{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:25:20Z","timestamp":1790270720638,"version":"4.1.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013064","name":"Key Research and Development Program of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Functional dyspepsia (FD) is a prevalent functional gastrointestinal disorder characterized by the absence of organic lesions; it affects nearly one-fifth of the global population. There is currently no specific drug for treating it. Citri reticulatae Pericarpium (CRP) has been utilized in China for millennia as a therapeutic agent for alleviating bloating and spleen\u2013stomach disharmony. Nonetheless, the curative efficacy and precise molecular mechanisms implicated in FD warrant further investigation. This study aims to address this gap by investigating the potential mechanisms of CRP against FD using HPLC-ESI-QTOF-MS, network analysis prediction, and experimental validation. In this study, 90 CRP metabolites were identified by HPLC-ESI-QTOF-MS; 70 common targets of CRP and FD were extracted, and the top ten overlapped targets included MAPK1, MAPK2, and MAPK3. KEGG enrichment analysis revealed that the MAPK pathways were predominant and involved the TLR4 signaling pathway.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments demonstrated that after 14\u00a0days of treatment, CRP improved body weight, gastric emptying rate, intestinal transit rate, and the pathological structure of the gastric tissue. Serum IL-6, TNF-\u03b1, and IL-1\u03b2 were downregulated, and the expressions of TLR4, MyD88, p-NF-\u03baB, and MAPKs were suppressed in gastric tissue. Furthermore, CRP increased the relative abundance of\n                    <jats:italic>Patescibateria<\/jats:italic>\n                    and\n                    <jats:italic>Bacteroidota<\/jats:italic>\n                    , accompanied by a reduction in the relative abundance of\n                    <jats:italic>Verrucomicrobota<\/jats:italic>\n                    and\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    . In brief, CRP could attenuate dyspepsia by reducing the activation of inflammation-related TLR4\/MyD88 and MAPK signaling pathways and by mediating gut microbial structure and composition. This study provides a unique perspective for further research on drugs for treating FD.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2025.1495799","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T02:08:59Z","timestamp":1739412539000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Network analysis and experimental validation to investigate chenpi against functional dyspepsia through TLR4\/MyD88 by regulating the gut microbial structure"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinfang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3390\/ijms19020584","article-title":"Anti-inflammatory and gastroprotective roles of Rabdosia inffexa through downregulation of pro-inflammatory cytokines and MAPK\/NF-\u03baB signaling pathways","volume":"19","author":"Akanda","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3892\/ijmm.20.5.717","article-title":"Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia","volume":"20","author":"Arisawa","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13020-021-00529-9","article-title":"A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer","volume":"16","author":"Bian","year":"2021","journal-title":"Chin. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e14372","DOI":"10.1111\/nmo.14372","article-title":"Role of the duodenal microbiota in functional dyspepsia","volume":"34","author":"Brown","year":"2022","journal-title":"Neurogastroenterol. Motil."},{"key":"B5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1159\/000357854","article-title":"Gastroduodenal mechanisms underlying functional gastric disorders","volume":"32","author":"Carbone","year":"2014","journal-title":"Dig. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"590477","DOI":"10.3389\/fphar.2021.590477","article-title":"Network pharmacology-based strategy for elucidating the molecular basis forthe pharmacologic effects of licorice (Glycyrrhiza spp.)","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"255","DOI":"10.5056\/jnm21204","article-title":"Yokukansan suppresses gastric hypersensitivity and eosinophil-associated microinflammation in rats with functional dyspepsia","volume":"28","author":"Duan","year":"2022","journal-title":"J. Neurogastroenterol. Motil."},{"key":"B9","doi-asserted-by":"publisher","first-page":"17081","DOI":"10.1038\/nrdp.2017.81","article-title":"Functional dyspepsia","volume":"3","author":"Enck","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/S0140-6736(20)30469-4","article-title":"Functional dyspepsia","volume":"396","author":"Ford","year":"2020","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1136\/gutjnl-2014-307843","article-title":"Global prevalence of, and risk factors for, uninvestigated dyspepsia: a meta-analysis","volume":"64","author":"Ford","year":"2015","journal-title":"Gut"},{"key":"B12","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1177\/0300060517726442","article-title":"Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying","volume":"46","author":"Guo","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.5056\/jnm.2010.16.1.30","article-title":"Post-infectious irritable bowel syndrome, an inflammation-immunological model with relevance for other IBS and functional dyspepsia","volume":"16","author":"Gwee","year":"2010","journal-title":"J. Neurogastroenterol. Motil."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1007\/s00394-016-1207-z","article-title":"Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells","volume":"56","author":"Hagenlocher","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1385159","DOI":"10.3389\/fnut.2024.1385159","article-title":"Supplementation of Crataegi Fructus alleviates functional dyspepsia and restores gut microbiota in mice","volume":"11","author":"Hao","year":"2024","journal-title":"Front. Nutr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.fct.2014.06.014","article-title":"Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)","volume":"71","author":"Ho","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"111834","DOI":"10.1016\/j.jep.2019.111834","article-title":"Banha-sasim-tang improves gastrointestinal function in loperamide-induced functional dyspepsia mouse model","volume":"238","author":"Jeon","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4941","DOI":"10.1113\/JP280023","article-title":"Hypothalamic-vagal oxytocinergic neurocircuitry modulates gastric emptying and motility following stress","volume":"598","author":"Jiang","year":"2020","journal-title":"J. Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40168-021-01007-y","article-title":"Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis","volume":"9","author":"Jing","year":"2021","journal-title":"Microbiome"},{"key":"B20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0300-483x(02)00514-0","article-title":"The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions","volume":"183","author":"Kahraman","year":"2003","journal-title":"Toxicology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"621","DOI":"10.5009\/gnl230130","article-title":"Associations among the duodenal ecosystem, gut microbiota, and nutrient intake in functional dyspepsia","volume":"18","author":"Kim","year":"2024","journal-title":"Gut Liver"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e9391","DOI":"10.7717\/peerj.9391","article-title":"Shannon diversity index: a call to replace the original Shannon\u2019s formula with unbiased estimator in the population genetics studies","volume":"8","author":"Konopi\u0144ski","year":"2020","journal-title":"PeerJ"},{"key":"B23","doi-asserted-by":"publisher","first-page":"6229","DOI":"10.1007\/s11033-020-05611-3","article-title":"Molecular link between dietary fibre, gut microbiota and health","volume":"47","author":"Kumar","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.2174\/13816128113199990572","article-title":"Gastrointestinal motility and functional gastrointestinal diseases","volume":"20","author":"Kusano","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"B25","doi-asserted-by":"publisher","first-page":"104501","DOI":"10.1016\/j.psyneuen.2019.104501","article-title":"Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: a transdisciplinary challenge","volume":"111","author":"Labanski","year":"2020","journal-title":"Psychoneuroendocrino"},{"key":"B26","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S1875-5364(13)60037-0","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ejphar.2013.06.017","article-title":"Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-\u03b1, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-\u03baB activation and MAPK pathway","volume":"715","author":"Li","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1080\/08923973.2017.1379088","article-title":"The gastroprotective effect of nobiletin against ethanol-induced acute gastric lesions in mice: impact on oxidative stress and inflammation","volume":"39","author":"Li","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.4103\/sjg.SJG_505_17","article-title":"Evaluation of a modified rat model for functional dyspepsia","volume":"24","author":"Liang","year":"2018","journal-title":"Saudi. J. Gastroenterol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5281","DOI":"10.3390\/nu14245281","article-title":"Hesperidin reversed long-term N-methyl- N-nitro- N-nitroguanidine exposure induced EMT and cell proliferation by activating autophagy in gastric tissues of rats","volume":"14","author":"Liang","year":"2022","journal-title":"Nutrients"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1038\/s41396-022-01253-4","article-title":"Ecological dynamics of the gut microbiome in response to dietary fiber","volume":"16","author":"Liu","year":"2022","journal-title":"ISME J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"549749","DOI":"10.3389\/fpsyt.2020.549749","article-title":"Unaltered brain GABA concentrations and resting fMRI activity in functional dyspepsia with and without comorbid depression","volume":"11","author":"Mak","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.jep.2017.09.008","article-title":"The hydro-alcoholic extracts of Sardinian wild thistles (Onopordum spp.) inhibit TNF\u03b1-induced IL-8 secretion and NF-\u03baB pathway in human gastric epithelial AGS cells","volume":"210","author":"Marengo","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/82_2011_187","article-title":"Lactobacillus: host-microbe relationships","volume":"358","author":"O\u2019Callaghan","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"C800","DOI":"10.1152\/ajpcell.00157.2008","article-title":"Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7","volume":"295","author":"Oshima","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1254\/fpj.94.17","article-title":"Pharmacological studies of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult","volume":"94","author":"Ozaki","year":"1989","journal-title":"Uncaria rhynchophylla Miq. Amsonia elliptica Roem. Schult. Nihon Yakurigaku Zasshi."},{"key":"B37","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000366206","article-title":"Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-\u03baB, transforming growth factor-\u03b2 and connective tissue growth factor","volume":"94","author":"Perez-Vargas","year":"2014","journal-title":"Pharmacology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"153926","DOI":"10.1016\/j.phymed.2022.153926","article-title":"Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4\/NF-\u03baB and Keap1\/Nrf2 signaling pathways: a comprehensive study on in-vitro and in-vivo experimental models","volume":"97","author":"Puppala","year":"2022","journal-title":"Phytomedicine"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s40265-020-01362-4","article-title":"Functional dyspepsia: diagnostic and therapeutic approaches","volume":"80","author":"Sayuk","year":"2020","journal-title":"Drugs"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e11159","DOI":"10.1016\/j.heliyon.2022.e11159","article-title":"Amelioration of ethanol-induced gastric ulcer in rats by quercetin: implication of Nrf2\/HO1 and HMGB1\/TLR4\/NF-\u03baB pathways","volume":"8","author":"Shams","year":"2022","journal-title":"Heliyon"},{"key":"B41","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nrgastro.2013.14","article-title":"Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria","volume":"10","author":"Tack","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.cgh.2015.09.043","article-title":"Efficacy of mirtazapine in patients with functional dyspepsia and weight loss","volume":"14","author":"Tack","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3904\/kjim.2016.091","article-title":"Functional dyspepsia: new insights into pathogenesis and therapy","volume":"31","author":"Talley","year":"2016","journal-title":"Korean J. Intern Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e1187325","DOI":"10.1080\/21688370.2016.1187325","article-title":"Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 Cells","volume":"4","author":"Thakre-Nighot","year":"2016","journal-title":"Tissue Barriers"},{"key":"B45","doi-asserted-by":"publisher","first-page":"583160","DOI":"10.3389\/fphar.2020.583160","article-title":"Treatment of spleen-deficiency syndrome with atractyloside A from bran-processed atractylodes lancea by protection of the intestinal mucosal barrier","volume":"11","author":"Tu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ajg.2016.499","article-title":"Pathophysiological abnormalities in functional dyspepsia subgroups according to the Rome III criteria","volume":"112","author":"Vanheel","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"526","DOI":"10.13703\/j.0255-2930.20191121-0002","article-title":"Effect of acupuncture on intestinal flora in rats with stress gastric ulcer","volume":"40","author":"Wang","year":"2020","journal-title":"Zhongguo Zhen Jiu"},{"key":"B48","doi-asserted-by":"publisher","first-page":"117659","DOI":"10.1016\/j.jep.2024.117954","article-title":"Effect of Chaihu-Shugan-San on functional dyspepsia and gut microbiota: a randomized, double-blind, placebo-controlled trial","volume":"322","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/gutjnl-2019-318536","article-title":"Novel concepts in the pathophysiology and treatment of functional dyspepsia","volume":"69","author":"Wauters","year":"2020","journal-title":"Gut"},{"key":"B50","doi-asserted-by":"publisher","first-page":"153764","DOI":"10.1016\/j.phymed.2021.153764","article-title":"Dehydroevodiamine ameliorates indomethacin-induced gastric injury via inhibition of ERK and p38 signaling pathway","volume":"93","author":"Wei","year":"2021","journal-title":"Phytomedicine"},{"key":"B51","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.98.2553.481","article-title":"Emotions and gastric function","volume":"98","author":"Wolf","year":"1943","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.yclnex.2017.02.001","article-title":"Effects of synbiotics on intestinal mucosal barrier in rat model","volume":"13","author":"Xue","year":"2017","journal-title":"Clin. Nutr. Exp."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s00210-021-02132-z","article-title":"Inflammation suppression in doxorubicin-induced cardiotoxicity: natural compounds as therapeutic options","volume":"394","author":"Yarmohammadi","year":"2021","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jep.2018.03.031","article-title":"Citri Reticulatae Pericarpium (Chenpi): botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine","volume":"220","author":"Yu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1039\/c9fo02907a","article-title":"Aged citrus peel (chenpi) extract causes dynamic alteration of colonic microbiota in high-fat diet induced obese mice","volume":"11","author":"Zhang","year":"2020","journal-title":"Food Funct."},{"key":"B56","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3892\/or.2015.3982","article-title":"Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells","volume":"34","author":"Zhang","year":"2015","journal-title":"Oncol. Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"154180","DOI":"10.1016\/j.phymed.2022.154180","article-title":"Wei-Tong-Xin ameliorates functional dyspepsia via inactivating TLR4\/MyD88 by regulating gut microbial structure and metabolites","volume":"102","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"B58","doi-asserted-by":"publisher","first-page":"586350","DOI":"10.3389\/fphar.2020.586350","article-title":"Integrating pharmacology and gut microbiota analysis to explore the mechanism of Citri reticulatae pericarpium against reserpine-induced spleen deficiency in rats","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e919815","DOI":"10.12659\/MSM.919815","article-title":"The effects of low-dose and high-dose decoctions of Fructus aurantii in a rat model of functional dyspepsia","volume":"26","author":"Zhu","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2390136","DOI":"10.1080\/19490976.2024.2390136","article-title":"Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice","volume":"16","author":"Zhu","year":"2024","journal-title":"Gut Microbes"},{"key":"B61","doi-asserted-by":"publisher","first-page":"113626","DOI":"10.1016\/j.biopha.2022.113626","article-title":"Citri Reticulatae Pericarpium (Chenpi): a multi-efficacy pericarp in treating cardiovascular diseases","volume":"154","author":"Zou","year":"2022","journal-title":"Biomed. Pharmacother."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1495799\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T02:09:03Z","timestamp":1739412543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1495799\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":61,"alternative-id":["10.3389\/fphar.2025.1495799"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1495799","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"article-number":"1495799"}}