{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:26:05Z","timestamp":1787959565698,"version":"build-2784847793"},"reference-count":129,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The interplay between mitochondria and endoplasmic reticulum (ER) is essential for cellular viability. The structures known as mitochondria-associated endoplasmic reticulum membranes (MAM) provide complicated connections between these organelles, which house a variety of proteins, each serving distinct roles across different cellular environments. Growing evidence indicates that disruptions in mitochondrial-ER interactions are linked to immune and inflammatory responses. The concurrent presence of rheumatoid arthritis (RA), an immune-mediated inflammatory condition, and depression has been well-documented. Alterations in proteins that mediate mitochondrial-ER interactions and MAM functionality are increasingly correlated with immune and inflammatory pathways. This suggests that a comprehensive understanding of disease mechanisms can be enhanced by examining the alterations in their intercommunication rather than viewing the organelles in isolation. In this review, we explore the pathophysiological mechanisms underlying RA in conjunction with depression, the relationships among mitochondria, the endoplasmic reticulum, mitochondrial-ER interactions, and their association with RA-associated depression, and propose that targeting MAM could offer a novel therapeutic approach for managing RA-associated depression.<\/jats:p>","DOI":"10.3389\/fphar.2025.1549060","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T06:08:03Z","timestamp":1759817283000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Rheumatoid arthritis-associated depression: focusing on the interactions between mitochondria and endoplasmic reticulum"],"prefix":"10.3389","volume":"16","author":[{"given":"Mingqin","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fnagi.2020.00252","article-title":"Mitochondrial dysfunction and alzheimer's disease: role of microglia","volume":"12","author":"Agrawal","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3389\/fnins.2018.00386","article-title":"Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression","volume":"12","author":"Allen","year":"2018","journal-title":"Front. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/j.1471-4159.2009.06000.x","article-title":"Anti-amnesic properties of (+\/-)-Ppcc, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats","volume":"109","author":"Antonini","year":"2009","journal-title":"J. Neurochem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s10787-017-0397-1","article-title":"Oxidative stress in inflammatory cells of patient with rheumatoid arthritis: clinical efficacy of dietary antioxidants","volume":"25","author":"Bala","year":"2017","journal-title":"Inflammopharmacol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"102343","DOI":"10.1016\/j.ceca.2020.102343","article-title":"Mitochondria associated membranes (mams): architecture and physiopathological role","volume":"94","author":"Barazzuol","year":"2021","journal-title":"Cell Calcium"},{"key":"B6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/bf00343816","article-title":"Submicroscopical structure of cytoplasmic basophils in the liver, pancreas and salivary gland; study of ultrafine slices by electron microscope","volume":"37","author":"Bernhard","year":"1952","journal-title":"Z Zellforsch Mikrosk Anat."},{"key":"B7","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"key":"B8","doi-asserted-by":"publisher","first-page":"5781","DOI":"10.1113\/jp271539","article-title":"Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation","volume":"594","author":"Bonaz","year":"2016","journal-title":"J. Physiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1080\/14728222.2021.1952987","article-title":"Drugs that offer the potential to reduce hospitalization and mortality from Sars-Cov-2 infection: the possible role of the Sigma-1 receptor and autophagy","volume":"25","author":"Brimson","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"B10","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41584-023-01037-w","article-title":"Immune mechanisms of depression in rheumatoid arthritis","volume":"19","author":"Brock","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.immuni.2015.08.008","article-title":"Endoplasmic reticulum stress activates the inflammasome via Nlrp3-and Caspase-2-Driven mitochondrial damage","volume":"43","author":"Bronner","year":"2015","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nri.2016.100","article-title":"Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis","volume":"16","author":"Cadwell","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fncel.2014.00430","article-title":"Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity","volume":"8","author":"Calabrese","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jad.2024.04.029","article-title":"Identification of novel endoplasmic reticulum-related genes and their association with immune cell infiltration in major depressive disorder","volume":"356","author":"Chang","year":"2024","journal-title":"J. Affect Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.2174\/1570159x20666220628153632","article-title":"Mitophagy and neuroinflammation: a compelling interplay","volume":"21","author":"Charmpilas","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"155567","DOI":"10.1016\/j.phymed.2024.155567","article-title":"Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging via mitochondria-associated membrane-mediated calcium homeostasis regulation","volume":"129","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1093\/rheumatology\/kex391","article-title":"Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis","volume":"57","author":"Choy","year":"2018","journal-title":"Rheumatol. Oxf."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"7536805","DOI":"10.1155\/2019\/7536805","article-title":"Oxidative stress in rheumatoid arthritis: what the future might hold regarding novel biomarkers and Add-on therapies","volume":"2019","author":"da Fonseca","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"108039","DOI":"10.1016\/j.meatsci.2019.108039","article-title":"Inhibition of mitochondrial calcium uniporter enhances postmortem proteolysis and tenderness in beef cattle","volume":"162","author":"Dang","year":"2020","journal-title":"Meat Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"105200","DOI":"10.1016\/j.jbspin.2021.105200","article-title":"Rheumatoid arthritis and depression","volume":"88","author":"Fakra","year":"2021","journal-title":"Jt. Bone Spine"},{"key":"B23","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3390\/biology12030414","article-title":"A perspective on the link between mitochondria-associated membranes (mams) and lipid droplets metabolism in neurodegenerative diseases","volume":"12","author":"Fernandes","year":"2023","journal-title":"Biol. (Basel)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/antiox10010045","article-title":"Insights in the role of lipids, oxidative stress and inflammation in rheumatoid arthritis unveiled by new trends in lipidomic investigations","volume":"10","author":"Ferreira","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"102776","DOI":"10.1016\/j.autrev.2021.102776","article-title":"Rheumatoid arthritis: extra-articular manifestations and comorbidities","volume":"20","author":"Figus","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2017.01.003","article-title":"The endoplasmic reticulum-mitochondria coupling in health and disease: molecules, functions and significance","volume":"62","author":"Filadi","year":"2017","journal-title":"Cell Calcium"},{"key":"B27","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41584-022-00827-y","article-title":"Global epidemiology of rheumatoid arthritis","volume":"18","author":"Finckh","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","article-title":"Immunopathogenesis of rheumatoid arthritis","volume":"46","author":"Firestein","year":"2017","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"53623","DOI":"10.18632\/oncotarget.17323","article-title":"The prevalence of depression in rheumatoid arthritis in China: a systematic review","volume":"8","author":"Fu","year":"2017","journal-title":"Oncotarget"},{"key":"B30","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3389\/fpsyt.2019.00337","article-title":"Is there a role of autophagy in depression and antidepressant action?","volume":"10","author":"Gassen","year":"2019","journal-title":"Front. Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"103214","DOI":"10.1016\/j.jaut.2024.103214","article-title":"Pparg-mediated autophagy activation alleviates inflammation in rheumatoid arthritis","volume":"146","author":"Geng","year":"2024","journal-title":"J. Autoimmun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1038\/cdd.2016.52","article-title":"The coming of age of the Mitochondria-Er contact: a matter of thickness","volume":"23","author":"Giacomello","year":"2016","journal-title":"Cell Death Differ."},{"key":"B33","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.molmed.2019.09.009","article-title":"Visualizing mitochondrial form and function within the cell","volume":"26","author":"Glancy","year":"2020","journal-title":"Trends Mol. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e594","DOI":"10.1016\/s2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the global burden of disease study 2021","volume":"5","author":"Global","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/mp.2016.3","article-title":"A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression","volume":"21","author":"Goldsmith","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.cub.2016.12.038","article-title":"The Er-Mitochondria tethering complex Vapb-Ptpip51 regulates autophagy","volume":"27","author":"Gomez-Suaga","year":"2017","journal-title":"Curr. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u0391 and C-Reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature11910","article-title":"Autophagosomes form at Er-Mitochondria contact sites","volume":"495","author":"Hamasaki","year":"2013","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mito.2017.10.009","article-title":"Mitophagy and the release of inflammatory cytokines","volume":"41","author":"Harris","year":"2018","journal-title":"Mitochondrion"},{"key":"B40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jphs.2014.11.010","article-title":"Activation of Sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication","volume":"127","author":"Hashimoto","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jphs.2014.07.001","article-title":"Sigma-1 receptor: the novel intracellular target of neuropsychotherapeutic drugs","volume":"127","author":"Hayashi","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3389\/fnins.2019.00733","article-title":"The Sigma-1 receptor in cellular stress signaling","volume":"13","author":"Hayashi","year":"2019","journal-title":"Front. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the Er-Mitochondrion interface regulate Ca(2+) signaling and cell survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-Reactive protein, Il-1, and Il-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0889-857x(05)70057-0","article-title":"Negative affect and pain in arthritis","volume":"25","author":"Huyser","year":"1999","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"B47","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/s41380-018-0241-z","article-title":"Linking unfolded protein response to inflammation and depression: potential pathologic and therapeutic implications","volume":"24","author":"Ii Timberlake","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.3390\/medicina58111637","article-title":"Depression in rheumatoid arthritis: a narrative review-diagnostic challenges, pathogenic mechanisms and effects","volume":"58","author":"Ionescu","year":"2022","journal-title":"Med. Kaunas."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1002\/1873-3468.14078","article-title":"Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases","volume":"595","author":"Jin","year":"2021","journal-title":"FEBS Lett."},{"key":"B50","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.redox.2017.04.007","article-title":"Loss of parkin reduces inflammatory arthritis by inhibiting P53 degradation","volume":"12","author":"Jung","year":"2017","journal-title":"Redox Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41375-022-01781-0","article-title":"Calr-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response","volume":"37","author":"Jutzi","year":"2023","journal-title":"Leukemia"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1172\/jci124609","article-title":"Neuro-immune crosstalk and allergic inflammation","volume":"129","author":"Kabata","year":"2019","journal-title":"J. Clin. Invest"},{"key":"B53","doi-asserted-by":"publisher","first-page":"117734","DOI":"10.1016\/j.lfs.2020.117734","article-title":"Role of autophagy in the pathogenesis of rheumatoid arthritis: latest evidence and therapeutic approaches","volume":"254","author":"Karami","year":"2020","journal-title":"Life Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/art.38190","article-title":"Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts","volume":"66","author":"Kato","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1223354","DOI":"10.3389\/fmolb.2023.1223354","article-title":"Editorial: the role of mitochondrial endoplasmic reticulum contact sites in human health and disease","volume":"10","author":"Katti","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"103030","DOI":"10.1016\/j.jaut.2023.103030","article-title":"Autophagy pathways in autoimmune diseases","volume":"136","author":"Keller","year":"2023","journal-title":"J. Autoimmun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mito.2020.06.005","article-title":"Altered mitochondrial proteome and functional dynamics in patients with rheumatoid arthritis","volume":"54","author":"Khanna","year":"2020","journal-title":"Mitochondrion"},{"key":"B58","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies","volume":"135","author":"K\u00f6hler","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"B59","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase Pink1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","first-page":"113987","DOI":"10.1016\/j.bbr.2022.113987","article-title":"Lysosomal dysfunction is associated with Nlrp3 inflammasome activation in chronic unpredictable mild stress-induced depressive mice","volume":"432","author":"Li","year":"2022","journal-title":"Behav. Brain Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3390\/biom12101383","article-title":"Calcium-permeable channels cooperation for rheumatoid arthritis: therapeutic opportunities","volume":"12","author":"Liang","year":"","journal-title":"Biomolecules"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/imm.13420","article-title":"Immunomodulatory functions of Trpm7 and its implications in autoimmune diseases","volume":"165","author":"Liang","year":"","journal-title":"Immunology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/annrheumdis-2012-201671","article-title":"Autophagy regulates Tnf\u03b1-Mediated joint destruction in experimental arthritis","volume":"72","author":"Lin","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"B64","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.molimm.2018.09.010","article-title":"The role of mitochondria in Nlrp3 inflammasome activation","volume":"103","author":"Liu","year":"2018","journal-title":"Mol. Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"992223","DOI":"10.3389\/fnbeh.2022.992223","article-title":"Research progress on rheumatoid arthritis-associated depression","volume":"16","author":"Liu","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41420-024-01918-3","article-title":"Mitochondria-associated endoplasmic reticulum membrane (mam): a dark horse for diabetic cardiomyopathy treatment","volume":"10","author":"Liu","year":"2024","journal-title":"Cell Death Discov."},{"key":"B67","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.tcb.2021.02.003","article-title":"Balancing Er-Mitochondrial Ca2+ fluxes in health and disease","volume":"31","author":"Loncke","year":"2021","journal-title":"Trends Cell Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1007\/s12035-020-02042-w","article-title":"A novel interaction of translocator protein 18 kda (tspo) with nadph oxidase in microglia","volume":"57","author":"Loth","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"910452","DOI":"10.3389\/fphys.2022.910452","article-title":"Compositions and functions of mitochondria-associated endoplasmic reticulum membranes and their contribution to cardioprotection by exercise preconditioning","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s12325-017-0482-2","article-title":"The impact of a single nucleotide polymorphism in Sigmar1 on depressive symptoms in major depressive disorder and bipolar disorder","volume":"34","author":"Mandelli","year":"2017","journal-title":"Adv. Ther."},{"key":"B71","doi-asserted-by":"publisher","first-page":"617","DOI":"10.2217\/ijr.11.6","article-title":"Depression in patients with rheumatoid arthritis: description, causes and mechanisms","volume":"6","author":"Margaretten","year":"2011","journal-title":"Int. J. Clin. Rheumtol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.tins.2018.05.009","article-title":"Er proteostasis control of neuronal physiology and synaptic function","volume":"41","author":"Mart\u00ednez","year":"2018","journal-title":"Trends Neurosci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s13075-021-02657-x","article-title":"Sustained microglial activation in the area postrema of collagen-induced arthritis mice","volume":"23","author":"Matsushita","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3390\/antiox11071306","article-title":"Endoplasmic reticulum stress, oxidative stress, and rheumatic diseases","volume":"11","author":"Miglioranza Scavuzzi","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B75","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41419-017-0027-2","article-title":"Mitochondria-associated membranes (mams) and inflammation","volume":"9","author":"Missiroli","year":"2018","journal-title":"Cell Death Dis."},{"key":"B76","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41418-022-01095-9","article-title":"Pml at mitochondria-associated membranes governs a trimeric complex with Nlrp3 and P2x7r that modulates the tumor immune microenvironment","volume":"30","author":"Missiroli","year":"2023","journal-title":"Cell Death Differ."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"B78","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1302\/2046-3758.1311.Bjr-2023-0361.R2","article-title":"Inhibition of Pa28\u03b3 expression can alleviate osteoarthritis by inhibiting endoplasmic reticulum stress and promoting Stat3 phosphorylation","volume":"13","author":"Mo","year":"2024","journal-title":"Bone Jt. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1038\/s41467-025-58538-3","article-title":"Mitochondrial complexity is regulated at Er-Mitochondria contact sites via Pdzd8-Fkbp8 tethering","volume":"16","author":"Nakamura","year":"2025","journal-title":"Nat. Commun."},{"key":"B80","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/s2215-0366(18)30255-4","article-title":"Rheumatoid arthritis and depression: an inflammatory perspective","volume":"6","author":"Nerurkar","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"B81","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1074\/jbc.M115.699447","article-title":"Disc1-Dependent regulation of mitochondrial dynamics controls the morphogenesis of complex neuronal dendrites","volume":"291","author":"Norkett","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jad.2023.07.073","article-title":"Relationship between circulating mitochondrial DNA and microrna in patients with major depression","volume":"339","author":"Ogata","year":"2023","journal-title":"J. Affect Disord."},{"key":"B84","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/cr.2013.169","article-title":"Historical landmarks of autophagy research","volume":"24","author":"Ohsumi","year":"2014","journal-title":"Cell Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.biopha.2017.12.098","article-title":"Jobelyn(\u00ae) attenuates inflammatory responses and neurobehavioural deficits associated with complete freund-adjuvant-induced arthritis in mice","volume":"98","author":"Omorogbe","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3346\/jkms.2014.29.1.2","article-title":"Role of endoplasmic reticulum stress in rheumatoid arthritis pathogenesis","volume":"29","author":"Park","year":"2014","journal-title":"J. Korean Med. Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1016\/j.celrep.2017.11.043","article-title":"Disc1 modulates neuronal stress responses by gate-keeping Er-Mitochondria Ca2+ transfer through the mam","volume":"21","author":"Park","year":"2017","journal-title":"Cell Rep."},{"key":"B88","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1478-811x-9-19","article-title":"Calcium signaling around mitochondria associated membranes (mams)","volume":"9","author":"Patergnani","year":"2011","journal-title":"Cell Commun. Signal"},{"key":"B89","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: an update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"110683","DOI":"10.1016\/j.isci.2024.110683","article-title":"Spastin regulates Er-Mitochondrial contact sites and mitochondrial homeostasis","volume":"27","author":"Raby","year":"2024","journal-title":"iScience"},{"key":"B91","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3390\/cells10112857","article-title":"Management of rheumatoid arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"key":"B92","doi-asserted-by":"publisher","first-page":"165752","DOI":"10.1016\/j.bbadis.2020.165752","article-title":"Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: do mitochondria-associated membranes (mams) play a role?","volume":"1866","author":"Resende","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B93","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbrc.2017.06.097","article-title":"Mitochondria-associated membranes (mams): an emerging platform connecting energy and immune sensing to metabolic flexibility","volume":"500","author":"Rieusset","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1126\/science.280.5370.1763","article-title":"Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses","volume":"280","author":"Rizzuto","year":"1998","journal-title":"Science"},{"key":"B95","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1093\/brain\/awq367","article-title":"The Sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke","volume":"134","author":"Ruscher","year":"2011","journal-title":"Brain"},{"key":"B96","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.bbr.2008.11.036","article-title":"Sigma-1 receptor knockout mice display a depressive-like phenotype","volume":"198","author":"Sabino","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative stress and the central nervous system","volume":"360","author":"Salim","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B98","doi-asserted-by":"publisher","first-page":"A207","DOI":"10.1161\/hyp.64.suppl_1.207","article-title":"Abstract 207: angiotensin -Ii (Ang-Ii) induces endoplasmic reticulum (er) stress-mediated overproduction of mitochondrial reactive oxygen species (mros) and alterations in mitochondria-associated membrane (mam) in neural cells","volume":"64","author":"Sarkar","year":"2014","journal-title":"Hypertension"},{"key":"B99","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.2147\/ndt.S53386","article-title":"Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study","volume":"9","author":"Shimizu","year":"2013","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B101","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ceb.2018.04.014","article-title":"Plastic mitochondria-endoplasmic reticulum (er) contacts use chaperones and tethers to mould their structure and signaling","volume":"53","author":"Simmen","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/jpm12030476","article-title":"Pathway phenotypes underpinning depression, anxiety, and chronic fatigue symptoms due to acute rheumatoid arthritis: a precision nomothetic psychiatry analysis","volume":"12","author":"Smesam","year":"2022","journal-title":"J. Pers. Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3858\/emm.2012.44.2.031","article-title":"Neuronal autophagy and neurodegenerative diseases","volume":"44","author":"Son","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2741\/s53","article-title":"Chemokines and chemokine receptors in arthritis","volume":"2","author":"Szekanecz","year":"2010","journal-title":"FBS"},{"key":"B105","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"115142","DOI":"10.1016\/j.bbr.2024.115142","article-title":"Cajaninstilbene acid ameliorates depression-like behaviors in mice by suppressing Tlr4\/Nf-\u039ab mediated neuroinflammation and promoting autophagy","volume":"471","author":"Tao","year":"2024","journal-title":"Behav. Brain Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/15548627.2019.1607686","article-title":"Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics","volume":"16","author":"Thangaraj","year":"2020","journal-title":"Autophagy"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1851420","DOI":"10.1155\/2016\/1851420","article-title":"Role of mitochondria-associated endoplasmic reticulum membrane in inflammation-mediated metabolic diseases","volume":"2016","author":"Thoudam","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"B109","doi-asserted-by":"publisher","first-page":"101368","DOI":"10.1016\/j.jbc.2021.101368","article-title":"Grp75 mediates endoplasmic reticulum\u2013mitochondria coupling during palmitate-induced pancreatic \u0392-Cell apoptosis","volume":"297","author":"Tiwary","year":"2021","journal-title":"J. Biol. Chem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3233\/jpd-160989","article-title":"Pink1, parkin, and mitochondrial quality control: what can we learn about parkinson's disease pathobiology?","volume":"7","author":"Truban","year":"2017","journal-title":"J. Park. Dis."},{"key":"B111","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s42358-021-00223-2","article-title":"Factors associated with anxiety and depression in rheumatoid arthritis patients: a cross-sectional study","volume":"61","author":"Uda","year":"2021","journal-title":"Adv. Rheumatol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1016\/j.molcel.2023.08.021","article-title":"Mitochondrial degradation: mitophagy and beyond","volume":"83","author":"Uoselis","year":"2023","journal-title":"Mol. Cell"},{"key":"B113","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.3892\/mmr.2018.9356","article-title":"Investigation of key autophagy-and mitophagy-related proteins and gene expression in balf cells from patients with ipf and Ra-Ild","volume":"18","author":"Vasarmidi","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1111\/jcmm.14837","article-title":"Inhibition of Dnm1l and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"774989","DOI":"10.3389\/fcell.2021.774989","article-title":"Endoplasmic reticulum-mitochondria contacts: a potential therapy target for cardiovascular remodeling-associated diseases","volume":"9","author":"Wang","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1038\/s41467-021-22771-3","article-title":"Fundc1-Dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis","volume":"12","author":"Wang","year":"","journal-title":"Nat. Commun."},{"key":"B117","doi-asserted-by":"publisher","first-page":"725","DOI":"10.21037\/atm-22-15","article-title":"Endoplasmic reticulum stress triggered autophagy and regulated the phenotype transformation of rheumatoid arthritis synovial fibroblasts via the Ire1\/Jnk pathway","volume":"10","author":"Wang","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1002\/2211-5463.12913","article-title":"Lncrna expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis","volume":"10","author":"Wen","year":"2020","journal-title":"FEBS Open Bio"},{"key":"B119","doi-asserted-by":"publisher","first-page":"109977","DOI":"10.1016\/j.celrep.2021.109977","article-title":"Tnf leads to mtdna release and Cgas\/sting-dependent interferon responses that support inflammatory arthritis","volume":"37","author":"Willemsen","year":"2021","journal-title":"Cell Rep."},{"key":"B120","doi-asserted-by":"publisher","first-page":"101951","DOI":"10.1016\/j.arr.2023.101951","article-title":"Novel tumor therapy strategies targeting endoplasmic reticulum-mitochondria signal pathways","volume":"88","author":"Wu","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"B121","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s41418-020-00657-z","article-title":"Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy","volume":"28","author":"Xian","year":"2021","journal-title":"Cell Death and Differ."},{"key":"B122","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12974-023-02715-y","article-title":"Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-Mediated mitophagy","volume":"20","author":"Yang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B123","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41467-021-21242-z","article-title":"Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation","volume":"12","author":"Ye","year":"2021","journal-title":"Nat. Commun."},{"key":"B124","doi-asserted-by":"publisher","first-page":"111443","DOI":"10.1016\/j.intimp.2023.111443","article-title":"Irisin mitigates rheumatoid arthritis by suppressing mitochondrial fission via inhibiting Yap-Drp1 signaling pathway","volume":"127","author":"Yu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B125","first-page":"199","article-title":"Relationship between oxidative stress and depression in patients with rheumatoid arthritis","volume":"44","author":"Zhang","year":"2012","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.7150\/thno.81067","article-title":"Hyperactive neuronal autophagy depletes bdnf and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"key":"B127","doi-asserted-by":"publisher","first-page":"108552","DOI":"10.1016\/j.reprotox.2024.108552","article-title":"Cypermethrin induces sertoli cell apoptosis through endoplasmic reticulum-mitochondrial coupling involving Ip3r1-Grp75-Vdac1","volume":"124","author":"Zhang","year":"","journal-title":"Reprod. Toxicol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"5199","DOI":"10.1038\/s41467-024-49597-z","article-title":"Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress","volume":"15","author":"Zhang","year":"","journal-title":"Nat. Commun."},{"key":"B129","doi-asserted-by":"publisher","first-page":"739882","DOI":"10.3389\/fendo.2022.739882","article-title":"New insights into the interplay among autophagy, the Nlrp3 inflammasome and inflammation in adipose tissue","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1549060\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T06:08:04Z","timestamp":1759817284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1549060\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,7]]},"references-count":129,"alternative-id":["10.3389\/fphar.2025.1549060"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1549060","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,7]]},"article-number":"1549060"}}