{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:58:46Z","timestamp":1789685926853,"version":"4.0.1"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, characterized by hepatic lipid accumulation. The Fufangduzhong formula (FFDZ) is a traditional Chinese medicine (TCM) formulation composed of\n                      <jats:italic>Eucommia ulmoides<\/jats:italic>\n                      Oliv.\n                      <jats:italic>, Leonurus artemisia<\/jats:italic>\n                      (Lour.) S. Y. Hu,\n                      <jats:italic>Prunella vulgaris<\/jats:italic>\n                      Linn\n                      <jats:italic>, Uncariarhynchophylla<\/jats:italic>\n                      (Miq.) Miq. ex Havil.,\n                      <jats:italic>and Scutellaria baicalensis<\/jats:italic>\n                      Georgi. It has demonstrated hepatoprotective effects and the ability to reduce lipid accumulation. However, its mechanisms against NAFLD remain unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      UPLC-MS\/MS was used to identify FFDZ metabolites. C57BL\/6J mice were fed a high-fat diet (HFD) supplemented with or without FFDZ (HFD+L, 0.45\u00a0g\/kg\/d; HFD+H, 0.9\u00a0g\/kg\/d) for 12\u00a0weeks. Biochemical indicators and histopathological observations were utilized to assess the extent of metabolic homeostasis disorder and hepatic steatosis. An analysis of differentially expressed genes and regulated signaling pathways was conducted using hepatic transcriptomics. Metabolomics analysis was performed to investigate the significantly changed endogenous metabolites associated with NAFLD in mice serum using UPLC-Q-TOF\/MS. Western blot was employed to detect proteins involved in the lipid metabolism-related signaling pathways. Oleic acid-induced hepatic steatosis was used to examine the lipid-lowering effect of FFDZ-containing serum\n                      <jats:italic>in vitro<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of eight active metabolites were identified from the FFDZ formula and FFDZ-containing serum through UPLC-MS\/MS analysis. FFDZ reduced body weight, liver weight, and levels of inflammatory cytokines, and it ameliorated hepatic steatosis, serum lipid profiles, insulin sensitivity, and glucose tolerance in mice with HFD-induced NAFLD. Transcriptomics revealed that FFDZ modulated the lipid metabolism-related pathways, including the PPAR signaling pathway, Fatty acid metabolism, and AMPK signaling pathway. Meanwhile, Western blot analysis indicated that FFDZ downregulated the expression of lipid synthesis-related proteins (Srebp-1c, Acly, Scd-1, Fasn, Acaca, and Cd36) and upregulated the fatty acid oxidation-related proteins (p-Ampk, Ppar-\u03b1, and Cpt-1). Furthermore, metabolomics identified FFDZ-mediated reversal of phospholipid dysregulation (PC, PE, LPC, LPE). Additionally, FFDZ-containing serum remarkedly reduced OA-induced lipid accumulation in HepG2 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present results demonstrate that FFDZ exerts anti-NAFLD effects by enhancing glucose tolerance and insulin sensitivity, as well as regulating the Ampk signaling pathway to ameliorate lipid metabolism disorder, lipotoxicity, hepatic steatosis, and inflammatory responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2025.1542143","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:05:28Z","timestamp":1741752328000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Unraveling the molecular mechanisms of Fufangduzhong formula in alleviating high-fat diet-induced non-alcoholic fatty liver disease in mice"],"prefix":"10.3389","volume":"16","author":[{"given":"Yu","family":"Mou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaacov","family":"Ben-David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"103043","DOI":"10.1016\/j.arcmed.2024.103043","article-title":"Global prevalence of nonalcoholic fatty liver disease: an updated review meta-analysis comprising a population of 78 million from 38 countries","volume":"55","author":"Amini-Salehi","year":"2024","journal-title":"Arch. Med. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1038\/s41467-019-09152-7","article-title":"Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism","volume":"10","author":"Bertolio","year":"2019","journal-title":"Nat. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","article-title":"Molecular pathways of nonalcoholic fatty liver disease development and progression","volume":"76","author":"Bessone","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"B5","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1016\/j.cmet.2021.06.012","article-title":"FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption","volume":"33","author":"Clifford","year":"2021","journal-title":"Cell Metab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/03602532.2017.1293683","article-title":"Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters","volume":"49","author":"Cobbina","year":"2017","journal-title":"Drug Metab. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"880298","DOI":"10.3389\/fimmu.2022.880298","article-title":"Association of inflammatory cytokines with non-alcoholic fatty liver disease","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.3748\/wjg.v24.i27.2974","article-title":"Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: from \u201ctwo hit theory\u201d to \u201cmultiple hit model\u201d","volume":"24","author":"Fang","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ebiom.2018.05.009","article-title":"Activation of AMPK for a break in hepatic lipid accumulation and circulating cholesterol","volume":"31","author":"Foretz","year":"2018","journal-title":"EBioMedicine"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.2147\/dddt.S315724","article-title":"Non-alcoholic steatohepatitis (NASH) - a review of a crowded clinical landscape, driven by a complex disease","volume":"15","author":"Fraile","year":"2021","journal-title":"Drug Des. Devel Ther."},{"key":"B13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41575-020-00366-5","article-title":"Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors","volume":"18","author":"Francque","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1093\/cvr\/cvad095","article-title":"Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options","volume":"119","author":"Grander","year":"2023","journal-title":"Cardiovasc Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1194\/jlr.M014787","article-title":"Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance","volume":"52","author":"Han","year":"2011","journal-title":"J. Lipid Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.3350\/cmh.2022.0424","article-title":"Non-alcoholic fatty liver disease: definition and subtypes","volume":"29","author":"Han","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.7326\/m22-1787","article-title":"Effect of calorie-unrestricted low-carbohydrate, high-fat diet versus high-carbohydrate, low-fat diet on type 2 diabetes and nonalcoholic fatty liver disease: a randomized controlled trial","volume":"176","author":"Hansen","year":"2023","journal-title":"Ann. Intern Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"105917","DOI":"10.1016\/j.phrs.2021.105917","article-title":"Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models","volume":"177","author":"Hu","year":"2022","journal-title":"Pharmacol. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13020-021-00482-7","article-title":"Traditional application and modern pharmacological research of Eucommia ulmoides Oliv","volume":"16","author":"Huang","year":"2021","journal-title":"Chin. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"156026","DOI":"10.1016\/j.phymed.2024.156026","article-title":"Multi-omics joint analysis reveals that the Miao medicine Yindanxinnaotong formula attenuates non-alcoholic fatty liver disease","volume":"135","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"B22","doi-asserted-by":"publisher","first-page":"116060","DOI":"10.1016\/j.jep.2022.116060","article-title":"Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation","volume":"306","author":"Huang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell Mol. Life Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"22403","DOI":"10.1074\/jbc.M110.108514","article-title":"Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity","volume":"285","author":"Jacobs","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"7873","DOI":"10.1021\/acs.jafc.5b02830","article-title":"Mass-spectrometry-based serum metabolomics of a C57bl\/6J mouse model of high-fat-diet-induced non-alcoholic fatty liver disease development","volume":"63","author":"Lai","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3390\/ijms20051149","article-title":"An updated review of lysophosphatidylcholine metabolism in human diseases","volume":"20","author":"Law","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"841","DOI":"10.3350\/cmh.2022.0239","article-title":"Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach","volume":"28","author":"Le","year":"2022","journal-title":"Clin. Mol. Hepatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.jhep.2020.04.025","article-title":"Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages(\u2606)","volume":"73","author":"Lefere","year":"2020","journal-title":"J. Hepatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"105715","DOI":"10.1016\/j.jff.2023.105715","article-title":"Polyphenolic compounds from Idesia polycarpa Maxim. fruits ameliorate non-alcoholic fatty liver disease by modulating lipid metabolism in oleic acid-induced HepG2 cells and high-fat diet-induced mice","volume":"108","author":"Lei","year":"2023","journal-title":"J. Funct. Foods"},{"key":"B30","doi-asserted-by":"publisher","first-page":"S302","DOI":"10.3350\/cmh.2022.0329","article-title":"Non-alcoholic fatty liver disease: the pathologist's perspective","volume":"29","author":"Leow","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"109199","DOI":"10.1016\/j.cbi.2020.109199","article-title":"High fat diet-triggered non-alcoholic fatty liver disease: a review of proposed mechanisms","volume":"330","author":"Lian","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"B32","doi-asserted-by":"publisher","first-page":"109060","DOI":"10.1016\/j.biopha.2019.109060","article-title":"Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: a comprehensive overview","volume":"117","author":"Miao","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.metabol.2016.02.014","article-title":"Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease","volume":"65","author":"Mota","year":"2016","journal-title":"Metabolism"},{"key":"B34","doi-asserted-by":"publisher","first-page":"903171","DOI":"10.3389\/fphar.2022.903171","article-title":"Prunella vulgaris L. - a review of its ethnopharmacology, phytochemistry, quality control and pharmacological effects","volume":"13","author":"Pan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/s41419-020-03003-w","article-title":"Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?","volume":"11","author":"Rada","year":"2020","journal-title":"Cell Death Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/s2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jep.2013.12.052","article-title":"Leonurus japonicus Houtt.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"152","author":"Shang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"E730","DOI":"10.1152\/ajpendo.00225.2016","article-title":"Treatment of nonalcoholic fatty liver disease: role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1007\/s10620-016-4054-0","article-title":"Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease","volume":"61","author":"Softic","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"116418","DOI":"10.1016\/j.jep.2023.116418","article-title":"Integrated serum pharmacochemistry, 16S rRNA sequencing and metabolomics to reveal the material basis and mechanism of Yinzhihuang granule against non-alcoholic fatty liver disease","volume":"310","author":"Tan","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.3350\/cmh.2022.0365","article-title":"Global incidence and prevalence of nonalcoholic fatty liver disease","volume":"29","author":"Teng","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"109901","DOI":"10.1016\/j.intimp.2023.109901","article-title":"Selegiline ameliorated dyslipidemia and hepatic steatosis in high-fat diet mice","volume":"117","author":"Tian","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"Veen","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"B44","doi-asserted-by":"publisher","first-page":"G526","DOI":"10.1152\/ajpgi.00243.2015","article-title":"Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice","volume":"310","author":"Veen","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20220319","article-title":"Serum metabolome alterations in patients with early nonalcoholic fatty liver disease","volume":"42","author":"Wang","year":"2022","journal-title":"Biosci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/13880209.2018.1492620","article-title":"A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis","volume":"56","author":"Wang","year":"2018","journal-title":"Pharm. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"117841","DOI":"10.1016\/j.jep.2024.117841","article-title":"Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPAR\u03b1 mediated lipotoxicity","volume":"326","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jtcme.2023.02.010","article-title":"Yinchenhao Tang alleviates high fat diet induced NAFLD by increasing NR1H4 and APOA1 expression","volume":"13","author":"Xu","year":"2023","journal-title":"J. Tradit. Complement. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e91436","DOI":"10.1371\/journal.pone.0091436","article-title":"Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques","volume":"9","author":"Yaligar","year":"2014","journal-title":"PLoS One"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6890","DOI":"10.3748\/wjg.v22.i30.6890","article-title":"Herbal medicines and nonalcoholic fatty liver disease","volume":"22","author":"Yao","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"118165","DOI":"10.1016\/j.jep.2024.118165","article-title":"Xiaozhi formula attenuates non-alcoholic fatty liver disease by regulating lipid metabolism via activation of AMPK and PPAR pathways","volume":"329","author":"You","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3168\/jds.2022-21938","article-title":"Graduate Student Literature Review: a scoping review on the impact of consumption of dairy products on phosphatidylcholine and lysophosphatidylcholine in circulation and the liver in human studies and animal models","volume":"106","author":"Yuzbashian","year":"2023","journal-title":"J. Dairy Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3410","DOI":"10.1039\/c9fo00284g","article-title":"Ellagic acid ameliorates AKT-driven hepatic steatosis in mice by suppressing de novo lipogenesis via the AKT\/SREBP-1\/FASN pathway","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."},{"key":"B54","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: an important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1149665","DOI":"10.3389\/fphar.2023.1149665","article-title":"Non-alcoholic fatty liver disease combined with rheumatoid arthritis exacerbates liver fibrosis by stimulating co-localization of PTRF and TLR4 in rats","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3969\/j.issn.1008-8849.2020.06.005","article-title":"Analysis of common TCM syndromes, nonalcoholic fatty liver and related risk factors in newly diagnosed type 2 diabetes","volume":"29","author":"Zhang","year":"2020","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.3390\/molecules27123697","article-title":"Neuroendocrine-immune regulatory network of Eucommia ulmoides oliver","volume":"27","author":"Zhao","year":"2022","journal-title":"Molecules"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3298","DOI":"10.7150\/ijbs.71431","article-title":"Quantitative proteomics of HFD-induced fatty liver uncovers novel transcription factors of lipid metabolism","volume":"18","author":"Zhi","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"123853","DOI":"10.1016\/j.ijbiomac.2023.123853","article-title":"Polysaccharides from Ostrea rivularis rebuild the balance of gut microbiota to ameliorate non-alcoholic fatty liver disease in ApoE(-\/-) mice","volume":"235","author":"Zhu","year":"2023","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1542143\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:05:32Z","timestamp":1741752332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1542143\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":59,"alternative-id":["10.3389\/fphar.2025.1542143"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1542143","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"article-number":"1542143"}}