{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:21:22Z","timestamp":1789154482786,"version":"build-2803163510"},"reference-count":193,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JUSRP124036"],"award-info":[{"award-number":["JUSRP124036"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Pulmonary hypertension (PH) is a complex and progressive vascular disease characterized by elevated pulmonary arterial pressure (PAP) and vascular resistance, leading to right ventricular failure and, ultimately, death. Current therapies primarily focus on vasodilation and symptom management, but there remains a critical need for treatments that address the underlying pathophysiological mechanisms of PH. Numerous studies have identified hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) as a potential therapeutic target in PH. Traditionally recognized for its toxic effects at high concentrations, H<jats:sub>2<\/jats:sub>S is now known to play crucial roles in various physiological processes, including vasodilation, anti-inflammation, and antioxidation, which are relevant to PH pathogenesis. Given its multifaceted roles in the pathophysiology of PH, H<jats:sub>2<\/jats:sub>S represents a promising therapeutic target. Strategies to enhance endogenous H<jats:sub>2<\/jats:sub>S production or administer exogenous H<jats:sub>2<\/jats:sub>S donors are being explored as potential treatments for PH. These approaches aim to harness the vasodilatory, anti-inflammatory, antioxidant, and anti-remodeling properties of H<jats:sub>2<\/jats:sub>S to mitigate disease progression and improve patient outcomes. Future research should focus on optimizing H<jats:sub>2<\/jats:sub>S-based therapies and exploring their clinical efficacy and safety in PH patients.<\/jats:p>","DOI":"10.3389\/fphar.2025.1510275","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T05:39:00Z","timestamp":1747028340000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation"],"prefix":"10.3389","volume":"16","author":[{"given":"Xue-Xue","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Bo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Bao","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wei","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-019-03506-x","article-title":"Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy","volume":"457","author":"Ahmed","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jaut.2019.01.011","article-title":"Primary immunodeficiency and autoimmunity: a comprehensive review","volume":"99","author":"Amaya-Uribe","year":"2019","journal-title":"J. Autoimmun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1021\/acs.chemrestox.5b00067","article-title":"Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity","volume":"28","author":"Angeloni","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1161\/CIRCRESAHA.115.303404","article-title":"The genetics of pulmonary arterial hypertension","volume":"115","author":"Austin","year":"2014","journal-title":"Circ. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.repc.2024.03.004","article-title":"Pulmonary arterial hypertension: navigating the pathways of progress in diagnosis, treatment, and patient care","volume":"43","author":"Azaredo Raposo","year":"2024","journal-title":"Rev. Port. Cardiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1161\/CIRCULATIONAHA.123.067005","article-title":"ErbB3 governs endothelial dysfunction in hypoxia-induced pulmonary hypertension","volume":"150","author":"Bian","year":"2024","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.3390\/ijms18071436","article-title":"A novel therapeutic approach in the treatment of pulmonary arterial hypertension: Allium ursinum liophylisate alleviates symptoms comparably to Sildenafil","volume":"18","author":"Bombicz","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"L710","DOI":"10.1152\/ajplung.00311.2016","article-title":"The mast cell-B cell axis in lung vascular remodeling and pulmonary hypertension","volume":"312","author":"Breitling","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3390\/antiox9121303","article-title":"Hydrogen sulfide and carnosine: modulation of oxidative stress and inflammation in kidney and brain Axis","volume":"9","author":"Calabrese","year":"2020","journal-title":"Antioxidants (Basel)."},{"key":"B11","doi-asserted-by":"publisher","first-page":"167519","DOI":"10.1016\/j.bbadis.2024.167519","article-title":"Unraveling the pathogenesis of viral-induced pulmonary arterial hypertension: possible new therapeutic avenues with mesenchymal stromal cells and their derivatives","volume":"1871","author":"Castillo-Gal\u00e1n","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.chembiol.2018.04.001","article-title":"S marks the spot: linking the antioxidant activity of N-acetyl cysteine to H(2)S and sulfane sulfur species","volume":"25","author":"Cerda","year":"2018","journal-title":"Cell. Chem. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1080\/10799893.2020.1738482","article-title":"Expression of pulmonary arterial elastin in rats with hypoxic pulmonary hypertension using H2S","volume":"40","author":"Chen","year":"2020","journal-title":"J. Recept Signal Transduct. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.resp.2012.03.009","article-title":"The message in the air: hydrogen sulfide metabolism in chronic respiratory diseases","volume":"184","author":"Chen","year":"2012","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B15","first-page":"694","article-title":"Endogenous hydrogen sulfide in patients with chronic obstructive pulmonary disease","volume":"28","author":"Chen","year":"2005","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"B16","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.1021\/jf304951p","article-title":"Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K\/Akt signaling pathways","volume":"61","author":"Chiang","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"11601","DOI":"10.1074\/jbc.M808026200","article-title":"H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia","volume":"284","author":"Chiku","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/s0006-291x(03)00256-0","article-title":"The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats","volume":"302","author":"Chunyu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.drudis.2014.04.007","article-title":"Inflammation in pulmonary hypertension: what we know and what we could logically and safely target first","volume":"19","author":"Cohen-Kaminsky","year":"2014","journal-title":"Drug Discov. Today"},{"key":"B21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s10863-008-9166-6","article-title":"The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance","volume":"40","author":"Cooper","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"B22","doi-asserted-by":"publisher","first-page":"12823","DOI":"10.3390\/ijms252312823","article-title":"Complement immune system in pulmonary hypertension-cooperating roles of circadian rhythmicity in complement-mediated vascular pathology","volume":"25","author":"Devaughn","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"szae095","DOI":"10.1093\/stcltm\/szae095","article-title":"Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential","volume":"14","author":"Doktor","year":"2025","journal-title":"Stem Cells Transl. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1089\/ars.2017.7195","article-title":"Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide","volume":"30","author":"Du","year":"2019","journal-title":"Antioxid. Redox Signal"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3390\/antiox11071255","article-title":"The role of organosulfur compounds as Nrf2 activators and their antioxidant effects","volume":"11","author":"Egbujor","year":"2022","journal-title":"Antioxidants (Basel)."},{"key":"B26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.pcad.2012.07.006","article-title":"Immune and inflammatory mechanisms in pulmonary arterial hypertension","volume":"55","author":"El Chami","year":"2012","journal-title":"Prog. Cardiovasc Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/ACO.0b013e3283421201","article-title":"Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing","volume":"24","author":"Evans","year":"2011","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/labinvest.2016.129","article-title":"H(2)S inhibits pulmonary arterial endothelial cell inflammation in rats with monocrotaline-induced pulmonary hypertension","volume":"97","author":"Feng","year":"2017","journal-title":"Lab. Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.4049\/jimmunol.1701287","article-title":"Inflammatory macrophage expansion in pulmonary hypertension depends upon mobilization of blood-borne monocytes","volume":"200","author":"Florentin","year":"2018","journal-title":"J. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1152\/japplphysiol.00083.2002","article-title":"Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression","volume":"93","author":"Fujita","year":"2002","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"R1479","DOI":"10.1152\/ajpregu.90566.2008","article-title":"Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values","volume":"295","author":"Furne","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1183\/09031936.00139009","article-title":"Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"34","author":"Gali\u00e8","year":"2009","journal-title":"Eur. Respir. J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"247372","DOI":"10.1155\/2014\/247372","article-title":"Effect of Th17 and Treg axis disorder on outcomes of pulmonary arterial hypertension in connective tissue diseases","volume":"2014","author":"Gaowa","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"B34","doi-asserted-by":"publisher","first-page":"117706","DOI":"10.1016\/j.biopha.2024.117706","article-title":"A new perspective on targeting pulmonary arterial hypertension: programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis)","volume":"181","author":"Ge","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B35","first-page":"106","article-title":"Hydrogen sulfide: a novel cardiovascular functional regulatory gas factor","volume":"36","author":"Geng","year":"2004","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1136\/heartjnl-2024-324237","article-title":"Low diffusing capacity for carbon monoxide in chronic thromboembolic pulmonary hypertension: a biomarker for microvascular disease?","volume":"110","author":"Gerges","year":"2024","journal-title":"Heart"},{"key":"B37","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.phrs.2016.08.019","article-title":"The novel mitochondria-targeted hydrogen sulfide (H(2)S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro","volume":"113","author":"Ger\u0151","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.freeradbiomed.2010.02.014","article-title":"Modulation of thiol homeostasis induced by H2S-releasing aspirin","volume":"48","author":"Giustarini","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1096\/fj.06-7407com","article-title":"Sulfide, the first inorganic substrate for human cells","volume":"21","author":"Goubern","year":"2007","journal-title":"Faseb J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1465-9921-15-47","article-title":"Inflammatory cytokines in pulmonary hypertension","volume":"15","author":"Groth","year":"2014","journal-title":"Respir. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"105979","DOI":"10.1016\/j.intimp.2019.105979","article-title":"Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2\/HIF-1\u03b1\/MAPK signaling pathway","volume":"81","author":"Guan","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1097\/HJH.0000000000003756","article-title":"Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire","volume":"42","author":"Halimi","year":"2024","journal-title":"J. Hypertens."},{"key":"B43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/bph.16208","article-title":"AhR-STAT3-HO-1\/COX-2 signalling pathway may restrict ferroptosis and improve hMSC accumulation and efficacy in mouse liver","volume":"181","author":"Han","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1089\/ars.2010.3821","article-title":"Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice","volume":"15","author":"Han","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"B45","doi-asserted-by":"publisher","first-page":"107216","DOI":"10.1016\/j.vph.2023.107216","article-title":"MicroRNAs and their regulators: potential therapeutic targets in pulmonary arterial hypertension","volume":"153","author":"He","year":"2023","journal-title":"Vasc. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1177\/0961203307087610","article-title":"Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report","volume":"17","author":"Hennigan","year":"2008","journal-title":"Lupus"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1111\/j.1742-4658.2008.06482.x","article-title":"Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria","volume":"275","author":"Hildebrandt","year":"2008","journal-title":"Febs J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1089\/ars.2016.6737","article-title":"Rapid antidepressant effect of hydrogen sulfide: evidence for activation of mTORC1-TrkB-AMPA receptor pathways","volume":"27","author":"Hou","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"B49","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1089\/ars.2012.4944","article-title":"The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613","volume":"19","author":"Hourihan","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.4252\/wjsc.v15.i11.1017","article-title":"Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: role of cystathionine \u03b3-lyase\/hydrogen sulfide pathway","volume":"15","author":"Hu","year":"2023","journal-title":"World J. Stem Cells"},{"key":"B51","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00424-007-0346-8","article-title":"Cyclooxygenase-2 mediates the delayed cardioprotection induced by hydrogen sulfide preconditioning in isolated rat cardiomyocytes","volume":"455","author":"Hu","year":"2008","journal-title":"Pflugers Arch."},{"key":"B52","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/antiox12030650","article-title":"H(2)S donors with cytoprotective effects in models of MI\/R injury and chemotherapy-induced cardiotoxicity","volume":"12","author":"Hu","year":"2023","journal-title":"Antioxidants (Basel)."},{"key":"B53","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2174\/0113892010302590240321073509","article-title":"Noncoding rna lipotherapeutics: a promising breakthrough in pulmonary hypertension treatment","volume":"26","author":"Hu","year":"2025","journal-title":"Curr. Pharm. Biotechnol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1089\/ars.2021.0213","article-title":"Sulfur dioxide: endogenous generation, biological effects, detection, and therapeutic potential","volume":"36","author":"Huang","year":"2022","journal-title":"Antioxid. Redox Signal"},{"key":"B55","doi-asserted-by":"publisher","first-page":"175455","DOI":"10.1016\/j.ejphar.2022.175455","article-title":"Hydrogen sulfide as a neuromodulator of the vascular tone","volume":"940","author":"Huerta De La Cruz","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.niox.2024.03.002","article-title":"Sulfide catabolism in hibernation and neuroprotection","volume":"146","author":"Ichinose","year":"2024","journal-title":"Nitric Oxide"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20221006","article-title":"Reactive sulfur species and their significance in health and disease","volume":"42","author":"Iciek","year":"2022","journal-title":"Biosci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/em.20474","article-title":"Biological properties of garlic and garlic-derived organosulfur compounds","volume":"50","author":"Iciek","year":"2009","journal-title":"Environ. Mol. Mutagen"},{"key":"B59","doi-asserted-by":"publisher","first-page":"6804","DOI":"10.1021\/bi300778t","article-title":"Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite","volume":"51","author":"Jackson","year":"2012","journal-title":"Biochemistry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1177\/1934578x1100600923","article-title":"Phenolic composition, antioxidant capacity and antibacterial activity of selected Irish Brassica vegetables","volume":"6","author":"Jaiswal","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"B61","doi-asserted-by":"publisher","first-page":"111226","DOI":"10.1016\/j.cbi.2024.111226","article-title":"Emerging roles of hydrogen sulfide in colorectal cancer","volume":"403","author":"Jiang","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"B62","first-page":"2235","article-title":"Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats","volume":"88","author":"Jin","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B63","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S biogenesis, decay and signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"B64","doi-asserted-by":"publisher","first-page":"108787","DOI":"10.1016\/j.pharmthera.2024.108787","article-title":"Essential role of sulfide oxidation in brain health and neurological disorders","volume":"266","author":"Kanemaru","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"B65","doi-asserted-by":"publisher","first-page":"H853","DOI":"10.1152\/ajpheart.00321.2019","article-title":"Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension","volume":"318","author":"Kang","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1378\/chest.127.4.1446","article-title":"Simvastatin treatment of pulmonary hypertension: an observational case series","volume":"127","author":"Kao","year":"2005","journal-title":"Chest"},{"key":"B67","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12016-011-8265-z","article-title":"The role of inflammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension","volume":"44","author":"Kherbeck","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1080\/14786419.2017.1323211","article-title":"Comparative studies of bioactive organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.)","volume":"32","author":"Kim","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"938520","DOI":"10.3389\/fbioe.2022.938520","article-title":"Tocopherol attenuates the oxidative stress of BMSCs by inhibiting ferroptosis through the PI3k\/AKT\/mTOR pathway","volume":"10","author":"Lan","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"812","DOI":"10.3390\/nu10070812","article-title":"Allicin bioavailability and bioequivalence from garlic supplements and garlic foods","volume":"10","author":"Lawson","year":"2018","journal-title":"Nutrients"},{"key":"B71","doi-asserted-by":"publisher","first-page":"848867","DOI":"10.3389\/fphys.2022.848867","article-title":"Benefits of curcumin in the vasculature: a therapeutic candidate for vascular remodeling in arterial hypertension and pulmonary arterial hypertension?","volume":"13","author":"Li","year":"2022","journal-title":"Front. Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13578-016-0090-x","article-title":"Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-\u03baB and JAK2-STAT3 pathways in the aging cardiomyocytes","volume":"6","author":"Li","year":"2016","journal-title":"Cell. Biosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","article-title":"Hydrogen sulfide and cell signaling","volume":"51","author":"Li","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"10384","DOI":"10.1039\/d0tb01821j","article-title":"Targeted miR-21 loaded liposomes for acute myocardial infarction","volume":"8","author":"Li","year":"2020","journal-title":"J. Mat. Chem. B"},{"key":"B75","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.niox.2013.07.001","article-title":"Chemical foundations of hydrogen sulfide biology","volume":"35","author":"Li","year":"2013","journal-title":"Nitric Oxide"},{"key":"B76","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1089\/ars.2014.6186","article-title":"Hydrogen sulfide maintains mitochondrial DNA replication via demethylation of TFAM","volume":"23","author":"Li","year":"2015","journal-title":"Antioxid. Redox Signal"},{"key":"B77","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2147\/DDDT.S293025","article-title":"L-cysteine provides neuroprotection of hypoxia-ischemia injury in neonatal mice via a PI3K\/Akt-Dependent mechanism","volume":"15","author":"Li","year":"2021","journal-title":"Drug Des. Devel Ther."},{"key":"B78","first-page":"3032","article-title":"Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow","volume":"122","author":"Li","year":"2009","journal-title":"Chin. Med. J. Engl."},{"key":"B79","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00380-008-1059-4","article-title":"Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow","volume":"23","author":"Li","year":"2008","journal-title":"Heart Vessels"},{"key":"B80","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/antiox9030205","article-title":"Inhibitory effect and mechanism of action of quercetin and quercetin diels-alder anti-dimer on erastin-induced ferroptosis in bone marrow-derived mesenchymal stem cells","volume":"9","author":"Li X.","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B81","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1111\/j.1745-7254.2006.00353.x","article-title":"Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats","volume":"27","author":"Li","year":"","journal-title":"Acta Pharmacol. Sin."},{"key":"B82","first-page":"159","article-title":"Impact of hydrogen sulfide donor on pulmonary vascular structure and vasoactive peptides in rats with pulmonary hypertension induced by high pulmonary blood flow","volume":"28","author":"Li","year":"","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"B83","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3892\/ijmm.2013.1579","article-title":"H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2\/PGI2","volume":"33","author":"Li","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.2147\/COPD.S314349","article-title":"Relationship between endogenous hydrogen sulfide and pulmonary vascular indexes on high-resolution computed tomography in patients with chronic obstructive pulmonary disease","volume":"16","author":"Liao","year":"2021","journal-title":"Int. J. Chron. Obstruct Pulmon Dis."},{"key":"B85","doi-asserted-by":"publisher","first-page":"12077","DOI":"10.1074\/jbc.RA119.009442","article-title":"Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells","volume":"294","author":"Libiad","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.4103\/0366-6999.215328","article-title":"Sirtuin 1 mediates hydrogen sulfide-induced cytoprotection effects in neonatal mouse cardiomyocytes","volume":"130","author":"Liu","year":"2017","journal-title":"Chin. Med. J. Engl."},{"key":"B87","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41420-022-00902-z","article-title":"The NSUN5-FTH1\/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells","volume":"8","author":"Liu J.","year":"2022","journal-title":"Stem Cells"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.3892\/ijmm.2018.3419","article-title":"Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK\/STAT signaling pathway","volume":"41","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1494557","DOI":"10.3389\/fcell.2024.1494557","article-title":"An update: epigenetic mechanisms underlying methamphetamine addiction","volume":"12","author":"Liu","year":"2024","journal-title":"Front. Cell. Dev. Biol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1282403","DOI":"10.3389\/fphar.2023.1282403","article-title":"Advances in the research of sulfur dioxide and pulmonary hypertension","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"911704","DOI":"10.3389\/fphar.2022.911704","article-title":"Hydrogen sulfide-induced vasodilation: the involvement of vascular potassium channels","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/ars.2011.4005","article-title":"Hydrogen sulfide in the mammalian cardiovascular system","volume":"17","author":"Liu","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"B93","doi-asserted-by":"publisher","first-page":"9362","DOI":"10.1111\/jcmm.15587","article-title":"Hydrogen sulphide ameliorating skeletal muscle atrophy in db\/db mice via Muscle RING finger 1 S-sulfhydration","volume":"24","author":"Lu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jare.2020.05.007","article-title":"Hydrogen sulfide and vascular regulation - an update","volume":"27","author":"Lv","year":"2021","journal-title":"J. Adv. Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1152\/japplphysiol.01049.2011","article-title":"Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung","volume":"112","author":"Madden","year":"2012","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejim.2024.07.030","article-title":"Pulmonary hypertension associated to left heart disease: phenotypes and treatment","volume":"129","author":"Madonna","year":"2024","journal-title":"Eur. J. Intern Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/bph.15991","article-title":"Recent therapeutic approaches to cystathionine beta-synthase-deficient homocystinuria","volume":"180","author":"Majtan","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/ars.2017.7009","article-title":"Biogenesis of hydrogen sulfide and thioethers by cystathionine beta-synthase","volume":"28","author":"Majtan","year":"2018","journal-title":"Antioxid. Redox Signal"},{"key":"B99","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1093\/bmb\/ldr018","article-title":"Cardiac cell therapy: where we've been, where we are, and where we should be headed","volume":"98","author":"Malliaras","year":"2011","journal-title":"Br. Med. Bull."},{"key":"B100","doi-asserted-by":"publisher","first-page":"100382","DOI":"10.1016\/j.phanu.2024.100382","article-title":"Therapeutic potential of organosulfur compounds in pulmonary hypertension","volume":"27","author":"Mirhadi","year":"2024","journal-title":"PharmaNutrition"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.3390\/antiox13101158","article-title":"Signaling paradigms of H2S-induced vasodilation: a comprehensive review","volume":"13","author":"Munteanu","year":"2024","journal-title":"A Compr. Rev."},{"key":"B102","doi-asserted-by":"publisher","first-page":"105977","DOI":"10.1016\/j.biocel.2021.105977","article-title":"Role of Kr\u00fcppel-like factors in pulmonary arterial hypertension","volume":"134","author":"Nicoleau","year":"2021","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1161\/CIRCRESAHA.120.316943","article-title":"Periostin: a potential therapeutic target for pulmonary hypertension?","volume":"127","author":"Nie","year":"2020","journal-title":"Circ. Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jphs.2024.04.005","article-title":"Sulfur metabolism as a new therapeutic target of heart failure","volume":"155","author":"Nishimura","year":"2024","journal-title":"J. Pharmacol. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bcp.2017.12.010","article-title":"H(2)S and polysulfide metabolism: conventional and unconventional pathways","volume":"149","author":"Olson","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.redox.2017.11.009","article-title":"Metabolism of hydrogen sulfide (H(2)S) and production of reactive sulfur species (RSS) by superoxide dismutase","volume":"15","author":"Olson","year":"2018","journal-title":"Redox Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.redox.2017.02.021","article-title":"Catalase as a sulfide-sulfur oxido-reductase: an ancient (and modern?) regulator of reactive sulfur species (RSS)","volume":"12","author":"Olson","year":"2017","journal-title":"Redox Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"R51","DOI":"10.1152\/ajpregu.00576.2009","article-title":"Hypoxic pulmonary vasodilation: a paradigm shift with a hydrogen sulfide mechanism","volume":"298","author":"Olson","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"109182","DOI":"10.1016\/j.jnutbio.2022.109182","article-title":"Sulforaphane alleviated vascular remodeling in hypoxic pulmonary hypertension via inhibiting inflammation and oxidative stress","volume":"111","author":"Pan","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3389\/fphar.2017.00686","article-title":"The role of hydrogen sulfide on cardiovascular homeostasis: an overview with update on immunomodulation","volume":"8","author":"Pan","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2022.05.005","article-title":"Cysteine metabolism and hydrogen sulfide signaling in Huntington's disease","volume":"186","author":"Paul","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B112","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H2S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.3390\/cells11213465","article-title":"Hydrogen sulfide regulates SERCA2a ubiquitylation via muscle RING finger-1 S-sulfhydration to affect cardiac contractility in db\/db mice","volume":"11","author":"Peng","year":"2022","journal-title":"Cells"},{"key":"B114","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1164\/rccm.201308-1543PP","article-title":"Novel and emerging therapies for pulmonary hypertension","volume":"189","author":"Pullamsetti","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.foodchem.2018.10.068","article-title":"An overview of organosulfur compounds from Allium spp.: from processing and preservation to evaluation of their bioavailability, antimicrobial, and anti-inflammatory properties","volume":"276","author":"Putnik","year":"2019","journal-title":"Food Chem."},{"key":"B116","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3892\/ijmm.2015.2396","article-title":"Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2\/ARE pathway","volume":"37","author":"Qi","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"7845503","DOI":"10.1155\/2022\/7845503","article-title":"Target nuclear factor erythroid 2-related factor 2 in pulmonary hypertension: molecular insight into application","volume":"2022","author":"Qin","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B118","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bbrc.2004.02.176","article-title":"Impact of hydrogen sulfide on carbon monoxide\/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension","volume":"317","author":"Qingyou","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1161\/CIRCRESAHA.113.301141","article-title":"Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension","volume":"115","author":"Rabinovitch","year":"2014","journal-title":"Circ. Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"389S","DOI":"10.3945\/jn.114.202192","article-title":"Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review","volume":"146","author":"Ried","year":"2016","journal-title":"J. Nutr."},{"key":"B121","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3390\/molecules23030624","article-title":"Isothiocyanates: an overview of their antimicrobial activity against human infections","volume":"23","author":"Romeo","year":"2018","journal-title":"Molecules"},{"key":"B122","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/bs.mie.2014.11.014","article-title":"GYY4137, a novel water-soluble, H2S-releasing molecule","volume":"554","author":"Rose","year":"2015","journal-title":"Methods Enzymol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3390\/cells10061477","article-title":"Hydrogen sulfide metabolism and pulmonary hypertension","volume":"10","author":"Roubenne","year":"2021","journal-title":"Cells"},{"key":"B124","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-3-030-63046-1_13","article-title":"Redox regulation, oxidative stress, and inflammation in group 3 pulmonary hypertension","volume":"1303","author":"Rudyk","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1081\/GNC-120005388","article-title":"Dual role of organosulfur compounds in foods: a review","volume":"20","author":"Sahu","year":"2002","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1007\/s11064-015-1784-x","article-title":"Pharmacological actions of hydrogen sulfide donors on sympathetic neurotransmission in the bovine anterior uvea, in vitro","volume":"41","author":"Salvi","year":"2016","journal-title":"Neurochem. Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1378\/chest.130.1.182","article-title":"Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension","volume":"130","author":"Sanchez","year":"2006","journal-title":"Chest"},{"key":"B128","doi-asserted-by":"publisher","first-page":"8600","DOI":"10.3390\/ijms22168600","article-title":"Anti-inflammatory effect of allicin associated with fibrosis in pulmonary arterial hypertension","volume":"22","author":"S\u00e1nchez-Gloria","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1080\/17476348.2021.1840981","article-title":"Understanding hydrogen sulfide signaling in neonatal airway disease","volume":"15","author":"Schiliro","year":"2021","journal-title":"Expert Rev. Respir. Med."},{"key":"B130","first-page":"566","article-title":"Effects of high pulmonary blood flow on pulmonary vascular structure and the gene expression of cystathionine-gamma-lyase","volume":"35","author":"Shi","year":"2003","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"key":"B131","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3109\/10641963.2012.721838","article-title":"Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension","volume":"35","author":"Sirmagul","year":"2013","journal-title":"Clin. Exp. Hypertens."},{"key":"B132","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00335-024-10043-6","article-title":"The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives","volume":"35","author":"Song","year":"2024","journal-title":"Mamm. Genome"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1303465","DOI":"10.3389\/fphar.2023.1303465","article-title":"Sulfur signaling pathway in cardiovascular disease","volume":"14","author":"Song","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"3715037","DOI":"10.1155\/2017\/3715037","article-title":"Hydrogen sulfide prevents formation of reactive oxygen species through PI3K\/Akt signaling and limits ventilator-induced lung injury","volume":"2017","author":"Spassov","year":"2017","journal-title":"Injury"},{"key":"B135","doi-asserted-by":"publisher","first-page":"3600","DOI":"10.1172\/JCI65592","article-title":"FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension","volume":"123","author":"Spiekerkoetter","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B136","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/cdd.2014.187","article-title":"MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27\/CDK2\/mTOR axis","volume":"22","author":"Su","year":"2015","journal-title":"Cell. Death Differ."},{"key":"B137","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.lfs.2016.11.005","article-title":"Endothelial dysfunction and cardiometabolic diseases: role of long non-coding RNAs","volume":"167","author":"Sun","year":"2016","journal-title":"Life Sci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"115008","DOI":"10.1016\/j.bcp.2022.115008","article-title":"Therapeutic potential of carbon monoxide in hypertension-induced vascular smooth muscle cell damage revisited: from physiology and pharmacology","volume":"199","author":"Sun","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"H2431","DOI":"10.1152\/ajpheart.00384.2006","article-title":"Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats","volume":"291","author":"Sun","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/bph.14601","article-title":"Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy","volume":"177","author":"Sun","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"772","DOI":"10.3390\/biom12060772","article-title":"Implications of hydrogen sulfide in development of pulmonary hypertension","volume":"12","author":"Sun Y.","year":"2022","journal-title":"Biomolecules"},{"key":"B142","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2174\/157016106775203144","article-title":"Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system","volume":"4","author":"Tang","year":"2006","journal-title":"Curr. Vasc. Pharmacol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"102869","DOI":"10.1016\/j.cpcardiol.2024.102869","article-title":"Discordance between the European and the United States guideline criteria for atrial septal defect closure in adult patients with pulmonary hypertension and its clinical impact","volume":"49","author":"Tangcharoen","year":"2024","journal-title":"Curr. Probl. Cardiol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1089\/ars.2023.0401","article-title":"Mechanisms underlying the hydrogen sulfide actions: target molecules and downstream signaling pathways","volume":"40","author":"Tao","year":"2024","journal-title":"Antioxid. Redox Signal."},{"key":"B145","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.tem.2020.06.001","article-title":"Estrogen-mediated gaseous signaling molecules in cardiovascular disease","volume":"31","author":"Teoh","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"B146","doi-asserted-by":"publisher","first-page":"j5492","DOI":"10.1136\/bmj.j5492","article-title":"Pulmonary arterial hypertension: pathogenesis and clinical management","volume":"360","author":"Thenappan","year":"2018","journal-title":"Bmj"},{"key":"B147","doi-asserted-by":"publisher","first-page":"3803","DOI":"10.3760\/cma.j.issn.0366-6999.20133031","article-title":"Advances in the study on endogenous sulfur dioxide in the cardiovascular system","volume":"127","author":"Tian","year":"2014","journal-title":"Chin. Med. J. Engl."},{"key":"B148","first-page":"98","article-title":"The role of gasotransmitters in the pathogenesis of hypoxic pulmonary hypertension","volume":"10","author":"Tian","year":"2008","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"B149","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/j.1365-2125.2010.03636.x","article-title":"Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide","volume":"69","author":"Toombs","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"175182","DOI":"10.1016\/j.ejphar.2022.175182","article-title":"H(2)S releasing sodium sulfide protects against pulmonary hypertension by improving vascular responses in monocrotaline-induced pulmonary hypertension","volume":"931","author":"Turhan","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1161\/HYPERTENSIONAHA.117.10094","article-title":"MicroRNA-221\/222 family counteracts myocardial fibrosis in pressure overload-induced heart failure","volume":"71","author":"Verjans","year":"2018","journal-title":"Hypertension"},{"key":"B152","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1089\/ars.2011.4310","article-title":"High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations","volume":"17","author":"Vitvitsky","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"B153","doi-asserted-by":"publisher","first-page":"8310","DOI":"10.1074\/jbc.M115.639831","article-title":"Sulfide oxidation by a noncanonical pathway in red blood cells generates thiosulfate and polysulfides","volume":"290","author":"Vitvitsky","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B154","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.3390\/antiox11112136","article-title":"Hydrogen sulfide biomedical research in China-20 Years of hindsight","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B155","doi-asserted-by":"publisher","first-page":"106238","DOI":"10.1016\/j.phrs.2022.106238","article-title":"Immunity and inflammation in pulmonary arterial hypertension: from pathophysiology mechanisms to treatment perspective","volume":"180","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1039\/d1fo04112f","article-title":"Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct."},{"key":"B157","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/j.1745-7254.2008.00796.x","article-title":"Hydrogen sulfide regulates lung tissue-oxidized glutathione and total antioxidant capacity in hypoxic pulmonary hypertensive rats","volume":"29","author":"Wei","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"B158","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/978-3-319-18144-8_16","article-title":"The pharmacological effects of S-Propargyl-Cysteine, a novel endogenous H2S-producing compound","volume":"230","author":"Wen","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"9735","DOI":"10.3390\/ijms24119735","article-title":"MicroRNA and lncRNA as the future of pulmonary arterial hypertension treatment","volume":"24","author":"Wo\u0142owiec","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190304","article-title":"H(2)S attenuates endoplasmic reticulum stress in hypoxia-induced pulmonary artery hypertension","volume":"39","author":"Wu","year":"2019","journal-title":"Biosci. Rep."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1253\/circj.69.1418","article-title":"Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats","volume":"69","author":"Xiaohui","year":"2005","journal-title":"Circ. J."},{"key":"B162","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen sulfide induces keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes"},{"key":"B163","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.cbi.2018.02.028","article-title":"NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K\/Akt\/mTOR signalling pathway to improve functional recovery after traumatic brain injury","volume":"286","author":"Xu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"B164","first-page":"300","article-title":"The relationship between endogenous hydrogen sulfide system and pulmonary hypertension induced by hypoxic hypercapnia","volume":"27","author":"Xu","year":"2011","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"B165","first-page":"359","article-title":"Role of hydrogen sulfide in the hypoxia pulmonary hypertension","volume":"39","author":"Yan","year":"2008","journal-title":"Sheng Li Ke Xue Jin Zhan"},{"key":"B166","doi-asserted-by":"publisher","first-page":"07","DOI":"10.3389\/fphar.2017.00007","article-title":"The new synthetic H(2)S-releasing SDSS protects mc3t3-E1 osteoblasts against H(2)O(2)-induced apoptosis by suppressing oxidative stress, inhibiting MAPKs, and activating the PI3K\/Akt pathway","volume":"8","author":"Yan","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.bbrc.2006.04.162","article-title":"Impact of L-arginine on hydrogen sulfide\/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension","volume":"345","author":"Yanfei","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B168","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"B169","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s42003-019-0431-5","article-title":"Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B(6)","volume":"2","author":"Yang","year":"2019","journal-title":"Commun. Biol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1002\/jcsm.13560","article-title":"Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating autophagy through promoting deubiquitination of adenosine 5'-monophosphate (AMP)-activated protein kinase \u03b11 via ubiquitin specific peptidase 5","volume":"15","author":"Yang","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"B171","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3892\/ijmm.2024.5460","article-title":"Role of DNA methylation transferase in urinary system diseases: from basic to clinical perspectives (Review)","volume":"55","author":"Yang","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"B172","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1080\/00071668.2012.728284","article-title":"Sodium hydrosulfide prevents hypoxia-induced pulmonary arterial hypertension in broilers","volume":"53","author":"Yang","year":"2012","journal-title":"Br. Poult. Sci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.niox.2024.11.009","article-title":"The relationship of nitric oxide synthase 3(NOS3) gene polymorphism in the risk of pulmonary arterial hypertension: a systematic review and meta-analysis","volume":"154","author":"Yi","year":"2025","journal-title":"Nitric Oxide"},{"key":"B174","doi-asserted-by":"publisher","first-page":"770","DOI":"10.3760\/cma.j.issn.0578-1426.2019.10.009","article-title":"Expression of nicotinamide adenine dinucleotide phosphate-reduced oxidase-4\/reactive oxygen species and cystathionine-\u03b3-lyase\/hydrogen sulfide in patients with chronic obstructive pulmonary disease-related pulmonary hypertension","volume":"58","author":"Yuan","year":"2019","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"B175","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1164\/rccm.202009-3481OC","article-title":"Safety and efficacy of B-cell depletion with rituximab for the treatment of systemic sclerosis-associated pulmonary arterial hypertension: a multicenter, double-blind, randomized, placebo-controlled trial","volume":"204","author":"Zamanian","year":"2021","journal-title":"Placebo-controlled Trial"},{"key":"B176","first-page":"488","article-title":"The regulatory effect of endogenous hydrogen sulfide on hypoxic pulmonary hypertension","volume":"35","author":"Zhang","year":"2003","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"key":"B177","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1042\/CS20190514","article-title":"Endogenous hydrogen sulfide sulfhydrates IKK\u03b2 at cysteine 179 to control pulmonary artery endothelial cell inflammation","volume":"133","author":"Zhang","year":"2019","journal-title":"Clin. Sci. (Lond)"},{"key":"B178","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3389\/fimmu.2018.00882","article-title":"The increased endogenous sulfur dioxide acts as a compensatory mechanism for the downregulated endogenous hydrogen sulfide pathway in the endothelial cell inflammation","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10557-022-07323-1","article-title":"Sulforaphane does not protect right ventricular systolic and diastolic functions in Nrf2 knockout pulmonary artery hypertension mice","volume":"36","author":"Zhang","year":"2022","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B180","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.3892\/ijmm.2019.4359","article-title":"Protective effect of hydrogen sulfide on monocrotaline-induced pulmonary arterial hypertension via inhibition of the endothelial mesenchymal transition","volume":"44","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"B181","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCRESAHA.124.324421","article-title":"o8G site-specifically modified tRF-1-AspGTC: a novel therapeutic target and biomarker for pulmonary hypertension","volume":"135","author":"Zhang","year":"2024","journal-title":"Hypertension"},{"key":"B182","doi-asserted-by":"publisher","first-page":"4840","DOI":"10.1016\/j.apsb.2023.07.006","article-title":"ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"B183","doi-asserted-by":"publisher","first-page":"5535","DOI":"10.1007\/s11033-020-05601-5","article-title":"LncRNAs and circular RNAs as endothelial cell messengers in hypertension: mechanism insights and therapeutic potential","volume":"47","author":"Zhang","year":"","journal-title":"Mol. Biol. Rep."},{"key":"B184","doi-asserted-by":"publisher","first-page":"145066","DOI":"10.1016\/j.gene.2020.145066","article-title":"Roles of circular RNAs in diabetic complications: from molecular mechanisms to therapeutic potential","volume":"763","author":"Zhang","year":"","journal-title":"Gene"},{"key":"B185","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41440-020-00553-6","article-title":"MiRNAs, lncRNAs, and circular RNAs as mediators in hypertension-related vascular smooth muscle cell dysfunction","volume":"44","author":"Zhang","year":"2021","journal-title":"Hypertens. Res."},{"key":"B186","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10557-020-07080-z","article-title":"Extracellular vesicle-mediated vascular cell communications in hypertension: mechanism insights and therapeutic potential of ncRNAs","volume":"36","author":"Zhang","year":"2022","journal-title":"Cardiovasc Drugs Ther."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.3389\/fphar.2018.01066","article-title":"Hydrogen sulfide (H(2)S)-Releasing compounds: therapeutic potential in cardiovascular diseases","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B188","first-page":"52","article-title":"Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension","volume":"36","author":"Zhang","year":"2004","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"key":"B189","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.niox.2024.11.008","article-title":"Application of hydrogen sulfide donor conjugates in different diseases","volume":"154","author":"Zhang","year":"2025","journal-title":"Nitric Oxide"},{"key":"B190","doi-asserted-by":"publisher","first-page":"1374506","DOI":"10.3389\/fimmu.2024.1374506","article-title":"The role of immune cells and inflammation in pulmonary hypertension: mechanisms and implications","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Immunol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"6903","DOI":"10.1007\/s12035-022-03004-0","article-title":"Hydrogen sulfide attenuates high-fat diet-induced obesity: involvement of mTOR\/IKK\/NF-\u03baB signaling pathway","volume":"59","author":"Zhao","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"B192","doi-asserted-by":"publisher","first-page":"20458940211051292","DOI":"10.1177\/20458940211051292","article-title":"Increased serum PCSK9 in patients with idiopathic pulmonary arterial hypertension: insights from inflammatory cytokines","volume":"11","author":"Zhong","year":"2021","journal-title":"Pulm. Circ."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1089\/ars.2023.0535","article-title":"The emerging roles of hydrogen sulfide in ferroptosis","volume":"41","author":"Zhu","year":"2024","journal-title":"Antioxid. Redox Signal."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1510275\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T05:39:03Z","timestamp":1747028343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1510275\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":193,"alternative-id":["10.3389\/fphar.2025.1510275"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1510275","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"article-number":"1510275"}}