{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:41:53Z","timestamp":1781188913826,"version":"3.54.1"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Parkinson\u2019s disease (PD) is a neurodegenerative disorder characterized by progressive dopaminergic neuronal loss, with oxidative stress and inflammation as key contributors to its pathogenesis.\n                    <jats:italic>Odontosoria biflora<\/jats:italic>\n                    (Kaulf.) C.Chr. [Lindsaeaceae], an endemic fern from Batanes Island, Philippines, is traditionally consumed as \u201ctubho tea\u201d and culturally associated with longevity. This study evaluated the pharmacological potential of\n                    <jats:italic>O. biflora<\/jats:italic>\n                    extract (OBE) in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    models of PD. Leaves and stems were sequentially extracted using hexane (HOBE), ethyl acetate (EOBE), methanol (MOBE), and aqueous (AOBE) solvents.\n                    <jats:italic>C. elegans<\/jats:italic>\n                    N2, UA57, and NL5901 strains were cultured under standard conditions, and sublethal toxicity screening was conducted. The initial assay determined the effects of the four OBEs on dopaminergic neuronal loss in transgenic\n                    <jats:italic>C. elegans<\/jats:italic>\n                    , identifying MOBE as the most pronounced extract. MOBE was subsequently evaluated for \u03b1-synuclein aggregation, lifespan, mechanosensation, and locomotion. Antioxidant capacity was assessed using DPPH, ABTS, and FRAP assays as analytical tools, total phenolic content was determined, and phytochemical analysis was performed using high-resolution ultraperformance liquid chromatography coupled with electrospray ionization\/quadrupole time-of-flight mass spectrometry. MOBE significantly reduced dopaminergic neuronal loss, decreased \u03b1-synuclein aggregation, extended lifespan, and improved mechanosensation and locomotion in transgenic\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    compared with both the negative and positive controls. Antioxidant assays demonstrated strong radical-scavenging activity consistent with its phenolic content (22.3 mg gallic acid equivalents [GAE]\/g), and multiple metabolites were identified, including 1,4-dihydroxyanthraquinone, flavonoid 8-C glycosides, 2-O-rhamnosylvitexin, khellin, isovitexin, apigenin-8-C glucoside, benzoic acid, and pterosin G. Taken together, these findings suggest that MOBE exhibits pharmacological potential in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    PD models and warrants further investigation in mammalian systems.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2025.1662877","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:35:21Z","timestamp":1768973721000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacological effects and phytochemical profile of methanolic Odontosoria biflora (Kaulf.) C.Chr. [Lindsaeaceae] extract in Caenorhabditis elegans models of Parkinson\u2019s disease"],"prefix":"10.3389","volume":"16","author":[{"given":"Meysam","family":"Hamel Darbandi","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila","place":["Manila, Philippines"]},{"name":"Department of Biochemistry, Nutrition and Molecular Biology, School of Medicine, Bohol Island State University","place":["Tagbilaran, Bohol, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Michelle M.","family":"Dalmacio","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila","place":["Manila, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Ma M.","family":"Angeles","sequence":"additional","affiliation":[{"name":"Department of Parasitology, College of Public Health, University of the Philippines Manila","place":["Manila, Philippines"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.17912\/micropub.biology.000634","article-title":"Effect of DMSO on lifespan and physiology in C. 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