{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:48:13Z","timestamp":1793296093253,"version":"4.5.0"},"reference-count":140,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Lipid metabolism plays a crucial role in maintaining homeostasis and overall health, as lipids are essential molecules involved in bioenergetic processes. An increasing body of research indicates that disorders of lipid metabolism can contribute to the development and progression of various diseases, including hyperlipidemia, obesity, non-alcoholic fatty liver disease (NAFLD), diabetes mellitus, atherosclerosis, and cancer, potentially leading to poor prognoses. The activation of the oxidative stress pathway disrupts lipid metabolism and induces cellular stress, significantly contributing to metabolic disorders. A well-documented crosstalk and interconnection between these metabolic disorders exists. Consequently, researchers have sought to identify antioxidant-rich substances in readily accessible everyday foods for potential use as complementary therapies. Curcumin, known for its anti-inflammatory and antioxidant properties, has been shown to enhance cellular antioxidant activity, mitigate oxidative stress, and alleviate lipid metabolism disorders by reducing reactive oxygen species (ROS) accumulation. These effects include decreasing fat deposition, increasing fatty acid uptake, and improving insulin sensitivity. A review of the existing literature reveals numerous studies emphasizing the role of curcumin in the prevention and management of metabolic diseases. Curcumin influences metabolic disorders through multiple mechanisms of action, with the oxidative stress pathway playing a central role in various lipid metabolism disorders. Thus, we aimed to elucidate the role of curcumin in various metabolic disorders through a unified mechanism of action, offering new insights into the prevention and treatment of metabolic diseases. Firstly, this article provides a brief overview of the basic pathophysiological processes of oxidative stress and lipid metabolism, as well as the role of oxidative stress in the pathogenesis of lipid metabolism disorders. Notably, the article reviews the role of curcumin in mitigating oxidative stress and in preventing and treating diseases associated with lipid metabolism disorders, including hyperlipidemia, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, obesity, and diabetes, thereby highlighting the therapeutic potential of curcumin in lipid metabolism-related diseases.<\/jats:p>","DOI":"10.3389\/fphar.2025.1517174","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:47:41Z","timestamp":1738230461000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders"],"prefix":"10.3389","volume":"16","author":[{"given":"Maojun","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feier","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.phymed.2018.04.039","article-title":"The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats","volume":"43","author":"Abdel-Mageid","year":"2018","journal-title":"Phytomedicine"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1016\/j.cell.2024.06.029","article-title":"Diabetes mellitus-Progress and opportunities in the evolving epidemic","volume":"187","author":"Abel","year":"2024","journal-title":"Cell."},{"key":"B3","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.intimp.2017.01.016","article-title":"Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-\u03baB translocation","volume":"44","author":"Afrin","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cbi.2008.05.003","article-title":"Antioxidant and radical scavenging properties of curcumin","volume":"174","author":"Ak","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"B5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-030-56153-6_2","article-title":"Turmeric and curcumin: from traditional to modern medicine","volume":"1291","author":"Akaberi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3389\/fphar.2019.00649","article-title":"The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials","volume":"10","author":"Akbari","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/molecules29010128","article-title":"Therapeutic potential of curcumin, a bioactive compound of turmeric, in prevention of streptozotocin-induced diabetes through the modulation of oxidative stress and inflammation","volume":"29","author":"Alsulaim","year":"2023","journal-title":"Molecules"},{"key":"B8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jtcme.2016.05.005","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - a review","volume":"7","author":"Amalraj","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2174\/1566524019666191016150757","article-title":"Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury","volume":"20","author":"Ashrafizadeh","year":"2020","journal-title":"Curr. Mol. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1023\/a:1006819605211","article-title":"Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats","volume":"166","author":"Babu","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2017.11.003","article-title":"Food components with antifibrotic activity and implications in prevention of liver disease","volume":"55","author":"Bae","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1210\/endrev\/bnab037","article-title":"A modern approach to dyslipidemia","volume":"43","author":"Berberich","year":"2022","journal-title":"Endocr. Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1210\/er.2018-00161","article-title":"Diabetic gastroparesis","volume":"40","author":"Bharucha","year":"2019","journal-title":"Endocr. Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e20201606","DOI":"10.1084\/jem.20201606","article-title":"Lipid metabolism and cancer","volume":"218","author":"Bian","year":"2021","journal-title":"J. Exp. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11892-018-1101-6","article-title":"Pathogenesis of lipid disorders in insulin resistance: a brief review","volume":"18","author":"Bjornstad","year":"2018","journal-title":"Curr. Diab Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s13105-012-0154-2","article-title":"Oxidative stress and inflammation interactions in human obesity","volume":"68","author":"Bondia-Pons","year":"2012","journal-title":"J. Physiol. Biochem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.niox.2014.09.001","article-title":"Curcumin improves endothelial dysfunction and vascular remodeling in 2K-1C hypertensive rats by raising nitric oxide availability and reducing oxidative stress","volume":"42","author":"Boonla","year":"2014","journal-title":"Nitric Oxide"},{"key":"B137","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12937-023-00905-1","article-title":"The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial","volume":"22","author":"Boshagh","year":"2023","journal-title":"Nutr. J."},{"key":"B139","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3390\/molecules24050846","article-title":"Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus","volume":"24","author":"Bulboac\u0103","year":"2019","journal-title":"Mol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1158\/1940-6207.CAPR-10-0098","article-title":"Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia","volume":"4","author":"Carroll","year":"2011","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.tem.2019.08.006","article-title":"Emerging molecular targets for treatment of nonalcoholic fatty liver disease","volume":"30","author":"Chen","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cicho\u017c-Lach","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"101055","DOI":"10.1016\/j.plipres.2020.101055","article-title":"Lipids in the tumor microenvironment: from cancer progression to treatment","volume":"80","author":"Corn","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/cells11030342","article-title":"Protective effects of curcumin in cardiovascular diseases-impact on oxidative stress and mitochondria","volume":"11","author":"Cox","year":"2022","journal-title":"Cells"},{"key":"B23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1042\/BSR20110043","article-title":"Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-\u03baB signalling in lymphoma-bearing mice","volume":"32","author":"Das","year":"2012","journal-title":"Biosci. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.3390\/nu11092147","article-title":"Dietary curcumin: correlation between bioavailability and health potential","volume":"11","author":"Dei Cas","year":"2019","journal-title":"Nutrients"},{"key":"B25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.lfs.2017.11.019","article-title":"Mitochondrial dysfunction in obesity","volume":"192","author":"de Mello","year":"2018","journal-title":"Life Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1089\/ars.2018.7674","article-title":"The role of NADPH oxidases in the etiology of obesity and metabolic syndrome: contribution of individual isoforms and cell biology","volume":"31","author":"DeVallance","year":"2019","journal-title":"Antioxid. Redox Signal"},{"key":"B27","doi-asserted-by":"publisher","first-page":"7069052","DOI":"10.1155\/2020\/7069052","article-title":"Curcumin improves the renal autophagy in rat experimental membranous nephropathy via regulating the PI3K\/AKT\/mTOR and Nrf2\/HO-1 signaling pathways","volume":"2020","author":"Di Tu","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1039\/d1fo04146k","article-title":"Lipid metabolism disorders and lipid mediator changes of mice in response to long-term exposure to high-fat and high sucrose diets and ameliorative effects of mulberry leaves","volume":"13","author":"Du","year":"2022","journal-title":"Food Funct."},{"key":"B136","doi-asserted-by":"publisher","first-page":"e14442","DOI":"10.1111\/jfbc.14442","article-title":"Curcumin nanoemulsion counteracts hepatic and cardiac complications associated with high-fat\/high-fructose diet in rats","volume":"46","author":"Elbaset","year":"2022","journal-title":"J. Food Biochem."},{"key":"B138","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.biopha.2018.01.071","article-title":"Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin","volume":"99","author":"Feng","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"B29","doi-asserted-by":"publisher","first-page":"101006","DOI":"10.1016\/j.plipres.2019.101006","article-title":"ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: an updated review","volume":"77","author":"Feng","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.3390\/nu12103179","article-title":"Curcumin: could this compound Be useful in pregnancy and pregnancy-related complications?","volume":"12","author":"Filardi","year":"2020","journal-title":"Nutrients"},{"key":"B31","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis","volume":"120","author":"F\u00f6rstermann","year":"2017","journal-title":"Circ. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00210-020-01979-y","article-title":"Cardioprotective effect of pioglitazone and curcumin against diabetic cardiomyopathy in type 1 diabetes mellitus: impact on CaMKII\/NF-\u03baB\/TGF-\u03b21 and PPAR-\u03b3 signaling pathway","volume":"394","author":"Gbr","year":"2021","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"116927","DOI":"10.1016\/j.jep.2023.116927","article-title":"Chinese herbal medicines: the modulator of nonalcoholic fatty liver disease targeting oxidative stress","volume":"318","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.3390\/nu15245053","article-title":"Molecular mechanisms of curcumin in the pathogenesis of metabolic dysfunction associated steatotic liver disease","volume":"15","author":"Guariglia","year":"2023","journal-title":"Nutrients"},{"key":"B37","doi-asserted-by":"publisher","first-page":"15489","DOI":"10.3390\/ijms232415489","article-title":"Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment","volume":"23","author":"Guo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"102447","DOI":"10.1016\/j.ctim.2020.102447","article-title":"A pilot study of the effect of curcumin on epigenetic changes and DNA damage among patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled, clinical trial","volume":"51","author":"Hariri","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.2174\/1871530321666210104145231","article-title":"Curcumin nanomicelle improves lipid profile, stress oxidative factors and inflammatory markers in patients undergoing coronary elective angioplasty; A randomized clinical trial","volume":"21","author":"Helli","year":"2021","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4440","DOI":"10.3390\/nu13124440","article-title":"Curcumin in metabolic health and disease","volume":"13","author":"Jabczyk","year":"2021","journal-title":"Nutrients"},{"key":"B41","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3389\/fphar.2020.00487","article-title":"Nanocurcumin: a promising candidate for therapeutic applications","volume":"11","author":"Karthikeyan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3390\/ijms23020639","article-title":"Curcumin and weight loss: does it work?","volume":"23","author":"Kasprzak-Drozd","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11883-017-0678-6","article-title":"Oxidative stress in atherosclerosis","volume":"19","author":"Kattoor","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.3390\/ijerph15102093","article-title":"Curcumin, cardiometabolic health and dementia","volume":"15","author":"Kim","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3390\/biom10101368","article-title":"Effects of curcumin in a mouse model of very high fat diet-induced obesity","volume":"10","author":"Koboziev","year":"2020","journal-title":"Biomolecules"},{"key":"B46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mce.2013.06.002","article-title":"Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease","volume":"379","author":"Koliaki","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/molecules24162930","article-title":"Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects","volume":"24","author":"Kotha","year":"2019","journal-title":"Molecules"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.3390\/cells10112978","article-title":"Lipid metabolism disorders in the comorbid course of nonalcoholic fatty liver disease and chronic obstructive pulmonary disease","volume":"10","author":"Kotlyarov","year":"2021","journal-title":"Cells"},{"key":"B49","doi-asserted-by":"publisher","first-page":"8725","DOI":"10.1111\/jcmm.16828","article-title":"Dehydrozingerone inhibits renal lipotoxicity in high-fat diet-induced obese mice","volume":"25","author":"Lee","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3892\/ijmm.2017.2924","article-title":"Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-\u03b3 activity and reducing oxidative stress","volume":"39","author":"Li","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1080\/19382014.2019.1690944","article-title":"Curcumin protects islet cells from glucolipotoxicity by inhibiting oxidative stress and NADPH oxidase activity both in vitro and in vivo","volume":"11","author":"Li","year":"2019","journal-title":"Islets"},{"key":"B52","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3389\/fphar.2020.00351","article-title":"The impacts of herbal medicines and natural products on regulating the hepatic lipid metabolism","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1038\/s41467-018-04363-w","article-title":"Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1036360","DOI":"10.1155\/2020\/1036360","article-title":"Curcumin, alone or in combination with aminoguanidine, increases antioxidant defenses and glycation product detoxification in streptozotocin-diabetic rats: a therapeutic strategy to mitigate glycoxidative stress","volume":"2020","author":"Lima","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B56","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.tcb.2023.09.001","article-title":"The ubiquitous role of ubiquitination in lipid metabolism","volume":"34","author":"Loix","year":"2024","journal-title":"Trends Cell. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/nu14010041","article-title":"An investigation into the effects of a curcumin extract (Curcugen\u00ae) on osteoarthritis pain of the knee: a randomised, double-blind, placebo-controlled study","volume":"14","author":"Lopresti","year":"2021","journal-title":"Nutrients"},{"key":"B58","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1038\/s41467-020-18412-w","article-title":"Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression","volume":"11","author":"Lundell","year":"2020","journal-title":"Nat. Commun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/cr.2017.8","article-title":"Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis","volume":"27","author":"Luo","year":"2017","journal-title":"Cell. Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial dysfunction and signaling in chronic liver diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"106217","DOI":"10.1016\/j.intimp.2020.106217","article-title":"Hyperlipidemia-induced lipotoxicity and immune activation in rats are prevented by curcumin and rutin","volume":"81","author":"Manzoni","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/ijms16010378","article-title":"Oxidative stress in obesity: a critical component in human diseases","volume":"16","author":"Marseglia","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"7898","DOI":"10.3390\/ijms24097898","article-title":"Mechanisms of oxidative stress in metabolic syndrome","volume":"24","author":"Masenga","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"7122","DOI":"10.2174\/0929867328666210329123449","article-title":"Impact of curcumin on microsomal enzyme activities: drug interaction and chemopreventive studies","volume":"28","author":"Mashayekhi-Sardoo","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/aps.2014.63","article-title":"Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-\u03b3 activation","volume":"35","author":"Meng","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"B66","doi-asserted-by":"publisher","first-page":"183","DOI":"10.15403\/jgld-179","article-title":"Effect of phytosomal curcumin on circulating levels of adiponectin and leptin in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial","volume":"28","author":"Mirhafez","year":"2019","journal-title":"J. Gastrointestin Liver Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"14366","DOI":"10.3390\/ijms241814366","article-title":"Therapeutic effects of curcumin derivatives against obesity and associated metabolic complications: a review of in vitro and in vivo studies","volume":"24","author":"Moetlediwa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.cmet.2022.05.004","article-title":"Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia","volume":"34","author":"Morrow","year":"2022","journal-title":"Cell. Metab."},{"key":"B69","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41573-021-00337-8","article-title":"Anti-obesity drug discovery: advances and challenges","volume":"21","author":"M\u00fcller","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.3390\/nu11102536","article-title":"Water extract of Curcuma longa L. Ameliorates non-alcoholic fatty liver disease","volume":"11","author":"Mun","year":"2019","journal-title":"Nutrients"},{"key":"B71","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.plipres.2012.11.002","article-title":"Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis","volume":"52","author":"Musso","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cbi.2015.04.006","article-title":"Ameliorative efficacy of tetrahydrocurcumin against arsenic induced oxidative damage, dyslipidemia and hepatic mitochondrial toxicity in rats","volume":"235","author":"Muthumani","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J. Med. Chem."},{"key":"B74","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.taap.2009.06.009","article-title":"Nrf2 signaling and cell survival","volume":"244","author":"Niture","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"111631","DOI":"10.1016\/j.ejmech.2019.111631","article-title":"Curcumin analogues and their hybrid molecules as multifunctional drugs","volume":"182","author":"Noureddin","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.2337\/db17-1032","article-title":"Oxidative stress inhibits healthy adipose expansion through suppression of SREBF1-mediated lipogenic pathway","volume":"67","author":"Okuno","year":"2018","journal-title":"Diabetes"},{"key":"B77","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/s0090-9556(24)15211-7","article-title":"Biotransformation of curcumin through reduction and glucuronidation in mice","volume":"27","author":"Pan","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.clnu.2014.12.019","article-title":"Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis","volume":"34","author":"Panahi","year":"2015","journal-title":"Clin. Nutr."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.nut.2016.03.018","article-title":"Effects of supplementation with curcumin on serum adipokine concentrations: a randomized controlled trial","volume":"32","author":"Panahi","year":"2016","journal-title":"Nutrition"},{"key":"B80","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10787-016-0301-4","article-title":"Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial","volume":"25","author":"Panahi","year":"2017","journal-title":"Inflammopharmacology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/S0140-6736(22)02403-5","article-title":"Contemporary medical, device, and surgical therapies for obesity in adults","volume":"401","author":"Perdomo","year":"2023","journal-title":"Lancet"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.3390\/ijms22041786","article-title":"Oxidative stress, plant natural antioxidants, and obesity","volume":"22","author":"P\u00e9rez-Torres","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B83","first-page":"535","article-title":"Chemopreventive efficacy and pharmacokinetics of curcumin in the min\/+ mouse, a model of familial adenomatous polyposis","volume":"11","author":"Perkins","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.3390\/nu11081837","article-title":"Curcumin and type 2 diabetes mellitus: prevention and treatment","volume":"11","author":"Pivari","year":"2019","journal-title":"Nutrients"},{"key":"B85","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/nu14010231","article-title":"Curcumin supplementation (Meriva\u00ae) modulates inflammation, lipid peroxidation and gut microbiota composition in chronic kidney disease","volume":"14","author":"Pivari","year":"2022","journal-title":"Nutrients"},{"key":"B86","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.2174\/138161213805289228","article-title":"Chemical and structural features influencing the biological activity of curcumin","volume":"19","author":"Priyadarsini","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"B87","doi-asserted-by":"publisher","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: from extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1172\/JCI85963","article-title":"HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage","volume":"127","author":"Qian","year":"2017","journal-title":"J. Clin. Investig."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1216708","DOI":"10.3389\/fendo.2023.1216708","article-title":"Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Qiu","year":"","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B90","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1021\/acs.jafc.6b00053","article-title":"Overdose intake of curcumin initiates the unbalanced state of bodies","volume":"64","author":"Qiu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"106786","DOI":"10.1016\/j.phrs.2023.106786","article-title":"Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)","volume":"192","author":"Qiu","year":"","journal-title":"Pharmacol. Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1161\/01.atv.0000020676.11586.f2","article-title":"Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits","volume":"22","author":"Quiles","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/antiox9121228","article-title":"Anti-viral potential and modulation of Nrf2 by curcumin: pharmacological implications","volume":"9","author":"Rahban","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B94","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.3390\/nu11102498","article-title":"Curcumin as a therapeutic strategy in liver diseases","volume":"11","author":"Rezzani","year":"2019","journal-title":"Nutrients"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1087260","DOI":"10.3389\/fendo.2022.1087260","article-title":"Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)","volume":"13","author":"Rong","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/ptr.4952","article-title":"Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals","volume":"27","author":"Sahebkar","year":"2013","journal-title":"Phytother. Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"111370","DOI":"10.1016\/j.biopha.2021.111370","article-title":"Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice","volume":"137","author":"Sampath","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1002\/ptr.6370","article-title":"Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: a randomized placebo-controlled clinical trial","volume":"33","author":"Saraf-Bank","year":"2019","journal-title":"Phytother. Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1161\/CIRCRESAHA.116.306842","article-title":"Lipid use and misuse by the heart","volume":"118","author":"Schulze","year":"2016","journal-title":"Circ. Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00394-011-0188-1","article-title":"New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases","volume":"50","author":"Shehzad","year":"2011","journal-title":"Eur. J. Nutr."},{"key":"B101","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3390\/antiox9090852","article-title":"Oxidative stress: concept and some practical aspects","volume":"9","author":"Sies","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B135","doi-asserted-by":"publisher","first-page":"104595","DOI":"10.1016\/j.jprot.2022.104595","article-title":"Curcumin prevents proteins expression changes of oxidative phosphorylation, cellular stress response, and lipid metabolism proteins in liver of mice fed a high-fructose diet","volume":"263","author":"Silva-Gaona","year":"2022","journal-title":"J. Proteomics"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1136\/gutjnl-2021-325724","article-title":"Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort","volume":"71","author":"Simon","year":"2022","journal-title":"Gut"},{"key":"B103","doi-asserted-by":"publisher","first-page":"4036","DOI":"10.3390\/molecules26134036","article-title":"Curcumin as a natural remedy for atherosclerosis: a pharmacological review","volume":"26","author":"Singh","year":"2021","journal-title":"Molecules"},{"key":"B104","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/0717-6287-47-74","article-title":"Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db\/db mice","volume":"47","author":"Soto-Urquieta","year":"2014","journal-title":"Biol. Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3390\/nu10101476","article-title":"Curcumin inhibits age-related vascular changes in aged mice fed a high-fat diet","volume":"10","author":"Takano","year":"2018","journal-title":"Nutrients"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.3390\/nu12041032","article-title":"Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3\u03b2 and islet amyloid polypeptide in adults with high risk of type 2 diabetes and alzheimer's disease","volume":"12","author":"Thota","year":"2020","journal-title":"Nutrients"},{"key":"B107","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1139\/apnm-2017-0670","article-title":"Curcumin supplementation ameliorated vascular dysfunction and improved antioxidant status in rats fed a high-sucrose, high-fat diet","volume":"43","author":"Tsai","year":"2018","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B108","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1600-0773.1978.tb02240.x","article-title":"A study on the fate of curcumin in the rat","volume":"43","author":"Wahlstr\u00f6m","year":"1978","journal-title":"Acta Pharmacol. Toxicol. (Copenh)"},{"key":"B109","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12944-023-01891-3","article-title":"Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1\/\u03b2-catenin pathway in atherosclerosis","volume":"22","author":"Wang","year":"2023","journal-title":"Lipids Health Dis."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1038\/oby.2009.456","article-title":"Respiration in adipocytes is inhibited by reactive oxygen species","volume":"18","author":"Wang","year":"2010","journal-title":"Obes. (Silver Spring)"},{"key":"B111","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/ncb3551","article-title":"Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation","volume":"19","author":"Wang","year":"2017","journal-title":"Nat. Cell. Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"723","DOI":"10.3390\/ijms22020723","article-title":"Oxidative stress and lipid mediators modulate immune cell functions in autoimmune diseases","volume":"22","author":"W\u00f3jcik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.jhep.2023.04.036","article-title":"Changing epidemiology, global trends and implications for outcomes of NAFLD","volume":"79","author":"Wong","year":"2023","journal-title":"J. Hepatol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"103132","DOI":"10.1016\/j.psj.2023.103132","article-title":"Dietary curcumin supplementation alleviates diquat-induced oxidative stress in the liver of broilers","volume":"102","author":"Wu","year":"2023","journal-title":"Poult Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.metabol.2014.08.010","article-title":"Diabetic dyslipidemia","volume":"63","author":"Wu","year":"2014","journal-title":"Metabolism"},{"key":"B134","doi-asserted-by":"publisher","first-page":"112350","DOI":"10.1016\/j.ecoenv.2021.112350","article-title":"Protective effects of curcumin on ATO-induced nephrotoxicity in ducks in relation to suppressed autophagy, apoptosis and dyslipidemia by regulating oxidative stress","volume":"219","author":"Wu","year":"2021","journal-title":"Ecotoxicol Environ. Saf."},{"key":"B115","doi-asserted-by":"publisher","first-page":"111803","DOI":"10.1016\/j.fct.2020.111803","article-title":"Curcumin anti-diabetic effect mainly correlates with its anti-apoptotic actions and PI3K\/Akt signal pathway regulation in the liver","volume":"146","author":"Xia","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3382\/ps\/pey315","article-title":"Curcumin supplementation regulates lipid metabolism in broiler chickens","volume":"98","author":"Xie","year":"2019","journal-title":"Poult. Sci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3892\/mmr.2017.7911","article-title":"Curcumin alleviates liver oxidative stress in type 1 diabetic rats","volume":"17","author":"Xie","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"B118","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","article-title":"Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies","volume":"73","author":"Xu","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"B119","doi-asserted-by":"publisher","first-page":"e1098","DOI":"10.1016\/S2468-2667(24)00251-2","article-title":"Diabetes in China part 2: prevention, challenges, and progress","volume":"9","author":"Xu","year":"2024","journal-title":"Lancet Public Health"},{"key":"B120","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.biopha.2018.05.135","article-title":"Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice","volume":"105","author":"Yan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B121","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2147\/DDDT.S445555","article-title":"Review of the protective mechanism of curcumin on cardiovascular disease","volume":"18","author":"Yang","year":"2024","journal-title":"Drug Des. Devel Ther."},{"key":"B122","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12944-019-1171-8","article-title":"Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review","volume":"19","author":"Yao","year":"2020","journal-title":"Lipids Health Dis."},{"key":"B123","doi-asserted-by":"publisher","first-page":"115041","DOI":"10.1016\/j.jep.2022.115041","article-title":"Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: a systematic review and meta-analysis","volume":"289","author":"Yin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.biopha.2018.04.143","article-title":"Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells","volume":"103","author":"Yu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"B124","doi-asserted-by":"publisher","first-page":"891822","DOI":"10.3389\/fimmu.2022.891822","article-title":"Efficacy and safety of curcumin and Curcuma longa extract in the treatment of arthritis: a systematic review and meta-analysis of randomized controlled trial","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Immunol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.3390\/ijms24043323","article-title":"Therapeutic effect of curcumin on metabolic diseases: evidence from clinical studies","volume":"24","author":"Zeng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1430284","DOI":"10.3389\/fphar.2024.1430284","article-title":"Role of Curcuma longae Rhizoma in medical applications: research challenges and opportunities","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ijbiomac.2015.11.045","article-title":"Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats","volume":"83","author":"Zhang","year":"","journal-title":"Int. J. Biol. Macromol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.phrs.2018.06.004","article-title":"Add-on therapy with traditional Chinese medicine: an efficacious approach for lipid metabolism disorders","volume":"134","author":"Zhang","year":"2018","journal-title":"Pharmacol. Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.3892\/or.2016.4669","article-title":"Curcumin inhibits tumor epithelial-mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells","volume":"35","author":"Zhang","year":"","journal-title":"Oncol. Rep."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.7150\/thno.80250","article-title":"GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1\/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis","volume":"13","author":"Zheng","year":"2023","journal-title":"Theranostics"},{"key":"B131","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1089\/ars.2016.6808","article-title":"Cluster of differentiation 36 deficiency aggravates macrophage infiltration and hepatic inflammation by upregulating monocyte chemotactic protein-1 expression of hepatocytes through histone deacetylase 2-dependent pathway","volume":"27","author":"Zhong","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"B132","doi-asserted-by":"publisher","first-page":"6798","DOI":"10.1039\/d3fo05739a","article-title":"The role of tetrahydrocurcumin in disease prevention and treatment","volume":"15","author":"Zhou","year":"2024","journal-title":"Food Funct."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1517174\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T09:47:46Z","timestamp":1738230466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1517174\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":140,"alternative-id":["10.3389\/fphar.2025.1517174"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1517174","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"article-number":"1517174"}}