{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:39:18Z","timestamp":1767595158590,"version":"3.48.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Chronic and infected wounds represent a persistent global health burden. Medicinal plants offer a promising source of wound-healing agents due to their multitarget activities, long history of traditional use, and accessibility.\n                      <jats:italic>Adiantum capillus-veneris<\/jats:italic>\n                      L. (ACV), traditionally used to treat a range of ailments, such as respiratory, urinary, and skin disorders, was investigated for its\n                      <jats:italic>in vitro<\/jats:italic>\n                      wound-healing potential following methanol extraction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the effects of methanol extracts of ACV (ACVM) on cell proliferation, migration and antioxidative capacity in human keratinocytes (HaCaT), and anti-inflammatory activity in RAW 264.7 cells. We also explored its combination with visible light phototherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chemical profiling via HPTLC analysis, UV\/Vis spectrophotometry and HPLC analysis, together confirmed that ACVM contained more metabolites than other extracts, yielding five visible-light absorption peaks and identifying rutin and chlorogenic acid as major metabolites. At \u2264100 \u03bcg\/mL, ACVM was non-toxic to HaCaT cells in the absence of visible light. However, phototoxicity was evident at 200 \u03bcg\/mL. ACVM (50 \u03bcg\/mL) significantly promoted HaCaT migration, with a further enhancement upon exposure to light. ACVM also suppressed H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      -induced ROS generation in a dose-dependent manner (\u226450 \u03bcg\/mL), while light exerted a bidirectional modulatory effect. Additionally, ACVM markedly inhibited LPS-induced secretion of CXCL2, CCL2, CXCL10, TNF-\u03b1, and IL-6 in RAW 264.7 macrophages, with effects evident at concentrations as low as 0.1 \u03bcg\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that ACVM, particularly in combination with light-assisted therapy, shows promise for accelerating wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2025.1729572","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:36:14Z","timestamp":1767594974000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Wound healing and photodynamic potential of Adiantum capillus-veneris L. (Pteridaceae): an evaluation of the cellular effects and molecular insights"],"prefix":"10.3389","volume":"16","author":[{"given":"Linru","family":"Mou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banaz","family":"Jalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majella E.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd L.","family":"Fiebich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Maake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3844\/ojbsci.2024.255.262","article-title":"Wound healing activity of chlorogenic acid in diabetic rats is mediated through antibacterial, antioxidant, and proliferative effects","volume":"24","author":"Al-Ghanayem","year":"2024","journal-title":"OnLine J. 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