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The variety of antidepressant drugs is large and the incidence of adverse effects is high. Selective serotonin reuptake inhibitors (SSRIs), as the first-line drugs for the treatment of depression, have remarkable efficacy, but at the same time there is a widespread abuse of them, which not only creates an unfavorable impact on one\u2019s own reproductive system, but also may cause reproductive damage to other non-target populations through pathways, such as the water column. The review provides an introduction to the reproductive toxicity of SSRIs from the aspects of male and female germ cell genesis, embryonic development, reproductive system maturation, and environmental contamination, and it briefly describes the potential mechanisms underlying SSRI-induced reproductive toxicity.<\/jats:p>","DOI":"10.3389\/fphar.2025.1567863","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T05:38:43Z","timestamp":1746077923000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Progress in the study of the effects of selective serotonin reuptake inhibitors (SSRIs) on the reproductive system"],"prefix":"10.3389","volume":"16","author":[{"given":"Yu","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"162280","DOI":"10.1016\/j.scitotenv.2023.162280","article-title":"Analyzing the potential environmental impact of niosh list of hazardous drugs (group 2)","volume":"873","author":"Abajo","year":"2023","journal-title":"Sci. total Environ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"14828","DOI":"10.3390\/ijms232314828","article-title":"Uptake and metabolization of serotonin by granulosa cells form a functional barrier in the mouse ovary","volume":"23","author":"Alyoshina","year":"2022","journal-title":"Int. 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