{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:40:10Z","timestamp":1768308010323,"version":"3.49.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human adenoviruses (HAdVs) cause a wide range of clinical diseases, yet effective antiviral therapies remain limited. Natural products, particularly medicinal plants, offer potential sources of antiviral agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study aimed to evaluate the antiviral potential of\n                      <jats:italic>Hellenia speciosa<\/jats:italic>\n                      (J.Koenig) S.R.Dutta [syn.\n                      <jats:italic>Costus speciosus<\/jats:italic>\n                      (J.Koenig) Sm.; Costaceae] rhizome against HAdVs using both\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in silico<\/jats:italic>\n                      approaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rhizome extracts were tested on Vero cells to assess cytotoxicity and antiviral activity. GC\u2013MS identified bioactive metabolites, which were screened against adenoviral DNA polymerase using molecular docking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Docking predicted strong interactions of selected metabolites with the viral polymerase, guiding selection for\n                      <jats:italic>in vitro<\/jats:italic>\n                      assays. The methanolic extract exhibited low cytotoxicity and potent antiviral effects, while the ethanolic extract also showed notable activity. Selectivity indices indicated a favorable therapeutic window.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. speciosa<\/jats:italic>\n                      rhizome contains bioactivemetabolites with potential anti-adenoviral activity. While preliminary results are promising, further\n                      <jats:italic>in vivo<\/jats:italic>\n                      and clinical studies are required to confirm pharmacological relevance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2025.1687104","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:35:53Z","timestamp":1768286153000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiviral activity of Hellenia speciosa (J. Koenig) S.R. 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