{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:30:52Z","timestamp":1779881452568,"version":"3.53.1"},"reference-count":195,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Natural products, especially those from medicinal plants, have been increasingly attractive to researchers. Wedelolactone (WL) is a natural coumestan that was first isolated from Wedelia Chinensis. The past decades have seen an increase in the pharmacological reports on this compound, which show that WL possesses anti-inflammatory, antiviral, antibacterial, antitumor and anti-osteoporosis activities, as well as protective effects on organ damages. This review integrates the recent progresses available on its pharmacological effects both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , and highlights its potential uses in multiple diseases.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2025.1670032","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:45:37Z","timestamp":1769582737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Wedelolactone, a natural coumestan with multiple pharmacological effects"],"prefix":"10.3389","volume":"16","author":[{"given":"Shanshan","family":"Han","sequence":"first","affiliation":[{"name":"The Affiliated Hospital to Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghe","family":"Li","sequence":"additional","affiliation":[{"name":"Brain Diseases Center, The Third Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Yang","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"655531","DOI":"10.3389\/fphar.2021.655531","article-title":"The combination of schisandrol B and wedelolactone synergistically reverses hepatic fibrosis Via modulating multiple signaling pathways in mice","volume":"12","author":"Ai","year":"2021","journal-title":"Front. 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