title":"Evaluation of soil mixing with carpet grasses for polyphenol reductive degradation of 1, 3-dinitrobenzene contaminated soils","volume":"235","author":"Wang","year":"","journal-title":"Water, Air, and Soil Pollut."},{"key":"B159","doi-asserted-by":"publisher","first-page":"102416","DOI":"10.1016\/j.arr.2024.102416","article-title":"The roles of dietary polyphenols at crosstalk between type 2 diabetes and Alzheimer's disease in ameliorating oxidative stress and mitochondrial dysfunction via PI3K\/Akt signaling pathways","volume":"99","author":"Wang","year":"","journal-title":"Ageing Res. Rev."},{"key":"B160","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.3390\/ijms25042009","article-title":"Parkinson\u2019s disease: cells succumbing to lifelong dopamine-related oxidative stress and other bioenergetic challenges","volume":"25","author":"Watanabe","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B161","doi-asserted-by":"publisher","first-page":"106353","DOI":"10.1016\/j.fitote.2024.106353","article-title":"Epigenetic regulation by naringenin and naringin: a literature review focused on the mechanisms underlying its pharmacological effects","volume":"181","author":"Wu","year":"2024","journal-title":"Fitoterapia"},{"key":"B162","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00204-023-03660-8","article-title":"Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases","volume":"98","author":"Xiang","year":"2024","journal-title":"Archives Toxicol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"109550","DOI":"10.1016\/j.jnutbio.2023.109550","article-title":"Promotion of transcription factor EB-dependent autophagic process by curcumin alleviates arsenic-caused lung oxidative stress and inflammation in mice","volume":"125","author":"Xu","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.3390\/ijms25031641","article-title":"What can inflammation tell us about therapeutic strategies for Parkinson\u2019s disease?","volume":"25","author":"Xue","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3897\/pharmacia.71.e122169","article-title":"The small phytomolecule resveratrol: a promising role in boosting tumor cell chemosensitivity","volume":"71","author":"Yahia","year":"2024","journal-title":"Pharmacia"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.3390\/nu16111715","article-title":"Nutraceuticals for diabetic retinopathy: recent advances and novel delivery systems","volume":"16","author":"Ye","year":"2024","journal-title":"Nutrients"},{"key":"B167","doi-asserted-by":"publisher","first-page":"115131","DOI":"10.1016\/j.bbr.2024.115131","article-title":"The combined effect of morin and hesperidin on memory ability and oxidative\/nitrosative stress in a streptozotocin-induced rat model of Alzheimer\u2019s disease","volume":"471","author":"Yilmazer","year":"2024","journal-title":"Behav. Brain Res."},{"key":"B168","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/s41419-024-06807-2","article-title":"Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases","volume":"15","author":"Zeng","year":"2024","journal-title":"Cell Death and Dis."},{"key":"B169","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1021\/acs.jafc.3c08886","article-title":"Study on the digestive behavior of chlorogenic acid in biomimetic dietary fiber and the antioxidative synergistic effect of polysaccharides and chlorogenic acid","volume":"72","author":"Zhang","year":"","journal-title":"J. Agric. Food Chem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s12013-024-01233-9","article-title":"Protective effect of resveratrol combined with levodopa against oxidative damage in dopaminergic neurons","volume":"82","author":"Zhang","year":"","journal-title":"Cell Biochem. Biophysics"},{"key":"B171","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13024-024-00712-0","article-title":"Updates on mouse models of Alzheimer\u2019s disease","volume":"19","author":"Zhong","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"B172","doi-asserted-by":"publisher","first-page":"877098","DOI":"10.3389\/fphar.2022.877098","article-title":"SIRT1 is involved in the neuroprotection of pterostilbene against amyloid \u03b2 25\u201335-induced cognitive deficits in mice","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1492517\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:04:39Z","timestamp":1738829079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1492517\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":172,"alternative-id":["10.3389\/fphar.2025.1492517"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1492517","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"article-number":"1492517"}}