{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:27:06Z","timestamp":1789784826145,"version":"4.0.1"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Hemorrhoids is one of the most prevalent diseases affecting people\u2019s health both in Thailand and worldwide. The therapeutic use of medicinal plants for hemorrhoidal treatments is widespread across many countries, supported by evidence demonstrating the efficacy of their pharmacological activity. This study aims to (1) conduct an in-depth literature review on plants used in Thailand for hemorrhoid treatment and (2) identify the most promising species in traditional Thai medicine to effectively treat hemorrhoids. A total of 53 references were methodically reviewed. The important medicinal plants were determined using ethnobotanical indices including use-value (UV) and choice value of species (CVs), and the important species were selected for an in-depth review of their pharmacological activities. Our literature review found that there were 181 species belonging to 147 genera and 78 families used to treat hemorrhoids among 18 ethnic groups. The most cited species were\n                    <jats:italic>Cissus quadrangularis<\/jats:italic>\n                    ,\n                    <jats:italic>Biancaea sappan<\/jats:italic>\n                    ,\n                    <jats:italic>Croton persimilis<\/jats:italic>\n                    ,\n                    <jats:italic>Mimosa pudica<\/jats:italic>\n                    ,\n                    <jats:italic>Aegle marmelos<\/jats:italic>\n                    ,\n                    <jats:italic>Leea indica<\/jats:italic>\n                    ,\n                    <jats:italic>Plumbago indica<\/jats:italic>\n                    ,\n                    <jats:italic>Rotheca serrata<\/jats:italic>\n                    , and\n                    <jats:italic>Tectona grandis<\/jats:italic>\n                    . Prevalent pharmacological activities such as anti-inflammatory, anti-oxidative, anti-microbial, anti-hemorrhoid, analgesic, and vasorelaxant activities are found in key species used for hemorrhoid treatment. This study identifies the most important species for ethnopharmacological explorations in hemorrhoid treatments, which is expected to inspire the selection of medicinal plants for development into pharmaceutical products.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1705134","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:41:05Z","timestamp":1777009265000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["An ethnobotanical review of medicinal plants used for treating hemorrhoids in Thailand"],"prefix":"10.3389","volume":"17","author":[{"given":"Angkhana","family":"Inta","sequence":"first","affiliation":[{"name":"Yunnan International Joint Laboratory of Health Plant Resources Development, Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences","place":["Kunming, China"]},{"name":"Department of Biology, Faculty of Science, Chiang Mai University","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapeeporn","family":"Kantasrila","sequence":"additional","affiliation":[{"name":"Yunnan International Joint Laboratory of Health Plant Resources Development, Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences","place":["Kunming, China"]},{"name":"Queen Sirikit Botanic Garden (QSBG), The Botanical Garden Organisation","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateep","family":"Panyadee","sequence":"additional","affiliation":[{"name":"Queen Sirikit Botanic Garden (QSBG), The Botanical Garden Organisation","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akharasit","family":"Bunsongthae","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Chiang Mai Rajabhat University","place":["Chiang Mai, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxian","family":"Shi","sequence":"additional","affiliation":[{"name":"Yunnan International Joint Laboratory of Health Plant Resources Development, Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences","place":["Kunming, China"]},{"name":"Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences","place":["Nay Pyi Taw, Myanmar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Fu","sequence":"additional","affiliation":[{"name":"Yunnan International Joint Laboratory of Health Plant Resources Development, Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences","place":["Kunming, China"]},{"name":"Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences","place":["Nay Pyi Taw, Myanmar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyu","family":"Yao","sequence":"additional","affiliation":[{"name":"Yunnan International Joint Laboratory of Health Plant Resources Development, Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/bjs.5378","article-title":"Meta-analysis of flavonoids for the treatment of haemorrhoids","volume":"93","author":"Alonso-Coello","year":"2006","journal-title":"Br. 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