{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:28:34Z","timestamp":1790706514986,"version":"4.1.0"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Shenling Baizhu San (SLBZS) is a formulation of traditional Chinese medicine (TCM) recorded in the Song Dynasty medical book <jats:italic>Taiping Huimin Heji Jufang<\/jats:italic> (AD 1078\u20131085). It comprises eleven herbs: Ginseng Radix Et Rhizoma, Atractylodis Macrocephalae Rhizoma, Poria, Dioscoreae Rhizoma, Nelumbinis Semen, Coicis Semen, Lablab Semen Album, Amomi Fructus, Platycodonis Radix, Glycyrrhizae Radix Et Rhizoma, and Jujubae Fructus. SLBZS has been employed for over 900 years in the treatment of pulmonary and gastrointestinal disorders because of its qualities that enhance spleen function, tonify the lungs, supplement qi, and mitigate diarrhoea. This study meticulously examined and synthesised the clinical relevance and pharmacological mechanisms of SLBZS, concentrating on respiratory diseases, in response to the increasing volume of clinical data about SLBZS. Meanwhile, according to the five principles of Q-marker determination, including quality transmission and traceability, metabolites specificity, formula compatibility environment, association between metabolites and effectiveness, metabolites measurability, the potential quality markers (Q-markers) that SLBZS in the treatment of respiratory diseases were predicted. This study will provide additional clinical research, clarify pharmacological mechanisms, and set quality control criteria for SLBZS in the treatment of respiratory diseases.<\/jats:p>","DOI":"10.3389\/fphar.2025.1575903","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T05:25:50Z","timestamp":1748496350000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical application, potential pharmacological targets and quality marker prediction of a TCM formulation used (Shenling Baizhu San) in the treatment of respiratory diseases"],"prefix":"10.3389","volume":"16","author":[{"given":"Zu","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaolan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxue","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.intimp.2015.06.022","article-title":"Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages","volume":"28","author":"Bao","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.13493\/j.issn.1672-7878.2018.09-017","article-title":"To investigate the effect of Shenling baizhu powder combined with pidotimod on children with recurrent respiratory tract infection and its influence on the improvement of inflammatory factors and immune indicators","volume":"15","author":"Chen","year":"2018","journal-title":"Anti-Infection Pharm."},{"key":"B3","doi-asserted-by":"publisher","first-page":"978558","DOI":"10.3389\/fphar.2022.978558","article-title":"Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: clinical evidence and potential mechanisms","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B4","first-page":"62","article-title":"Research progress on chemical constituents and pharmacological activities ofDioscorea opposita thunb","volume":"48","author":"Chen","year":"2020","journal-title":"Acta Chin. Med. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1007\/s10753-015-0159-4","article-title":"Anti-asthmatic effects of ginsenoside Rb1 in a mouse model of allergic asthma through relegating Th1\/Th2","volume":"38","author":"Chen","year":"2015","journal-title":"Inflammation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"104803","DOI":"10.1016\/j.fitote.2020.104803","article-title":"Recent advances in chemical analysis of licorice (Gan-Cao)","volume":"149","author":"Cheng","year":"2021","journal-title":"Fitoterapia"},{"key":"B7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.16448\/j.cjtcm.2019.0092","article-title":"Clinical observation on treatment of bronchial asthma inChildren with flixotide combined with shenling baizhu powder","volume":"31","author":"Cui","year":"2019","journal-title":"Clin. J. Traditional Chin. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1080\/10286020.2013.771344","article-title":"Liquiritigenin prevents Staphylococcus aureus-mediated lung cell injury via inhibiting the production of \u03b1-hemolysin","volume":"15","author":"Dai","year":"2013","journal-title":"J. Asian Nat. Prod. Res."},{"key":"B9","first-page":"2081","article-title":"Experimental study of modified Shenlingbaizhu powder regulating Nrf2\/keap1\/NLRP3 signaling pathway to improve idiopathic pulmonary fibrosis","volume":"35","author":"Deng","year":"2024","journal-title":"Lishizhen Med. Materia Medica Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1177\/0960327120964555","article-title":"Glycyrrhizic acid ameliorates sodium nitrite-induced lung and salivary gland toxicity: impact on oxidative stress, inflammation and fibrosis","volume":"40","author":"Elsherbini","year":"2021","journal-title":"Hum. and Exp. Toxicol."},{"key":"B11","first-page":"521","article-title":"Anti-inflammatory and antioxidant effect of ginsenoside re on the lung injury induced by intestinal ischemia reperfusion in rats","volume":"12","author":"Fang","year":"2014","journal-title":"Cent. South Pharm."},{"key":"B12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12906-020-02958-9","article-title":"Shen-ling-Bai-zhu-san ameliorates inflammation and lung injury by increasing the gut microbiota in the murine model of Streptococcus pneumonia-induced pneumonia","volume":"20","author":"Feng","year":"2020","journal-title":"BMC complementary Med. Ther."},{"key":"B13","doi-asserted-by":"publisher","first-page":"118615","DOI":"10.1016\/j.jep.2024.118615","article-title":"Amomum villosum Lour.: an insight into ethnopharmacological, phytochemical, and pharmacological overview","volume":"335","author":"Feng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e360802","DOI":"10.1590\/ACB360802","article-title":"Atractylenolide III alleviates sepsis-mediated lung injury via inhibition of FoxO1 and VNN1 protein","volume":"36","author":"Fu","year":"2021","journal-title":"Acta cir. bras."},{"key":"B15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.19528\/j.issn.1003-3548.2022.08.045","article-title":"Effect of Shenling baizhu powder combined with fluticasone propionate aerosol on children with asthma of lung-spleen qi deficiency in remission stage","volume":"42","author":"Gao","year":"2022","journal-title":"Clin. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"117728","DOI":"10.1016\/j.jep.2024.117728","article-title":"Exploration the mechanism of Shenling Baizhu San in the treatment of chronic obstructive pulmonary disease based on UPLC-Q-TOF-MS\/MS, network pharmacology and in vitro experimental verification","volume":"324","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.14033\/j.cnki.cfmr.2022.10.010","article-title":"Effect of modified shenling baizhu powder in the AdjuvantTreatment of allergic rhinitis in children with lung spleen qi deficiency syndrome","volume":"20","author":"Ge","year":"2022","journal-title":"Chin. Foreign Med. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"7171404","DOI":"10.1155\/2017\/7171404","article-title":"Ginsenoside Rg1 attenuates cigarette smoke-induced pulmonary epithelial-mesenchymal transition via inhibition of the TGF-\u03b21\/smad pathway","volume":"2017","author":"Guan","year":"2017","journal-title":"BioMed Res. Int."},{"key":"B19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.15586\/aei.v49i5.468","article-title":"Pachymic acid inhibits inflammation and cell apoptosis in lipopolysaccharide (LPS)-induced rat model with pneumonia by regulating NF-\u03baB and MAPK pathways","volume":"49","author":"Gui","year":"2021","journal-title":"Allergologia Immunopathol."},{"key":"B20","first-page":"195","article-title":"Content determination and component analysis of total saponins in LablabSemen albums","volume":"49","author":"Han","year":"2021","journal-title":"J. Anhui Agric. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.3390\/molecules23071835","article-title":"Stereoselective and simultaneous analysis of ginsenosides from ginseng berry extract in rat plasma by UPLC-MS\/MS: application to a pharmacokinetic study of ginseng berry extract","volume":"23","author":"Han","year":"2018","journal-title":"Mol. Basel, Switz."},{"key":"B22","doi-asserted-by":"publisher","first-page":"156360","DOI":"10.1016\/j.phymed.2024.156360","article-title":"Integration of transcriptomics and metabolomics reveals the mechanism of Glycyrrhizae Radix Et Rhizoma extract inhibiting CCL5 in the treatment of acute pharyngitis","volume":"137","author":"Han","year":"2025","journal-title":"Phytomedicine Int. J. phytotherapy Phytopharm."},{"key":"B23","first-page":"159","article-title":"Shenling baizhu powder combined with western medicine inthe treatment of chronic obstructive pulmonary disease withLung and spleen qi deficiency Type","volume":"22","author":"He","year":"2024","journal-title":"Chin. Med. Mod. Distance Educ. China"},{"key":"B24","first-page":"1294","article-title":"Study on the protective effect and mechanism of the method ofstrengthening the spleen to benefit the lung on themitochondrial energy metabolism of skeletal muscle of micewith chronic obstructive pulmonary disease","volume":"37","author":"Hu","year":"2020","journal-title":"Tianjin J. Traditional Chin. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13020-024-00886-1","article-title":"The SIRT1\/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin","volume":"19","author":"Hua","year":"2024","journal-title":"Chin. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1080\/08923973.2020.1806871","article-title":"Atractylenolide III attenuates bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2\/NQO1\/HO-1 pathway activation","volume":"42","author":"Huai","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"B27","first-page":"730","article-title":"Effect of Shenling Baizhu powder combined with salmeterol and fluticasone inthe treatment of chronic bronchial asthma on the balance of body oxidationand antioxidation","volume":"44","author":"Huang","year":"2023","journal-title":"Shaanxi J. Traditional Chin. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.molimm.2018.11.003","article-title":"Protective effect of ginsenoside Rg1 on LPS-induced apoptosis of lung epithelial cells","volume":"136","author":"Ji","year":"2021","journal-title":"Mol. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1142\/S0192415X21500592","article-title":"Apigenin alleviates oxidative stress-induced cellular senescence via modulation of the SIRT1-NAD[formula: see text]-CD38 Axis","volume":"49","author":"Li","year":"","journal-title":"Am. J. Chin. Med."},{"key":"B30","first-page":"3","article-title":"Study on the therapeutic effect of shenling baizhu san onAlleviating bronchial asthma in mice by regulating Th17\/treg balance","volume":"46","author":"Li","year":"","journal-title":"Hubei J. Traditional Chin. Med."},{"key":"B31","volume-title":"Study on the antidiarrheal ingredients and quality standard standardization of white lentil","author":"Li","year":"2018"},{"key":"B32","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"","journal-title":"J. Transl. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"5382","DOI":"10.1002\/tox.23824","article-title":"Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats","volume":"39","author":"Li","year":"2023","journal-title":"Environ. Toxicol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"553","DOI":"10.19378\/j.issn.1003-9783.2024.04.013","article-title":"Analysis on chemical composition and constituents absorbedin the blood of shenling baizhu san by UPLC-Q-TOF-MS\/MS","volume":"35","author":"Li","year":"","journal-title":"Traditional Chin. Drug Res. Clin. Pharmacol."},{"key":"B35","first-page":"3549","article-title":"Content changes of chemical constituents in ginseng radix and AtractylodisMacrocephalae rhizoma before and after compatibility","volume":"45","author":"Li","year":"2014","journal-title":"Chin. Traditional Herb. Drugs"},{"key":"B36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12931-020-01356-6","article-title":"Different expression levels of interleukin-35 in asthma phenotypes","volume":"21","author":"Li","year":"2020","journal-title":"Respir. Res."},{"key":"B37","first-page":"3004","article-title":"Effect of Shenling baizhu powder combined with azithromycin in the treatment of children with mycoplasma pneumoniae pneumonia","volume":"30","author":"Li","year":"2021","journal-title":"Henan Med. Res."},{"key":"B38","first-page":"12","article-title":"Study on HPLC characteristic fingerprint of shenlingbaizhu powder and simultaneous determination of lts five indicative components","volume":"27","author":"Liu","year":"2018","journal-title":"China Pharm."},{"key":"B39","first-page":"2511","article-title":"Five-year review on development of quality markers of traditional Chinese medicine","volume":"52","author":"Liu","year":"2021","journal-title":"Chin. Traditional Herb. Drugs"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14786419.2024.2337117","article-title":"Rapid identification and determination of chemical components of huai yam based on UPLC-Q-Exactive-MS and fragmentation patterns","author":"Liu","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.intimp.2018.10.046","article-title":"Apigenin reverses lung injury and immunotoxicity in paraquat-treated mice","volume":"65","author":"Liu","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"102198","DOI":"10.1016\/j.ceca.2020.102198","article-title":"Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury","volume":"88","author":"Liu","year":"2020","journal-title":"Cell calcium"},{"key":"B43","first-page":"56","article-title":"Determination of 13 components in panacis japonici rhizoma and lts tota saponins by UPLC-Q\/TOF-MS","volume":"39","author":"Long","year":"2022","journal-title":"J. Hubei Minzu Univ. Ed."},{"key":"B44","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.19540\/j.cnki.cjcmm.20220421.201","article-title":"Research progress of Shenling Baizhu San and predictive analysis on its quality markers","volume":"47","author":"Lu","year":"2022","journal-title":"China J. Chin. Materia Medica"},{"key":"B45","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1631\/jzus.B2000594","article-title":"Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit","volume":"22","author":"Lu","year":"2021","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"B46","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jep.2013.04.021","article-title":"Immunoregulatory effects of glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1\/Th2 cytokines and enhancement of CD4(+)CD25(+)Foxp3+ regulatory T cells in ovalbumin-sensitized mice","volume":"148","author":"Ma","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"113927","DOI":"10.1016\/j.jep.2021.113927","article-title":"Efficacy of Shenling Baizhu San on stable chronic obstructive pulmonary disease patients: a systematic review and meta-analysis","volume":"272","author":"Mao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B48","first-page":"46","article-title":"Effects of Platycodonis radix on the chemical constituents in shenling baizhu san by UPLC-Q-TOF-MS\/MS","volume":"38","author":"Ou","year":"2024","journal-title":"Res. Pract. Chin. Med."},{"key":"B49","first-page":"1282","article-title":"Effect of shen ling baizhu powder on airway inflammation and regulation of GutMicrobiota in asthmatic mice","volume":"31","author":"Ouyang","year":"2020","journal-title":"Traditional Chin. Drug Res. Clin. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"812","DOI":"10.19378\/j.issn.1003-9783.2019.07.010","article-title":"Inhibitory effect of ShenLing baizhu powder on AirwayInflammation in young asthmatic rats","volume":"30","author":"Ouyang","year":"2019","journal-title":"Traditional Chin. Drug Res. Clin. Pharmacol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1129874","DOI":"10.3389\/fphar.2023.1129874","article-title":"Coicis Semen for the treatment of malignant tumors of the female reproductive system: a review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics, and pharmacodynamics","volume":"14","author":"Pan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B52","article-title":"Chemical constituents of differents parts from","volume-title":"Nelumbo nucifera","author":"Pei","year":"2021"},{"key":"B53","first-page":"4293","article-title":"Quality evaluation of Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle basedon HPLC fingerprint and multi-component quantitative analysis by QAMS","volume":"50","author":"Pei","year":"2019","journal-title":"Chin. Traditional Herb. Drugs"},{"key":"B54","first-page":"2042","article-title":"Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K\/AKT\/mTOR pathway","volume":"11","author":"Qu","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jgr.2020.02.004","article-title":"Pharmacological potential of ginseng and its major component ginsenosides","volume":"45","author":"Ratan","year":"2020","journal-title":"J. ginseng Res."},{"key":"B56","first-page":"1304","article-title":"Determination of four active components in radix glycyrrhizae by HPLC-CAD","volume":"24","author":"Ren","year":"2020","journal-title":"Anhui Med. Pharm. J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"8372","DOI":"10.1038\/s41598-023-34790-9","article-title":"A randomized controlled trial of effects of open-label placebo compared to double-blind placebo and treatment-as-usual on symptoms of allergic rhinitis","volume":"13","author":"Schaefer","year":"2023","journal-title":"Sci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"115686","DOI":"10.1016\/j.jep.2022.115686","article-title":"Chemical analysis of the Chinese herbal medicine licorice (Gan-Cao): an update review","volume":"299","author":"Shang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.micpath.2019.05.003","article-title":"Ginsenoside Rb1 ameliorates Staphylococcus aureus-induced Acute Lung Injury through attenuating NF-\u03baB and MAPK activation","volume":"132","author":"Shaukat","year":"2019","journal-title":"Microb. Pathog."},{"key":"B60","first-page":"145","article-title":"To observe the effect of Shenlingbaizhu powder combined with tiotropium bromide in the treatment of chronic obstructive pulmonary disease in remission stage and its influence on pulmonary function","volume":"28","author":"Shi","year":"2024","journal-title":"Med. Forum"},{"key":"B61","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.intimp.2019.02.023","article-title":"Chikusetsusaponin V attenuates lipopolysaccharide-induced acute lung injury in mice by modulation of the NF-\u03baB and LXR\u03b1","volume":"70","author":"Su","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"100024","DOI":"10.1016\/j.labinv.2022.100024","article-title":"Atractylenolide III ameliorated autophagy dysfunction via epidermal growth factor receptor-mammalian target of rapamycin signals and alleviated silicosis fibrosis in mice","volume":"103","author":"Tan","year":"2023","journal-title":"Laboratory investigation; a J. Tech. methods pathology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e70073","DOI":"10.1002\/jssc.70073","article-title":"Separation and purification of ginsenosides and flavonoids in from the leaves and stems of Panax quinquefolium by high-speed countercurrent chromatography and online-storage inner-recycling countercurrent chromatography","volume":"48","author":"Wang","year":"2025","journal-title":"J. Sep. Sci."},{"key":"B64","first-page":"826","article-title":"Study on Herbal Drug Pair of Platycodonis Radix and Glycyrrhizae Radix et Rhizomain Classical Prescription Jiegeng Tang","volume":"23","author":"Wang","year":"2021","journal-title":"Mod. Chin. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"15347354221081214","DOI":"10.1177\/15347354221081214","article-title":"Herbal formula shenling baizhu san for chronic diarrhea in adults: a systematic review and meta-analysis","volume":"21","author":"Wang","year":"2022","journal-title":"Integr. cancer Ther."},{"key":"B66","doi-asserted-by":"publisher","first-page":"6453296","DOI":"10.1155\/2019\/6453296","article-title":"Ginsenoside Rg1 regulates SIRT1 to ameliorate sepsis-induced lung inflammation and injury via inhibiting endoplasmic reticulum stress and inflammation","volume":"2019","author":"Wang","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1007\/s12010-023-04686-5","article-title":"Pachymic acid protects against bleomycin-induced pulmonary fibrosis by suppressing fibrotic, inflammatory, and oxidative stress pathways in mice","volume":"196","author":"Wang","year":"2023","journal-title":"Appl. Biochem. Biotechnol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"216","DOI":"10.19378\/j.issn.1003-9783.2024.02.008","article-title":"Effect of atractylenolide l on lung injury in rats with RecurrentRespiratory tract infection of lung and spleen qi deficiency byRegulating the Pl3K\/Akt\/mTOR signaling pathway","volume":"35","author":"Wang","year":"","journal-title":"Traditional Chin. Drug Res. Clin. Pharmacol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"136917","DOI":"10.1016\/j.foodchem.2023.136917","article-title":"Prediction performance and reliability evaluation of three ginsenosides in Panax ginseng using hyperspectral imaging combined with a novel ensemble chemometric model","volume":"430","author":"Wang","year":"","journal-title":"Food Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.24976\/Discov.Med.202436191.220","article-title":"A new perspective for improving COPD: ginsenoside Rg3 links SIRT1 to inhibit mitochondrial autophagy","volume":"36","author":"Wang","year":"","journal-title":"Discov. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"33","DOI":"10.19656\/j.cnki.1002-2406.200126","article-title":"Effects of shenling baizhu powder on lmmune function in ratswith recurrent respiratory tract infections of qi-deficiency ofLung and spleen","volume":"37","author":"Wang","year":"2020","journal-title":"Inf. Traditional Chin. Med."},{"key":"B72","first-page":"95","article-title":"Effect of Shenlingbaizhu powder combined with massage on cough in children","volume":"39","author":"Wang","year":"2024","journal-title":"Guangming J. Chin. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1328632","DOI":"10.3389\/fphar.2024.1328632","article-title":"Jiawei Kongsheng Zhenzhong Pill: marker compounds, absorption into the serum (rat), and Q-markers identified by UPLC-Q-TOF-MS\/MS","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"105856","DOI":"10.1016\/j.fitote.2024.105856","article-title":"Integrated analysis and separation of 5-lipoxygenase inhibitors from triterpenes of Poria cocos using bioaffinity ultrafiltration UPLC-Q-Exactive, molecular docking and target-based multiple complex networks","volume":"175","author":"Wu","year":"2024","journal-title":"Fitoterapia"},{"key":"B75","doi-asserted-by":"publisher","first-page":"79","DOI":"10.19879\/j.cnki.1005-5304.202111648","article-title":"Effect of shenling baizhu powder on pulmonary lmmuneInflammatory response in juvenile mice with intestina dysbiosis","volume":"29","author":"Wu","year":"2022","journal-title":"Chin. J. Inf. Traditional Chin. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.3390\/molecules28103987","article-title":"Chemical constitution, pharmacological effects and the underlying mechanism of atractylenolides: a review","volume":"28","author":"Xie","year":"2023","journal-title":"Mol. Basel, Switz."},{"key":"B77","doi-asserted-by":"publisher","first-page":"119305","DOI":"10.1016\/j.jep.2024.119305","article-title":"Effects and mechanism of combination of Platycodon grandiflorum polysaccharides and Platycodon saponins in the treatment of chronic obstructive pulmonary disease rats through the gut-lung axis","volume":"341","author":"Xu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3518241","DOI":"10.1155\/2021\/3518241","article-title":"Simultaneous determination of ten bioactive components from shenling baizhu san in rat plasma by UHPLC-MS\/MS: application to a comparative pharmacokinetic study in normal and two models of ulcerative colitis rats","volume":"2021","author":"Xu","year":"2021","journal-title":"Evidence-based complementary Altern. Med."},{"key":"B79","first-page":"83","article-title":"Content determination of vanillic Acid,Ferulic acid and apigenin in kalimeris indica by HPLC","volume":"32","author":"Yang","year":"2023","journal-title":"China Pharm."},{"key":"B80","doi-asserted-by":"publisher","first-page":"154646","DOI":"10.1016\/j.phymed.2023.154646","article-title":"Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway","volume":"111","author":"Yu","year":"2023","journal-title":"Phytomedicine Int. J. phytotherapy Phytopharm."},{"key":"B81","first-page":"61","article-title":"GC-MS in analysis of chemical composition of volatile oil in different ratio ofAtractylodis Macrocephalae rhizoma and Poria","volume":"24","author":"Yue","year":"2018","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B82","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ejphar.2015.08.022","article-title":"Atractylenolide I protects mice from lipopolysaccharide-induced acute lung injury","volume":"765","author":"Zhang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4149\/gpb_2020046","article-title":"Protective effects of Atractylenolide III on inflammation and oxidative stress in ovalbumin-induced asthma mice and its possible mechanisms","volume":"40","author":"Zhang","year":"2021","journal-title":"General physiology biophysics"},{"key":"B84","doi-asserted-by":"publisher","first-page":"109","DOI":"10.13192\/j.issn.1000-1719.2023.12.031","article-title":"Effect and mechanism of shenling baizhu powder in treatment of stable phase of chronic obstructive pulmonary disease","volume":"50","author":"Zhang","year":"2023","journal-title":"Liaoning J. Traditional Chin. Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"154422","DOI":"10.1016\/j.phymed.2022.154422","article-title":"Platycodon grandiflorum (Jacq.) A. DC.: a review of phytochemistry, pharmacology, toxicology and traditional use","volume":"106","author":"Zhang","year":"2022","journal-title":"Phytomedicine Int. J. phytotherapy Phytopharm."},{"key":"B86","volume-title":"Study on the compatibility mechanism of Ginseng Radixcombined with Atractylodis Macrocephalae Rhizoma in thetreatment ofchronic atrophic gastritis","author":"Zhang","year":"2019"},{"key":"B87","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1369\/0022155415610168","article-title":"Glycyrrhizic acid prevents sepsis-induced acute lung injury and mortality in rats","volume":"64","author":"Zhao","year":"2016","journal-title":"J. Histochem. Cytochem. official J. Histochem. Soc."},{"key":"B88","volume-title":"Research on quality evaluation and effectiveness of the compatibility ofginseng and other 4 Chinese medicines","author":"Zhao","year":"2015"},{"key":"B89","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.13935\/j.cnki.sjzx.241116","article-title":"Clinical efficacy of shenling baizhu powder combined withAcupuncture and moxibustion on allergic rhinitis with QiDeficiency in lungs and spleen syndrome and effect on SerumIFN-y and lL-17 levels","volume":"19","author":"Zhao","year":"2024","journal-title":"World J. Integr. Traditional West. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"108852","DOI":"10.1016\/j.intimp.2022.108852","article-title":"Isoliquiritin apioside relieves intestinal ischemia\/reperfusion-induced acute lung injury by blocking Hif-1\u03b1-mediated ferroptosis","volume":"108","author":"Zhongyin","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13020-023-00739-3","article-title":"Liquiritin exhibits anti-acute lung injury activities through suppressing the JNK\/Nur77\/c-Jun pathway","volume":"18","author":"Zhou","year":"2023","journal-title":"Chin. Med."},{"key":"B92","first-page":"369","article-title":"Protective mechanism of Shenling Baizhu powder on the injured cells of COPDskeletal muscle based on mitochondrial autophagy","volume":"36","author":"Zhou","year":"2020","journal-title":"J. Guangdong Pharm. Univ."},{"key":"B93","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jep.2018.08.023","article-title":"The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: a review","volume":"226","author":"Zhu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1111\/1440-1681.13306","article-title":"Atractylenolide III reduces NLRP3 inflammasome activation and Th1\/Th2 imbalances in both in vitro and in vivo models of asthma","volume":"47","author":"Zhu","year":"2020","journal-title":"Clin. Exp. Pharmacol. and physiology"},{"key":"B95","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jpba.2017.11.066","article-title":"Qualitatively and quantitatively comparing secondary metabolites in three medicinal parts derived from Poria cocos (Schw.) Wolf using UHPLC-QTOF-MS\/MS-based chemical profiling","volume":"150","author":"Zhu","year":"","journal-title":"J. Pharm. Biomed. analysis"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.3390\/molecules23092200","article-title":"Correlation between quality and geographical origins of Poria cocos revealed by qualitative fingerprint profiling and quantitative determination of triterpenoid acids","volume":"23","author":"Zhu","year":"","journal-title":"Mol. Basel, Switz."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1575903\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T05:26:06Z","timestamp":1748496366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1575903\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":96,"alternative-id":["10.3389\/fphar.2025.1575903"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1575903","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"article-number":"1575903"}}