{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:11:46Z","timestamp":1778739106675,"version":"3.51.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Etomidate is commonly used for sedation during gastroscopy but is associated with a high incidence of myoclonus. This study evaluated the effectiveness of oliceridine pretreatment in reducing etomidate-induced myoclonus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, double-blind, randomized controlled trial, 150 patients undergoing painless gastroscopy were assigned to receive oliceridine at 0.01\u00a0mg\/kg (Group A\n                      <jats:sub>1<\/jats:sub>\n                      ), 0.02\u00a0mg\/kg (Group A\n                      <jats:sub>2<\/jats:sub>\n                      ), or normal saline (Group S) prior to etomidate administration. Remifentanil (0.2\u00a0\u03bcg\/kg) and etomidate (0.3\u00a0mg\/kg) were then administered. The incidence and severity of myoclonus were assessed within 60\u00a0s post-etomidate injection. Hemodynamic parameters, adverse effects, and satisfaction scores were also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of myoclonus was significantly lower in Groups A\n                      <jats:sub>1<\/jats:sub>\n                      (28%) and A\n                      <jats:sub>2<\/jats:sub>\n                      (16%) compared to Group S (58%) (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). Severe myoclonus occurred less frequently in the oliceridine groups. Heart rate (HR) at T\n                      <jats:sub>1<\/jats:sub>\n                      and T\n                      <jats:sub>2<\/jats:sub>\n                      was significantly lower in Groups A\n                      <jats:sub>1<\/jats:sub>\n                      and A\n                      <jats:sub>2<\/jats:sub>\n                      than in Group S (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05). No significant intergroup differences were observed in mean arterial pressure (MAP) or pulse oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ). Injection pain, hiccups, and cough were less frequent in the oliceridine groups, although not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pretreatment with oliceridine effectively reduces the incidence and severity of etomidate-induced myoclonus during painless gastroscopy without compromising hemodynamic stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>http:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      , identifier ChiCTR2500103005.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1664835","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:33:58Z","timestamp":1778736838000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pretreatment with different doses of oliceridine attenuates etomidate-induced myoclonus during painless gastroscopy: a randomized controlled trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Yingchuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","place":["Xiamen, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","place":["Xiamen, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","place":["Xiamen, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaijian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","place":["Xiamen, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","place":["Xiamen, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/0970-9185.173382","article-title":"Comparative study evaluating efficacy of sufentanil versus midazolam in preventing myoclonic movements following etomidate","volume":"32","author":"Alipour","year":"2016","journal-title":"J. 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