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Nobiletin has received increasing attention in promoting fracture healing. Thus, the aim of this review article was to investigate the effects of nobiletin on macrophages during fracture healing, with a major focus on the potential mechanisms and applications, and to provide a reference for further research on this compound.<\/jats:p>","DOI":"10.3389\/fphar.2025.1724568","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:34:08Z","timestamp":1767681248000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nobiletin promotes fracture healing by modulating macrophage polarization: a review"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhiqi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangquan","family":"Shou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.18388\/pb.2021_515","article-title":"MicroRNA-mediated gene regulation and the resilience of multicellular animals","volume":"70","author":"Ambros","year":"2024","journal-title":"Postepy Biochem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"9517","DOI":"10.1073\/pnas.1119038109","article-title":"Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization","volume":"109","author":"Arranz","year":"2012","journal-title":"Proc. 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