{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:33:06Z","timestamp":1761283986975,"version":"build-2065373602"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study investigated the protective effects of baicalin on retinal ganglion cells (RGCs) subjected to ischemia-reperfusion injury and explored the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      By establishing an\n                      <jats:italic>in vitro<\/jats:italic>\n                      model of oxygen-glucose deprivation\/reperfusion (OGD\/R) in a microglia-RGC co-culture system, we examined the protective role of baicalin against RGC injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results demonstrated that baicalin significantly suppressed the M1 polarization of microglia, promoted their shift toward M2 polarization, and alleviated oxidative stress and ferroptosis in RGCs by inhibiting the JAK2\/STAT3 signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals that baicalin protects RGCs by modulating microglial polarization and inhibiting ferroptosis, providing novel insights for the treatment of glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2025.1660294","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:28:19Z","timestamp":1761283699000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2\/STAT3 pathway"],"prefix":"10.3389","volume":"16","author":[{"given":"Huan","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaozong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1934578X1701200815","DOI":"10.1177\/1934578x1701200815","article-title":"Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) analysis of palytoxin","volume":"12","author":"Abe","year":"2017","journal-title":"Nat. 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