{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:45:45Z","timestamp":1793389545403,"version":"4.5.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Paris spp., as a traditional medicinal plant, are widely used globally due to their diverse therapeutic properties, including clearing heat and detoxifying, reducing swelling and relieving pain, calming the liver and suppressing convulsions. This review summarizes the research progress of <jats:italic>Paris<\/jats:italic> species in the fields of ethnopharmacology, phytochemistry, pharmacological effects, and applications in recent years. The study systematically retrieved information related to the keywords \u201cphytochemistry,\u201d \u201cpharmacology,\u201d and \u201ctoxicology\u201d from authoritative databases such as CNKI, PubMed, Elsevier, Web of Science, and SpringerLink, using \u201c<jats:italic>Paris<\/jats:italic> L.\u201d as a keyword to collect research materials related to this genus. During this process, a total of 431 metabolites were isolated and identified, with steroidal saponins being the most abundant. In addition to their medicinal uses, <jats:italic>Paris<\/jats:italic> spp. have also been applied in hair care products, cosmetics, and health products. Despite their demonstrated significant pharmacological activities and potential clinical applications, the field of <jats:italic>Paris<\/jats:italic> spp. research still faces several challenges. For example, the specific mechanisms of action against certain diseases are not fully understood, and multiple studies have shown that <jats:italic>Paris<\/jats:italic> species\u2019 extracts may cause adverse reactions and even toxicity. Therefore, further in-depth research and systematic evaluation are needed to promote the safe application and clinical translation of <jats:italic>Paris<\/jats:italic> spp.<\/jats:p>","DOI":"10.3389\/fphar.2025.1570818","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:46:59Z","timestamp":1748584019000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Paris spp (Liliaceae): a review of its botany, ethnopharmacology, phytochemistry, pharmacological activities, and practical applications"],"prefix":"10.3389","volume":"16","author":[{"given":"Ji","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"B1","first-page":"1900","article-title":"Progress of dendritie cell vaccine in immunotherapy of acute myeloid leukemia","volume":"25","author":"Bai","year":"2019","journal-title":"Med. 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