{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:37:02Z","timestamp":1791841022838,"version":"4.3.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alcoholic liver disease (ALD) remains a major global health burden, and effective therapeutic options are limited. Quercetin, a dietary flavonoid with antioxidant and anti-inflammatory properties, has shown hepatoprotective potential, but its mechanisms in acute alcohol-induced liver injury require clarification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty male BALB\/c mice were randomly divided into five groups (n = 10\/group): control (CG), model (MG), low-dose quercetin (LQ, 50 mg\/kg), high-dose quercetin (HQ, 100 mg\/kg), and oyster soybean carnitine mice in the oyster soybean carnitine group (OG) were administered oyster soybean carnitine at a volume of 20 mL\/kg.(OG, 20 mL\/kg). All treatments were administered orally once daily for 14 days. Acute alcohol injury was induced on Day 14 using 52% (v\/v) ethanol. Behavioral intoxication indices, serum biochemistry, liver oxidative stress markers, inflammatory cytokines, histopathology, lipid accumulation, and the expression of lipid-metabolismrelated genes and proteins (FAS, SCD1, ACC1, CPT1, PGC-1\u03b1, PPAR\u03b1) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HQ significantly prolonged alcohol tolerance time (P &amp;lt; 0.01) and shortened sober-up time (P &amp;lt; 0.01). HQ markedly reduced serum AST, ALT, TG, FFA, and glycerol levels (P &amp;lt; 0.01). Quercetin also lowered hepatic TG, TNF-\u03b1, and IL-6 and increased SOD, GSH, and CAT activities. Histological and Oil Red O staining confirmed reduced steatosis. Mechanistically, quercetin downregulated hepatic FAS, SCD1, and ACC1 while upregulating CPT1, PGC-1\u03b1, and PPAR\u03b1 at both mRNA and protein levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quercetin exerts hepatoprotective effects against acute alcohol-induced liver injury through coordinated regulation of lipid metabolism, oxidative stress, and inflammatory responses.The study did not include a quercetin-only group or measure blood ethanol levels, which should be addressed in future work.These findings support the potential of quercetin as a natural candidate for preventing alcohol-related hepatic injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1702639","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:56:14Z","timestamp":1771397774000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Quercetin attenuates acute alcohol-induced liver injury in mice by modulating lipid metabolism, oxidative stress, and inflammation"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenjing","family":"He","sequence":"first","affiliation":[{"name":"Department of Medical Intensive Care Unit, The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Jilin Ruiguo Technology Co., Ltd.","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/MPA.0b013e318264ccae","article-title":"The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo","volume":"42","author":"Angst","year":"2013","journal-title":"Pancreas"},{"key":"B2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. 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