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With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demonstrate that they mainly function through inhibition of cancer cell proliferation, migration, and invasion, induction of cancer cell apoptosis and autophagy, regulation of the cell cycle, suppression of tumor angiogenesis, and anti-inflammatory and anti-oxidant properties. Herein, we systematically explore the well-documented ESCM\u2019s extracts or constituents with explicit anti-cancer properties, alongside their underlying mechanisms and pathways. The review further highlights both the primary preventions and clinical trials of ESCM-related products, offering valuable insights for the development of novel dietary approaches and therapeutic interventions in cancer management.<\/jats:p>","DOI":"10.3389\/fphar.2025.1598978","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:22:18Z","timestamp":1750396938000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhongqi","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.canlet.2015.05.015","article-title":"Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells","volume":"365","author":"Amorim","year":"2015","journal-title":"Cancer Lett."},{"key":"B2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s12032-023-02044-3","article-title":"Cancer-biomarkers associated with sex hormone receptors and recent therapeutic advancements: a comprehensive review","volume":"40","author":"Anbarasu","year":"2023","journal-title":"Med. 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