{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:43:48Z","timestamp":1778035428461,"version":"3.51.4"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Stevens\u2013Johnson syndrome is a rare, severe cutaneous adverse reaction. There is a lack of literature reporting the complications of the bladder and ureter caused by Stevens\u2013Johnson syndrome. In this case, we describe a 10-year-old boy with hydronephrosis and nephrogenic adenoma secondary to Stevens\u2013Johnson syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case description<\/jats:title><jats:p>A boy was admitted to our hospital after a CT scan revealed bilateral hydronephrosis. He had been diagnosed with Stevens\u2013Johnson syndrome earlier. Ureteroscopy and bilateral retrograde ureteral stenting were performed. After the guidewires were introduced, a mass of mucosal debris gushed from the ureteral orifices. Biopsy findings of the mucosal lesions were consistent with nephrogenic adenoma. Two months later, ultrasonography revealed worsening hydronephrosis. The double-J stents were removed. Follow-up ultrasonography showed an improvement in the hydronephrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stevens\u2013Johnson syndrome is a life-threatening mucocutaneous disorder. Ureteral obstruction and hydronephrosis can be caused by mucosal debris in patients with Stevens\u2013Johnson syndrome, which may contribute to and exacerbate renal dysfunction. Nephrogenic adenoma can occur to patient with Stevens\u2013Johnson syndrome as a result of the proliferation of implanted renal tubular cells. Routine ultrasonography should be conducted to monitor the urinary system.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphar.2025.1624432","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:52:12Z","timestamp":1755244332000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Hydronephrosis and nephrogenic adenoma secondary to Stevens-Johnson syndrome"],"prefix":"10.3389","volume":"16","author":[{"given":"Chuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e265","DOI":"10.1097\/BCR.0b013e31829a4374","article-title":"The first reported case of ureteral perforation in a patient with severe toxic epidermal necrolysis syndrome","volume":"35","author":"Baccaro","year":"2014","journal-title":"J. Burn Care Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.humpath.2005.09.013","article-title":"Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma","volume":"37","author":"Hartmann","year":"2006","journal-title":"Hum. Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/1752-1947-2-164","article-title":"Adenocarcinoma of the bladder following nephrogenic adenoma: a case report","volume":"2","author":"Hungerhuber","year":"2008","journal-title":"J. Med. Case Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/s1081-1206(10)61112-x","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature","volume":"94","author":"Letko","year":"2005","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1056\/NEJMoa013413","article-title":"Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients","volume":"347","author":"Mazal","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.mcna.2021.04.001","article-title":"Recognition and management of severe cutaneous adverse drug reactions (including drug reaction with eosinophilia and systemic symptoms, stevens-Johnson syndrome, and toxic epidermal necrolysis)","volume":"105","author":"Owen","year":"2021","journal-title":"Med. Clin. North Am."},{"key":"B7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.burns.2015.03.012","article-title":"Complications of Stevens-Johnson syndrome beyond the eye and skin","volume":"42","author":"Saeed","year":"2016","journal-title":"Burns"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s12325-017-0530-y","article-title":"Stevens-johnson syndrome and toxic epidermal necrolysis: a concise review with a comprehensive summary of Therapeutic interventions Emphasizing supportive measures","volume":"34","author":"Schneider","year":"2017","journal-title":"Adv. Ther."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1624432\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:52:15Z","timestamp":1755244335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2025.1624432\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":8,"alternative-id":["10.3389\/fphar.2025.1624432"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2025.1624432","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"article-number":"1624432"}}