{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:22:17Z","timestamp":1778937737131,"version":"3.51.4"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tanshinone \u2161A (Tan \u2161A) is a monomer extracted from <jats:italic>Salvia miltiorrhiza<\/jats:italic> Bunge. Animal studies have demonstrated its potential in providing cognitive protection in Alzheimer\u2019s disease (AD), but the overall effects remain inconclusive, and its multiple mechanisms have not been systematically summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This systematic review and meta-analysis (SR\/MA) aimed to evaluate the overall effects of Tan \u2161A on cognitive function in AD animal models and to summarize the mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven databases (PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Chinese Biological Medical Disc, Chongqing VIP, and Wanfang databases) and grey literature were retrieved. Risk of bias was evaluated following the Systematic Review Center for Laboratory Animal Experiments. The mean difference (MD) or standard mean difference (SMD) with 95% confidence intervals (CIs) were used to evaluate the effect of Tan \u2161A on cognitive function, neuropathology, neuroinflammation, oxidative stress, apoptosis, and neural\/synaptic plasticity, with <jats:italic>P<\/jats:italic> &amp;lt; 0.05 considered a significant difference. The effect and potential mechanisms of Tan \u2161A were demonstrated by performing multiple subgroup analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen studies involving 581 AD animals were identified. The included studies showed satisfactory reporting quality but had certain risks of bias in methodology. Tan \u2161A ameliorated cognitive deficits, evidenced by reducing escape latency (MD = \u221217.94 s; 95% CI: \u221222.92 to \u221212.96) and increasing time spent in the target quadrant (MD = 10.69 s; 95% CI: 7.32\u201314.07). It attenuated neuropathological damage by reducing amyloid-\u03b2 (A\u03b2) plaques in thioflavine S staining (SMD = \u22123.46; 95% CI: \u22125.65 to \u22121.26) and increasing neuronal density in Nissl staining (SMD = 2.82; 95% CI: 2.11\u20133.52) and NeuN staining (SMD = 2.89; 95% CI: 1.71\u20134.08). Tan \u2161A also demonstrated anti-inflammatory effects through downregulation of pro-inflammatory cytokines [tumor necrosis factor-alpha (TNF-\u03b1), interleukin-1 beta (IL-1\u03b2), and interleukin-6 (IL-6)] and antioxidant stress properties by increasing superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels while reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels. Additionally, it exhibited antiapoptotic effects by increasing the B-cell lymphoma-2\/Bcl-2-associated X protein (Bcl-2\/Bax) ratio and decreasing Caspase-3 expression. Moreover, treatment improved neuronal\/synaptic plasticity by upregulating postsynaptic density-95 (PSD-95) and brain-derived neurotrophic factor (BDNF) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tan \u2161A could improve cognitive function and neuropathology through multiple mechanisms. This suggests that Tan IIA may serve as a viable candidate for the development of therapeutic strategies for AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42024588415<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphar.2025.1603861","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T05:24:40Z","timestamp":1752211480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Preclinical evidence and potential mechanisms of tanshinone \u2161A on cognitive function in animal models of Alzheimer\u2019s disease: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuanhang","family":"Rong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenna","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.2174\/1570159x20666211231090659","article-title":"Stem cell-based therapeutic and diagnostic approaches in Alzheimer's disease","volume":"20","author":"Abdi","year":"2022","journal-title":"Curr. 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