{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:36:32Z","timestamp":1789475792731,"version":"build-2803163510"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Magnesium deficiency is common in patients with cirrhosis, but there is a lack of real-world evidence to support the effect of magnesium supplementation on prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore whether magnesium sulfate supplementation is beneficial for patients with cirrhosis using data from the MIMIC-IV database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with cirrhosis were divided into magnesium sulfate group and non-magnesium sulfate group according to medication use during hospitalization after admission to the intensive care unit (ICU). In-hospital all-cause mortality was the primary outcome, and 180-day all-cause mortality was the secondary outcome. Propensity score matching (PSM) method, univariate and multivariate regression analysis were used to evaluate the effect of magnesium sulfate on prognosis, and Kaplan-Meier curves, subgroup analysis and sensitivity analysis were performed to clarify the stability of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prematched cohort included 3,312 patients, while the propensity score matched cohort included 1,308 patients. In the PSM analysis, the in-hospital all-cause mortality in the magnesium sulfate group was 22.0% (144\/654), and that in the non-use group was 31.0% (203\/654). Magnesium sulfate use was associated with lower in-hospital mortality (odds ratio [OR], 0.47; 95% confidence interval [CI], 0.33\u20130.69; P &amp;lt; 0.001) and reduced all-cause mortality at 180\u00a0days after ICU admission (hazard ratio [HR], 0.61; 95% CI, 0.51\u20130.72; P &amp;lt; 0.001). Sensitivity analyses confirmed the robustness of these results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Magnesium sulfate use is associated with reduced in-hospital and 180-day all-cause mortality in ICU patients with cirrhosis, which needs to be verified in prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphar.2025.1551495","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T04:14:24Z","timestamp":1760933664000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The use of magnesium sulfate can reduce the mortality risk of cirrhosis patients: a retrospective cohort study"],"prefix":"10.3389","volume":"16","author":[{"given":"Boxian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouji","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqi","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.3390\/medicina59071190","article-title":"Hypermagnesemia in clinical practice","volume":"59","author":"Aal-Hamad","year":"2023","journal-title":"Med. 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