{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:48:51Z","timestamp":1788835731723,"version":"build-2803163510"},"reference-count":151,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016968","name":"Fondo Nacional de Innovaci\u00f3n y Desarrollo Cient\u00edfico\u2013Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    The review systematically maps the ethnomedicinal uses and chemistry of\n                    <jats:italic>Pinus<\/jats:italic>\n                    spp., with an emphasis on the under-studied\n                    <jats:italic>Pinus occidentalis<\/jats:italic>\n                    Swartz, known as \u201cpino criollo\u201d, \u201cpino de cuaba\u201d or \u201cpin creole\u201d. It is the only native pine species of Hispaniola, and holds ecological, cultural, and medicinal significance across the Dominican Republic and Haiti. A data search was conducted across several databases (Google Scholar, SciFinder, Scopus, ScienceDirect, PubMed\/Medline, and TRIP) to evaluate the existing knowledge of\n                    <jats:italic>P. occidentalis<\/jats:italic>\n                    spp. and compare it to that of other\n                    <jats:italic>Pinus<\/jats:italic>\n                    species for medicinal uses. The search showed evidence about the medicinal use of this pine species for treating respiratory ailments (cough, cold, and flu), skin infections, wounds, and inflammatory conditions, mainly through hot decoctions of pine needles, bark, cone tender sprouts, and the resin in some locations in Hispaniola. Still, phytochemical data were scarce, limited to the composition of the needle\u2019s essential oil and resin\u2019s turpentine oil in the 20th century. Systematic pharmacological validation of these limited ethnopharmacological findings is still pending, along with the determination of phytochemicals. Research on\n                    <jats:italic>P. occidentalis<\/jats:italic>\n                    shows potential as a natural health product. The urgent need for sustainable strategies is emphasized by conservation concerns related to habitat loss and deforestation. Future research should focus on detailed ethnopharmacology, conservation and propagation techniques for its exploitation, extraction technologies, chemical profiling, and pharmacological screening according to ethnomedicinal surveys, to set\n                    <jats:italic>P. occidentalis<\/jats:italic>\n                    as a promising candidate for phytotherapeutic development and integrative health applications in Hispaniola. These gaps underscore the need for a research roadmap of this endemic tree across the island. The review represents the first comprehensive synthesis of the ethnomedical applications of\n                    <jats:italic>P. occidentalis<\/jats:italic>\n                    Swartz, systematically mapping its cultural and therapeutic significance across Hispaniola.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2025.1680390","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:30:09Z","timestamp":1763015409000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ethnopharmacology of Pinus species with focus on the Hispaniola pine (Pinus occidentalis Swartz): evidence, gaps, and research roadmap"],"prefix":"10.3389","volume":"16","author":[{"given":"Alberto J.","family":"N\u00fa\u00f1ez-Selles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauro","family":"Nuevas-Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa A.","family":"G\u00f3mez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11157-022-09624-1","article-title":"Chemical composition and industrial applications of maritime pine (Pinus pinaster Ait.) bark and other non-wood parts","volume":"21","author":"Alonso-Esteban","year":"2022","journal-title":"Rev. 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