{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:23:53Z","timestamp":1787318633642,"version":"build-2736575974"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    spp., encompassing various species within the genus, is a traditional Chinese botanical drug. It is known for its pharmacological effects, including qi tonification, yin nourishment, spleen invigoration, lung moistening, and kidney tonification.\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    contains abundant bioactive metabolites, such as polysaccharides, steroidal saponins, flavonoids, volatile metabolites, and alkaloids. Recent research primarily revolves around its anti-inflammatory, anti-ageing, and glycaemic regulatory properties, while its antitumor potential remains comparatively underexplored. Malignant tumors represent a considerable global public health obstacle and are now a leading contributor to the global disease burden. The identification of effective antitumor agents and therapeutic strategies is urgent. Bioactive metabolites in\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    have shown strong cytotoxic and pro-apoptotic impacts\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . However, current research mostly focuses on isolated metabolites, lacking comprehensive narrative analysis. This review endeavors to narratively summarize recent advances on the antitumor activity and underlying mechanisms of\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    , critically evaluate existing research gaps, and proposes future directions to facilitate the development of\n                    <jats:italic>Polygonatum<\/jats:italic>\n                    as a potential novel anticancer agent.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2025.1662839","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T06:29:51Z","timestamp":1762756191000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The antitumor potential of Polygonatum spp.: a narrative review of traditional uses, bioactive metabolites, and multi-targeted mechanisms"],"prefix":"10.3389","volume":"16","author":[{"given":"Mengqin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S0165-6147(00)89019-7","article-title":"Progress in traditional Chinese medicine","volume":"16","author":"Chan","year":"1995","journal-title":"Trends Pharmacol. 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