{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:35:46Z","timestamp":1792798546821,"version":"4.5.0"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Aortic dissection (AD) is a life-threatening vascular condition marked by the separation or tearing of the aortic media. Ferroptosis, a form of iron-dependent programmed cell death, occurs alongside lipid peroxidation and the accumulation of reactive oxygen species (ROS). The relationship between ferroptosis and AD lies in its damaging effect on vascular cells. In AD, ferroptosis worsens the damage to vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), thereby weakening the vascular wall\u2019s structural integrity and accelerating the onset and progression of the condition. However, the molecular mechanisms through which ferroptosis regulates the onset and progression of AD remain poorly understood. This article explores the relationship between ferroptosis and AD.<\/jats:p>","DOI":"10.3389\/fphar.2025.1519273","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:17:44Z","timestamp":1738714664000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhaoshan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10549-011-1536-9","article-title":"Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles","volume":"132","author":"Agyeman","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"B2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12979-024-00492-7","article-title":"Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity","volume":"21","author":"Balamurugan","year":"2024","journal-title":"Immun. Ageing"},{"key":"B3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2015.07.019","article-title":"Iron and oxidative stress in cardiomyopathy in thalassemia","volume":"88","author":"Berdoukas","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1161\/01.cir.99.16.2138","article-title":"Mechanisms underlying aortic dilatation in congenital aortic valve malformation","volume":"99","author":"Bonderman","year":"1999","journal-title":"Circulation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/cvr\/cvt205","article-title":"Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm","volume":"100","author":"Branchetti","year":"2013","journal-title":"Cardiovasc Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","article-title":"Glutathione peroxidases","volume":"1830","author":"Brigelius-Floh\u00e9","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5018410","DOI":"10.1155\/2019\/5018410","article-title":"BCL6 attenuates proliferation and oxidative stress of vascular smooth muscle cells in hypertension","volume":"2019","author":"Chen","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8396","article-title":"Melodinines J induces apoptosis in temozolomide-resistant glioma cells by disrupting TMX1-dependent homeostasis of endoplasmic reticulum-mitochondria-associated membrane contacts","author":"Chen","year":"2024","journal-title":"Phytother. Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e99823","DOI":"10.1371\/journal.pone.0099823","article-title":"PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e0255238","DOI":"10.1371\/journal.pone.0255238","article-title":"Expression and role of lumican in acute aortic dissection: a human and mouse study","volume":"16","author":"Chen","year":"2021","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1021\/acs.jmedchem.0c00137","article-title":"CN128: a new orally active hydroxypyridinone iron chelator","volume":"63","author":"Chen","year":"2020","journal-title":"J. Med. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00011-016-1002-6","article-title":"Activation of the TXNIP\/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline","volume":"66","author":"Chen","year":"2017","journal-title":"Inflamm. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","article-title":"The interaction between ferroptosis and inflammatory signaling pathways","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"166915","DOI":"10.1016\/j.bbadis.2023.166915","article-title":"Deciphering disease signatures and molecular targets in vascular Ehlers-Danlos syndrome through transcriptome and miRNome sequencing of dermal fibroblasts","volume":"1870","author":"Chiarelli","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.3390\/antiox13111282","article-title":"Anti-inflammatory and autophagy activation effects of 7-methylsulfonylheptyl isothiocyanate could suppress skin aging: in vitro evidence","volume":"13","author":"Cho","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e148668","DOI":"10.1172\/jci.insight.148668","article-title":"Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension","volume":"6","author":"Chrysanthopoulou","year":"2021","journal-title":"JCI Insight"},{"key":"B20","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3109\/07853890.2015.1073346","article-title":"Stanford-A acute aortic dissection, inflammation, and metalloproteinases: a review","volume":"47","author":"Cifani","year":"2015","journal-title":"Ann. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.cardiores.2006.02.033","article-title":"Reactive oxygen species signaling in vascular smooth muscle cells","volume":"71","author":"Clempus","year":"2006","journal-title":"Cardiovasc Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00726-011-0867-5","article-title":"The oxidative stress-inducible cystine\/glutamate antiporter, system x (c) (-): cystine supplier and beyond","volume":"42","author":"Conrad","year":"2012","journal-title":"Amino Acids"},{"key":"B23","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.bbrc.2019.11.110","article-title":"ESCRT-III-dependent membrane repair blocks ferroptosis","volume":"522","author":"Dai","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/s0003-4975(10)65594-4","article-title":"Management of acute aortic dissections","volume":"10","author":"Daily","year":"1970","journal-title":"Ann. Thorac. Surg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000355253","article-title":"The multitasking role of macrophages in Stanford type A acute aortic dissection","volume":"127","author":"Del Porto","year":"2014","journal-title":"Cardiology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del Re","year":"2019","journal-title":"Physiol. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1089\/ars.2012.4918","article-title":"Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension","volume":"20","author":"Dikalov","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e02523","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"B30","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/s1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"B34","doi-asserted-by":"publisher","first-page":"117047","DOI":"10.1016\/j.ecoenv.2024.117047","article-title":"Morroniside repairs atrazine-induced skin damage by ameliorating lipid metabolism disorders and inhibiting ferroptosis","volume":"285","author":"Du","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B35","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2013.07.003","article-title":"Oxidative stress and vascular inflammation in aging","volume":"65","author":"El Assar","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1182\/blood-2002-09-2785","article-title":"Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-kappaB","volume":"102","author":"El Bekay","year":"2003","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1007\/bf00226842","article-title":"Ubiquinol: an endogenous antioxidant in aerobic organisms","volume":"71","author":"Ernster","year":"1993","journal-title":"Clin. Investig."},{"key":"B38","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.freeradbiomed.2024.11.052","article-title":"Ferroptosis suppressor protein 1 regulated oligodendrocytes ferroptosis rescued by idebenone in spinal cord injury","volume":"227","author":"Fan","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e371","DOI":"10.1038\/oncsis.2017.65","article-title":"Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis","volume":"6","author":"Fan","year":"2017","journal-title":"Oncogenesis"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/s0962-8924(97)01187-2","article-title":"The Golgi apparatus: 100 years of progress and controversy","volume":"8","author":"Farquhar","year":"1998","journal-title":"Trends Cell Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1161\/circresaha.116.309326","article-title":"Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis","volume":"120","author":"F\u00f6rstermann","year":"2017","journal-title":"Circ. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"9070","DOI":"10.1016\/s0021-9258(19)86810-2","article-title":"The O2(-) -forming oxidase responsible for the respiratory burst in human neutrophils. Properties of the solubilized enzyme","volume":"254","author":"Gabig","year":"1979","journal-title":"J. Biol. Chem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00395-024-01053-1","article-title":"Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections","volume":"119","author":"Ganizada","year":"2024","journal-title":"Basic Res. Cardiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.18632\/aging.204777","article-title":"Regulation of endothelial ferroptosis by SESN1 in atherosclerosis and its related mechanism","volume":"15","author":"Gao","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"B46","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"w14489","DOI":"10.4414\/smw.2017.14489","article-title":"Acute aortic dissection: pathogenesis, risk factors and diagnosis","volume":"147","author":"Gawinecka","year":"2017","journal-title":"Swiss Med. Wkly."},{"key":"B48","doi-asserted-by":"publisher","first-page":"254","DOI":"10.18632\/aging.100017","article-title":"Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc","volume":"1","author":"Gertz","year":"2009","journal-title":"Aging (Albany NY)"},{"key":"B49","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.cell.2005.05.011","article-title":"Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis","volume":"122","author":"Giorgio","year":"2005","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1161\/atvbaha.117.309813","article-title":"Endothelial functions","volume":"37","author":"Godo","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e026076","DOI":"10.1161\/jaha.122.026076","article-title":"Prevention of oxidative damage in spinal cord ischemia upon aortic surgery: first-in-human results of Shock wave therapy prove safety and feasibility","volume":"11","author":"Graber","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1126\/science.1201940","article-title":"Mitochondria and the autophagy-inflammation-cell death axis in organismal aging","volume":"333","author":"Green","year":"2011","journal-title":"Science"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1161\/01.res.74.6.1141","article-title":"Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells","volume":"74","author":"Griendling","year":"1994","journal-title":"Circ. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s0022-2143(98)90019-1","article-title":"Redox control of vascular smooth muscle proliferation","volume":"132","author":"Griendling","year":"1998","journal-title":"J. Lab. Clin. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1007\/s00018-010-0276-z","article-title":"Spontaneous arterial dissection: phenotype and molecular pathogenesis","volume":"67","author":"Grond-Ginsbach","year":"2010","journal-title":"Cell Mol. Life Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s10020-019-0080-7","article-title":"HDAC6 is associated with the formation of aortic dissection in human","volume":"25","author":"Guo","year":"2019","journal-title":"Mol. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.abb.2011.02.001","article-title":"Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages","volume":"508","author":"Harada","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"B58","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3389\/fphys.2014.00352","article-title":"Reactive oxygen species at the crossroads of inflammasome and inflammation","volume":"5","author":"Harijith","year":"2014","journal-title":"Front. Physiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e23401","DOI":"10.1096\/fj.202300198RRR","article-title":"Ferrostatin-1 inhibits ferroptosis of vascular smooth muscle cells and alleviates abdominal aortic aneurysm formation through activating the SLC7A11\/GPX4 axis","volume":"38","author":"He","year":"","journal-title":"Faseb J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.freeradbiomed.2024.04.220","article-title":"SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells","volume":"219","author":"He","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.3390\/antiox11101958","article-title":"Roles of oxidative stress and inflammation in vascular endothelial dysfunction-related disease","volume":"11","author":"Higashi","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B62","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1089\/ars.2006.1519","article-title":"Hypoxia-mediated induction of heme oxygenase type I and carbon monoxide release from astrocytes protects nearby cerebral neurons from hypoxia-mediated apoptosis","volume":"9","author":"Imuta","year":"2007","journal-title":"Antioxid. Redox Signal"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"12387","DOI":"10.1016\/s0021-9258(18)43284-x","article-title":"Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine","volume":"256","author":"Ishii","year":"1981","journal-title":"J. Biol. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1161\/01.Cir.0000154569.08857.7a","article-title":"Thoracic and abdominal aortic aneurysms","volume":"111","author":"Isselbacher","year":"2005","journal-title":"Circulation"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1161\/hypertensionaha.115.07085","article-title":"Mitochondrial cyclophilin D in vascular oxidative stress and hypertension","volume":"67","author":"Itani","year":"2016","journal-title":"Hypertension"},{"key":"B67","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/1050-1738(94)90064-7","article-title":"Animal models of restenosis","volume":"4","author":"Jackson","year":"1994","journal-title":"Trends Cardiovasc Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1093\/eurheartj\/ehu235","article-title":"Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure","volume":"35","author":"Jankowska","year":"2014","journal-title":"Eur. Heart J."},{"key":"B69","first-page":"5125","article-title":"Experimental in vivo and ex vivo models for the study of human aortic dissection: promises and challenges","volume":"8","author":"Jiang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.2174\/13816128113196660748","article-title":"eNOS uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation","volume":"20","author":"Karbach","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1089\/ars.2017.7176","article-title":"The roles of NRF2 in modulating cellular iron homeostasis","volume":"29","author":"Kerins","year":"2018","journal-title":"Antioxid. Redox Signal"},{"key":"B73","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13020-024-01051-4","article-title":"Magnolia kobus DC. suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model","volume":"20","author":"Kim","year":"2025","journal-title":"Chin. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"C749","DOI":"10.1152\/ajpcell.00346.2016","article-title":"ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis","volume":"312","author":"Kim","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1042\/bj20121778","article-title":"Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4","volume":"452","author":"Kozie\u0142","year":"2013","journal-title":"Biochem. J."},{"key":"B76","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"24393","DOI":"10.18632\/oncotarget.5162","article-title":"Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death","volume":"6","author":"Kwon","year":"2015","journal-title":"Oncotarget"},{"key":"B78","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41467-024-51578-1","article-title":"Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)","volume":"16","author":"Larrea","year":"2025","journal-title":"Nat. Commun."},{"key":"B79","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/jfb15120378","article-title":"Targeting reactive oxygen species for diagnosis of various diseases","volume":"15","author":"Lee","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"B80","doi-asserted-by":"publisher","first-page":"e276","DOI":"10.1002\/ctm2.276","article-title":"Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells","volume":"11","author":"Li","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41392-020-00216-5","article-title":"The interaction between ferroptosis and lipid metabolism in cancer","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1161\/hypertensionaha.118.11354","article-title":"High salt enhances reactive oxygen species and angiotensin II contractions of glomerular afferent arterioles from mice with reduced renal mass","volume":"72","author":"Li","year":"","journal-title":"Hypertension"},{"key":"B83","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.7150\/ijbs.72528","article-title":"Targeting ferroptosis as a novel approach to alleviate aortic dissection","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41419-017-0213-2","article-title":"EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection","volume":"9","author":"Li","year":"","journal-title":"Cell Death Dis."},{"key":"B85","doi-asserted-by":"publisher","first-page":"116927","DOI":"10.1016\/j.lfs.2019.116927","article-title":"Targeted depletion of monocyte\/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta","volume":"254","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ebiom.2019.09.041","article-title":"Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1\u03b1-ADAM17 pathway(\u2730)","volume":"49","author":"Lian","year":"2019","journal-title":"EBioMedicine"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1093\/cvr\/cvae081","article-title":"Ncf1 knockout in smooth muscle cells exacerbates angiotensin II-induced aortic aneurysm and dissection by activating the STING pathway","volume":"120","author":"Liu","year":"","journal-title":"Cardiovasc Res."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01414-2","article-title":"AKAP1\/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis","author":"Liu","year":"","journal-title":"Cell Death Differ"},{"key":"B89","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.freeradbiomed.2022.02.005","article-title":"Melatonin alleviates PM(2.5)-triggered macrophage M1 polarization and atherosclerosis via regulating NOX2-mediated oxidative stress homeostasis","volume":"181","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1472813","DOI":"10.3389\/fphar.2024.1472813","article-title":"Didang Tang alleviates neuronal ferroptosis after intracerebral hemorrhage by modulating the PERK\/eIF2\u03b1\/ATF4\/CHOP\/GPX4 signaling pathway","volume":"15","author":"Lu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.redox.2017.11.012","article-title":"Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS\/NF\u03baB\/mTOR\/P70S6K signaling cascade","volume":"14","author":"Lu","year":"2018","journal-title":"Redox Biol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1161\/circulationaha.119.041460","article-title":"Critical role of cytosolic DNA and its sensing adaptor STING in aortic degeneration, dissection, and rupture","volume":"141","author":"Luo","year":"2020","journal-title":"Circulation"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.jtcvs.2021.11.091","article-title":"The Society of Thoracic Surgeons\/American Association for Thoracic Surgery clinical practice guidelines on the management of type B aortic dissection","volume":"163","author":"MacGillivray","year":"2022","journal-title":"J. Thorac. Cardiovasc Surg."},{"key":"B94","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1089\/ars.2016.6642","article-title":"Lysyl oxidase induces vascular oxidative stress and contributes to arterial stiffness and abnormal elastin structure in hypertension: role of p38MAPK","volume":"27","author":"Mart\u00ednez-Revelles","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"B96","doi-asserted-by":"publisher","first-page":"7931","DOI":"10.1073\/pnas.92.17.7931","article-title":"Cell-free activation of neutrophil NADPH oxidase by a phosphatidic acid-regulated protein kinase","volume":"92","author":"McPhail","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/j.bbalip.2014.07.011","article-title":"Protein kinase C-beta: an emerging connection between nutrient excess and obesity","volume":"1841","author":"Mehta","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B98","doi-asserted-by":"publisher","first-page":"738654","DOI":"10.3389\/fcvm.2021.738654","article-title":"Chronic stress A potential suspect zero of atherosclerosis: a systematic review","volume":"8","author":"Meng","year":"2021","journal-title":"Front. Cardiovasc Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/jb\/mvm190","article-title":"Epidermal growth factor receptor phosphorylates protein kinase C {delta} at Tyr332 to form a trimeric complex with p66Shc in the H2O2-stimulated cells","volume":"143","author":"Morita","year":"2008","journal-title":"J. Biochem."},{"key":"B100","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/biof.156","article-title":"Non-mitochondrial coenzyme Q","volume":"37","author":"Morr\u00e9","year":"2011","journal-title":"Biofactors"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1161\/res.0000000000000104","article-title":"Mitochondrial function, biology, and role in disease: a scientific statement from the American heart association","volume":"118","author":"Murphy","year":"2016","journal-title":"Circ. Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"16053","DOI":"10.1038\/nrdp.2016.53","article-title":"Aortic dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B103","doi-asserted-by":"publisher","first-page":"e007389","DOI":"10.1161\/jaha.117.007389","article-title":"Role of macrophage Socs3 in the pathogenesis of aortic dissection","volume":"7","author":"Ohno-Urabe","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1126\/science.3576226","article-title":"Expression and properties of two types of protein kinase C: alternative splicing from a single gene","volume":"236","author":"Ono","year":"1987","journal-title":"Science"},{"key":"B105","doi-asserted-by":"publisher","first-page":"708","DOI":"10.2174\/1389201019666180808162011","article-title":"Role of NLRP-3 inflammasome in hypertension: a potential therapeutic target","volume":"19","author":"Pasqua","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.jacc.2016.05.091","article-title":"Changing pathology of the thoracic aorta from acute to chronic dissection: literature review and insights","volume":"68","author":"Peterss","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1456406","DOI":"10.3389\/fmicb.2024.1456406","article-title":"Total Alkaloids of Rhizoma Corydalis regulates gut microbiota and restores gut immune barrier to ameliorate cognitive dysfunction in diabetic rats","volume":"15","author":"Qi","year":"","journal-title":"Front. Microbiol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/s41419-024-07309-x","article-title":"Dual functions of silibinin in attenuating aortic dissection via regulating iron homeostasis and endoplasmic reticulum stress against ferroptosis","volume":"15","author":"Qi","year":"","journal-title":"Cell Death Dis."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.4049\/jimmunol.171.3.1534","article-title":"Proangiogenic function of CD40 ligand-CD40 interactions","volume":"171","author":"Reinders","year":"2003","journal-title":"J. Immunol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/ijms16010823","article-title":"Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress","volume":"16","author":"Rubattu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"H508","DOI":"10.1152\/ajpheart.00559.2019","article-title":"Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells","volume":"318","author":"Sampilvanjil","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"11455","DOI":"10.1074\/jbc.274.17.11455","article-title":"Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins","volume":"274","author":"Sato","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B113","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1089\/ars.2013.5633","article-title":"NADPH oxidases in redox regulation of cell adhesion and migration","volume":"20","author":"Schr\u00f6der","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"B114","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/MNH.0b013e32832923c3","article-title":"Molecular mechanisms of hypertension: role of Nox family NADPH oxidases","volume":"18","author":"Sedeek","year":"2009","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"B115","doi-asserted-by":"publisher","first-page":"106366","DOI":"10.1016\/j.phrs.2022.106366","article-title":"Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway","volume":"183","author":"Shi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"B116","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s10020-023-00694-7","article-title":"Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1\u03b1\/HMOX1 axis","volume":"29","author":"Shi","year":"2023","journal-title":"Mol. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1161\/01.ATV.0000214999.12921.4f","article-title":"Inflammation and cellular immune responses in abdominal aortic aneurysms","volume":"26","author":"Shimizu","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5758\/vsi.240090","article-title":"Long-term patency and complications of endovascular and surgical revascularization for takayasu arteritis","volume":"40","author":"Shin","year":"2024","journal-title":"Vasc. Spec. Int."},{"key":"B119","doi-asserted-by":"publisher","first-page":"e22857","DOI":"10.1016\/j.heliyon.2023.e22857","article-title":"Oxidative stress drives vascular smooth muscle cell damage in acute Stanford type A aortic dissection through HIF-1\u03b1\/HO-1 mediated ferroptosis","volume":"9","author":"Song","year":"2023","journal-title":"Heliyon"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e3074","DOI":"10.1038\/cddis.2017.470","article-title":"NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension","volume":"8","author":"Sun","year":"2017","journal-title":"Cell Death Dis."},{"key":"B123","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"B124","doi-asserted-by":"publisher","first-page":"13304","DOI":"10.1074\/jbc.M110.192138","article-title":"The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4","volume":"286","author":"Takac","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.avsg.2017.10.006","article-title":"Elevated plasma levels of LDL cholesterol promote dissecting thoracic aortic aneurysms in angiotensin II-induced mice","volume":"48","author":"Tanaka","year":"2018","journal-title":"Ann. Vasc. Surg."},{"key":"B126","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1179\/135100002125000596","article-title":"Iron and carcinogenesis: from Fenton reaction to target genes","volume":"7","author":"Toyokuni","year":"2002","journal-title":"Redox Rep."},{"key":"B127","doi-asserted-by":"publisher","first-page":"135","DOI":"10.6705\/j.jacme.202412_14(4).0001","article-title":"Neurological manifestations of aortic dissection: a scoping review","volume":"14","author":"Varela-Jaramillo","year":"2024","journal-title":"J. Acute Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1136\/hrt.2008.153650","article-title":"Acute aortic syndrome: a new look at an old conundrum","volume":"86","author":"Vilacosta","year":"2010","journal-title":"Postgrad. Med. J."},{"key":"B129","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/hep.29117","article-title":"Characterization of ferroptosis in murine models of hemochromatosis","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"B130","doi-asserted-by":"publisher","first-page":"3558","DOI":"10.7150\/ijbs.85454","article-title":"Effects of DNA, RNA, and protein methylation on the regulation of ferroptosis","volume":"19","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.3390\/cells10092433","article-title":"Inflammasomes in the pathophysiology of aortic disease","volume":"10","author":"Wortmann","year":"2021","journal-title":"Cells"},{"key":"B132","doi-asserted-by":"publisher","first-page":"4222","DOI":"10.7150\/ijbs.99511","article-title":"IL-6 signaling accelerates iron overload by upregulating DMT1 in endothelial cells to promote aortic dissection","volume":"20","author":"Xie","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"B134","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"key":"B135","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"e2417252121","DOI":"10.1073\/pnas.2417252121","article-title":"Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling","volume":"122","author":"Yardeni","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B139","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/jcmm.13008","article-title":"Ferroptosis, a new form of cell death, and its relationships with tumourous diseases","volume":"21","author":"Yu","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"B140","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","article-title":"Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Discov."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B142","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s43556-022-00105-z","article-title":"The anti-ferroptotic role of FSP1: current molecular mechanism and therapeutic approach","volume":"3","author":"Zeng","year":"2022","journal-title":"Mol. Biomed."},{"key":"B143","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.65.14.34","article-title":"Endoplasmic reticulum stress induces ROS production and activates NLRP3 inflammasome via the PERK-CHOP signaling pathway in dry eye disease","volume":"65","author":"Zha","year":"2024","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"103473","DOI":"10.1016\/j.redox.2024.103473","article-title":"Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia","volume":"79","author":"Zhang","year":"","journal-title":"Redox Biol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00418-016-1512-x","article-title":"TRPV1 attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation in hypertension","volume":"147","author":"Zhang","year":"2017","journal-title":"Histochem Cell Biol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s10020-022-00549-7","article-title":"Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice","volume":"28","author":"Zhang","year":"2022","journal-title":"Mol. Med."},{"key":"B147","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41419-024-07001-0","article-title":"TCP1 expression alters the ferroptosis sensitivity of diffuse large B-cell lymphoma subtypes by stabilising ACSL4 and influences patient prognosis","volume":"15","author":"Zhang","year":"","journal-title":"Cell Death Dis."},{"key":"B148","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.freeradbiomed.2021.11.002","article-title":"Exercise improves vascular health: role of mitochondria","volume":"177","author":"Zhang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B149","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.3390\/nu15071640","article-title":"Low zinc alleviates the progression of thoracic aortic dissection by inhibiting inflammation","volume":"15","author":"Zhu","year":"2023","journal-title":"Nutrients"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1519273\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:17:51Z","timestamp":1738714671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1519273\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":149,"alternative-id":["10.3389\/fphar.2025.1519273"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1519273","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"article-number":"1519273"}}