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Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To clarify the mechanism by which\n                      <jats:italic>Schisandra chinensis<\/jats:italic>\n                      regulates the disease-related gut microbiota and to identify potential directions for future research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant literature published between 2020 and 2025 was retrieved from Google scholar and NCBI PubMed. Two authors screened the literature based on titles and abstracts, followed by full-text screening by another two authors to ensure the inclusion of eligible studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found in 61 studies that\n                      <jats:italic>S. chinensis<\/jats:italic>\n                      rich in polysaccharides and lignans, which are primary bioactive compounds involved in modulating gut microbiota composition. These compounds have been extensively studied for their ability to rebalance gut microbiota, repair the intestinal barrier function, increase short-chain fatty acids levels, and regulate metabolic pathways. Therefore,\n                      <jats:italic>S. chinensis<\/jats:italic>\n                      alleviates the symptoms caused by ulcerative colitis, antibiotic-associated diarrhea, alcohol-associated liver disease, type 2 diabetes mellitus, Alzheimer\u2019s disease, non-alcoholic fatty liver disease, systemic inflammation, and neurobehavioral alterations associated with mental illness. Additionally, another study suggested that lignans influence bile acid production by modulating gut microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Current research on\n                      <jats:italic>S. chinensis<\/jats:italic>\n                      regulate gut microbiota, which have demonstrated therapeutic effects in disease. However, the precis mechanisms of\n                      <jats:italic>S. chinensis<\/jats:italic>\n                      regulated the gut microbiota remain unclear, and high-quality clinical trials are lacking to validate the efficacy of\n                      <jats:italic>S. chinensis<\/jats:italic>\n                      in humans.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1721950","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:19:45Z","timestamp":1776403185000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Modulation of disease-associated gut microbiota by Schisandra chinensis: a literature review"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhimei","family":"Liu","sequence":"first","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital to Changchun University of Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Fan","sequence":"additional","affiliation":[{"name":"The 3rd Affiliated Hospital of CCUCM","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Yue","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxia","family":"Sun","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Sun","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital to Changchun University of Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7618","DOI":"10.3390\/ijerph17207618","article-title":"The gut microbiota and inflammation: an overview","volume":"17","author":"Al Bander","year":"2020","journal-title":"Int. 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