{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:37:34Z","timestamp":1790030254718,"version":"4.0.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The main aim of this study was to identify adverse events (AEs) in neonates admitted to a Neonatal Intensive Care Unit (NICU) using a trigger-based approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted at Hospital Estadual Sumar\u00e9 -Dr. Leandro Franceschini, Sumar\u00e9, SP, Brazil, over 6\u00a0months in 2021. Data from 120 electronic medical records of neonates hospitalized for \u226548\u00a0h and prescribed at least one medication were analyzed. Seventeen triggers, such as healthcare-associated infections (HAIs), antimicrobial use, accidental extubation, electrolyte disorders, and others, were employed to identify AEs, including those specific to adverse drug reaction (ADRs). AE severity was assessed using the Neonatal Adverse Event Severity Scale (NAESS) and the World Health Organization (WHO) classification, while ADR causality was evaluated using the WHO criteria and the algorithm proposed by Du et at. Risk factors such as gestational age, birth weight, and length of hospital stay were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 249 triggers identified 168 confirmed AEs, resulting in a Positive Predictive Value (PPV) of 67.5%. At least one AE was observed in 50.0% of neonates and 40.8% experienced ADRs. The most frequent triggers that identified AEs included HAIs and antimicrobial use (30.8\/100 records, each), followed by hyperglycemia (22.5\/100 records), increased frequency of bowel movements (16.7\/100 records), and hyponatremia (10.8\/100 records). Severe complications such as necrotizing enterocolitis (2.5\/100 records) and accidental extubation (5.0\/100 records) were also recorded. Triggers with a PPV of 100% included necrotizing enterocolitis, accidental extubation, hypocalcemia, HAIs, and antimicrobial use. According to the NAESS, most AEs were classified as grade 2 - moderate, (44.0%) or grade 3 \u2013 severe (51.2%). Critical events, such as life-threatening conditions (grade 4) and death (grade 5), were less common, totaling 4.8%. Regarding ADRs, the majority were classified as possible or unlikely by both methods. The distribution of AEs varied by neonatal subgroups, with extremely preterm showing higher rates of AEs, including hyponatremia (53.8%) and accidental extubation (66.7%). Among all events, elevated serum creatinine (75.0%), necrotizing enterocolitis (66.7%), and hypercalcemia (100.0%) predominantly occurred in neonates with extremely low birth weight (ELBW). In contrast, neonates with appropriate birth weight experienced fewer AEs and lower AE severity. This association was not assessed for gestational age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that prematurity, low birth weight, and prolonged hospitalization are relevant risk factors for AEs in NICUs. Nonetheless, trigger tools proved effective in identifying severe events and enhancing patient safety in this high-risk setting. Prevention strategies based on these findings can help mitigate risks and optimize neonatal care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2025.1539687","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:14:08Z","timestamp":1748578448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Adverse events in the neonatal intensive care unit identified by triggers"],"prefix":"10.3389","volume":"16","author":[{"given":"Fabiana Bragan\u00e7a","family":"Albanese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deise de Souza","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Maur\u00edcio Wesley","family":"Perroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Nogueira de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Vieira","family":"Morau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Berlofa","family":"Visacri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Moriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/S0169-409X(03)00030-9","article-title":"Pharmacokinetics in the newborn","volume":"55","author":"Alcorn","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"25784","DOI":"10.1161\/JAHA.122.025784","article-title":"Patent ductus arteriosus: a contemporary perspective for the pediatric and adult cardiac care provider","volume":"11","author":"Backes","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1590\/S0325-00752010000400003","article-title":"Epidemiolog\u00eda de eventos adversos en el servicio de neonatolog\u00eda de un hospital p\u00fablico regional en la Argentina","volume":"108","author":"Barrionuevo","year":"2010","journal-title":"Arch. Argent. Pediatr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2165\/00003088-200645110-00003","article-title":"Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations","volume":"45","author":"Bartelink","year":"2006","journal-title":"Clin. Pharmacokinet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.33448\/rsd-v10i6.15884","article-title":"Unidade de terapia intensiva neonatal (utin): A import\u00e2ncia na sobrevida dos rec\u00e9m nascidos","author":"Batista","year":"2021","journal-title":"Res. Soc. Dev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"641306","DOI":"10.3389\/fped.2021.641306","article-title":"Hyperglycaemia in the newborn infant. Physiology verses pathology","volume":"9","author":"Beardsall","year":"2021","journal-title":"Front. Pediatr."},{"key":"B7","volume-title":"Crit\u00e9rios Diagn\u00f3sticos de Infec\u00e7\u00e3o Associada \u00e0 Assist\u00eancia \u00e0 Sa\u00fade Neonatologia. S\u00e9rie Seguran\u00e7a do Paciente e Qualidade em Servi\u00e7os de Sa\u00fade","year":"2017"},{"key":"B8","volume-title":"Guia para Profissionais de Sa\u00fade. Problemas Respirat\u00f3rios, Cardiocirculat\u00f3rios, Metab\u00f3licos, Neurol\u00f3gicos, Ortop\u00e9dicos e Dermatol\u00f3gicos","year":"2014"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1178632919845630","article-title":"Predicting neonatal skin injury: the first step to reducing skin injuries in neonates","volume":"12","author":"Broom","year":"2019","journal-title":"Heal Serv. Insights"},{"key":"B10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.53771\/ijbpsa.2023.5.2.0033","article-title":"Adverse drug reactions in neonatal intensive care unit: characteristics and risk factors","volume":"5","author":"Canto-Rodr\u00edguez","year":"2023","journal-title":"Int. J. Biol. Pharm. Sci. Arch."},{"key":"B11","volume-title":"Pediatric trigger toolkit: measuring adverse drug events in the children\u2019s hospital","year":"2007"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1001\/jama.1991.03470200059035","article-title":"Computerized surveillance of adverse drug events in hospital patients","volume":"266","author":"Classen","year":"1991","journal-title":"JAMA"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e246969","DOI":"10.5205\/1981-8963.2021.246969","article-title":"Notifica\u00e7\u00e3o de eventos adversos em uma unidade de terapia intensiva neonatal","volume":"15","author":"Cossul","year":"2021","journal-title":"Rev. Enferm. UFPE online."},{"key":"B14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.7705\/biomedica.v37i1.3192","article-title":"Reacciones adversas a medicamentos en neonatos hospitalizados en unidades de cuidado intensivo neonatal en Barranquilla, Colombia","volume":"37","author":"De Las Salas","year":"2017","journal-title":"Biomedica"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.11606\/s1518-8787.2022056003527","article-title":"Recurrent preterm birth: data from the study \u201cBirth in Brazil\u201d","volume":"56","author":"Dias","year":"2022","journal-title":"Rev. Saude Publica"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1111\/apa.16814","article-title":"Identifying neonatal adverse events in preterm and term infants using a paediatric trigger tool","volume":"112","author":"Dillner","year":"2023","journal-title":"Acta Paediatr."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.3390\/pharmaceutics15102431","article-title":"Pediatric drug development: reviewing challenges and opportunities by tracking innovative therapies","volume":"15","author":"Domingues","year":"2023","journal-title":"Pharmaceutics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1177\/0091270011433327","article-title":"An algorithm to detect adverse drug reactions in the neonatal intensive care unit","volume":"53","author":"Du","year":"2013","journal-title":"J. Clin. Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1590\/0102-311X00069817","article-title":"Rastreadores para a busca ativa de eventos adversos a medicamentos em rec\u00e9m-nascidos","author":"Fabretti","year":"2018","journal-title":"Cad. Saude Publica"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e585","DOI":"10.1097\/PTS.0000000000000871","article-title":"Neonatal adverse events\u2019 trigger tool setup with random forest","volume":"18","author":"Feng","year":"2022","journal-title":"J. Patient Saf."},{"key":"B21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1053\/j.semperi.2015.12.005","article-title":"Hemodynamic instability in the critically ill neonate: an approach to cardiovascular support based on disease pathophysiology","volume":"40","author":"Giesinger","year":"2016","journal-title":"Semin. Perinatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1590\/s1415-790x2012000300002","article-title":"Vigil\u00e2ncia de eventos adversos a medicamentos em hospitais: aplica\u00e7\u00e3o e desempenho de rastreadores","volume":"15","author":"Giordani","year":"2012","journal-title":"Rev. Bras. Epidemiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1136\/qshc.2007.025080","article-title":"Detection of adverse events in surgical patients using the Trigger Tool approach","volume":"17","author":"Griffin","year":"2008","journal-title":"Qual. Saf. Heal Care"},{"key":"B24","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1197\/jamia.M2369","article-title":"A systematic review of the performance characteristics of clinical event monitor signals used to detect adverse drug events in the hospital setting","volume":"14","author":"Handler","year":"2007","journal-title":"J. Am. Med. Inf. Assoc."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.3889\/oamjms.2019.558","article-title":"Prevalence and risk factors for hyponatremia in preterm infants","volume":"7","author":"Hao","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pedneo.2021.07.001","article-title":"Risk factors for hyperglycemia in extremely low birth weight infants during the first 14 days","volume":"63","author":"Inage","year":"2022","journal-title":"Pediatr. Neonatol."},{"key":"B27","volume-title":"IHI global trigger tool for measuring adverse events","year":"2009"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1111\/bcp.13034","article-title":"Neonatal adverse drug reactions: an analysis of reports to the French pharmacovigilance database","volume":"82","author":"Kaguelidou","year":"2016","journal-title":"Br. J. Clin. Pharmacol"},{"key":"B29","first-page":"342","article-title":"\u00c1gua, eletr\u00f3litos e glicose","volume-title":"PEDIATRIA neonatologia","author":"Krebs","year":"2020"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e073304","DOI":"10.1136\/bmjopen-2023-073304","article-title":"Temporal profile of adverse drug reactions and associated clinical factors: a prospective observational study in a neonatal intensive care unit","volume":"13","author":"Leopoldino","year":"2023","journal-title":"BMJ Open"},{"key":"B31","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1136\/amiajnl-2013-001914","article-title":"Phenotyping for patient safety: algorithm development for electronic health record based automated adverse event and medical error detection in neonatal intensive care","volume":"21","author":"Li","year":"2014","journal-title":"Am. Med. Inf. Assoc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/S0140-6736(08)60204-4","article-title":"Iatrogenic events in admitted neonates: a prospective cohort study","volume":"371","author":"Ligi","year":"2008","journal-title":"Lancet"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1093\/ajhp\/zxz161","article-title":"Pharmacokinetic considerations in pediatric pharmacotherapy","volume":"76","author":"Lim","year":"2019","journal-title":"Am. J. Heal Syst. Pharm."},{"key":"B34","first-page":"32","volume-title":"Interna\u00e7\u00e3o de Rec\u00e9m-Nascidos de Risco em Unidades de Terapia Intensiva Neonatal no Brasil: uma an\u00e1lise especial","author":"Magluta","year":"2021"},{"key":"B35","first-page":"504","volume-title":"Manual de Neonatologia UNICAMP. CAISM- Centro de Aten\u00e7\u00e3o Integral \u00e0 Sa\u00fade da Mulher","author":"Marba","year":"2008"},{"key":"B36","first-page":"1684","volume-title":"Fanaroff and Martin\u2019s Medicina Neonatal e Perinatal: Doen\u00e7as do Feto e do Neonato","author":"Martin","year":"2017"},{"key":"B37","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1136\/bmjqs.2010.041152","article-title":"Description of the development and validation of the Canadian paediatric trigger tool","volume":"20","author":"Matlow","year":"2011","journal-title":"BMJ Qual. Saf."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e20210025","DOI":"10.1590\/1983-1447.2021.20210025","article-title":"Association between professional qualification and adverse events in neonatal and pediatric intensive treatment units","volume":"42","author":"Maziero","year":"2021","journal-title":"Rev. Ga\u00facha Enferm."},{"key":"B39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/00152192-200603000-00006","article-title":"A retrospective chart review of risk factors for extravasation among neonates receiving peripheral intravascular fluids","volume":"33","author":"Mccullen","year":"2006","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1016\/j.clnu.2018.06.947","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: carbohydrates","volume":"37","author":"Mesotten","year":"2018","journal-title":"Clin. Nutr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2146\/ajhp100019","article-title":"Systematic review of medication safety assessment methods","volume":"68","author":"Meyer-Massetti","year":"2011","journal-title":"Am. J. Heal Syst. Pharm."},{"key":"B42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1590\/1980-549720200088","article-title":"Fatores associados \u00e0 interna\u00e7\u00e3o e \u00e0 mortalidade neonatal em uma coorte de rec\u00e9m-nascidos do Sistema \u00danico de Sa\u00fade, no munic\u00edpio de S\u00e3o Paulo","author":"Moura","year":"2020","journal-title":"Rev. Bras. Epidemiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/intqhc\/mzp027","article-title":"A comparison of hospital adverse events identified by three widely used detection methods","volume":"21","author":"Naessens","year":"2009","journal-title":"Int. J. Qual. Heal Care"},{"key":"B44","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/jamia\/ocx156","article-title":"Designing and evaluating an automated system for real-time medication administration error detection in a neonatal intensive care unit","volume":"25","author":"Ni","year":"2018","journal-title":"J. Am. Med. Inf. Assoc."},{"key":"B45","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2471\/BLT.14.139790","article-title":"Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: (2000\u20132013)","volume":"93","author":"Oza","year":"2013","journal-title":"Bull. World Health Organ"},{"key":"B46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000479606","article-title":"Trigger Tool na Seguran\u00e7a do Doente: Uma Revis\u00e3o Sistem\u00e1tica de Literatura","volume":"35","author":"Pierdevara","year":"2017","journal-title":"Port. J. Public Heal"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e20192002","DOI":"10.1542\/peds.2019-2002","article-title":"Improving quality of care can mitigate persistent disparities","volume":"144","author":"Ravi","year":"2019","journal-title":"Pediatrics"},{"key":"B48","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/s1553-7250(06)32076-4","article-title":"A trigger tool to identify adverse events in the intensive care unit","volume":"32","author":"Resar","year":"2006","journal-title":"J. Comm. J. Qual. Patient Saf."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1136\/archdischild-2019-317399","article-title":"Development of a neonatal adverse event severity scale through a Delphi consensus approach","volume":"104","author":"Salaets","year":"2019","journal-title":"Arch. Dis. Child."},{"key":"B50","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/bcp.15465","article-title":"Roadmap to optimal pharmacovigilance practice in neonatal intensive care units","volume":"89","author":"Samiee-Zafarghandy","year":"2023","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1542\/peds.2006-0565","article-title":"Adverse events in the neonatal intensive care unit: development, testing, and findings of an NICU-focused trigger tool to identify harm in north American NICUs","volume":"118","author":"Sharek","year":"2006","journal-title":"Pediatrics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"F210","DOI":"10.1136\/adc.2007.135020","article-title":"Specialty-based, voluntary incident reporting in neonatal intensive care: description of 4846 incident reports","volume":"94","author":"Snijders","year":"2009","journal-title":"Arch. Dis. Child. - Fetal Neonatal Ed."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1007\/s00431-012-1799-0","article-title":"Factors associated with iatrogenesis in neonatal intensive care units: an observational multicenter study","volume":"171","author":"Srulovici","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"B54","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"21341","DOI":"10.1038\/s41598-020-78358-3","article-title":"Effects of the number of drugs used on the prevalence of adverse drug reactions in children","volume":"10","author":"Sugioka","year":"2020","journal-title":"Sci. Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e927","DOI":"10.1542\/peds.2007-1779","article-title":"Development, testing, and findings of a pediatric-focused trigger tool to identify medication-related harm in US children's hospitals Children\u2019s Hospitals","volume":"121","author":"Takata","year":"2008","journal-title":"Pediatrics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"170","DOI":"10.5863\/1551-6776-16.3.170","article-title":"Neonatal pharmacology: extensive interindividual variability despite limited size","volume":"16","author":"Tayman","year":"2011","journal-title":"J. Pediatr. Pharmacol. Ther."},{"key":"B58","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1186\/s12913-014-0655-5","article-title":"Validation of triggers and development of a pediatric trigger tool to identify adverse events","volume":"14","author":"Unbeck","year":"2014","journal-title":"BMC Health Serv. Res."},{"key":"B59","first-page":"28","volume-title":"Monitoriza\u00e7\u00e3o da seguran\u00e7a de medicamentos: diretrizes para cria\u00e7\u00e3o e funcionamento de um centro de farmacovigil\u00e2ncia","year":"2005"},{"key":"B60","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1590\/s0034-71672012000100007","article-title":"Adverse events in a neonatal intensive care unit","volume":"65","author":"Ventura","year":"2012","journal-title":"Rev. Bras. Enferm."},{"key":"B61","doi-asserted-by":"publisher","first-page":"4318075","DOI":"10.1155\/2019\/4318075","article-title":"Clinical approach to hypocalcemia in newborn period and infancy: who should Be treated?","volume":"2019","author":"Vuralli","year":"2019","journal-title":"Int. J. Pediatr."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2333794X221084070","DOI":"10.1177\/2333794X221084070","article-title":"Adverse neonatal outcomes and associated risk factors: a case-control study","volume":"9","author":"Workineh","year":"2022","journal-title":"Glob. Pediatr. Heal"},{"key":"B63","volume-title":"Every newborn: an action plan to end preventable deaths","year":"2014"},{"key":"B64","unstructured":"ATC\/DDD index 2024 Norwegian Institute of public health\n          \n          \n          2024"},{"key":"B65","article-title":"Conceptual framework for the international classification for patient safety","year":"2009","journal-title":"Version 1.1. Final Technical Report Geneva"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.3390\/children9121826","article-title":"An artificial intelligence approach to support detection of neonatal adverse drug reactions based on severity and probability scores: a new risk score as web-tool","volume":"9","author":"Yal\u00e7\u0131n","year":"2022","journal-title":"Children"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1539687\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:14:13Z","timestamp":1748578453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1539687\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":66,"alternative-id":["10.3389\/fphar.2025.1539687"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1539687","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"article-number":"1539687"}}