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To address these critical bottlenecks\u2014particularly the escalating regulatory demands and trade barriers due to contamination incidents\u2014this review establishes the first integrated \u2018dual track\u2019 quality control framework for TCM contaminants. We propose a novel risk stratified strategy synergizing laboratory grade accuracy with field deployable screening, overcoming the sensitivity portability trade-off. This work provides a roadmap for establishing globally harmonized standards. Future research should prioritize high-throughput methods, intelligent analytics, and green detection technologies. Integrating AI-driven automation with data traceability could establish unified systems for contaminant detection and degradation, enhancing TCM quality control and global competitiveness.<\/jats:p>","DOI":"10.3389\/fphar.2025.1658241","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:35:33Z","timestamp":1755149733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Advances in research on novel technologies for the detection of exogenous contaminants in traditional Chinese medicine"],"prefix":"10.3389","volume":"16","author":[{"given":"Ziyu","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"139836","DOI":"10.1016\/j.foodchem.2024.139836","article-title":"Rapid qualitative and quantitative analysis of benzo(b)fluoranthene (BbF) in shrimp using SERS-Based sensor coupled with chemometric models","volume":"454","author":"Adade","year":"2024","journal-title":"Food Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.fct.2019.04.047","article-title":"Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: a systematic literature review, 2001-2018","volume":"129","author":"Al-Jaal","year":"2019","journal-title":"Food Chem. 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