{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:05:53Z","timestamp":1779375953438,"version":"3.53.1"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Canine osteoarthritis (OA) is a prevalent disease characterized by progressive joint degeneration, pain, and impaired mobility. In older dogs, OA affects approximately 80% of the population. Current pharmacological treatments are often limited in efficacy and may cause significant adverse effects. In this context, cannabinoids have emerged as a promising therapeutic alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This double-blind, randomized study aimed to evaluate the efficacy and safety of a full-spectrum cannabis extract in managing OA-related pain and dysfunction in dogs. Seventeen dogs with OA were randomly assigned to receive either the cannabis extract (containing measured amounts of CBD, THC, CBG, CBC, and other cannabinoids) or a placebo for 90 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although the cannabis treatment did not significantly reduce pain levels according to the Helsinki Chronic Pain Index (HCPI) [F(1,14) = 0.001, p = 0.981, \u03b7\n                      <jats:sup>2<\/jats:sup>\n                      = 0.000], a reduction of 2.4 points in HCPI scores compared to the placebo was observed at 90 days. Additionally, the treatment proved to be entirely safe, with no significant adverse effects reported. The few mild side effects observed resolved spontaneously within 24 h. Biomarker analysis revealed no significant differences between the cannabis and placebo groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that full-spectrum cannabis extract containing CBD and THC is safe for use in dogs for up to 90 days. However, further research is needed to determine the optimal doses and formulations required to effectively alleviate OA-induced pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2025.1539704","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:29:32Z","timestamp":1763965772000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cannabis-based extract for managing pain in dogs with osteoarthritis: efficacy and safety assessment"],"prefix":"10.3389","volume":"16","author":[{"given":"Neide Maria","family":"Griebeler","sequence":"first","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Penayo","family":"Cremonese","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin Rafaela","family":"Fakih Correa","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Romero Mazzini","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Furjan","family":"Rial","sequence":"additional","affiliation":[{"name":"POP-VET Veterinary Hospital","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria Luz","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Renato","family":"Marques das Almas","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Santa Cannabis","place":["Florian\u00f3polis, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedice Borges","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Environmental and Food Interdisciplinary Studies Laboratory - LEIMAA, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cezar-dos-Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Theodoro","family":"Toci","sequence":"additional","affiliation":[{"name":"Environmental and Food Interdisciplinary Studies Laboratory - LEIMAA, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Mojoli Le-Quesne","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisney Pinto","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laboratory of Cannabis and Psychedelics - LCP, Universidade Federal da Integra\u00e7\u00e3o Latino Americana (UNILA)","place":["Foz do Igua\u00e7u, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1124\/jpet.111.180257","article-title":"Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain","volume":"338","author":"Ahn","year":"2011","journal-title":"J. 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